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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTD-BCAS3 (FusionGDB2 ID:HG686TG54828)

Fusion Gene Summary for BTD-BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: BTD-BCAS3
Fusion gene ID: hg686tg54828
HgeneTgene
Gene symbol

BTD

BCAS3

Gene ID

686

54828

Gene namebiotinidaseBCAS3 microtubule associated cell migration factor
Synonyms-GAOB1|MAAB
Cytomap('BTD')('BCAS3')

3p25.1

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionbiotinidasebiotinasebreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2020031320200313
UniProtAcc

P43251

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000303498, ENST00000383778, 
ENST00000437172, ENST00000449107, 
ENST00000482824, 
Fusion gene scores* DoF score3 X 3 X 2=1845 X 32 X 19=27360
# samples 353
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(53/27360*10)=-5.6899320603227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTD [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTD(15686438)-BCAS3(59445688), # samples:2
Anticipated loss of major functional domain due to fusion event.BTD-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTD-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTD-BCAS3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check buttonFusion gene breakpoints across BTD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BCAS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L2-01ABTDchr3

15686438

+BCAS3chr17

59445688

+
ChimerDB4SARCTCGA-DX-A8BJ-01ABTDchr3

15686438

+BCAS3chr17

59445688

+


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Fusion Gene ORF analysis for BTD-BCAS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000303498ENST00000585812BTDchr3

15686438

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000383778ENST00000585812BTDchr3

15686438

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000437172ENST00000585812BTDchr3

15686438

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000449107ENST00000585812BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000390652BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000407086BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000408905BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000585744BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000588462BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000588874BTDchr3

15686438

+BCAS3chr17

59445688

+
Frame-shiftENST00000437172ENST00000589222BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000390652BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000407086BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000408905BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000585744BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000588462BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000588874BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000303498ENST00000589222BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000390652BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000407086BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000408905BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000585744BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000588462BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000588874BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000383778ENST00000589222BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000390652BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000407086BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000408905BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000585744BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000588462BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000588874BTDchr3

15686438

+BCAS3chr17

59445688

+
In-frameENST00000449107ENST00000589222BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000390652BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000407086BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000408905BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000585744BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000588462BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000588874BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3CDSENST00000482824ENST00000589222BTDchr3

15686438

+BCAS3chr17

59445688

+
intron-3UTRENST00000482824ENST00000585812BTDchr3

15686438

+BCAS3chr17

59445688

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449107BTDchr315686438+ENST00000589222BCAS3chr1759445688+238412046571219
ENST00000449107BTDchr315686438+ENST00000407086BCAS3chr1759445688+222712046571219
ENST00000449107BTDchr315686438+ENST00000390652BCAS3chr1759445688+223412046571219
ENST00000449107BTDchr315686438+ENST00000408905BCAS3chr1759445688+229312046571219
ENST00000449107BTDchr315686438+ENST00000588462BCAS3chr1759445688+229312046571219
ENST00000449107BTDchr315686438+ENST00000585744BCAS3chr1759445688+152112045701109179
ENST00000449107BTDchr315686438+ENST00000588874BCAS3chr1759445688+222612045701109179
ENST00000303498BTDchr315686438+ENST00000589222BCAS3chr1759445688+2639145967216218
ENST00000303498BTDchr315686438+ENST00000407086BCAS3chr1759445688+2482145967216218
ENST00000303498BTDchr315686438+ENST00000390652BCAS3chr1759445688+2489145967216218
ENST00000303498BTDchr315686438+ENST00000408905BCAS3chr1759445688+2548145967216218
ENST00000303498BTDchr315686438+ENST00000588462BCAS3chr1759445688+2548145967216218
ENST00000303498BTDchr315686438+ENST00000585744BCAS3chr1759445688+177614595851124179
ENST00000303498BTDchr315686438+ENST00000588874BCAS3chr1759445688+248114595851124179
ENST00000383778BTDchr315686438+ENST00000589222BCAS3chr1759445688+27021522861313182
ENST00000383778BTDchr315686438+ENST00000407086BCAS3chr1759445688+25451522861313182
ENST00000383778BTDchr315686438+ENST00000390652BCAS3chr1759445688+25521522861313182
ENST00000383778BTDchr315686438+ENST00000408905BCAS3chr1759445688+26111522861313182
ENST00000383778BTDchr315686438+ENST00000588462BCAS3chr1759445688+26111522861313182
ENST00000383778BTDchr315686438+ENST00000585744BCAS3chr1759445688+18391522861313182
ENST00000383778BTDchr315686438+ENST00000588874BCAS3chr1759445688+25441522861313182

