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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:C3-APOA1 (FusionGDB2 ID:HG718TG335)

Fusion Gene Summary for C3-APOA1

Fusion gene summary

Fusion gene information	Fusion gene name: C3-APOA1
	Fusion gene ID: hg718tg335
		Hgene	Tgene
	Gene symbol	C3	APOA1
	Gene ID	718	335
	Gene name	complement C3	apolipoprotein A1
	Synonyms	AHUS5\|ARMD9\|ASP\|C3a\|C3b\|CPAMD1\|HEL-S-62p	HPALP2\|apo(a)
	Cytomap	('C3')('APOA1') 19p13.3	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding pr	apolipoprotein A-Iapo-AIepididymis secretory sperm binding protein
	Modification date	20200327	20200329
	UniProtAcc	.	P02647
	Ensembl transtripts involved in fusion gene	ENST00000245907, ENST00000599668,
Fusion gene scores	* DoF score	28 X 24 X 14=9408	4 X 3 X 2=24
	# samples	33	4
	** MAII score	log2(33/9408*10)=-4.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: C3 [Title/Abstract] AND APOA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C3(6678383)-APOA1(116707865), # samples:1
Anticipated loss of major functional domain due to fusion event.	C3-APOA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C3-APOA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C3-APOA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C3-APOA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	C3	GO:0001934	positive regulation of protein phosphorylation	15833747
Hgene	C3	GO:0010575	positive regulation of vascular endothelial growth factor production	16452172
Hgene	C3	GO:0010828	positive regulation of glucose transmembrane transport	9059512\|15833747
Hgene	C3	GO:0010866	regulation of triglyceride biosynthetic process	10432298
Hgene	C3	GO:0010884	positive regulation of lipid storage	9555951
Hgene	C3	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	15833747
Tgene	APOA1	GO:0002740	negative regulation of cytokine secretion involved in immune response	12458630
Tgene	APOA1	GO:0006656	phosphatidylcholine biosynthetic process	4335615
Tgene	APOA1	GO:0007179	transforming growth factor beta receptor signaling pathway	23726972
Tgene	APOA1	GO:0007186	G protein-coupled receptor signaling pathway	16443932
Tgene	APOA1	GO:0007229	integrin-mediated signaling pathway	23726972
Tgene	APOA1	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	21571275
Tgene	APOA1	GO:0010873	positive regulation of cholesterol esterification	4335615
Tgene	APOA1	GO:0010875	positive regulation of cholesterol efflux	27472885
Tgene	APOA1	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	14967812
Tgene	APOA1	GO:0018158	protein oxidation	12576517
Tgene	APOA1	GO:0018206	peptidyl-methionine modification	12576517
Tgene	APOA1	GO:0030301	cholesterol transport	10559507
Tgene	APOA1	GO:0032489	regulation of Cdc42 protein signal transduction	16443932
Tgene	APOA1	GO:0033344	cholesterol efflux	11162594\|14703508\|15358760\|16443932\|21481393
Tgene	APOA1	GO:0033700	phospholipid efflux	11162594\|14703508
Tgene	APOA1	GO:0034115	negative regulation of heterotypic cell-cell adhesion	21571275
Tgene	APOA1	GO:0034375	high-density lipoprotein particle remodeling	21481393
Tgene	APOA1	GO:0034380	high-density lipoprotein particle assembly	190223
Tgene	APOA1	GO:0035025	positive regulation of Rho protein signal transduction	23726972
Tgene	APOA1	GO:0042632	cholesterol homeostasis	21571275
Tgene	APOA1	GO:0050713	negative regulation of interleukin-1 beta secretion	12458630
Tgene	APOA1	GO:0050728	negative regulation of inflammatory response	21571275
Tgene	APOA1	GO:0050766	positive regulation of phagocytosis	20495215
Tgene	APOA1	GO:0050821	protein stabilization	17655203\|20495215
Tgene	APOA1	GO:0050919	negative chemotaxis	23726972
Tgene	APOA1	GO:0051345	positive regulation of hydrolase activity	7638166
Tgene	APOA1	GO:0051496	positive regulation of stress fiber assembly	23726972
Tgene	APOA1	GO:0055091	phospholipid homeostasis	21571275
Tgene	APOA1	GO:0060354	negative regulation of cell adhesion molecule production	21571275
Tgene	APOA1	GO:0060761	negative regulation of response to cytokine stimulus	21571275
Tgene	APOA1	GO:0070328	triglyceride homeostasis	21571275
Tgene	APOA1	GO:0070371	ERK1 and ERK2 cascade	23726972
Tgene	APOA1	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	23726972
Tgene	APOA1	GO:1902995	positive regulation of phospholipid efflux	27472885

Fusion gene breakpoints across C3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across APOA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-G3-A25Z-01A	C3	chr19	6678383	-	APOA1	chr11	116707865	-

