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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT3-IQGAP3 (FusionGDB2 ID:HG7203TG128239)

Fusion Gene Summary for CCT3-IQGAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3-IQGAP3
Fusion gene ID: hg7203tg128239
HgeneTgene
Gene symbol

CCT3

IQGAP3

Gene ID

7203

128239

Gene namechaperonin containing TCP1 subunit 3IQ motif containing GTPase activating protein 3
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5-
Cytomap('CCT3')('IQGAP3')

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5ras GTPase-activating-like protein IQGAP3
Modification date2020032720200329
UniProtAcc.

Q86VI3

Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368259, 
ENST00000368261, ENST00000472765, 
ENST00000368256, 
Fusion gene scores* DoF score24 X 18 X 12=51845 X 5 X 6=150
# samples 287
** MAII scorelog2(28/5184*10)=-4.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND IQGAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT3(156280349)-IQGAP3(156510708), # samples:4
Anticipated loss of major functional domain due to fusion event.CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CCT3-IQGAP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IQGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EK-A2H0-01ACCT3chr1

156280349

-IQGAP3chr1

156510708

-
ChimerDB4CESCTCGA-ZJ-A8QQ-01ACCT3chr1

156280349

-IQGAP3chr1

156510708

-
ChimerDB4LIHCTCGA-ED-A627-01ACCT3chr1

156294763

-IQGAP3chr1

156495344

-


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Fusion Gene ORF analysis for CCT3-IQGAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000295688ENST00000361170CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-3UTRENST00000368259ENST00000361170CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-3UTRENST00000368261ENST00000361170CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-3UTRENST00000472765ENST00000361170CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-intronENST00000295688ENST00000498755CCT3chr1

156280349

-IQGAP3chr1

156510708

-
5CDS-intronENST00000295688ENST00000498755CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-intronENST00000368259ENST00000498755CCT3chr1

156280349

-IQGAP3chr1

156510708

-
5CDS-intronENST00000368259ENST00000498755CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-intronENST00000368261ENST00000498755CCT3chr1

156280349

-IQGAP3chr1

156510708

-
5CDS-intronENST00000368261ENST00000498755CCT3chr1

156294763

-IQGAP3chr1

156495344

-
5CDS-intronENST00000472765ENST00000498755CCT3chr1

156280349

-IQGAP3chr1

156510708

-
5CDS-intronENST00000472765ENST00000498755CCT3chr1

156294763

-IQGAP3chr1

156495344

-
Frame-shiftENST00000295688ENST00000361170CCT3chr1

156280349

-IQGAP3chr1

156510708

-
Frame-shiftENST00000368259ENST00000361170CCT3chr1

156280349

-IQGAP3chr1

156510708

-
Frame-shiftENST00000472765ENST00000361170CCT3chr1

156280349

-IQGAP3chr1

156510708

-
In-frameENST00000368261ENST00000361170CCT3chr1

156280349

-IQGAP3chr1

156510708

-
intron-3CDSENST00000368256ENST00000361170CCT3chr1

156280349

-IQGAP3chr1

156510708

-
intron-3UTRENST00000368256ENST00000361170CCT3chr1

156294763

-IQGAP3chr1

156495344

-
intron-intronENST00000368256ENST00000498755CCT3chr1

156280349

-IQGAP3chr1

156510708

-
intron-intronENST00000368256ENST00000498755CCT3chr1

156294763

-IQGAP3chr1

156495344

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000368261CCT3chr1156280349-ENST00000361170IQGAP3chr1156510708-5205175818084123771

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368261ENST00000361170CCT3chr1156280349-IQGAP3chr1156510708-0.0084828360.9915172

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Fusion Genomic Features for CCT3-IQGAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CCT3-IQGAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156280349/chr1:156510708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IQGAP3

Q86VI3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQGAP3chr1:156280349chr1:156510708ENST000003611702138988_12218431632.0DomainRas-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQGAP3chr1:156280349chr1:156510708ENST00000361170213834_1498431632.0DomainCalponin-homology (CH)
TgeneIQGAP3chr1:156280349chr1:156510708ENST000003611702138730_7598431632.0DomainIQ 1
TgeneIQGAP3chr1:156280349chr1:156510708ENST000003611702138760_7898431632.0DomainIQ 2
TgeneIQGAP3chr1:156280349chr1:156510708ENST000003611702138790_8198431632.0DomainIQ 3
TgeneIQGAP3chr1:156280349chr1:156510708ENST000003611702138820_8498431632.0DomainIQ 4