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449107ENST00000589222BTDchr315686438+BCAS3chr1759445688+0.0093291380.9906709
ENST00000449107ENST00000407086BTDchr315686438+BCAS3chr1759445688+0.0088590080.99114096
ENST00000449107ENST00000390652BTDchr315686438+BCAS3chr1759445688+0.009032170.9909678
ENST00000449107ENST00000408905BTDchr315686438+BCAS3chr1759445688+0.0122199330.9877801
ENST00000449107ENST00000588462BTDchr315686438+BCAS3chr1759445688+0.0122199330.9877801
ENST00000449107ENST00000585744BTDchr315686438+BCAS3chr1759445688+0.0050431340.9949569
ENST00000449107ENST00000588874BTDchr315686438+BCAS3chr1759445688+0.0087779020.99122214
ENST00000303498ENST00000589222BTDchr315686438+BCAS3chr1759445688+0.0123837430.98761624
ENST00000303498ENST00000407086BTDchr315686438+BCAS3chr1759445688+0.0134721990.98652786
ENST00000303498ENST00000390652BTDchr315686438+BCAS3chr1759445688+0.013586220.9864138
ENST00000303498ENST00000408905BTDchr315686438+BCAS3chr1759445688+0.0127727650.98722726
ENST00000303498ENST00000588462BTDchr315686438+BCAS3chr1759445688+0.0127727650.98722726
ENST00000303498ENST00000585744BTDchr315686438+BCAS3chr1759445688+0.0096147680.9903852
ENST00000303498ENST00000588874BTDchr315686438+BCAS3chr1759445688+0.0135475940.98645246
ENST00000383778ENST00000589222BTDchr315686438+BCAS3chr1759445688+0.038370890.9616291
ENST00000383778ENST00000407086BTDchr315686438+BCAS3chr1759445688+0.0386048070.96139526
ENST00000383778ENST00000390652BTDchr315686438+BCAS3chr1759445688+0.038128680.9618713
ENST00000383778ENST00000408905BTDchr315686438+BCAS3chr1759445688+0.0581893180.94181067
ENST00000383778ENST00000588462BTDchr315686438+BCAS3chr1759445688+0.0581893180.94181067
ENST00000383778ENST00000585744BTDchr315686438+BCAS3chr1759445688+0.031792870.9682072
ENST00000383778ENST00000588874BTDchr315686438+BCAS3chr1759445688+0.03889460.9611054

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Fusion Genomic Features for BTD-BCAS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BTD-BCAS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:15686438/chr17:59445688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTD

P43251

BCAS3

Q9H6U6

FUNCTION: Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTDchr3:15686438chr17:59445688ENST00000303498+1472_3510544.0DomainCN hydrolase


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Fusion Gene Sequence for BTD-BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10508_10508_1_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000390652_length(transcript)=2489nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGC
TACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTG
GCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCC
AAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTG
TCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTAT
TTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCC
ACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCC
CCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCT
GTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCC
CTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCATCCCTGA

>10508_10508_1_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000390652_length(amino acids)=218AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALSAPS
ALNMRMRHSPFTAPKTLQLADSETMARGLRVRLLTCFA

--------------------------------------------------------------
>10508_10508_2_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000407086_length(transcript)=2482nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGC
TACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTG
GCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCC
AAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTG
TCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTAT
TTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCC
ACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCC
CCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCT
GTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCC
CTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_2_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000407086_length(amino acids)=218AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALSAPS
ALNMRMRHSPFTAPKTLQLADSETMARGLRVRLLTCFA