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Fusion Gene ORF analysis for C3-APOA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000245907	ENST00000236850	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5CDS-intron	ENST00000245907	ENST00000375323	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5CDS-intron	ENST00000245907	ENST00000375329	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5UTR-3CDS	ENST00000599668	ENST00000359492	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5UTR-3CDS	ENST00000599668	ENST00000375320	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5UTR-intron	ENST00000599668	ENST00000236850	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5UTR-intron	ENST00000599668	ENST00000375323	C3	chr19	6678383	-	APOA1	chr11	116707865	-
5UTR-intron	ENST00000599668	ENST00000375329	C3	chr19	6678383	-	APOA1	chr11	116707865	-
In-frame	ENST00000245907	ENST00000359492	C3	chr19	6678383	-	APOA1	chr11	116707865	-
In-frame	ENST00000245907	ENST00000375320	C3	chr19	6678383	-	APOA1	chr11	116707865	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000245907	C3	chr19	6678383	-	ENST00000375320	APOA1	chr11	116707865	-	5617	4807	69	4811	1580
ENST00000245907	C3	chr19	6678383	-	ENST00000359492	APOA1	chr11	116707865	-	5617	4807	69	4811	1580

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000245907	ENST00000375320	C3	chr19	6678383	-	APOA1	chr11	116707865	-	0.002843272	0.99715674
ENST00000245907	ENST00000359492	C3	chr19	6678383	-	APOA1	chr11	116707865	-	0.002843272	0.99715674

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Fusion Genomic Features for C3-APOA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for C3-APOA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:6678383/chr11:116707865)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	APOA1 P02647
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269\|PubMed:1909888}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr19:6678383

