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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TAF4-GATA5 (FusionGDB2 ID:HG6874TG140628)

Fusion Gene Summary for TAF4-GATA5

check button Fusion gene summary
Fusion gene informationFusion gene name: TAF4-GATA5
Fusion gene ID: hg6874tg140628
HgeneTgene
Gene symbol

TAF4

GATA5

Gene ID

6874

140628

Gene nameTATA-box binding protein associated factor 4GATA binding protein 5
SynonymsTAF2C|TAF2C1|TAF4A|TAFII130|TAFII135CHTD5|GATAS|bB379O24.1
Cytomap('TAF4')('GATA5')

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
Descriptiontranscription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit CTAF(II)130TAF(II)135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaTAF4A RNA polymerase II, TATA box binding protein (TBPtranscription factor GATA-5GATA binding factor-5
Modification date2020031320200313
UniProtAcc.

Q9BWX5

Ensembl transtripts involved in fusion geneENST00000252996, ENST00000609045, 
Fusion gene scores* DoF score13 X 9 X 7=8192 X 2 X 1=4
# samples 173
** MAII scorelog2(17/819*10)=-2.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/4*10)=2.90689059560852
Context

PubMed: TAF4 [Title/Abstract] AND GATA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTAF4(60639507)-GATA5(61040977), # samples:3
Anticipated loss of major functional domain due to fusion event.TAF4-GATA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF4-GATA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF4-GATA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TAF4-GATA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTAF4

GO:0006352

DNA-templated transcription, initiation

9603525

HgeneTAF4

GO:0006367

transcription initiation from RNA polymerase II promoter

9603525

HgeneTAF4

GO:0045893

positive regulation of transcription, DNA-templated

12771217

TgeneGATA5

GO:0045944

positive regulation of transcription by RNA polymerase II

14986113

TgeneGATA5

GO:0060575

intestinal epithelial cell differentiation

9566909


check buttonFusion gene breakpoints across TAF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GATA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A13D-01ATAF4chr20

60639507

-GATA5chr20

61040977

-
ChimerDB4BRCATCGA-A7-A13DTAF4chr20

60639506

-GATA5chr20

61040977

-


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Fusion Gene ORF analysis for TAF4-GATA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252996ENST00000252997TAF4chr20

60639507

-GATA5chr20

61040977

-
In-frameENST00000252996ENST00000252997TAF4chr20

60639506

-GATA5chr20

61040977

-
intron-3CDSENST00000609045ENST00000252997TAF4chr20

60639507

-GATA5chr20

61040977

-
intron-3CDSENST00000609045ENST00000252997TAF4chr20

60639506

-GATA5chr20

61040977

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000252996TAF4chr2060639507-ENST00000252997GATA5chr2061040977-3068136001496498
ENST00000252996TAF4chr2060639506-ENST00000252997GATA5chr2061040977-3068136001496498

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252996ENST00000252997TAF4chr2060639507-GATA5chr2061040977-0.089666540.91033345
ENST00000252996ENST00000252997TAF4chr2060639506-GATA5chr2061040977-0.089666540.91033345

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Fusion Genomic Features for TAF4-GATA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TAF4-GATA5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60639507/chr20:61040977)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GATA5

Q9BWX5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888). {ECO:0000250|UniProtKB:P97489, ECO:0000269|PubMed:23289003, ECO:0000269|PubMed:25543888}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115142_1484531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115270_2774531086.0Compositional biasNote=Poly-Pro
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115333_3394531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-11539_424531086.0Compositional biasNote=Poly-His
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-11552_574531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-11598_1014531086.0Compositional biasNote=Poly-Gly
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115142_1484531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115270_2774531086.0Compositional biasNote=Poly-Pro
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115333_3394531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-11539_424531086.0Compositional biasNote=Poly-His
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-11552_574531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-11598_1014531086.0Compositional biasNote=Poly-Gly

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115682_6854531086.0Compositional biasNote=Poly-Pro
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115810_8154531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115830_8334531086.0Compositional biasNote=Poly-Asp
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115682_6854531086.0Compositional biasNote=Poly-Pro
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115810_8154531086.0Compositional biasNote=Poly-Ala
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115830_8334531086.0Compositional biasNote=Poly-Asp
HgeneTAF4chr20:60639506chr20:61040977ENST00000252996-115590_6874531086.0DomainTAFH
HgeneTAF4chr20:60639507chr20:61040977ENST00000252996-115590_6874531086.0DomainTAFH
TgeneGATA5chr20:60639506chr20:61040977ENST0000025299737189_213275398.0Zinc fingerGATA-type 1
TgeneGATA5chr20:60639506chr20:61040977ENST0000025299737243_267275398.0Zinc fingerGATA-type 2
TgeneGATA5chr20:60639507chr20:61040977ENST0000025299737189_213275398.0Zinc fingerGATA-type 1
TgeneGATA5chr20:60639507chr20:61040977ENST0000025299737243_267275398.0Zinc fingerGATA-type 2


