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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPN5-HSD17B14 (FusionGDB2 ID:HG726TG51171)

Fusion Gene Summary for CAPN5-HSD17B14

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN5-HSD17B14
Fusion gene ID: hg726tg51171
HgeneTgene
Gene symbol

CAPN5

HSD17B14

Gene ID

726

51171

Gene namecalpain 5hydroxysteroid 17-beta dehydrogenase 14
SynonymsADNIV|HTRA3|VRNI|nCL-3DHRS10|SDR47C1|retSDR3
Cytomap('CAPN5')('HSD17B14')

11q13.5

19q13.33

Type of geneprotein-codingprotein-coding
Descriptioncalpain-5calpain htra-3new calpain 3testis tissue sperm-binding protein Li 91mP17-beta-hydroxysteroid dehydrogenase 1417-beta-HSD 1417-beta-hydroxysteroid dehydrogenase DHRS10dehydrogenase/reductase (SDR family) member 10retinal short-chain dehydrogenase/reductase 3retinal short-chain dehydrogenase/reductase retSDR3short chain
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000278559, ENST00000456580, 
ENST00000529629, ENST00000531028, 
Fusion gene scores* DoF score8 X 5 X 5=20010 X 3 X 7=210
# samples 89
** MAII scorelog2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPN5 [Title/Abstract] AND HSD17B14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPN5(76804859)-HSD17B14(49318398), # samples:3
Anticipated loss of major functional domain due to fusion event.CAPN5-HSD17B14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN5-HSD17B14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSD17B14

GO:0006706

steroid catabolic process

17067289


check buttonFusion gene breakpoints across CAPN5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HSD17B14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AAE2-01ACAPN5chr11

76804859

-HSD17B14chr19

49318398

-
ChimerDB4LIHCTCGA-DD-AAE2-01ACAPN5chr11

76804859

+HSD17B14chr19

49318398

-
ChimerDB4LIHCTCGA-DD-AAE2CAPN5chr11

76804859

+HSD17B14chr19

49318398

-


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Fusion Gene ORF analysis for CAPN5-HSD17B14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000278559ENST00000263278CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
In-frameENST00000278559ENST00000599157CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
In-frameENST00000456580ENST00000263278CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
In-frameENST00000456580ENST00000599157CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
In-frameENST00000529629ENST00000263278CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
In-frameENST00000529629ENST00000599157CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
intron-3CDSENST00000531028ENST00000263278CAPN5chr11

76804859

+HSD17B14chr19

49318398

-
intron-3CDSENST00000531028ENST00000599157CAPN5chr11

76804859

+HSD17B14chr19

49318398

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000278559CAPN5chr1176804859+ENST00000263278HSD17B14chr1949318398-108848663929288
ENST00000278559CAPN5chr1176804859+ENST00000599157HSD17B14chr1949318398-108148663929288
ENST00000529629CAPN5chr1176804859+ENST00000263278HSD17B14chr1949318398-112552343966307
ENST00000529629CAPN5chr1176804859+ENST00000599157HSD17B14chr1949318398-111852343966307
ENST00000456580CAPN5chr1176804859+ENST00000263278HSD17B14chr1949318398-115655411997328
ENST00000456580CAPN5chr1176804859+ENST00000599157HSD17B14chr1949318398-114955411997328

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278559ENST00000263278CAPN5chr1176804859+HSD17B14chr1949318398-0.0294550450.97054493
ENST00000278559ENST00000599157CAPN5chr1176804859+HSD17B14chr1949318398-0.029760650.97023934
ENST00000529629ENST00000263278CAPN5chr1176804859+HSD17B14chr1949318398-0.0723723550.9276276
ENST00000529629ENST00000599157CAPN5chr1176804859+HSD17B14chr1949318398-0.0731388260.92686117
ENST00000456580ENST00000263278CAPN5chr1176804859+HSD17B14chr1949318398-0.091557850.9084422
ENST00000456580ENST00000599157CAPN5chr1176804859+HSD17B14chr1949318398-0.0922116860.90778834

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Fusion Genomic Features for CAPN5-HSD17B14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CAPN5-HSD17B14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:76804859/chr19:49318398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN5chr11:76804859chr19:49318398ENST00000278559+31326_34399641.0DomainCalpain catalytic
HgeneCAPN5chr11:76804859chr19:49318398ENST00000278559+313499_61499641.0DomainC2
HgeneCAPN5chr11:76804859chr19:49318398ENST00000529629+41426_34399641.0DomainCalpain catalytic
HgeneCAPN5chr11:76804859chr19:49318398ENST00000529629+414499_61499641.0DomainC2
HgeneCAPN5chr11:76804859chr19:49318398ENST00000278559+313344_49699641.0RegionNote=Domain III
HgeneCAPN5chr11:76804859chr19:49318398ENST00000529629+414344_49699641.0RegionNote=Domain III
TgeneHSD17B14chr11:76804859chr19:49318398ENST000002632784913_40123271.0Nucleotide bindingNAD


