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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EZR-EFCAB2 (FusionGDB2 ID:HG7430TG84288)

Fusion Gene Summary for EZR-EFCAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: EZR-EFCAB2
Fusion gene ID: hg7430tg84288
HgeneTgene
Gene symbol

EZR

EFCAB2

Gene ID

7430

84288

Gene nameezrinEF-hand calcium binding domain 2
SynonymsCVIL|CVL|HEL-S-105|VIL2CFAP200|DRC8
Cytomap('EZR')('EFCAB2')

6q25.3

1q44

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)dynein regulatory complex protein 8EF-hand calcium-binding domain-containing protein 2dynein regulatory complex subunit 8
Modification date2020032220200313
UniProtAcc

P15311

.
Ensembl transtripts involved in fusion geneENST00000337147, ENST00000367075, 
ENST00000392177, ENST00000476189, 
Fusion gene scores* DoF score26 X 22 X 10=57206 X 6 X 3=108
# samples 326
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EZR [Title/Abstract] AND EFCAB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEZR(159239114)-EFCAB2(245222688), # samples:1
Anticipated loss of major functional domain due to fusion event.EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EFCAB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1402-02AEZRchr6

159239114

-EFCAB2chr1

245222688

+


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Fusion Gene ORF analysis for EZR-EFCAB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337147ENST00000487845EZRchr6

159239114

-EFCAB2chr1

245222688

+
5CDS-3UTRENST00000367075ENST00000487845EZRchr6

159239114

-EFCAB2chr1

245222688

+
5CDS-3UTRENST00000392177ENST00000487845EZRchr6

159239114

-EFCAB2chr1

245222688

+
5UTR-3CDSENST00000476189ENST00000366522EZRchr6

159239114

-EFCAB2chr1

245222688

+
5UTR-3CDSENST00000476189ENST00000366523EZRchr6

159239114

-EFCAB2chr1

245222688

+
5UTR-3CDSENST00000476189ENST00000447569EZRchr6

159239114

-EFCAB2chr1

245222688

+
5UTR-3UTRENST00000476189ENST00000487845EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000337147ENST00000366522EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000337147ENST00000366523EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000337147ENST00000447569EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000392177ENST00000366522EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000392177ENST00000366523EZRchr6

159239114

-EFCAB2chr1

245222688

+
Frame-shiftENST00000392177ENST00000447569EZRchr6

159239114

-EFCAB2chr1

245222688

+
In-frameENST00000367075ENST00000366522EZRchr6

159239114

-EFCAB2chr1

245222688

+
In-frameENST00000367075ENST00000366523EZRchr6

159239114

-EFCAB2chr1

245222688

+
In-frameENST00000367075ENST00000447569EZRchr6

159239114

-EFCAB2chr1

245222688

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367075EZRchr6159239114-ENST00000366523EFCAB2chr1245222688+10371814261142
ENST00000367075EZRchr6159239114-ENST00000366522EFCAB2chr1245222688+568918133373864175
ENST00000367075EZRchr6159239114-ENST00000447569EFCAB2chr1245222688+5061814261142

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367075ENST00000366523EZRchr6159239114-EFCAB2chr1245222688+0.035335910.9646641
ENST00000367075ENST00000366522EZRchr6159239114-EFCAB2chr1245222688+0.31655810.6834419
ENST00000367075ENST00000447569EZRchr6159239114-EFCAB2chr1245222688+0.103447240.89655274

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Fusion Genomic Features for EZR-EFCAB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EZRchr6159239113-EFCAB2chr1245222687+0.0791606750.92083937
EZRchr6159239113-EFCAB2chr1245222687+0.0791606750.92083937

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EZR-EFCAB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159239114/chr1:245222688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

