Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZR-SNX9 (FusionGDB2 ID:HG7430TG51429)

Fusion Gene Summary for EZR-SNX9

check button Fusion gene summary
Fusion gene informationFusion gene name: EZR-SNX9
Fusion gene ID: hg7430tg51429
HgeneTgene
Gene symbol

EZR

SNX9

Gene ID

7430

51429

Gene nameezrinsorting nexin 9
SynonymsCVIL|CVL|HEL-S-105|VIL2SDP1|SH3PX1|SH3PXD3A|WISP
Cytomap('EZR')('SNX9')

6q25.3

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)sorting nexin-9SH3 and PX domain-containing protein 1SH3 and PX domain-containing protein 3AWiskott-Aldrich syndrome protein (WASP) interactor protein
Modification date2020032220200313
UniProtAcc

P15311

.
Ensembl transtripts involved in fusion geneENST00000476189, ENST00000367075, 
ENST00000337147, ENST00000392177, 
Fusion gene scores* DoF score26 X 22 X 10=572010 X 12 X 6=720
# samples 3213
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EZR [Title/Abstract] AND SNX9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZR(159239114)-SNX9(158317859), # samples:2
EZR(159239113)-SNX9(158317858), # samples:2
Anticipated loss of major functional domain due to fusion event.EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131

TgeneSNX9

GO:0043547

positive regulation of GTPase activity

15703209

TgeneSNX9

GO:0045860

positive regulation of protein kinase activity

18388313

TgeneSNX9

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

18353773

TgeneSNX9

GO:0060988

lipid tube assembly

17948057

TgeneSNX9

GO:0065003

protein-containing complex assembly

15703209

TgeneSNX9

GO:0097320

plasma membrane tubulation

18388313


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SNX9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VP-A875-01AEZRchr6

159239114

-SNX9chr6

158317859

+
ChimerDB4PRADTCGA-VP-A875EZRchr6

159239113

-SNX9chr6

158317858

+
ChimerDB4PRADTCGA-VP-A875EZRchr6

159239114

-SNX9chr6

158317859

+


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Fusion Gene ORF analysis for EZR-SNX9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000476189ENST00000392185EZRchr6

159239114

-SNX9chr6

158317859

+
5UTR-3CDSENST00000476189ENST00000392185EZRchr6

159239113

-SNX9chr6

158317858

+
Frame-shiftENST00000367075ENST00000392185EZRchr6

159239114

-SNX9chr6

158317859

+
Frame-shiftENST00000367075ENST00000392185EZRchr6

159239113

-SNX9chr6

158317858

+
In-frameENST00000337147ENST00000392185EZRchr6

159239114

-SNX9chr6

158317859

+
In-frameENST00000337147ENST00000392185EZRchr6

159239113

-SNX9chr6

158317858

+
In-frameENST00000392177ENST00000392185EZRchr6

159239114

-SNX9chr6

158317859

+
In-frameENST00000392177ENST00000392185EZRchr6

159239113

-SNX9chr6

158317858

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000337147EZRchr6159239114-ENST00000392185SNX9chr6158317859+3873146621633523
ENST00000392177EZRchr6159239114-ENST00000392185SNX9chr6158317859+3879152681639523
ENST00000337147EZRchr6159239113-ENST00000392185SNX9chr6158317858+3873146621633523
ENST00000392177EZRchr6159239113-ENST00000392185SNX9chr6158317858+3879152681639523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337147ENST00000392185EZRchr6159239114-SNX9chr6158317859+0.0002070480.999793
ENST00000392177ENST00000392185EZRchr6159239114-SNX9chr6158317859+0.0002016550.99979836
ENST00000337147ENST00000392185EZRchr6159239113-SNX9chr6158317858+0.0002070480.999793
ENST00000392177ENST00000392185EZRchr6159239113-SNX9chr6158317858+0.0002016550.99979836

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Fusion Genomic Features for EZR-SNX9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EZRchr6159239113-SNX9chr6158317858+0.142461060.85753894
EZRchr6159239113-SNX9chr6158317858+0.142461060.85753894
EZRchr6159239113-SNX9chr6158317858+0.142461060.85753894
EZRchr6159239113-SNX9chr6158317858+0.142461060.85753894

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EZR-SNX9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159239114/chr6:158317859)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

