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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC1-CAMK2A (FusionGDB2 ID:HG7265TG815)

Fusion Gene Summary for TTC1-CAMK2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC1-CAMK2A
Fusion gene ID: hg7265tg815
HgeneTgene
Gene symbol

TTC1

CAMK2A

Gene ID

7265

815

Gene nametetratricopeptide repeat domain 1calcium/calmodulin dependent protein kinase II alpha
SynonymsTPR1CAMKA|CaMKIINalpha|CaMKIIalpha|MRD53|MRT63
Cytomap('TTC1')('CAMK2A')

5q33.3

5q32

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 1TPR repeat protein 1calcium/calmodulin-dependent protein kinase type II subunit alphaCaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitcaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM kinase) II alp
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000520274, ENST00000231238, 
ENST00000522793, 
Fusion gene scores* DoF score7 X 7 X 3=1477 X 7 X 6=294
# samples 87
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC1 [Title/Abstract] AND CAMK2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC1(159470176)-CAMK2A(149602780), # samples:1
Anticipated loss of major functional domain due to fusion event.TTC1-CAMK2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TTC1-CAMK2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK2A

GO:0006468

protein phosphorylation

17052756

TgeneCAMK2A

GO:0038166

angiotensin-activated signaling pathway

20584908


check buttonFusion gene breakpoints across TTC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAMK2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ATTC1chr5

159470176

+CAMK2Achr5

149602780

-


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Fusion Gene ORF analysis for TTC1-CAMK2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000520274ENST00000348628TTC1chr5

159470176

+CAMK2Achr5

149602780

-
3UTR-5UTRENST00000520274ENST00000351010TTC1chr5

159470176

+CAMK2Achr5

149602780

-
3UTR-5UTRENST00000520274ENST00000398376TTC1chr5

159470176

+CAMK2Achr5

149602780

-
5CDS-5UTRENST00000231238ENST00000351010TTC1chr5

159470176

+CAMK2Achr5

149602780

-
5CDS-5UTRENST00000231238ENST00000398376TTC1chr5

159470176

+CAMK2Achr5

149602780

-
5CDS-5UTRENST00000522793ENST00000351010TTC1chr5

159470176

+CAMK2Achr5

149602780

-
5CDS-5UTRENST00000522793ENST00000398376TTC1chr5

159470176

+CAMK2Achr5

149602780

-
In-frameENST00000231238ENST00000348628TTC1chr5

159470176

+CAMK2Achr5

149602780

-
In-frameENST00000522793ENST00000348628TTC1chr5

159470176

+CAMK2Achr5

149602780

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000522793TTC1chr5159470176+ENST00000348628CAMK2Achr5149602780-410064898880260
ENST00000231238TTC1chr5159470176+ENST00000348628CAMK2Achr5149602780-4103651101883260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000522793ENST00000348628TTC1chr5159470176+CAMK2Achr5149602780-0.0013539880.9986461
ENST00000231238ENST00000348628TTC1chr5159470176+CAMK2Achr5149602780-0.0013254020.99867463

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Fusion Genomic Features for TTC1-CAMK2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TTC1-CAMK2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:159470176/chr5:149602780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC1chr5:159470176chr5:149602780ENST00000231238+58116_149180293.0RepeatNote=TPR 1
HgeneTTC1chr5:159470176chr5:149602780ENST00000522793+58116_149180293.0RepeatNote=TPR 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC1chr5:159470176chr5:149602780ENST00000231238+58155_188180293.0RepeatNote=TPR 2
HgeneTTC1chr5:159470176chr5:149602780ENST00000231238+58189_222180293.0RepeatNote=TPR 3
HgeneTTC1chr5:159470176chr5:149602780ENST00000522793+58155_188180293.0RepeatNote=TPR 2
HgeneTTC1chr5:159470176chr5:149602780ENST00000522793+58189_222180293.0RepeatNote=TPR 3
TgeneCAMK2Achr5:159470176chr5:149602780ENST00000348628151813_271401479.0DomainProtein kinase
TgeneCAMK2Achr5:159470176chr5:149602780ENST00000398376161913_271412490.0DomainProtein kinase
TgeneCAMK2Achr5:159470176chr5:149602780ENST00000348628151819_27401479.0Nucleotide bindingATP
TgeneCAMK2Achr5:159470176chr5:149602780ENST00000398376161919_27412490.0Nucleotide bindingATP
TgeneCAMK2Achr5:159470176chr5:149602780ENST000003486281518290_300401479.0RegionNote=Calmodulin-binding
TgeneCAMK2Achr5:159470176chr5:149602780ENST000003983761619290_300412490.0RegionNote=Calmodulin-binding