.
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000036652228228_263172270.0DomainEF-hand 2
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000036652328150_18536163.0DomainEF-hand 1
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000036652328228_26336163.0DomainEF-hand 2
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000044756917150_18536134.0DomainEF-hand 1
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000044756917228_26336134.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159239114chr1:245222688ENST00000337147-1132_2954587.0DomainFERM
HgeneEZRchr6:159239114chr1:245222688ENST00000367075-2142_2954587.0DomainFERM
HgeneEZRchr6:159239114chr1:245222688ENST00000337147-113115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159239114chr1:245222688ENST00000367075-214115_1204587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneEFCAB2chr6:159239114chr1:245222688ENST0000036652228150_185172270.0DomainEF-hand 1


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Fusion Gene Sequence for EZR-EFCAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28113_28113_1_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000366522_length(transcript)=5689nt_BP=181nt
GGACCCGCCCCGCCGGGGCTTTTGGGAGCGCGGGCAGCGAGCGCACTCGGCGGACGCAAGGGCGGCGGGGAGCACACGGAGCACTGCAGG
CGCCGGGTTGGGACAGCGTCTTCGCTGCTGCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACC
AAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTGCAGAGGTAGAGGAAGAAGAAC
CCACTGGATACATTCGATTCGAAAAATTTCTTCCGGTGATGACAGAAATACTACTAGAAAGAAAATACAGACCAATTCCAGAAGATGTCC
TTCTTCGAGCTTTTGAGGTTTTAGATTCAGCTAAACGTGGGTTTCTTACTAAGGACGAGCTGATCAAGTATATGACTGAAGAAGATGGAG
TTTCGCTCCGTCGCCCAGGCTGAAGTGCAGTGGCGTGATCTTGGCTCGTTGCAACCTCCACCTCCCGGGTTCAAGAGATTCTCCTGCCTC
AGCCTCCTGAGCAGCTGGGATGACAGGCACACACCACCACGCCTGGCTAATTTCTGTATTTTTAGTAGAGACGGGGTTTCACCATGGTCT
GGTGACCTCCTGGTCTCGAACTCCTGACCTCAAGTGATCCTCCCGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCATGAGCCACCGCA
CCCGGCTGCTTCCTTAACTCTTGATCTCCTCTCTGTATCTTGCTTTGTCTAGCTGTTCTCTTCTCTCCATATTCATCCAAACATTTGCTT
AGAAGTACCCAGAAGCATGGCGTTGAATGTGGTACACCTTGAACGAAGGGTGAAGAAACGAGGCAGAGTGACTTAGTAGCAAGTGACAGC
ACACAGTTTAAATTTTAATATTAGCCCATTTACAAACAACAGCTTATATAATAGTCATTCACATACCTCAACACTCACCATCCCCTCCCC
ACTTTTTTTCTGGAGACAGGGTTTCACTGTCACCCCAGCTGGAATGCAGGTGGCATGATCACAGCTCACTGTAGCATCGACCTCCTGGAC