--------------------------------------------------------------
>10508_10508_3_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000408905_length(transcript)=2548nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAACTTCAGCGAGAGGGA
AGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAAT
GAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGG
AGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCA
TCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGA
GACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGG
CGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTG
GACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGA
GGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTC
TTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTC
CAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_3_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000408905_length(amino acids)=218AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALSAPS
ALNMRMRHSPFTAPKTLQLADSETMARGLRVRLLTCFA

--------------------------------------------------------------
>10508_10508_4_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000585744_length(transcript)=1776nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGC
TACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAG

>10508_10508_4_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000585744_length(amino acids)=179AA_BP=
MSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYY
IQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

--------------------------------------------------------------
>10508_10508_5_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000588462_length(transcript)=2548nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAACTTCAGCGAGAGGGA
AGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAAT
GAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGG
AGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCA
TCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGA
GACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGG
CGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTG
GACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGA
GGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTC
TTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTC
CAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_5_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000588462_length(amino acids)=218AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALSAPS
ALNMRMRHSPFTAPKTLQLADSETMARGLRVRLLTCFA

--------------------------------------------------------------
>10508_10508_6_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000588874_length(transcript)=2481nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGC
TACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTG
GCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCC
AAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTG
TCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTAT
TTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCC
ACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCC
CCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCT
GTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCC
CTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCC

>10508_10508_6_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000588874_length(amino acids)=179AA_BP=
MSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYY
IQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

--------------------------------------------------------------
>10508_10508_7_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000589222_length(transcript)=2639nt_BP=1459nt
AGCAGGAGATTGCTGCCTATGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTTT
TCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATTATGTCTGGAGC
CAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGA
GGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGA
GCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGG
CATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCT
GGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCAC
TGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGG
GGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCC
CTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGAC
ACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTT
CTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGG
CTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGAC
AGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTG
GGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTC
ACATTTATCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAATAAATGTCAGTTTA
TATTTTACACATCCACAAAGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCAC
ATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCC
GGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGGGAAAAAAAAAGGAAAA
AAAAAACAATGCCAACAGCCCAGCGTCCGTGAGCAACCCAACAGTAACAAAGCATGCGTTCGGGATGGAGGAAGAACTTCAGCGAGAGGG
AAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAA
TGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAG
GAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCC
ATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAG
AGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGG
GCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGT
GGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGG
AGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTT
CTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGT
CCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_7_BTD-BCAS3_BTD_chr3_15686438_ENST00000303498_BCAS3_chr17_59445688_ENST00000589222_length(amino acids)=218AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALSAPS
ALNMRMRHSPFTAPKTLQLADSETMARGLRVRLLTCFA

--------------------------------------------------------------
>10508_10508_8_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000390652_length(transcript)=2552nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGC
ATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAG
AGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGG
GGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCC
TACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGAC
TGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGG
GTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGAC
AGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGC
CCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTA
TCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAA
TAAATCACGCTGCAGTTGGTGTCCATCCCTGA

>10508_10508_8_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000390652_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_9_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000407086_length(transcript)=2545nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGC
ATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAG
AGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGG
GGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCC
TACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGAC
TGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGG
GTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGAC
AGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGC
CCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTA
TCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAA
TAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_9_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000407086_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_10_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000408905_length(transcript)=2611nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCA
GTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCA
GGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCG
ACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTAC
CCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTT
CTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTAT
GTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGAC
CAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTG
GCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAG
GGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTC
CTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCC
A

>10508_10508_10_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000408905_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_11_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000585744_length(transcript)=1839nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGC
ATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAG
AGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAG

>10508_10508_11_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000585744_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_12_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000588462_length(transcript)=2611nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCA
GTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCA
GGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCG
ACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTAC
CCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTT
CTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTAT
GTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGAC
CAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTG
GCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAG
GGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTC
CTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCC
A

>10508_10508_12_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000588462_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_13_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000588874_length(transcript)=2544nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGC
ATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAG
AGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGG
GGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCC
TACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGAC
TGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGG
GTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGAC
AGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGC
CCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTA
TCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAA
TAAATCACGCTGCAGTTGGTGTCC