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Fusion Gene Sequence for TTC1-CAMK2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>94930_94930_1_TTC1-CAMK2A_TTC1_chr5_159470176_ENST00000231238_CAMK2A_chr5_149602780_ENST00000348628_length(transcript)=4103nt_BP=651nt
ATCGACGGAAGTGCACCTGACTGAGCGGAAGTAGGAGCTCTCAGAGGCTAAGAAGGTGGAGACCGGAGAAGCTGTGAGGTTCTTTAGCGT
CACCTCCCTCACTGGGCAGCATGGGGGAGAAGTCAGAGAACTGTGGGGTTCCAGAGGATCTGTTAAATGGTTTGAAGGTTACAGATACTC
AGGAAGCCGAGTGTGCTGGCCCTCCAGTTCCTGATCCCAAAAATCAGCATTCCCAGAGTAAGCTGCTCAGGGATGATGAGGCCCATCTCC
AGGAGGACCAGGGAGAAGAGGAGTGTTTTCATGACTGCAGTGCCTCATTTGAGGAGGAGCCAGGAGCGGACAAGGTTGAGAACAAATCTA
ATGAAGATGTGAATTCCTCTGAACTAGATGAAGAATACCTAATAGAACTGGAAAAAAACATGTCGGATGAAGAGAAACAGAAAAGAAGAG
AAGAGAGCACTAGACTAAAGGAGGAGGGAAATGAACAGTTTAAGAAAGGAGATTATATAGAAGCTGAAAGTTCTTATAGTCGAGCCCTCG
AAATGTGCCCATCCTGCTTCCAAAAGGAGAGGTCGATTCTATTTTCAAATAGAGCTGCAGCAAGGATGAAACAGGACAAGAAAGAAATGG
CCATCAATGACTGCAGCAAAGTGTGGTCCCGGAACAGCAAGCCCGTGCACACCACCATCCTGAATCCCCACATCCACCTGATGGGCGACG
AGTCAGCCTGCATCGCCTACATCCGCATCACGCAGTACCTGGACGCTGGCGGCATCCCACGCACCGCCCAGTCGGAGGAGACCCGTGTCT
GGCACCGCCGGGATGGCAAATGGCAGATCGTCCACTTCCACAGATCTGGGGCGCCCTCCGTCCTGCCCCACTGAGGGACCAGGCTGGGGT
CGCTGCGTTGCTGTGCCGCAGAGATCCACTCTGTCCGTGGAGTGGAGCTGCTGGTTCTCCCAGGTGGATTTTGCTGGAATTCTCCCATGT
CATCACCCCACCACCGTCACTTCTGTACCTGCATCAAGAAAACCTGCTTGTTCACAAAAGTCATCGCAACTTCAGAGCGAACGGCCACAT
CTCCCCACCTCTCACCCCCACCCTCTCCCCTGCCAGGCTGGGGCTTCCTCAGGCATGGGTGTCCACAGCACTGGCCCCCTCTCCCCAGCC
TCAGCTGCTGTCCGCCTGATCTGTCTTGGGCTGTAGGCTAGAATGCCCGGGCTGGTGCCCACCAGGGGCTGGGGAGAAGGAGGGGTGGCA
TGATGAGGAAGGCAGCATCCGTCCGTCCCTCTCCCAGACCTCTCCTCTTCCAGTGTCCCCGGGGAAGGGCAGATGACACTCCCTTCCCCC
TAAGCCAACCGCACTGAAGGAGTGGGGAGAAGAGCATACGCCAGGAGCCTCCTGCCTCAAAGTGCTCCCCTAAGTCTTCTTCCTCCTGTG
CTGACCTCAGGGTGGTCTGACCCTTCCCTCGGTGTGGGGGATGTGGCCCTCTCAGGTGCCCCTACTTGCTTTCTGCTTCCTTCTGGTGAA
GTCCACCTCCAACATTAACCTGCCCACCCCACCCCCGTCATCCCTGGAGAATTCCAGCTTTGTCGTATCTCAGAGAGGGAATCTAATTGT
TTTTGGGGGGCAAAAGAAAGCAACGTTTAGGTATCACTTCTACTTGGACCGCATGCCTTTTTATAGCCAAATTTCTGTGTATTTCGTAAA
TGGATTTCGCGTTAATGGATATTTATGTAATAACTAGACTTCTCAGATTATTGTGAGAAGGGTCAGGTTGGAAGGGGTGTAGGAAGAGGG
GTGAGGGGTAGTTTTTTTCTGTTCTAGTTTTTTTTTTTTTTTTTGTCATCTCTGAGGTGGACCTTGTCACCTGTGGTTATTGGGGCCAAG