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Fusion Gene Sequence for CAPN5-HSD17B14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12888_12888_1_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1088nt_BP=486nt
GAATGCGAGCGCCAGCCCCCGCCGCAGGCCAGTCCCAGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCC
GCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCGGCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCA
GCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGCCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTC
GAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCCGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATC
TGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGC
TCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGC
CTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGAT
GAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGAC
CCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTG
GCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACC
CCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCT
GTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACGATTTGCA

>12888_12888_1_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=288AA_BP=141
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVT
AMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELG

--------------------------------------------------------------
>12888_12888_2_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1081nt_BP=486nt
GAATGCGAGCGCCAGCCCCCGCCGCAGGCCAGTCCCAGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCC
GCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCGGCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCA
GCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGCCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTC
GAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCCGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATC
TGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGC
TCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGC
CTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGAT
GAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGAC
CCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTG
GCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACC
CCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCT
GTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACGATTTGCA

>12888_12888_2_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=288AA_BP=141
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVT
AMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELG

--------------------------------------------------------------
>12888_12888_3_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1156nt_BP=554nt
AGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCG
GCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAG
CCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGC
CGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGTACAGTGGCCATTCGCTGGCCCCTCACAGGCCTGGCTGGGGAGATGCACGGAGAATGG
AGAATGTCCCCAGGCCTGGGAGCTCAGGGTGTCCGTCCTCCTCGCTCAGGGCCCGGGACCTGGGCATCTGCGAGGACCCCCGCCTCTTTG
TGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGT
CGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGG
CCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAG
TCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGG
GCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCA
CGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCC
CTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGC

>12888_12888_3_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=328AA_BP=181
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKYSGHSLAPHRPGWGDARRMENVPRPGSSGCPSSSLRARDLGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQ
KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLA

--------------------------------------------------------------
>12888_12888_4_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1149nt_BP=554nt
AGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCG
GCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAG
CCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGC
CGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGTACAGTGGCCATTCGCTGGCCCCTCACAGGCCTGGCTGGGGAGATGCACGGAGAATGG
AGAATGTCCCCAGGCCTGGGAGCTCAGGGTGTCCGTCCTCCTCGCTCAGGGCCCGGGACCTGGGCATCTGCGAGGACCCCCGCCTCTTTG
TGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGT
CGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGG
CCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAG
TCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGG
GCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCA
CGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCC
CTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGC

>12888_12888_4_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=328AA_BP=181
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKYSGHSLAPHRPGWGDARRMENVPRPGSSGCPSSSLRARDLGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQ
KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLA

--------------------------------------------------------------
>12888_12888_5_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1125nt_BP=523nt
AGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAG
CCCGGCTGGACCCGCGGCGGCTCGGCCGATGAGAATTCTGAAGCACAAAGAGGTTAACTGCTTTGCACCTCGCTGGCCTCAGTCTCCCCA
TCTGAGGACGGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGC
CCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCC
GGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATCTGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCA
GGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCT
GCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGG
GGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGAC
CCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGG
CCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGC
AGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGC
CCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGC

>12888_12888_5_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=307AA_BP=160
MQPPLQRPRRALHPGSPAGPAAARPMRILKHKEVNCFAPRWPQSPHLRTGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFED
PLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLV
GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS

--------------------------------------------------------------
>12888_12888_6_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1118nt_BP=523nt
AGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAG
CCCGGCTGGACCCGCGGCGGCTCGGCCGATGAGAATTCTGAAGCACAAAGAGGTTAACTGCTTTGCACCTCGCTGGCCTCAGTCTCCCCA
TCTGAGGACGGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGC
CCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCC
GGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATCTGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCA
GGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCT
GCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGG
GGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGAC
CCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGG
CCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGC
AGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGC
CCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGC

>12888_12888_6_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=307AA_BP=160
MQPPLQRPRRALHPGSPAGPAAARPMRILKHKEVNCFAPRWPQSPHLRTGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFED
PLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLV
GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS

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Fusion Gene PPI Analysis for CAPN5-HSD17B14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPN5-HSD17B14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPN5-HSD17B14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPN5C0242852Proliferative vitreoretinopathy1CTD_human;ORPHANET;UNIPROT
HgeneCAPN5C4721549Autosomal dominant neovascular inflammatory vitreoretinopathy1ORPHANET