.
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSNX9chr6:159239113chr6:158317858ENST00000392185318250_361100596.0DomainPX
TgeneSNX9chr6:159239113chr6:158317858ENST00000392185318392_595100596.0DomainNote=BAR
TgeneSNX9chr6:159239114chr6:158317859ENST00000392185318250_361100596.0DomainPX
TgeneSNX9chr6:159239114chr6:158317859ENST00000392185318392_595100596.0DomainNote=BAR
TgeneSNX9chr6:159239113chr6:158317858ENST00000392185318201_213100596.0RegionNote=Critical for tubulation activity
TgeneSNX9chr6:159239114chr6:158317859ENST00000392185318201_213100596.0RegionNote=Critical for tubulation activity

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159239113chr6:158317858ENST00000337147-1132_2954587.0DomainFERM
HgeneEZRchr6:159239113chr6:158317858ENST00000367075-2142_2954587.0DomainFERM
HgeneEZRchr6:159239114chr6:158317859ENST00000337147-1132_2954587.0DomainFERM
HgeneEZRchr6:159239114chr6:158317859ENST00000367075-2142_2954587.0DomainFERM
HgeneEZRchr6:159239113chr6:158317858ENST00000337147-113115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159239113chr6:158317858ENST00000367075-214115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159239114chr6:158317859ENST00000337147-113115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159239114chr6:158317859ENST00000367075-214115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneSNX9chr6:159239113chr6:158317858ENST000003921853181_62100596.0DomainSH3
TgeneSNX9chr6:159239114chr6:158317859ENST000003921853181_62100596.0DomainSH3


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Fusion Gene Sequence for EZR-SNX9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28130_28130_1_EZR-SNX9_EZR_chr6_159239113_ENST00000337147_SNX9_chr6_158317858_ENST00000392185_length(transcript)=3873nt_BP=146nt
GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA
TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGA
GTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCA
ACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGC
CCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGA
AAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAGAGAAAA
TTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAGGCTCCA
AAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACTTTGACT
GGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTGAAGAGG
AATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTTTCCAGC
AGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATATTTTCCA
CCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGGATGACG
GCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAAAGGCCT
TGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGACTTATG
AAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTCTTGGCT
GCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCACCCTAC
AAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGATCTATG
ATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCAGCCGCT
TTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTTTTTCCC
CTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGCGTCAGT
TATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAAGTTACC
AGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGTCTTATA
TAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACTATGCCA
GAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCCTTTCAC
TGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGTGGCAGG
TGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACATTTCTGA
TGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAAGAATAC
ATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGAGGGCCT
GGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTGCTGTGG
CCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCCATTAGA
TGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAGACCAGC
GCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCAAAACAG
GACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGTGCCTTA
CCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACACCAAAA
ATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTCCCCACT
TGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATAAATGTT
TTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTTTCAAAA
CACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAATTCTTC
CCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCACCTGGGA
GTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATGGGGGAA
ATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCACGGGAT
TTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTAGATACG
TTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAAATATAG

>28130_28130_1_EZR-SNX9_EZR_chr6_159239113_ENST00000337147_SNX9_chr6_158317858_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------
>28130_28130_2_EZR-SNX9_EZR_chr6_159239113_ENST00000392177_SNX9_chr6_158317858_ENST00000392185_length(transcript)=3879nt_BP=152nt
GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT
GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAG
CCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACA
CTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGG
ATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCAT
CCATGAAAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAG
AGAAAATTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAG
GCTCCAAAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACT
TTGACTGGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTG
AAGAGGAATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTT
TCCAGCAGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATAT
TTTCCACCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGG
ATGACGGCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAA
AGGCCTTGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGA
CTTATGAAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTC
TTGGCTGCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCA
CCCTACAAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGA
TCTATGATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCA
GCCGCTTTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTT
TTTCCCCTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGC
GTCAGTTATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAA
GTTACCAGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGT
CTTATATAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACT
ATGCCAGAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCC
TTTCACTGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGT
GGCAGGTGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACAT
TTCTGATGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAA
GAATACATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGA
GGGCCTGGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTG
CTGTGGCCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCC
ATTAGATGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAG
ACCAGCGCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCA
AAACAGGACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGT
GCCTTACCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACA
CCAAAAATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTC
CCCACTTGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATA
AATGTTTTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTT
TCAAAACACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAA
TTCTTCCCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCAC
CTGGGAGTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATG
GGGGAAATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCA
CGGGATTTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTA
GATACGTTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAA