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Fusion Gene Sequence for CCT3-IQGAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14300_14300_1_CCT3-IQGAP3_CCT3_chr1_156280349_ENST00000368261_IQGAP3_chr1_156510708_ENST00000361170_length(transcript)=5205nt_BP=1758nt
CTCTCTCCAGAAGGTTCTGCCGGTTCCCCCAGCTCTGGGTACCCGGCTCTGCATCGCGTCGCCATGATGGGCCATCGTCCAGTGCTCGTG
CTCAAGACGGAGTTTCACCATGTTGACCAGGCTGGTCTCCAACTGCTGATGAGCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGCT
GAGATTACAGGCGTGAGCCACCGCGCCCGGTCCCTTATTTTTTTCTGATGAGCACCACCTCCATTGTCTTCCTTTGGCCAGAACACAAAG
CGTGAATCCGGAAGAAAAGTTCAATCTGGAAACATCAATGCTGCCAAGACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCC
ATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCA
GCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATG
CTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGC
ACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTACCAAAGCCATC
AGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATA
AAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACAAGGATGTGACC
CATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTCTGGAATACAAGAAAGGAGAAAGCCAGACTGAC
ATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACATCCAGCAGCTCTGTGAGGACATTATCCAACTG
AAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTATGCGGGCCAATATCACAGCCATCCGCAGAGTC
CGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATGATGTTGGAACA
GGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTGACTGCAAAGACCCCAAGGCCTGCACCATTCTC
CTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTCTCCTGGACCCT
CAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTGTGGAACAATGG
CCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTCTACTTACCTCC
CTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGAAGGAACTGGGCATA
TGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGTGCATGCACCCCACCCTCCTCTCAGTGTGGTACGCAGATTTG
CCCATCTCTTGAATCAAAGCCAGCAAGACTTCTTGGCTGAGGCAGAGCTGCTGAAGCTCCAGGAAGAGGTAGTTAGGAAGATCCGATCCA
ATCAGCAGCTGGAGCAGGACCTCAACATCATGGACATCAAGATTGGCCTGCTGGTGAAGAACCGGATCACTCTGCAGGAAGTGGTCTCCC
ACTGCAAGAAGCTGACCAAGAGGAATAAGGAACAGCTGTCAGATATGATGGTTCTGGACAAGCAGAAGGGTTTAAAGTCGCTGAGCAAAG
AGAAACGGCAGAAACTAGAAGCATACCAACACCTCTTCTACCTGCTCCAGACTCAGCCCATCTACCTGGCCAAGCTGATCTTTCAGATGC
CACAGAACAAAACCACCAAGTTCATGGAGGCAGTGATTTTCAGCCTGTACAACTATGCCTCCAGCCGCCGAGAGGCCTATCTCCTGCTCC
AGCTGTTCAAGACAGCACTCCAGGAGGAAATCAAGTCAAAGGTGGAGCAGCCCCAGGACGTGGTGACAGGCAACCCAACAGTGGTGAGGC
TGGTGGTGAGATTCTACCGTAATGGGCGGGGACAGAGTGCCCTGCAGGAGATTCTGGGCAAGGTTATCCAGGATGTGCTAGAAGACAAAG
TGCTCAGCGTCCACACAGACCCTGTCCACCTCTATAAGAACTGGATCAACCAGACTGAGGCCCAGACAGGGCAGCGCAGCCATCTCCCAT
ATGATGTCACCCCGGAGCAGGCCTTGAGCCACCCCGAGGTCCAGAGACGACTGGACATCGCCCTACGCAACCTCCTCGCCATGACTGATA
AGTTCCTTTTAGCCATCACCTCATCTGTGGACCAAATTCCGTATGGGATGCGATATGTGGCCAAAGTCCTGAAGGCAACTCTGGCAGAGA
AATTCCCTGACGCCACAGACAGCGAGGTCTATAAGGTGGTCGGGAACCTCCTGTACTACCGCTTCCTGAACCCAGCTGTGGTGGCTCCTG
ACGCCTTCGACATTGTGGCCATGGCAGCTGGTGGAGCCCTGGCTGCCCCCCAGCGCCATGCCCTGGGGGCTGTGGCTCAGCTCCTACAGC
ACGCTGCGGCTGGCAAGGCCTTCTCTGGGCAGAGCCAGCACCTACGGGTCCTGAATGACTATCTGGAGGAAACACACCTCAAGTTCAGGA
AGTTCATCCATAGAGCCTGCCAGGTGCCAGAGCCAGAGGAGCGTTTTGCAGTGGACGAGTACTCAGACATGGTGGCTGTGGCCAAACCCA
TGGTGTACATCACCGTGGGGGAGCTGGTCAACACGCACAGGCTGTTGCTGGAGCACCAGGACTGCATTGCCCCTGATCACCAAGACCCCC
TGCATGAGCTCCTGGAGGATCTTGGGGAGCTGCCCACCATCCCTGACCTTATTGGTGAGAGCATCGCTGCAGATGGGCACACGGACCTGA