chr11:116707865

ENST00000245907

693_728

1571

1664.0

Domain

Anaphylatoxin-like

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

68_267

268.0

Region

Note=10 X approximate tandem repeats

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

68_267

268.0

Region

Note=10 X approximate tandem repeats

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

68_267

268.0

Region

Note=10 X approximate tandem repeats

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

68_267

268.0

Region

Note=10 X approximate tandem repeats

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

112_122

268.0

Repeat

Note=3%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

123_144

268.0

Repeat

Note=4

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

145_166

268.0

Repeat

Note=5

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

167_188

268.0

Repeat

Note=6

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

189_210

268.0

Repeat

Note=7

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

211_232

268.0

Repeat

Note=8

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

233_243

268.0

Repeat

Note=9%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

244_267

268.0

Repeat

Note=10

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

68_89

268.0

Repeat

Note=1

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000236850

90_111

268.0

Repeat

Note=2

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

112_122

268.0

Repeat

Note=3%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

123_144

268.0

Repeat

Note=4

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

145_166

268.0

Repeat

Note=5

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

167_188

268.0

Repeat

Note=6

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

189_210

268.0

Repeat

Note=7

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

211_232

268.0

Repeat

Note=8

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

233_243

268.0

Repeat

Note=9%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

244_267

268.0

Repeat

Note=10

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

68_89

268.0

Repeat

Note=1

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000359492

90_111

268.0

Repeat

Note=2

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

112_122

268.0

Repeat

Note=3%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

123_144

268.0

Repeat

Note=4

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

145_166

268.0

Repeat

Note=5

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

167_188

268.0

Repeat

Note=6

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

189_210

268.0

Repeat

Note=7

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

211_232

268.0

Repeat

Note=8

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

233_243

268.0

Repeat

Note=9%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

244_267

268.0

Repeat

Note=10

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

68_89

268.0

Repeat

Note=1

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375320

90_111

268.0

Repeat

Note=2

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

112_122

268.0

Repeat

Note=3%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

123_144

268.0

Repeat

Note=4

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

145_166

268.0