GTGGACTCAGCTCCGGGGAGAAGGGCCTCTCTGCCATTTCGGTCCCAAGGTGAGCTGACACAGGCGTTCCTTTTGGGACTGTGGAAGCAT
CAGATGCCAGCACTGACTCAGGAACAGCAAGTCAGGGCAGAGAGGAGGAGGGAGGCTGTCAGGATGGAAATACCTGGACTTTTCTTTGCT
TCCCTCGCAAACTGGGGTCTTCTCTACCGAACTTCCCAGGATTTCATCTCACCATATCTGTGTGCCGCCCCCAGCACCCCCCACCCACCT
CTGGGGGGCCCGTGAGCGTGTGTCTTCATTGCCTCTCTCCCCTTGGCGTCTGATGACCACAGCAAAGCACTGGGAATTTCTACTCTTCAT
GCCTCATCCTGCAGCCTCGGGTTCGCATTCTCTCTTTCTTTTCCTCTTTCCCTCTTTCCCTGGGATTGACTCTGAGTGGAATACCTTGGC
ACATCCACTAGGATCTACTGTCTGCACTGTTTTCTTTGCATGACTTTATACGCAGTAAGTATGTTGAAAACAAACAAAAAGAAGAAAACA
CTCAACAAAACCAATCTACATGTTTTGGACTAAAAAAAAAAATAGAGGTTGTATTCTCAGTGTCCGACTCGGAATTATGTTGCTGCCTCT
CTGTGCTTTTGGCCTCTGTGTGGCCGTGTTTTGCCAGCATGAGATACTGTCCCCTCTGGAGGATTTTAGGGGAGGAAGAGCCACGTCCCC
AGGGATTGGAGGAGGCTCCGGTACCCTCGACCCTCCTGGGTGTTGGTTGGAGCAGAACTGGTGAGGATGTTTGATCCGAGATTTTCTGAG
CTCTCCCCAATCACCAGCTGTCTGCTGGGTTCTTTTCTCAAGTCCTGCTGCCCAGGCCCAGGTGAGACAGGCAACGCCAGGTCTGCAGGC
CAGGAGAGATGCTGCCCAGGCCTCCTGGTTTCCAAGCTGGTCCATCACTGGCCTCTGTCCTTGGCAGAGACCTTGCTGCCCAGGCCCAGG
GGCAGGCTCTTGGCCTGCCCCAGGCCCAGAGGGCTTCCCAGTAAGGCCCAGTGATCCCATTATCCCAGGGGCAAAACCACCTGTCCCCTT
TTGAGCTGCCAGTTCCCTACAGCCATCCCCAGTCAAGGGTGAGGGTGTGGCCTTCACCAGGGGCTGCTGTAATTACCGAGCAAGGTCTGA
GCTCTTCTTCAGCCTCAGTTCCCTCATTGGTTAAAAGGGTTCTTTGTTCCCATCCAGCCGATGAAGGAGCAAACGTCTGGCTATGTGAAG
CCTAATTTACCTGCAGGAACTGGCAGGGATAGTCACTGGCTGGACTCCTGTTTACTTCTAGACCTGGTCAGGCTCCATCCCCTCCCCCAC
CTGCCCCTGATTCCCCTCGTCGGTGCCTGTCAACTGCTTTTCAGCAGTGGACTGCAGGGGAAAGAGCAGTGATTTGGGGTGAGTAGGCTT
CAATTCCCAGCTCTGACCAGACTTGCTGTGTGACCTTGGGCAAGTTCCTTTCCCTCTTTGGAGCTTGGTTTCCCTGCCAGAGGAAACTGA
GCTGGAGGAGCCTGAGGTCCTGCCTTTCATTGGCTGACACACCTCCTGTCCACTGTGTCACTCTCCAAGTGCCAGAGAAGTGGAGGCAGA
TCGCTACCCCAGGCTGAGATGGCCCCCACTGTGAAGGCCACGCCTGTGGGTGGGCAGCCACCTGGTGCCACCACAGGGCACCAGGGATGA
TCCTGATGTGGCAGGCAGGGGAGACTCACAGAAAAATCTGCCCAGAGCCTACCCTCACCAGACAAACTCTGTGCTCCTCCAAAACATCCT
TTAGATGCAAAATAATAATAATAATAATAATAAATAAATAAATAAAAATCCAAACCCAAGTCAAAACCTTGGCTCCAGCATGAAAACACG
TTTACAGGAAAGTGTTCTCCTGGGTTTGTGCCCACCATGGTGCGAATCCTGACCCAAGGCCTCCTGTCTCCCTTCAAAGGGAGACCCTTT
TGGGGGATGAGTTTGCCAGACTCCCCGTGCTGGTTTCTTTGTTACTATTTGTTTGGGGTTTTGTTTTAGTTCTTTTTTTTTTTCTTTTCT
TTTTTAAAAATATGTGGCTGTGAACTTGAATGAACACTGCTCAAACTTTCTGCTATTGGGGGGGGCGGGTGGGATGGGAAGAAGGGGCGT