>10508_10508_13_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000588874_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_14_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000589222_length(transcript)=2702nt_BP=1522nt
AGTTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGCTGTTTGTGCGTTGCTGCT
GTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTACGCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTAT
TGTAGCGCACGTTACTTAAATCCAGAAGCAGATGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCT
GAGATCCTGAATCCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGATTTGTGGTCTGCATTAT
GTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGA
CCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGA
GGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCC
AGAAGATGGCATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAA
CCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAG
GAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTC
CCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAG
CTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTT
GGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTT
CCTTTGTTTCTGACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTG
TCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCAT
CATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTAAGGGCAGGAGCCCACTTCTGTGGCACCAGAT
TCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCAGATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGTACCTTT
GACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAG
GGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCA
GTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGGGAAAAAAAAAGGAAAAAAAAAACAATGCCAACAGCCCAGCGTC
CGTGAGCAACCCAACAGTAACAAAGCATGCGTTCGGGATGGAGGAAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTC
AGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCC
GACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTA
CCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCT
TCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTA
TGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGA
CCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCT
GGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAA
GGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGT
CCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTC
CA

>10508_10508_14_BTD-BCAS3_BTD_chr3_15686438_ENST00000383778_BCAS3_chr17_59445688_ENST00000589222_length(amino acids)=182AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSSRCSFH
RL

--------------------------------------------------------------
>10508_10508_15_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000390652_length(transcript)=2234nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCA
AGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCA
ACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCA
TCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGC
CCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTG
GATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGA
CAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGC
TTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCC
TTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACC
GTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCATCCCTGA

>10508_10508_15_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000390652_length(amino acids)=219AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALHRQQ
SPASPASLWHSGARMEEPRRERSSDWRTRVFTFSPLPGS

--------------------------------------------------------------
>10508_10508_16_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000407086_length(transcript)=2227nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCA
AGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCA
ACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCA
TCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGC
CCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTG
GATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGA
CAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGC
TTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCC
TTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACC
GTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_16_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000407086_length(amino acids)=219AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALHRQQ
SPASPASLWHSGARMEEPRRERSSDWRTRVFTFSPLPGS

--------------------------------------------------------------
>10508_10508_17_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000408905_length(transcript)=2293nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAA
CTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCT
CCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCC
CTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGT
GACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAG
GCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACC
ATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCA
TTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAG
CACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGG
AAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAA
AGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_17_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000408905_length(amino acids)=219AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALHRQQ
SPASPASLWHSGARMEEPRRERSSDWRTRVFTFSPLPGS

--------------------------------------------------------------
>10508_10508_18_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000585744_length(transcript)=1521nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCA
AGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAG

>10508_10508_18_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000585744_length(amino acids)=179AA_BP=
MSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYY
IQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

--------------------------------------------------------------
>10508_10508_19_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000588462_length(transcript)=2293nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGAA
CTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCT
CCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCCC
CTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAGT
GACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGAG
GCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAACC
ATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCCA
TTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCAG
CACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGGG
AAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAAA
AGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_19_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000588462_length(amino acids)=219AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALHRQQ
SPASPASLWHSGARMEEPRRERSSDWRTRVFTFSPLPGS

--------------------------------------------------------------
>10508_10508_20_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000588874_length(transcript)=2226nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCA
AGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCA
ACCTGCTTCTGACTGGCCAGCCCCCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCA
TCAACCACCTTCCCCAAGCTTAGTGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGC
CCTCTGCCACACCTGTCGGTGGAGGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTG
GATCCGCTTTTGTATTTTTTAACCATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGA
CAGAGTTGATCGTCCACCTGGCCATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGC
TTCCCTTGGTCAGCCCCACTCCAGCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCC
TTTCTTTCCCCATCTGTTCATGGGAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACC
GTGGTTACTGAGGCCCTGTTGAAAAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCC

>10508_10508_20_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000588874_length(amino acids)=179AA_BP=
MSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYY
IQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