Repeat

Note=5

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

167_188

268.0

Repeat

Note=6

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

189_210

268.0

Repeat

Note=7

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

211_232

268.0

Repeat

Note=8

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

233_243

268.0

Repeat

Note=9%3B half-length

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

244_267

268.0

Repeat

Note=10

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

68_89

268.0

Repeat

Note=1

Tgene

APOA1

chr19:6678383

chr11:116707865

ENST00000375323

90_111

268.0

Repeat

Note=2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr19:6678383

chr11:116707865

ENST00000245907

1518_1661

1571

1664.0

Domain

NTR

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Fusion Gene Sequence for C3-APOA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11685_11685_1_C3-APOA1_C3_chr19_6678383_ENST00000245907_APOA1_chr11_116707865_ENST00000359492_length(transcript)=5617nt_BP=4807nt
AGATAAAAAGCCAGCTCCAGCAGGCGCTGCTCACTCCTCCCCATCCTCTCCCTCTGTCCCTCTGTCCCTCTGACCCTGCACTGTCCCAGC
ACCATGGGACCCACCTCAGGTCCCAGCCTGCTGCTCCTGCTACTAACCCACCTCCCCCTGGCTCTGGGGAGTCCCATGTACTCTATCATC
ACCCCCAACATCTTGCGGCTGGAGAGCGAGGAGACCATGGTGCTGGAGGCCCACGACGCGCAAGGGGATGTTCCAGTCACTGTTACTGTC
CACGACTTCCCAGGCAAAAAACTAGTGCTGTCCAGTGAGAAGACTGTGCTGACCCCTGCCACCAACCACATGGGCAACGTCACCTTCACG
ATCCCAGCCAACAGGGAGTTCAAGTCAGAAAAGGGGCGCAACAAGTTCGTGACCGTGCAGGCCACCTTCGGGACCCAAGTGGTGGAGAAG
GTGGTGCTGGTCAGCCTGCAGAGCGGGTACCTCTTCATCCAGACAGACAAGACCATCTACACCCCTGGCTCCACAGTTCTCTATCGGATC
TTCACCGTCAACCACAAGCTGCTACCCGTGGGCCGGACGGTCATGGTCAACATTGAGAACCCGGAAGGCATCCCGGTCAAGCAGGACTCC
TTGTCTTCTCAGAACCAGCTTGGCGTCTTGCCCTTGTCTTGGGACATTCCGGAACTCGTCAACATGGGCCAGTGGAAGATCCGAGCCTAC
TATGAAAACTCACCACAGCAGGTCTTCTCCACTGAGTTTGAGGTGAAGGAGTACGTGCTGCCCAGTTTCGAGGTCATAGTGGAGCCTACA
GAGAAATTCTACTACATCTATAACGAGAAGGGCCTGGAGGTCACCATCACCGCCAGGTTCCTCTACGGGAAGAAAGTGGAGGGAACTGCC
TTTGTCATCTTCGGGATCCAGGATGGCGAACAGAGGATTTCCCTGCCTGAATCCCTCAAGCGCATTCCGATTGAGGATGGCTCGGGGGAG
GTTGTGCTGAGCCGGAAGGTACTGCTGGACGGGGTGCAGAACCCCCGAGCAGAAGACCTGGTGGGGAAGTCTTTGTACGTGTCTGCCACC
GTCATCTTGCACTCAGGCAGTGACATGGTGCAGGCAGAGCGCAGCGGGATCCCCATCGTGACCTCTCCCTACCAGATCCACTTCACCAAG
ACACCCAAGTACTTCAAACCAGGAATGCCCTTTGACCTCATGGTGTTCGTGACGAACCCTGATGGCTCTCCAGCCTACCGAGTCCCCGTG
GCAGTCCAGGGCGAGGACACTGTGCAGTCTCTAACCCAGGGAGATGGCGTGGCCAAACTCAGCATCAACACACACCCCAGCCAGAAGCCC
TTGAGCATCACGGTGCGCACGAAGAAGCAGGAGCTCTCGGAGGCAGAGCAGGCTACCAGGACCATGCAGGCTCTGCCCTACAGCACCGTG
GGCAACTCCAACAATTACCTGCATCTCTCAGTGCTACGTACAGAGCTCAGACCCGGGGAGACCCTCAACGTCAACTTCCTCCTGCGAATG
GACCGCGCCCACGAGGCCAAGATCCGCTACTACACCTACCTGATCATGAACAAGGGCAGGCTGTTGAAGGCGGGACGCCAGGTGCGAGAG
CCCGGCCAGGACCTGGTGGTGCTGCCCCTGTCCATCACCACCGACTTCATCCCTTCCTTCCGCCTGGTGGCGTACTACACGCTGATCGGT
GCCAGCGGCCAGAGGGAGGTGGTGGCCGACTCCGTGTGGGTGGACGTCAAGGACTCCTGCGTGGGCTCGCTGGTGGTAAAAAGCGGCCAG
TCAGAAGACCGGCAGCCTGTACCTGGGCAGCAGATGACCCTGAAGATAGAGGGTGACCACGGGGCCCGGGTGGTACTGGTGGCCGTGGAC
AAGGGCGTGTTCGTGCTGAATAAGAAGAACAAACTGACGCAGAGTAAGATCTGGGACGTGGTGGAGAAGGCAGACATCGGCTGCACCCCG
GGCAGTGGGAAGGATTACGCCGGTGTCTTCTCCGACGCAGGGCTGACCTTCACGAGCAGCAGTGGCCAGCAGACCGCCCAGAGGGCAGAA
CTTCAGTGCCCGCAGCCAGCCGCCCGCCGACGCCGTTCCGTGCAGCTCACGGAGAAGCGAATGGACAAAGTCGGCAAGTACCCCAAGGAG
CTGCGCAAGTGCTGCGAGGACGGCATGCGGGAGAACCCCATGAGGTTCTCGTGCCAGCGCCGGACCCGTTTCATCTCCCTGGGCGAGGCG
TGCAAGAAGGTCTTCCTGGACTGCTGCAACTACATCACAGAGCTGCGGCGGCAGCACGCGCGGGCCAGCCACCTGGGCCTGGCCAGGAGT