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Fusion Gene Sequence for TAF4-GATA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88801_88801_1_TAF4-GATA5_TAF4_chr20_60639506_ENST00000252996_GATA5_chr20_61040977_ENST00000252997_length(transcript)=3068nt_BP=1360nt
ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG
TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC
CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC
CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG
CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC
GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC
GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC
GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG
CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG
CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC
GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG
CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC
CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG
CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC
AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG
CTGCCCCCAGGTGCCGCGGCCTCTGGCTATGAAGAAGGAAAGCATCCAGACACGGAAGCGGAAGCCAAAGACCATCGCCAAGGCCAGGGG
CTCCTCAGGATCCACAAGGAATGCCTCGGCCTCCCCATCTGCTGTCGCCAGCACTGACAGCTCAGCAGCCACTTCGAAAGCCAAGCCCAG
CCTGGCGTCCCCAGTGTGCCCTGGGCCCAGCATGGCCCCCCAGGCCTCTGGCCAGGAGGATGACTCTCTTGCCCCCGGCCACTTGGAGTT
CAAGTTCGAGCCTGAGGACTTTGCCTTCCCCTCCACGGCCCCAAGCCCCCAGGCTGGCCTCAGGGGGGCTCTGCGCCAAGAGGCCTGGTG
TGCGCTGGCCTTGGCCTAGGTCCCCAGGCCAGCCCATGTCAGGGGAACAGCCTGGAACAGACCACCCACTGAGTCACCTCCGTGCCTGCT
TTGCTCCAGCACAGCAGAGACCAGCAGGCCCCCCAACCCAGAGACTGGGTCTGCTGGAGTCTCCACACAGTGGTGGGGAGGCCTTCTGGA
CAGACGGCAGTCGGGCCCCAGAGCAAGAAGGCTGGTGAGGGAAGGGCTCAGCTTCCCACCCCACGTACAGCAAGGGACTCCCCAGGTGCG
GCCCAAGGCTCCGGACCACACTGGCCCCCTGCGGCGGAGGCCAACGCAGGGCACCACCACCACCAACTTGAATTCCGTCATCAATGCTCA
CCGTCAATATGTTTACAAGTTGTAGCAGTTGGGGGAAAACAGTCAACCTCCCAGTGTAAAACCAAGATTCCCAGTGAAGCACCTGAGGCC
AAGCAGGGGAGAGGAATGAGGGGAGCAGCTGGACATGGGCCTCCTGAGGCCTCGGGGCTGTCCTTCATTGCCCACATGGATAGACGGAGC
TGTGGTGCAGAGAACTTTTCCCGCAACAGGTGCAGGACTGCCAGGGATCGGAGTGCGGGCCGCGCACGGTGCCAGGATTCCGCCGAGGGG
AAGCCGCTCACATTGCAGTCATCACAGACTTACGCACTTGTTTGGACAGTTTTTCCAGAGGGGATGGGAAAGGGCCTTGTTCTAGCTGAA
TCTGTGTATCATGACCATTTCTGACAGGCAGAATGAATTGTCTGGTAGCCCTGTCCTGACCCATCCAAGCGCTGTTGGGGCTGGTGGTGA
CGTGGTCACATGTCCTGGCATATCTGGGGCCACGCAGTTTAGTCTCTTGTCCCAGGAGAATTGTTAGTGACCCCTCTTTCTCTTGCAAGC
CCCCTCCACACTGGGTTGGATGATACCTTAATGAGTGACGCTGGCGAGAGGCACCCTACCCGACGCAGCTGTGAATGGCCGGTGATGTAT
GTCAGGAGGCCACAGGGAGCAGAGGAGCGGGGCAGGCAGCCACAGGGCCCTGCGGGGAGCACATCCTCGCCTCCGTCCGGCTGCTGCCCT
TCAACAACAAGCCCTGATTTTTCCAGCAATGCCAGAAACCTGGATTTTAAGTCTTCCAATTTGATTCAAAAATATTTTTAACATTGTGAG
CCAGCTAGACCCCCAGTGCACCACCCCATATTGAAAAACAGTTGTCTGGCATCAGCTTCAGGAGCGGGTCCGGTCATTCTGAAACTGTCC
CTCCAGAGGTTCTTCCAGCCCCACTTCTATGCGATGTCATCTTTTCTAAAAGAGACAAATGAAGCCACAGGGAAAGTGAAATAAAGCCTT