>94930_94930_1_TTC1-CAMK2A_TTC1_chr5_159470176_ENST00000231238_CAMK2A_chr5_149602780_ENST00000348628_length(amino acids)=260AA_BP=183
MGSMGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDV
NSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAIND

--------------------------------------------------------------
>94930_94930_2_TTC1-CAMK2A_TTC1_chr5_159470176_ENST00000522793_CAMK2A_chr5_149602780_ENST00000348628_length(transcript)=4100nt_BP=648nt
ATCGACGGAAGTGCACCTGACTGAGCGGAAGTAGGAGCTCTCAGAGGCTAAGAAGGTGGAGACCGGAGAAGCTGTGAGCTTTAGCGTCAC
CTCCCTCACTGGGCAGCATGGGGGAGAAGTCAGAGAACTGTGGGGTTCCAGAGGATCTGTTAAATGGTTTGAAGGTTACAGATACTCAGG
AAGCCGAGTGTGCTGGCCCTCCAGTTCCTGATCCCAAAAATCAGCATTCCCAGAGTAAGCTGCTCAGGGATGATGAGGCCCATCTCCAGG
AGGACCAGGGAGAAGAGGAGTGTTTTCATGACTGCAGTGCCTCATTTGAGGAGGAGCCAGGAGCGGACAAGGTTGAGAACAAATCTAATG
AAGATGTGAATTCCTCTGAACTAGATGAAGAATACCTAATAGAACTGGAAAAAAACATGTCGGATGAAGAGAAACAGAAAAGAAGAGAAG
AGAGCACTAGACTAAAGGAGGAGGGAAATGAACAGTTTAAGAAAGGAGATTATATAGAAGCTGAAAGTTCTTATAGTCGAGCCCTCGAAA
TGTGCCCATCCTGCTTCCAAAAGGAGAGGTCGATTCTATTTTCAAATAGAGCTGCAGCAAGGATGAAACAGGACAAGAAAGAAATGGCCA
TCAATGACTGCAGCAAAGTGTGGTCCCGGAACAGCAAGCCCGTGCACACCACCATCCTGAATCCCCACATCCACCTGATGGGCGACGAGT
CAGCCTGCATCGCCTACATCCGCATCACGCAGTACCTGGACGCTGGCGGCATCCCACGCACCGCCCAGTCGGAGGAGACCCGTGTCTGGC
ACCGCCGGGATGGCAAATGGCAGATCGTCCACTTCCACAGATCTGGGGCGCCCTCCGTCCTGCCCCACTGAGGGACCAGGCTGGGGTCGC
TGCGTTGCTGTGCCGCAGAGATCCACTCTGTCCGTGGAGTGGAGCTGCTGGTTCTCCCAGGTGGATTTTGCTGGAATTCTCCCATGTCAT
CACCCCACCACCGTCACTTCTGTACCTGCATCAAGAAAACCTGCTTGTTCACAAAAGTCATCGCAACTTCAGAGCGAACGGCCACATCTC
CCCACCTCTCACCCCCACCCTCTCCCCTGCCAGGCTGGGGCTTCCTCAGGCATGGGTGTCCACAGCACTGGCCCCCTCTCCCCAGCCTCA
GCTGCTGTCCGCCTGATCTGTCTTGGGCTGTAGGCTAGAATGCCCGGGCTGGTGCCCACCAGGGGCTGGGGAGAAGGAGGGGTGGCATGA
TGAGGAAGGCAGCATCCGTCCGTCCCTCTCCCAGACCTCTCCTCTTCCAGTGTCCCCGGGGAAGGGCAGATGACACTCCCTTCCCCCTAA
GCCAACCGCACTGAAGGAGTGGGGAGAAGAGCATACGCCAGGAGCCTCCTGCCTCAAAGTGCTCCCCTAAGTCTTCTTCCTCCTGTGCTG
ACCTCAGGGTGGTCTGACCCTTCCCTCGGTGTGGGGGATGTGGCCCTCTCAGGTGCCCCTACTTGCTTTCTGCTTCCTTCTGGTGAAGTC
CACCTCCAACATTAACCTGCCCACCCCACCCCCGTCATCCCTGGAGAATTCCAGCTTTGTCGTATCTCAGAGAGGGAATCTAATTGTTTT
TGGGGGGCAAAAGAAAGCAACGTTTAGGTATCACTTCTACTTGGACCGCATGCCTTTTTATAGCCAAATTTCTGTGTATTTCGTAAATGG
ATTTCGCGTTAATGGATATTTATGTAATAACTAGACTTCTCAGATTATTGTGAGAAGGGTCAGGTTGGAAGGGGTGTAGGAAGAGGGGTG