AACCTGGATGAGGACATCATTGCAGAAGAGAACATCGTTTCCCGAAGTGAGTTCCCAGAGAGCTGGCTGTGGAACGTTGAGGACTTGAAA
GAGCCACCGAAAAATGGAATCTCTACGAAGCTCATGAATATATTTTTGAAAGACTCCATCACCACGTGGGAGATTCTGGCTGTGAGCATG
TCGGACAAGAAAGGGATCTGTGTGGCAGACCCCTTCGAGGTCACAGTAATGCAGGACTTCTTCATCGACCTGCGGCTACCCTACTCTGTT
GTTCGAAACGAGCAGGTGGAAATCCGAGCCGTTCTCTACAATTACCGGCAGAACCAAGAGCTCAAGGTGAGGGTGGAACTACTCCACAAT
CCAGCCTTCTGCAGCCTGGCCACCACCAAGAGGCGTCACCAGCAGACCGTAACCATCCCCCCCAAGTCCTCGTTGTCCGTTCCATATGTC
ATCGTGCCGCTAAAGACCGGCCTGCAGGAAGTGGAAGTCAAGGCTGCTGTCTACCATCATTTCATCAGTGACGGTGTCAGGAAGTCCCTG
AAGGTCGTGCCGGAAGGAATCAGAATGAACAAAACTGTGGCTGTTCGCACCCTGGATCCAGAACGCCTGGGCCGTGAAGGAGTGCAGAAA
GAGGACATCCCACCTGCAGACCTCAGTGACCAAGTCCCGGACACCGAGTCTGAGACCAGAATTCTCCTGCAAGGGACCCCAGTGGCCCAG
ATGACAGAGGATGCCGTCGACGCGGAACGGCTGAAGCACCTCATTGTGACCCCCTCGGGCTGCGGGGAACAGAACATGATCGGCATGACG
CCCACGGTCATCGCTGTGCATTACCTGGATGAAACGGAGCAGTGGGAGAAGTTCGGCCTAGAGAAGCGGCAGGGGGCCTTGGAGCTCATC
AAGAAGGGGTACACCCAGCAGCTGGCCTTCAGACAACCCAGCTCTGCCTTTGCGGCCTTCGTGAAACGGGCACCCAGCACCTGGCTGACC
GCCTACGTGGTCAAGGTCTTCTCTCTGGCTGTCAACCTCATCGCCATCGACTCCCAAGTCCTCTGCGGGGCTGTTAAATGGCTGATCCTG
GAGAAGCAGAAGCCCGACGGGGTCTTCCAGGAGGATGCGCCCGTGATACACCAAGAAATGATTGGTGGATTACGGAACAACAACGAGAAA
GACATGGCCCTCACGGCCTTTGTTCTCATCTCGCTGCAGGAGGCTAAAGATATTTGCGAGGAGCAGGTCAACAGCCTGCCAGGCAGCATC
ACTAAAGCAGGAGACTTCCTTGAAGCCAACTACATGAACCTACAGAGATCCTACACTGTGGCCATTGCTGGCTATGCTCTGGCCCAGATG
GGCAGGCTGAAGGGGCCTCTTCTTAACAAATTTCTGACCACAGCCAAAGATAAGAACCGCTGGGAGGACCCTGGTAAGCAGCTCTACAAC
GTGGAGGCCACATCCTATGCCCTCTTGGCCCTACTGCAGCTAAAAGACTTTGACTTTGTGCCTCCCGTCGTGCGTTGGCTCAATGAACAG
AGATACTACGGTGGTGGCTATGGCTCTACCCAGGCCACCTTCATGGTGTTCCAAGCCTTGGCTCAATACCAAAAGGACGCCCCTGACCAC
CAGGAACTGAACCTTGATGTGTCCCTCCAACTGCCCAGCCGCAGCTCCAAGATCACCCACCGTATCCACTGGGAATCTGCCAGCCTCCTG
CGATCAGAAGAGACCAAGGAAAATGAGGGTTTCACAGTCACAGCTGAAGGAAAAGGCCAAGGCACCTTGTCGGTGGTGACAATGTACCAT
GCTAAGGCCAAAGATCAACTCACCTGTAATAAATTCGACCTCAAGGTCACCATAAAACCAGCACCGGAAACAGAAAAGAGGCCTCAGGAT
GCCAAGAACACTATGATCCTTGAGATCTGTACCAGGTACCGGGGAGACCAGGATGCCACTATGTCTATATTGGACATATCCATGATGACT
GGCTTTGCTCCAGACACAGATGACCTGAAGCAGCTGGCCAATGGTGTTGACAGATACATCTCCAAGTATGAGCTGGACAAAGCCTTCTCC
GATAGGAACACCCTCATCATCTACCTGGACAAGGTCTCACACTCTGAGGATGACTGTCTAGCTTTCAAAGTTCACCAATACTTTAATGTA
GAGCTTATCCAGCCTGGAGCAGTCAAGGTCTACGCCTATTACAACCTGGAGGAAAGCTGTACCCGGTTCTACCATCCGGAAAAGGAGGAT
GGAAAGCTGAACAAGCTCTGCCGTGATGAACTGTGCCGCTGTGCTGAGGAGAATTGCTTCATACAAAAGTCGGATGACAAGGTCACCCTG
GAAGAACGGCTGGACAAGGCCTGTGAGCCAGGAGTGGACTATGTGTACAAGACCCGACTGGTCAAGGTTCAGCTGTCCAATGACTTTGAC
GAGTACATCATGGCCATTGAGCAGACCATCAAGTCAGCCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACCTTCAGCAAGCTGC
GCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAAAAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGG
AGGAGGTGAAGGCCAAGGTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGCCAGAAGGTGGAGC
CGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAGCTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACC
GCGCGCGCGCCCATGTGGACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCGCGCCTTGAGGCTC
TCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCCACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGC
TCGAGGACCTCCGCCAAGGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTACACTAAGAAGCTCA
ACACCCAGTGAGGCGCCCGCCGCCGCCCCCCTTCCCGGTGCTCAGAATAAACGTTTCCAAAGTGGGAAGCTCGGCATTTCTGGCAGCAAG
ATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACTGTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGT
CCCAGTTTGAAGGCTCCGCCTTGGGAAAACAGCTAAA