GCAAGCTAGAAGTGTCCCTGACGCTGACCAACAAGTTTGAAGGACTAGAGGCAGATGCTGATGACTCCAACACCCGTAGCCTGCTTCTGA
GCACCAAGCAGCTGTTGGCCGATATCATACAGTTCCATCCTGGGGACACCCTCAAGGAGATCCTGTCCCTCTCGGCTTCCAGAGAGCAAG
AAGCAGCCCACAAGCAGCTGATGAGCCGACGCCAGGCCTGTACAGCCCAGACACCGGAGCCACTGCGACGACACCGCTCACTGACAGCTC
ACTCCCTCCTGCCACTGGCAGAGAAGCAGCGGCGCGTCCTGCGGAACCTACGCCGACTTGAAGCCCTGGGGTTGGTCAGCGCCAGAAATG
GCTACCAGGGGCTAGTGGACGAGCTGGCCAAGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGAAGGCAGAGCTGGTGAAGCTGC
AGGCCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGGTGACTACTACAGCCAGTACATCCGGGCCTGCCTGGACC
ACCTGGCCCCCGACTCCAAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTCCTGGAAAAGGGTGTCT
TGGTGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATCACGCCGGGAGATGAGGCAGGAAAGTTTGAAGTAA
ATGCCAAGTTCCTGGGTGTGGACATGGAGCGATTTCAGCTTCACTATCAGGATCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGA
AACTCTTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCGGAAGTGACAGAGGCAAAGGGTGC
TACCCAAGCCCCTCTTACCTCTCTGGATGCTTTCTTTAACACTAACTCACCACTGTGCTTCCCTGCAGACACCTAGAGCTCAGGACTGGG
CAAGGCCCAGGGATTCTCACCCCTTCCCCAGCTGGGAGGAGCTTGCCTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGTGGG
CCTTGCCCAGAGTCCAGCTGTGTGGCTTTTATCATGCATGACAAACCCCTGGCTTTCCTGCCAGATGGTAGGACATGGACCTTGACCTGG
GAAAGCCATTACTCTTGTGTCTGCTACTGCCCTCCCACAGTCACCCCAATATTACAAGCACTGCCCCAGCGGCTTGATTTCCCCTCTGCC
TTCCTTCTCTCTGCACTCCCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGTTCCTGCCCTTCCTG
AGTCTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTCCAACCTGGGCAGGGACTGGGGGGATGCAGTGTGTGTTAGTGCCCATGTGGCA
TTGTGGCACTGTTGCCCCCCATGGCGGCATGGGCAAGATGACCTTCCATTAGCTTCAAGTCTTGTTCTCTTGTCTGTGGTCTGTTTAATA
TGTGGGTCACTAGGGTATTTATTCTTTCTCCCATCCTTACACTCTGGATCATTGTGCAGACTTAATCAGGGTTTTAACGCTTTCATTTTT
TTTTTTTTTTTTTTTTTTTTGAGCTCAAAGAGAGTTCTCATTTTCCCTATTCAAACTAATACCCATGCCGTGTTTTTTACCTTGGATTTA
AAGTCACCTTAGGTTGGGGCAACAGATTCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCAAAGAGGAGTCTTTCCCTT
TTCTCTTTTACCCTCAGGATTCTCATCCCTTACAGCTGACTCTTCCAGGCAATTTCCATAGATCTGCAGTCCTGCCTCTGCCACAGTCTC

>14300_14300_1_CCT3-IQGAP3_CCT3_chr1_156280349_ENST00000368261_IQGAP3_chr1_156510708_ENST00000361170_length(amino acids)=771AA_BP=
MNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKR
QKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVV
RFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFL
LAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAA
AGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHE
LLEDLGELPTIPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAA
HKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQAT
LQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCT3-IQGAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT3-IQGAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT3-IQGAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCT3C0019193Hepatitis, Toxic1CTD_human
HgeneCCT3C0019693HIV Infections1CTD_human
HgeneCCT3C0860207Drug-Induced Liver Disease1CTD_human
HgeneCCT3C1262760Hepatitis, Drug-Induced1CTD_human
HgeneCCT3C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCCT3C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCCT3C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneCCT3C4505456HIV Coinfection1CTD_human
TgeneC1510586Autism Spectrum Disorders1CTD_human
TgeneC2239176Liver carcinoma1CTD_human