AGGGGTAGTTTTTTTCTGTTCTAGTTTTTTTTTTTTTTTTTGTCATCTCTGAGGTGGACCTTGTCACCTGTGGTTATTGGGGCCAAGGTG
GACTCAGCTCCGGGGAGAAGGGCCTCTCTGCCATTTCGGTCCCAAGGTGAGCTGACACAGGCGTTCCTTTTGGGACTGTGGAAGCATCAG
ATGCCAGCACTGACTCAGGAACAGCAAGTCAGGGCAGAGAGGAGGAGGGAGGCTGTCAGGATGGAAATACCTGGACTTTTCTTTGCTTCC
CTCGCAAACTGGGGTCTTCTCTACCGAACTTCCCAGGATTTCATCTCACCATATCTGTGTGCCGCCCCCAGCACCCCCCACCCACCTCTG
GGGGGCCCGTGAGCGTGTGTCTTCATTGCCTCTCTCCCCTTGGCGTCTGATGACCACAGCAAAGCACTGGGAATTTCTACTCTTCATGCC
TCATCCTGCAGCCTCGGGTTCGCATTCTCTCTTTCTTTTCCTCTTTCCCTCTTTCCCTGGGATTGACTCTGAGTGGAATACCTTGGCACA
TCCACTAGGATCTACTGTCTGCACTGTTTTCTTTGCATGACTTTATACGCAGTAAGTATGTTGAAAACAAACAAAAAGAAGAAAACACTC
AACAAAACCAATCTACATGTTTTGGACTAAAAAAAAAAATAGAGGTTGTATTCTCAGTGTCCGACTCGGAATTATGTTGCTGCCTCTCTG
TGCTTTTGGCCTCTGTGTGGCCGTGTTTTGCCAGCATGAGATACTGTCCCCTCTGGAGGATTTTAGGGGAGGAAGAGCCACGTCCCCAGG
GATTGGAGGAGGCTCCGGTACCCTCGACCCTCCTGGGTGTTGGTTGGAGCAGAACTGGTGAGGATGTTTGATCCGAGATTTTCTGAGCTC
TCCCCAATCACCAGCTGTCTGCTGGGTTCTTTTCTCAAGTCCTGCTGCCCAGGCCCAGGTGAGACAGGCAACGCCAGGTCTGCAGGCCAG
GAGAGATGCTGCCCAGGCCTCCTGGTTTCCAAGCTGGTCCATCACTGGCCTCTGTCCTTGGCAGAGACCTTGCTGCCCAGGCCCAGGGGC
AGGCTCTTGGCCTGCCCCAGGCCCAGAGGGCTTCCCAGTAAGGCCCAGTGATCCCATTATCCCAGGGGCAAAACCACCTGTCCCCTTTTG
AGCTGCCAGTTCCCTACAGCCATCCCCAGTCAAGGGTGAGGGTGTGGCCTTCACCAGGGGCTGCTGTAATTACCGAGCAAGGTCTGAGCT
CTTCTTCAGCCTCAGTTCCCTCATTGGTTAAAAGGGTTCTTTGTTCCCATCCAGCCGATGAAGGAGCAAACGTCTGGCTATGTGAAGCCT
AATTTACCTGCAGGAACTGGCAGGGATAGTCACTGGCTGGACTCCTGTTTACTTCTAGACCTGGTCAGGCTCCATCCCCTCCCCCACCTG
CCCCTGATTCCCCTCGTCGGTGCCTGTCAACTGCTTTTCAGCAGTGGACTGCAGGGGAAAGAGCAGTGATTTGGGGTGAGTAGGCTTCAA
TTCCCAGCTCTGACCAGACTTGCTGTGTGACCTTGGGCAAGTTCCTTTCCCTCTTTGGAGCTTGGTTTCCCTGCCAGAGGAAACTGAGCT
GGAGGAGCCTGAGGTCCTGCCTTTCATTGGCTGACACACCTCCTGTCCACTGTGTCACTCTCCAAGTGCCAGAGAAGTGGAGGCAGATCG
CTACCCCAGGCTGAGATGGCCCCCACTGTGAAGGCCACGCCTGTGGGTGGGCAGCCACCTGGTGCCACCACAGGGCACCAGGGATGATCC
TGATGTGGCAGGCAGGGGAGACTCACAGAAAAATCTGCCCAGAGCCTACCCTCACCAGACAAACTCTGTGCTCCTCCAAAACATCCTTTA
GATGCAAAATAATAATAATAATAATAATAAATAAATAAATAAAAATCCAAACCCAAGTCAAAACCTTGGCTCCAGCATGAAAACACGTTT
ACAGGAAAGTGTTCTCCTGGGTTTGTGCCCACCATGGTGCGAATCCTGACCCAAGGCCTCCTGTCTCCCTTCAAAGGGAGACCCTTTTGG
GGGATGAGTTTGCCAGACTCCCCGTGCTGGTTTCTTTGTTACTATTTGTTTGGGGTTTTGTTTTAGTTCTTTTTTTTTTTCTTTTCTTTT
TTAAAAATATGTGGCTGTGAACTTGAATGAACACTGCTCAAACTTTCTGCTATTGGGGGGGGCGGGTGGGATGGGAAGAAGGGGCGTTTG