>11685_11685_1_C3-APOA1_C3_chr19_6678383_ENST00000245907_APOA1_chr11_116707865_ENST00000359492_length(amino acids)=1580AA_BP=
MTLHCPSTMGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNH
MGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEG
IPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYG
KKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSP
YQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQ
ALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLV
AYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEK
ADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTR
FISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTW
EILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKS
SLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILL
QGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKR
APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQV
NSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPV
VRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTL
SVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKY
ELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQK
SDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSA

--------------------------------------------------------------
>11685_11685_2_C3-APOA1_C3_chr19_6678383_ENST00000245907_APOA1_chr11_116707865_ENST00000375320_length(transcript)=5617nt_BP=4807nt
AGATAAAAAGCCAGCTCCAGCAGGCGCTGCTCACTCCTCCCCATCCTCTCCCTCTGTCCCTCTGTCCCTCTGACCCTGCACTGTCCCAGC
ACCATGGGACCCACCTCAGGTCCCAGCCTGCTGCTCCTGCTACTAACCCACCTCCCCCTGGCTCTGGGGAGTCCCATGTACTCTATCATC
ACCCCCAACATCTTGCGGCTGGAGAGCGAGGAGACCATGGTGCTGGAGGCCCACGACGCGCAAGGGGATGTTCCAGTCACTGTTACTGTC
CACGACTTCCCAGGCAAAAAACTAGTGCTGTCCAGTGAGAAGACTGTGCTGACCCCTGCCACCAACCACATGGGCAACGTCACCTTCACG
ATCCCAGCCAACAGGGAGTTCAAGTCAGAAAAGGGGCGCAACAAGTTCGTGACCGTGCAGGCCACCTTCGGGACCCAAGTGGTGGAGAAG
GTGGTGCTGGTCAGCCTGCAGAGCGGGTACCTCTTCATCCAGACAGACAAGACCATCTACACCCCTGGCTCCACAGTTCTCTATCGGATC
TTCACCGTCAACCACAAGCTGCTACCCGTGGGCCGGACGGTCATGGTCAACATTGAGAACCCGGAAGGCATCCCGGTCAAGCAGGACTCC
TTGTCTTCTCAGAACCAGCTTGGCGTCTTGCCCTTGTCTTGGGACATTCCGGAACTCGTCAACATGGGCCAGTGGAAGATCCGAGCCTAC
TATGAAAACTCACCACAGCAGGTCTTCTCCACTGAGTTTGAGGTGAAGGAGTACGTGCTGCCCAGTTTCGAGGTCATAGTGGAGCCTACA
GAGAAATTCTACTACATCTATAACGAGAAGGGCCTGGAGGTCACCATCACCGCCAGGTTCCTCTACGGGAAGAAAGTGGAGGGAACTGCC
TTTGTCATCTTCGGGATCCAGGATGGCGAACAGAGGATTTCCCTGCCTGAATCCCTCAAGCGCATTCCGATTGAGGATGGCTCGGGGGAG
GTTGTGCTGAGCCGGAAGGTACTGCTGGACGGGGTGCAGAACCCCCGAGCAGAAGACCTGGTGGGGAAGTCTTTGTACGTGTCTGCCACC
GTCATCTTGCACTCAGGCAGTGACATGGTGCAGGCAGAGCGCAGCGGGATCCCCATCGTGACCTCTCCCTACCAGATCCACTTCACCAAG
ACACCCAAGTACTTCAAACCAGGAATGCCCTTTGACCTCATGGTGTTCGTGACGAACCCTGATGGCTCTCCAGCCTACCGAGTCCCCGTG
GCAGTCCAGGGCGAGGACACTGTGCAGTCTCTAACCCAGGGAGATGGCGTGGCCAAACTCAGCATCAACACACACCCCAGCCAGAAGCCC
TTGAGCATCACGGTGCGCACGAAGAAGCAGGAGCTCTCGGAGGCAGAGCAGGCTACCAGGACCATGCAGGCTCTGCCCTACAGCACCGTG
GGCAACTCCAACAATTACCTGCATCTCTCAGTGCTACGTACAGAGCTCAGACCCGGGGAGACCCTCAACGTCAACTTCCTCCTGCGAATG
GACCGCGCCCACGAGGCCAAGATCCGCTACTACACCTACCTGATCATGAACAAGGGCAGGCTGTTGAAGGCGGGACGCCAGGTGCGAGAG
CCCGGCCAGGACCTGGTGGTGCTGCCCCTGTCCATCACCACCGACTTCATCCCTTCCTTCCGCCTGGTGGCGTACTACACGCTGATCGGT
GCCAGCGGCCAGAGGGAGGTGGTGGCCGACTCCGTGTGGGTGGACGTCAAGGACTCCTGCGTGGGCTCGCTGGTGGTAAAAAGCGGCCAG
TCAGAAGACCGGCAGCCTGTACCTGGGCAGCAGATGACCCTGAAGATAGAGGGTGACCACGGGGCCCGGGTGGTACTGGTGGCCGTGGAC
AAGGGCGTGTTCGTGCTGAATAAGAAGAACAAACTGACGCAGAGTAAGATCTGGGACGTGGTGGAGAAGGCAGACATCGGCTGCACCCCG
GGCAGTGGGAAGGATTACGCCGGTGTCTTCTCCGACGCAGGGCTGACCTTCACGAGCAGCAGTGGCCAGCAGACCGCCCAGAGGGCAGAA
CTTCAGTGCCCGCAGCCAGCCGCCCGCCGACGCCGTTCCGTGCAGCTCACGGAGAAGCGAATGGACAAAGTCGGCAAGTACCCCAAGGAG