TCAAGGGGTCCTCGCGCCTCAGCCTCCTGAGTAGCTGGGACCACAGGTGCATGCCACCACGCCCAGCTAATGTTTTTTTTTATTTTTTGT
AGAGACAGGGTCTGGCTATGTTGCTTAGGCTGGTCTCAAACTCCTGGGTTCAAGCGATCCTGCCACCTCAGCCTCCCAAAGTGTTAGGAT
TACAGATGTGAGCCACTGTGCCCAGCCAACATTCACCCCATTCAAGTGTGCAATTCAATGGATTCTAGTATCTTCACAGTGCTGTGCAAC
TATCACTCCTATCTACTTACAAAGCATTTCCATCATCTTAAAAAGAATCCCCATGTCCAATAGCAGTTCCCCTTCCCCCACCGTCATCCT
CGGGCAACCGCTAATCTTCCTGTGTGTCTGTGGATTTGCCTCTTCAGGGCATTTCACATAAACACAATCATACAATATGTGGCCTTCTGT
GTCTGGCTTCTTTCATTTAGTGTAAGGCTTTTGAGGTTCATCCATGTTGTAATGTATATCCTTAGTTCATTCTTTTTTGTTAAGCTCACA
AATAAAAAGCCTCACTTTTTATTTGAGGCAAGGAGACTGGCTACAGGGATTACAGTTCCAGCAGTCAAAACGCAACTCCAAGTGGCACTA
TTTGGACCGTAGGTTTTGCTTCATTTTGGCTGGAAAAGGGTATTCAGGATGTACTTCTCCCAGCCGGACAAGAAAAAGGGCAAAGAAAAC
TGGAAGAGACGTCTCGTCTACACAAACTGCTCTTTGGACACAGCATCAACCTGACCACACCCGTGCTGGCCAGTCTGCAGGTTGCTGACC
CGCCGTTAAGGGACACAGGCCATACTACACTTGCTAGAAAAACTGAGGCAGGAAAAAGAGGTGCAAGGCACTGGGGGAAGAGCAGGTACC
TATAGCTTTAAAGCTCAGTGTTGAAGGGGTAATCCTTGCAGGAGGCACAGCTCACCAAGACACAGACCCTCCCGTTCCTGTTGTAGCTGA
CTACAGTGGTCACATCAGGCTGCTCAGTTGAAAGTCGAAGTCCTCCAAGTTTTCAGCAGTGCGTTCCAGCATCACCACCGAAATGATGAT
AGGAATTACCACCAAATTCCTATGCATGGGAAACCAGATCAGAACCTGGGCTGCGTTTTTATTTGTTTATTTTTTTTACTGTGCTTGGCT
GTGATTGCTTTGGTGCTGGGATCCCCCAGACCTGTCACGAGAGCTGAGGGGACTACAGGCAGTCACCACCTTGCCTTTGGATTGGCAGCC
CTGGATTAACTTCTCCTGAGGTGGGTGCAGGTGGCACTCACTGTGGTTAACCACTGTTTTTAAGCCAGGTTTCTTTTTTTCTGTCTGTCA
TATATATATATATATATTTAGAGACAGGGTCTCACTCTATCACTCAGGCCTGGAGTGTAGTGGCATGATCATAACTCACTGCAGCCTCGA
GTTCCTGGGCTCAAGTGATCCTCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTGAGACACCACACCTGGTCTTAAGCCAGGTTT
CTTTACCATCTCTTGGAGATGGCTGCAGTTGGAGATTCCAAAAGCTTTCAGAGCCCTTCATCCACCAGCTCCTCCATGTGGCCACCCATG
TGACATGAAGTTGGTGTCACTAGGTACCACGTTGTCTGTCCCATCCAACAGGAAAAATAGCCTGTTGGCCAGTGAATAAGGTAGGAATCC
AGGTGGTCCCCTGAGGGTCTTCTGACAGGCTCCTTTATCAGGCTCTTCTCATGGTATGAGCACCGCAGCTTGCTGACAGTGGCAACGTTC
TCAAGCTTCACAGACTCCGTCACTTGGCCTGGAGGGGAATTCTAGGTGTCCAGCCCCAGGACAGGCATTTTGGCACCATGATTGAGCACG
ATATGGTGAGCCATCCTCACAGGATTAAGAAGAATTCTGGACAGAAATATAGTTGTAAGTAAGCATCAGTCAGCCTGCACTTTGACCCAC
TTCCTTGTAACCAACAGTGACGTAGCACTAGGTAACATTTGCATCCCCGTTGTTCCTATAGATACAATTTCTGACCTTAGAATCACAAGG
CTTTTGTTTAAAATAGATGGGATCTCTGACATTAGAATCATAAGATTTTTGTTTAAGACTTGCTTAAGATGTTTTTCAGATCCTGAATTC