>94930_94930_2_TTC1-CAMK2A_TTC1_chr5_159470176_ENST00000522793_CAMK2A_chr5_149602780_ENST00000348628_length(amino acids)=260AA_BP=183
MGSMGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDV
NSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAIND

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTC1-CAMK2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCAMK2Achr5:159470176chr5:149602780ENST000003486281518310_320401.3333333333333479.0BAALC
TgeneCAMK2Achr5:159470176chr5:149602780ENST000003983761619310_320412.3333333333333490.0BAALC


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC1-CAMK2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC1-CAMK2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4540481MENTAL RETARDATION, AUTOSOMAL DOMINANT 534UNIPROT
TgeneC3714756Intellectual Disability2GENOMICS_ENGLAND
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0009171Cocaine Abuse1CTD_human
TgeneC0011570Mental Depression1PSYGENET
TgeneC0011581Depressive disorder1PSYGENET
TgeneC0019202Hepatolenticular Degeneration1CTD_human
TgeneC0019209Hepatomegaly1CTD_human
TgeneC0020429Hyperalgesia1CTD_human
TgeneC0041696Unipolar Depression1PSYGENET
TgeneC0236736Cocaine-Related Disorders1CTD_human
TgeneC0458247Allodynia1CTD_human
TgeneC0600427Cocaine Dependence1CTD_human
TgeneC0751211Hyperalgesia, Primary1CTD_human
TgeneC0751212Hyperalgesia, Secondary1CTD_human
TgeneC0751213Tactile Allodynia1CTD_human
TgeneC0751214Hyperalgesia, Thermal1CTD_human
TgeneC1269683Major Depressive Disorder1PSYGENET
TgeneC1527352Hepatic Form of Wilson Disease1CTD_human
TgeneC2936719Mechanical Allodynia1CTD_human
TgeneC4748167MENTAL RETARDATION, AUTOSOMAL RECESSIVE 631UNIPROT