CTGCGCAAGTGCTGCGAGGACGGCATGCGGGAGAACCCCATGAGGTTCTCGTGCCAGCGCCGGACCCGTTTCATCTCCCTGGGCGAGGCG
TGCAAGAAGGTCTTCCTGGACTGCTGCAACTACATCACAGAGCTGCGGCGGCAGCACGCGCGGGCCAGCCACCTGGGCCTGGCCAGGAGT
AACCTGGATGAGGACATCATTGCAGAAGAGAACATCGTTTCCCGAAGTGAGTTCCCAGAGAGCTGGCTGTGGAACGTTGAGGACTTGAAA
GAGCCACCGAAAAATGGAATCTCTACGAAGCTCATGAATATATTTTTGAAAGACTCCATCACCACGTGGGAGATTCTGGCTGTGAGCATG
TCGGACAAGAAAGGGATCTGTGTGGCAGACCCCTTCGAGGTCACAGTAATGCAGGACTTCTTCATCGACCTGCGGCTACCCTACTCTGTT
GTTCGAAACGAGCAGGTGGAAATCCGAGCCGTTCTCTACAATTACCGGCAGAACCAAGAGCTCAAGGTGAGGGTGGAACTACTCCACAAT
CCAGCCTTCTGCAGCCTGGCCACCACCAAGAGGCGTCACCAGCAGACCGTAACCATCCCCCCCAAGTCCTCGTTGTCCGTTCCATATGTC
ATCGTGCCGCTAAAGACCGGCCTGCAGGAAGTGGAAGTCAAGGCTGCTGTCTACCATCATTTCATCAGTGACGGTGTCAGGAAGTCCCTG
AAGGTCGTGCCGGAAGGAATCAGAATGAACAAAACTGTGGCTGTTCGCACCCTGGATCCAGAACGCCTGGGCCGTGAAGGAGTGCAGAAA
GAGGACATCCCACCTGCAGACCTCAGTGACCAAGTCCCGGACACCGAGTCTGAGACCAGAATTCTCCTGCAAGGGACCCCAGTGGCCCAG
ATGACAGAGGATGCCGTCGACGCGGAACGGCTGAAGCACCTCATTGTGACCCCCTCGGGCTGCGGGGAACAGAACATGATCGGCATGACG
CCCACGGTCATCGCTGTGCATTACCTGGATGAAACGGAGCAGTGGGAGAAGTTCGGCCTAGAGAAGCGGCAGGGGGCCTTGGAGCTCATC
AAGAAGGGGTACACCCAGCAGCTGGCCTTCAGACAACCCAGCTCTGCCTTTGCGGCCTTCGTGAAACGGGCACCCAGCACCTGGCTGACC
GCCTACGTGGTCAAGGTCTTCTCTCTGGCTGTCAACCTCATCGCCATCGACTCCCAAGTCCTCTGCGGGGCTGTTAAATGGCTGATCCTG
GAGAAGCAGAAGCCCGACGGGGTCTTCCAGGAGGATGCGCCCGTGATACACCAAGAAATGATTGGTGGATTACGGAACAACAACGAGAAA
GACATGGCCCTCACGGCCTTTGTTCTCATCTCGCTGCAGGAGGCTAAAGATATTTGCGAGGAGCAGGTCAACAGCCTGCCAGGCAGCATC
ACTAAAGCAGGAGACTTCCTTGAAGCCAACTACATGAACCTACAGAGATCCTACACTGTGGCCATTGCTGGCTATGCTCTGGCCCAGATG
GGCAGGCTGAAGGGGCCTCTTCTTAACAAATTTCTGACCACAGCCAAAGATAAGAACCGCTGGGAGGACCCTGGTAAGCAGCTCTACAAC
GTGGAGGCCACATCCTATGCCCTCTTGGCCCTACTGCAGCTAAAAGACTTTGACTTTGTGCCTCCCGTCGTGCGTTGGCTCAATGAACAG
AGATACTACGGTGGTGGCTATGGCTCTACCCAGGCCACCTTCATGGTGTTCCAAGCCTTGGCTCAATACCAAAAGGACGCCCCTGACCAC
CAGGAACTGAACCTTGATGTGTCCCTCCAACTGCCCAGCCGCAGCTCCAAGATCACCCACCGTATCCACTGGGAATCTGCCAGCCTCCTG
CGATCAGAAGAGACCAAGGAAAATGAGGGTTTCACAGTCACAGCTGAAGGAAAAGGCCAAGGCACCTTGTCGGTGGTGACAATGTACCAT
GCTAAGGCCAAAGATCAACTCACCTGTAATAAATTCGACCTCAAGGTCACCATAAAACCAGCACCGGAAACAGAAAAGAGGCCTCAGGAT
GCCAAGAACACTATGATCCTTGAGATCTGTACCAGGTACCGGGGAGACCAGGATGCCACTATGTCTATATTGGACATATCCATGATGACT
GGCTTTGCTCCAGACACAGATGACCTGAAGCAGCTGGCCAATGGTGTTGACAGATACATCTCCAAGTATGAGCTGGACAAAGCCTTCTCC
GATAGGAACACCCTCATCATCTACCTGGACAAGGTCTCACACTCTGAGGATGACTGTCTAGCTTTCAAAGTTCACCAATACTTTAATGTA
GAGCTTATCCAGCCTGGAGCAGTCAAGGTCTACGCCTATTACAACCTGGAGGAAAGCTGTACCCGGTTCTACCATCCGGAAAAGGAGGAT
GGAAAGCTGAACAAGCTCTGCCGTGATGAACTGTGCCGCTGTGCTGAGGAGAATTGCTTCATACAAAAGTCGGATGACAAGGTCACCCTG
GAAGAACGGCTGGACAAGGCCTGTGAGCCAGGAGTGGACTATGTGTACAAGACCCGACTGGTCAAGGTTCAGCTGTCCAATGACTTTGAC
GAGTACATCATGGCCATTGAGCAGACCATCAAGTCAGCCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACCTTCAGCAAGCTGC
GCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAAAAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGG
AGGAGGTGAAGGCCAAGGTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGCCAGAAGGTGGAGC
CGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAGCTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACC
GCGCGCGCGCCCATGTGGACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCGCGCCTTGAGGCTC
TCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCCACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGC
TCGAGGACCTCCGCCAAGGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTACACTAAGAAGCTCA
ACACCCAGTGAGGCGCCCGCCGCCGCCCCCCTTCCCGGTGCTCAGAATAAACGTTTCCAAAGTGGGAAGCTCGGCATTTCTGGCAGCAAG
ATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACTGTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGT
CCCAGTTTGAAGGCTCCGCCTTGGGAAAACAGCTAAA