>88801_88801_1_TAF4-GATA5_TAF4_chr20_60639506_ENST00000252996_GATA5_chr20_61040977_ENST00000252997_length(amino acids)=498AA_BP=62
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPP
PAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP
GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAP
PPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT
LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQ

--------------------------------------------------------------
>88801_88801_2_TAF4-GATA5_TAF4_chr20_60639507_ENST00000252996_GATA5_chr20_61040977_ENST00000252997_length(transcript)=3068nt_BP=1360nt
ATGGCGGCGGGCTCGGATCTGCTGGACGAGGTCTTCTTCAACAGCGAGGTGGACGAGAAAGTGGTGAGCGACCTGGTGGGCTCGCTGGAG
TCGCAGCTGGCGGCCAGCGCGGCCCACCACCACCACCTCGCGCCGCGCACGCCCGAGGTGCGGGCCGCGGCCGCCGGCGCGCTCGGGAAC
CATGTTGTGAGCGGCAGCCCGGCCGGAGCCGCGGGCGCAGGGCCGGCCGCCCCCGCCGAGGGCGCGCCCGGAGCGGCGCCGGAGCCGCCC
CCCGCAGGTAGAGCGCGGCCGGGGGGCGGGGGGCCGCAGCGCCCGGGCCCCCCCTCACCGCGCCGCCCCCTTGTCCCCGCAGGGCCCGCG
CCGCCCGCCGCGAAGCTGAGGCCGCCGCCCGAGGGCAGCGCGGGGTCCTGCGCCCCGGTGCCCGCCGCCGCCGCCGTCGCCGCGGGGCCC
GAGCCCGCCCCCGCCGGCCCCGCCAAGCCCGCCGGCCCCGCCGCGCTGGCCGCCCGCGCCGGCCCCGGCCCCGGGCCCGGCCCCGGCCCC
GGCCCCGGCCCTGGCCCTGGCAAGCCCGCCGGCCCCGGCGCCGCGCAAACTTTGAATGGGAGCGCCGCGCTGCTGAACTCGCACCACGCC
GCCGCACCTGCTGTCAGCCTGGTCAACAACGGGCCCGCCGCGCTGCTGCCGCTGCCCAAGCCCGCCGCCCCCGGCACTGTCATCCAGACG
CCCCCCTTCGTGGGCGCCGCCGCGCCCCCCGCGCCCGCCGCGCCCTCGCCCCCCGCCGCCCCCGCGCCCGCCGCCCCCGCCGCCGCCCCG
CCCCCGCCACCCCCCGCGCCCGCCACTCTGGCCCGGCCGCCCGGCCACCCCGCCGGACCCCCGACCGCCGCGCCCGCCGTGCCGCCCCCC
GCCGCCGCCCAGAACGGGGGCAGCGCCGGGGCAGCCCCCGCCCCCGCCCCGGCCGCCGGGGGCCCCGCGGGGGTCAGCGGCCAACCCGGG
CCCGGCGCGGCGGCTGCGGCGCCGGCGCCGGGGGTCAAGGCCGAGTCGCCCAAGAGGGTGGTGCAGGCGGCGCCCCCGGCGGCGCAGACC
CTGGCGGCCAGCGGCCCGGCCAGCACGGCGGCCAGCATGGTCATCGGGCCAACTATGCAAGGGGCGCTGCCCAGCCCGGCCGCCGTCCCG
CCGCCCGCCCCCGGGACCCCCACCGGGCTGCCCAAAGGCGCGGCCGGCGCAGTGACCCAGAGCCTGTCCCGGACGCCCACGGCCACCACC
AGCGGGATTCGGGCCACCCTGACGCCCACCGTGCTGGCCCCCCGCTTGCCGCAGCCGCCTCAGAACCCGACCAACATCCAGAACTTCCAG
CTGCCCCCAGGTGCCGCGGCCTCTGGCTATGAAGAAGGAAAGCATCCAGACACGGAAGCGGAAGCCAAAGACCATCGCCAAGGCCAGGGG
CTCCTCAGGATCCACAAGGAATGCCTCGGCCTCCCCATCTGCTGTCGCCAGCACTGACAGCTCAGCAGCCACTTCGAAAGCCAAGCCCAG
CCTGGCGTCCCCAGTGTGCCCTGGGCCCAGCATGGCCCCCCAGGCCTCTGGCCAGGAGGATGACTCTCTTGCCCCCGGCCACTTGGAGTT
CAAGTTCGAGCCTGAGGACTTTGCCTTCCCCTCCACGGCCCCAAGCCCCCAGGCTGGCCTCAGGGGGGCTCTGCGCCAAGAGGCCTGGTG
TGCGCTGGCCTTGGCCTAGGTCCCCAGGCCAGCCCATGTCAGGGGAACAGCCTGGAACAGACCACCCACTGAGTCACCTCCGTGCCTGCT