>28130_28130_2_EZR-SNX9_EZR_chr6_159239113_ENST00000392177_SNX9_chr6_158317858_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------
>28130_28130_3_EZR-SNX9_EZR_chr6_159239114_ENST00000337147_SNX9_chr6_158317859_ENST00000392185_length(transcript)=3873nt_BP=146nt
GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA
TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGA
GTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCA
ACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGC
CCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGA
AAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAGAGAAAA
TTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAGGCTCCA
AAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACTTTGACT
GGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTGAAGAGG
AATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTTTCCAGC
AGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATATTTTCCA
CCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGGATGACG
GCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAAAGGCCT
TGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGACTTATG
AAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTCTTGGCT
GCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCACCCTAC
AAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGATCTATG
ATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCAGCCGCT
TTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTTTTTCCC
CTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGCGTCAGT
TATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAAGTTACC
AGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGTCTTATA
TAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACTATGCCA
GAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCCTTTCAC
TGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGTGGCAGG
TGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACATTTCTGA
TGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAAGAATAC
ATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGAGGGCCT
GGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTGCTGTGG
CCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCCATTAGA
TGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAGACCAGC
GCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCAAAACAG
GACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGTGCCTTA
CCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACACCAAAA
ATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTCCCCACT
TGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATAAATGTT
TTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTTTCAAAA
CACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAATTCTTC
CCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCACCTGGGA
GTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATGGGGGAA
ATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCACGGGAT
TTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTAGATACG
TTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAAATATAG

>28130_28130_3_EZR-SNX9_EZR_chr6_159239114_ENST00000337147_SNX9_chr6_158317859_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------
>28130_28130_4_EZR-SNX9_EZR_chr6_159239114_ENST00000392177_SNX9_chr6_158317859_ENST00000392185_length(transcript)=3879nt_BP=152nt
GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT
GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAG
CCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACA
CTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGG
ATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCAT
CCATGAAAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAG
AGAAAATTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAG
GCTCCAAAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACT
TTGACTGGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTG
AAGAGGAATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTT
TCCAGCAGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATAT
TTTCCACCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGG
ATGACGGCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAA
AGGCCTTGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGA
CTTATGAAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTC
TTGGCTGCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCA
CCCTACAAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGA
TCTATGATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCA
GCCGCTTTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTT
TTTCCCCTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGC
GTCAGTTATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAA
GTTACCAGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGT
CTTATATAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACT
ATGCCAGAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCC
TTTCACTGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGT
GGCAGGTGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACAT
TTCTGATGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAA
GAATACATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGA
GGGCCTGGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTG
CTGTGGCCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCC
ATTAGATGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAG
ACCAGCGCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCA
AAACAGGACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGT
GCCTTACCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACA
CCAAAAATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTC
CCCACTTGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATA
AATGTTTTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTT
TCAAAACACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAA
TTCTTCCCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCAC
CTGGGAGTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATG
GGGGAAATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCA
CGGGATTTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTA
GATACGTTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAA

>28130_28130_4_EZR-SNX9_EZR_chr6_159239114_ENST00000392177_SNX9_chr6_158317859_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZR-SNX9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159239113chr6:158317858ENST00000337147-113244_5864.0587.0SCYL3
HgeneEZRchr6:159239113chr6:158317858ENST00000367075-214244_5864.0587.0SCYL3
HgeneEZRchr6:159239114chr6:158317859ENST00000337147-113244_5864.0587.0SCYL3
HgeneEZRchr6:159239114chr6:158317859ENST00000367075-214244_5864.0587.0SCYL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZR-SNX9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZR-SNX9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEZRC0033578Prostatic Neoplasms3CTD_human
HgeneEZRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEZRC0007097Carcinoma1CTD_human
HgeneEZRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneEZRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEZRC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneEZRC0027627Neoplasm Metastasis1CTD_human
HgeneEZRC0029408Degenerative polyarthritis1CTD_human
HgeneEZRC0086743Osteoarthrosis Deformans1CTD_human
HgeneEZRC0205696Anaplastic carcinoma1CTD_human
HgeneEZRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEZRC0205698Undifferentiated carcinoma1CTD_human
HgeneEZRC0205699Carcinomatosis1CTD_human
HgeneEZRC1257925Mammary Carcinoma, Animal1CTD_human