>11685_11685_2_C3-APOA1_C3_chr19_6678383_ENST00000245907_APOA1_chr11_116707865_ENST00000375320_length(amino acids)=1580AA_BP=
MTLHCPSTMGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNH
MGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEG
IPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYG
KKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSP
YQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQ
ALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLV
AYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEK
ADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTR
FISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTW
EILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKS
SLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILL
QGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKR
APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQV
NSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPV
VRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTL
SVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKY
ELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQK
SDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for C3-APOA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	C3	chr19:6678383	chr11:116707865	ENST00000245907	-	39	41	1634_1659	1571.3333333333333	1664.0	CFP/properdin

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for C3-APOA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	APOA1	P02647	DB14548	Zinc sulfate, unspecified form	Inducer\|Ligand	Small molecule	Approved\|Experimental
Tgene	APOA1	P02647	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	APOA1	P02647	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	APOA1	P02647	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	APOA1	P02647	DB14533	Zinc chloride	Inducer\|Ligand	Small molecule	Approved\|Investigational

Top

Related Diseases for C3-APOA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	C3	C3151071	COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	C3	C0242383	Age related macular degeneration	4	CTD_human;GENOMICS_ENGLAND
Hgene	C3	C2752037	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5	4	GENOMICS_ENGLAND;UNIPROT
Hgene	C3	C1969651	Macular Degeneration, Age-Related, 9	2	CTD_human;UNIPROT
Hgene	C3	C0003257	Antibody Deficiency Syndrome	1	CTD_human
Hgene	C3	C0007787	Transient Ischemic Attack	1	CTD_human
Hgene	C3	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	C3	C0013221	Drug toxicity	1	CTD_human
Hgene	C3	C0017665	Membranous glomerulonephritis	1	CTD_human
Hgene	C3	C0019061	Hemolytic-Uremic Syndrome	1	GENOMICS_ENGLAND
Hgene	C3	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	C3	C0021051	Immunologic Deficiency Syndromes	1	CTD_human
Hgene	C3	C0021655	Insulin Resistance	1	CTD_human
Hgene	C3	C0022660	Kidney Failure, Acute	1	CTD_human
Hgene	C3	C0030524	Paratuberculosis	1	CTD_human
Hgene	C3	C0030807	Pemphigus	1	CTD_human
Hgene	C3	C0030809	Pemphigus Vulgaris	1	CTD_human
Hgene	C3	C0034152	Henoch-Schoenlein Purpura	1	CTD_human
Hgene	C3	C0041755	Adverse reaction to drug	1	CTD_human
Hgene	C3	C0042386	Vasculitis, Hemorrhagic	1	CTD_human
Hgene	C3	C0086445	Idiopathic Membranous Glomerulonephritis	1	CTD_human
Hgene	C3	C0086922	Rheumatoid Purpura	1	CTD_human
Hgene	C3	C0238281	Middle Cerebral Artery Syndrome	1	CTD_human
Hgene	C3	C0242461	Purpura, Nonthrombocytopenic	1	CTD_human
Hgene	C3	C0263313	Pemphigus Foliaceus	1	CTD_human
Hgene	C3	C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
Hgene	C3	C0376362	Purpura Hemorrhagica	1	CTD_human
Hgene	C3	C0472381	Posterior Circulation Transient Ischemic Attack	1	CTD_human
Hgene	C3	C0740376	Middle Cerebral Artery Thrombosis	1	CTD_human
Hgene	C3	C0740391	Middle Cerebral Artery Occlusion	1	CTD_human
Hgene	C3	C0740392	Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	C3	C0751019	Carotid Circulation Transient Ischemic Attack	1	CTD_human
Hgene	C3	C0751020	Transient Ischemic Attack, Vertebrobasilar Circulation	1	CTD_human
Hgene	C3	C0751021	Crescendo Transient Ischemic Attacks	1	CTD_human
Hgene	C3	C0751022	Brain Stem Ischemia, Transient	1	CTD_human
Hgene	C3	C0751845	Middle Cerebral Artery Embolus	1	CTD_human
Hgene	C3	C0751846	Left Middle Cerebral Artery Infarction	1	CTD_human
Hgene	C3	C0751847	Embolic Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	C3	C0751848	Thrombotic Infarction, Middle Cerebral Artery	1	CTD_human
Hgene	C3	C0751849	Right Middle Cerebral Artery Infarction	1	CTD_human
Hgene	C3	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	C3	C0917805	Transient Cerebral Ischemia	1	CTD_human
Hgene	C3	C0920563	Insulin Sensitivity	1	CTD_human
Hgene	C3	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	C3	C1332655	Complement component 3 deficiency	1	GENOMICS_ENGLAND
Hgene	C3	C1527335	Transient Ischemic Attack, Anterior Circulation	1	CTD_human
Hgene	C3	C1565662	Acute Kidney Insufficiency	1	CTD_human
Hgene	C3	C1704378	Heymann Nephritis	1	CTD_human
Hgene	C3	C2609414	Acute kidney injury	1	CTD_human
Hgene	C3	C2931788	Atypical Hemolytic Uremic Syndrome	1	CTD_human;GENOMICS_ENGLAND
Hgene	C3	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	C3	C4087273	C3 glomerulopathy	1	GENOMICS_ENGLAND
Hgene	C3	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	C3	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene		C0268389	Amyloidosis, familial visceral	8	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C1704429	Hypoalphalipoproteinemia, Familial	3	GENOMICS_ENGLAND;ORPHANET
Tgene		C0024623	Malignant neoplasm of stomach	2	CTD_human
Tgene		C0038356	Stomach Neoplasms	2	CTD_human
Tgene		C0342898	Apolipoprotein A-I deficiency	2	ORPHANET
Tgene		C1708349	Hereditary Diffuse Gastric Cancer	2	CTD_human
Tgene		C0001418	Adenocarcinoma	1	CTD_human
Tgene		C0003129	Anoxemia	1	CTD_human
Tgene		C0003130	Anoxia	1	CTD_human
Tgene		C0004943	Behcet Syndrome	1	CTD_human
Tgene		C0010054	Coronary Arteriosclerosis	1	CTD_human
Tgene		C0011609	Drug Eruptions	1	CTD_human
Tgene		C0013604	Edema	1	CTD_human
Tgene		C0017665	Membranous glomerulonephritis	1	CTD_human
Tgene		C0019193	Hepatitis, Toxic	1	CTD_human
Tgene		C0019693	HIV Infections	1	CTD_human
Tgene		C0020538	Hypertensive disease	1	CTD_human
Tgene		C0021368	Inflammation	1	CTD_human
Tgene		C0024121	Lung Neoplasms	1	CTD_human
Tgene		C0038454	Cerebrovascular accident	1	CTD_human
Tgene		C0079221	Determination of Death	1	CTD_human
Tgene		C0086445	Idiopathic Membranous Glomerulonephritis	1	CTD_human
Tgene		C0151603	Anasarca	1	CTD_human
Tgene		C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene		C0154251	Lipid Metabolism Disorders	1	CTD_human
Tgene		C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene		C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene		C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene		C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene		C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene		C0242184	Hypoxia	1	CTD_human
Tgene		C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene		C0242488	Acute Lung Injury	1	CTD_human
Tgene		C0345967	Malignant mesothelioma	1	CTD_human
Tgene		C0376297	Cardiac Death	1	CTD_human
Tgene		C0406537	Morbilliform Drug Reaction	1	CTD_human
Tgene		C0700292	Hypoxemia	1	CTD_human
Tgene		C0751956	Acute Cerebrovascular Accidents	1	CTD_human
Tgene		C0853897	Diabetic Cardiomyopathies	1	CTD_human
Tgene		C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene		C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene		C1704378	Heymann Nephritis	1	CTD_human
Tgene		C1848533	Ataxia with vitamin E deficiency	1	CTD_human
Tgene		C1956346	Coronary Artery Disease	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human
Tgene		C2362324	Pediatric Obesity	1	CTD_human
Tgene		C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene		C4087498	Familial LCAT deficiency	1	GENOMICS_ENGLAND
Tgene		C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene		C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene		C4317171	Adolescent Obesity	1	CTD_human
Tgene		C4505456	HIV Coinfection	1	CTD_human
Tgene		C4521075	Childhood Overweight	1	CTD_human
Tgene		C4553478	Infantile Obesity	1	CTD_human
Tgene		C4704955	Infant Overweight	1	CTD_human
Tgene		C4704956	Adolescent Overweight	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:C3-APOA1 (FusionGDB2 ID:HG718TG335)

Fusion Gene Summary for C3-APOA1

Fusion Gene ORF analysis for C3-APOA1

Fusion Genomic Features for C3-APOA1

Fusion Protein Features for C3-APOA1

Fusion Gene Sequence for C3-APOA1

Fusion Gene PPI Analysis for C3-APOA1

Related Drugs for C3-APOA1

Related Diseases for C3-APOA1

Fusion Gene Studies
in Kim Lab