--------------------------------------------------------------
>10508_10508_21_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000589222_length(transcript)=2384nt_BP=1204nt
CACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTCTCTTCTCGGCTCCTCCATTCGCGCGCCAGAAT
GCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTATGCAAAGCAGATTTGTGGTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGC
TCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGGGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGT
GGCTGCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAACCAGAA
CCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAA
CTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGGAACCCATGCCTGGAGCCTCACCGCTT
CAATGACACAGAGGTAAGTTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACC
AAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTAT
CTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTGGGGGTCTTTGAT
GGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAA
ATCACAGAGGCCACGGGGATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATG
ACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCT
CTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGGCGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCA
CAGGCTACAAGCCCTGGGACCATCTTTCTGCCTTGTACCTTTGACAGGAGCGTGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGC
TTCGGGCTGCGGCACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAGTCACCTAGCCGG
GACGTCGTGGGATCCGGAACAGACACAGCCCTTGACGTAGCAGTAAAAACCTTCCCCCCTGAGAGACACGTGGCAGTGAAGTGTTTTGGG
AAAAAAAAAGGAAAAAAAAAACAATGCCAACAGCCCAGCGTCCGTGAGCAACCCAACAGTAACAAAGCATGCGTTCGGGATGGAGGAAGA
ACTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATC
TCCGCTGCCCACCAATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAGGTACCAGCAACCTGCTTCTGACTGGCCAGCCC
CCTCCCCTGCTGGAGGAGGGGAGAAGCCCCGCTCTGGTCCTACCCTTCAGTCTCTGCTCTTCCTTCATCAACCACCTTCCCCAAGCTTAG
TGACAGCAGCCGCCCATCCTACCTGGATGGAGAAGAGACCCTTCTCCAAGCACCTCAGCGCACTTGCCCTCTGCCACACCTGTCGGTGGA
GGCTGTGGCCAGGAGAGACTGTAGAAGCTCGGTCCCTGTGTATGTTTGCATATGACATCCTGCATTGGATCCGCTTTTGTATTTTTTAAC
CATACCCACGGTGGGGCGGGTGGGGGGAGCCTGGAACAGTGACCAGATCTGGGGGCCTGAGTGGGGACAGAGTTGATCGTCCACCTGGCC
ATTTTGACCCTGAGTGGACAGTCACAGCCTCAGCTCATGTCTGGCTGTGACACACACTGCCCCCAGCTTCCCTTGGTCAGCCCCACTCCA
GCACGGGGTGAACGGAGGCCCAGAGTACTAGGGAAGGAGGAAGGGAGGACATGCCTCTTCTTCCTCCTTTCTTTCCCCATCTGTTCATGG
GAAGAGTTTGTCTTTCTTATCTTTAAGCCCCTTTACCCTGGTCCTGTACTGATCAGTGAAGGAAACCGTGGTTACTGAGGCCCTGTTGAA
AAGTGCACGTCTTGTCCAATAAATCACGCTGCAGTTGGTGTCCA

>10508_10508_21_BTD-BCAS3_BTD_chr3_15686438_ENST00000449107_BCAS3_chr17_59445688_ENST00000589222_length(amino acids)=219AA_BP=
MWEEHSRSTWWPHHSGLPEHPSHSTDRLTKFLKTYLCVIEAVRLQAWVPPDHLGRRHEVQKWINGCSCKVESMNAIFWKHYNLYILLGCS
HHLLFIDVKVLVHELQGLLAADESQRVQTQDGWMLIHGSHIIFSLVMVSHALLPGVGSQGNHVTAAEEKSKLTSGSRHNADHKSALHRQQ
SPASPASLWHSGARMEEPRRERSSDWRTRVFTFSPLPGS

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Fusion Gene PPI Analysis for BTD-BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTD-BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTD-BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBTDC0220754Biotinidase Deficiency13CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBTDC0004352Autistic Disorder1CTD_human
HgeneBTDC0019193Hepatitis, Toxic1CTD_human
HgeneBTDC0860207Drug-Induced Liver Disease1CTD_human
HgeneBTDC1262760Hepatitis, Drug-Induced1CTD_human
HgeneBTDC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneBTDC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneBTDC4279912Chemically-Induced Liver Toxicity1CTD_human