TTGCTCCAGCACAGCAGAGACCAGCAGGCCCCCCAACCCAGAGACTGGGTCTGCTGGAGTCTCCACACAGTGGTGGGGAGGCCTTCTGGA
CAGACGGCAGTCGGGCCCCAGAGCAAGAAGGCTGGTGAGGGAAGGGCTCAGCTTCCCACCCCACGTACAGCAAGGGACTCCCCAGGTGCG
GCCCAAGGCTCCGGACCACACTGGCCCCCTGCGGCGGAGGCCAACGCAGGGCACCACCACCACCAACTTGAATTCCGTCATCAATGCTCA
CCGTCAATATGTTTACAAGTTGTAGCAGTTGGGGGAAAACAGTCAACCTCCCAGTGTAAAACCAAGATTCCCAGTGAAGCACCTGAGGCC
AAGCAGGGGAGAGGAATGAGGGGAGCAGCTGGACATGGGCCTCCTGAGGCCTCGGGGCTGTCCTTCATTGCCCACATGGATAGACGGAGC
TGTGGTGCAGAGAACTTTTCCCGCAACAGGTGCAGGACTGCCAGGGATCGGAGTGCGGGCCGCGCACGGTGCCAGGATTCCGCCGAGGGG
AAGCCGCTCACATTGCAGTCATCACAGACTTACGCACTTGTTTGGACAGTTTTTCCAGAGGGGATGGGAAAGGGCCTTGTTCTAGCTGAA
TCTGTGTATCATGACCATTTCTGACAGGCAGAATGAATTGTCTGGTAGCCCTGTCCTGACCCATCCAAGCGCTGTTGGGGCTGGTGGTGA
CGTGGTCACATGTCCTGGCATATCTGGGGCCACGCAGTTTAGTCTCTTGTCCCAGGAGAATTGTTAGTGACCCCTCTTTCTCTTGCAAGC
CCCCTCCACACTGGGTTGGATGATACCTTAATGAGTGACGCTGGCGAGAGGCACCCTACCCGACGCAGCTGTGAATGGCCGGTGATGTAT
GTCAGGAGGCCACAGGGAGCAGAGGAGCGGGGCAGGCAGCCACAGGGCCCTGCGGGGAGCACATCCTCGCCTCCGTCCGGCTGCTGCCCT
TCAACAACAAGCCCTGATTTTTCCAGCAATGCCAGAAACCTGGATTTTAAGTCTTCCAATTTGATTCAAAAATATTTTTAACATTGTGAG
CCAGCTAGACCCCCAGTGCACCACCCCATATTGAAAAACAGTTGTCTGGCATCAGCTTCAGGAGCGGGTCCGGTCATTCTGAAACTGTCC
CTCCAGAGGTTCTTCCAGCCCCACTTCTATGCGATGTCATCTTTTCTAAAAGAGACAAATGAAGCCACAGGGAAAGTGAAATAAAGCCTT

>88801_88801_2_TAF4-GATA5_TAF4_chr20_60639507_ENST00000252996_GATA5_chr20_61040977_ENST00000252997_length(amino acids)=498AA_BP=62
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPP
PAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP
GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAP
PPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQT
LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQ

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Fusion Gene PPI Analysis for TAF4-GATA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TAF4-GATA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TAF4-GATA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4693563CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 510GENOMICS_ENGLAND;UNIPROT
TgeneC1843687ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)3ORPHANET
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0039685Tetralogy of Fallot1ORPHANET
TgeneC0149630Bicuspid aortic valve1ORPHANET
TgeneC0428791Aortic valve calcification1ORPHANET
TgeneC1260873Aortic valve disorder1ORPHANET
TgeneC3887892Aortic Valve Disease 11ORPHANET