CAGCAAAACAGCCGACACCAACCAGTTTGAAGACCCCCACAGAGGAATGTGATCAGCATGAAAATACAGCTTCGTCTCCCTCTCCCATGA
CTCCACCCTGCACACTTCGACCAATCAACCATCTCCACACTCCAGTCTCCACTCCCAAACCCTTAAAAACCCCAGCCCCAAACTCCTCAG
GGAGATGGATTTGACGTTTCCTCCCATTTCCTCCTTCGGTGGCCCTACGATGAAACCTCTTTCTCTGCTACAACCCTATGCCTCGGCGTA
TTCACTTTCTGGTCCCATCCAGCGATGGACCCATCGTGGTTACCGTGGCTGGCCAAGCCTGCTGTGCTTCACAGACCCCACTCAGGATCA
CACCACTTCGTTCCACTGTTTGGAGATGCCATGTTTGCTTATCCCTTCATCAGCTGATGAGCATTTGTGCTGTTTTCACTTTTTGGCTAT
TACGAAAATGTTGCTACGAGCATCCATGATATTCGCCCATTTAAAAAAGTGTTTTTCACCATTACTGCTGTGGGAAATTTCTCCCTGGCT
CTGTCCTTTCTTTGTAGCCCAGCCTTCCCCCAGGTTTTGGCTCTCCCTCTCTGGCTCAATGTCAGCTCCTTGTCTCACCTCCTAGAGCAA
TTCCACTCTCCCACCTCCTGCTGCGGCATTTCCAAAGCCTCTGCTTAGCAAGGGACCACCCATTCTGCACCTCTCCCCTTAGGGCTGCAA
GCACCTGCACAAACTTGGTGGTTATCCTATGCCTCAACTCAATCAAATTCTCTCAGTTTTCCATCAGCAATCTTTTTAAGCCAAAGGGAA
GGCAAGGACTTGATCTTCACATCACATGAATCATGACACCTGCCTTAGAAGGCAGAAGCAACTGTAGTTGGAATAGCAATTGTTTTTCAA
CATATGGGATGATATCAAGGCTCTTTCCTCCCCATATGTCCTGCCCTGTTAGTGGCTGGGGCTGAGGGTTTTCCCAGGAAGCCAGATTGT
CCTCACAAGTTCCTCAGGACCCTAGGGCTTCCACAGATAGTAGGACTGTTATCAGAAAGAAGTCTCGATCCAGACGCCGAGAGAGGGTTC
TTGGATATCGCCCAAGAAAGAATTCAGGGGGAGTCCATAGAGTGAAGTGAAAGCAAGTTTGTTAAGAAAACAAAGGAGTAAAGAATGGCT
ACTCCATAGGCAGAGCAGCTCCGAGGGCTGCTGGTTGCCCATTTTTTTTTTTTTTTCTTTGAGATGGAGTCTGGCTCTGTCGCCCAGGCT
GGAGTGCGGTGGCACAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGAC
TACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGAGGTTTCACATGTTAGCCAGGATGGTCTCGATCTCCT
GACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATGACAGGCGTGACTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTG
GGATTACAGGCGTGAGTCACCACGCCGGGCCGGTTGCCCATTTTTATGATTATTTCTTGATTATATGCTAAACAAGGGCTGGATTATTCA
TGAGGGAAAGGGGTGGGCAATTCCTGGAACGGAGGGTTCCTCCCCCTTTTAGACCGTGTAGGATAACTTCTTGACATTGCCCTGGCATTT
GTAAACTGTCATGGCGCAGGTGGGAGTGTCTCTTAGCATGCTAATGCATTATAATTAGCATATAATGAGCAGTGAGGTCGACCAGAGGCC
ACTCTCATCACCATTTTGGGTTTGGTGGGTTTTGGCCACTTCTCTACTGCAACCTGTTTTATCAGTAAGGTCTTTATGACCTGTATCTTG
TGGTGACCTCCTGTCTCATCCTGTGACTTAGAATGCCTAACAGGCTGGGGACGCAGCCCAGCAGATCTCAGCCTCATTTTACTCAGCCCC
TCATCACTCTGATTCAAATGCCTCTGACATGACCACGCAGATTTGAGAAACAGGCCCTCAGCCAACCAGACTCTGGCTCTACGACACACT
TAATACTGTGAAAAGAAGATTACGGGTCATAGTCACAAATACCAGGGGTGCAAAACTTCAGATTAGAAGACACTTGTCAGACTCAGAGGC
TCATCCAACTCCACGGAGATCATTATCACCACAAGTTCTTCAGACAGGTGTGGAGGTTTTCTAAGGGATATTTTTATTTTCTGGATTGCA
ATTTTGTTTAGGAAGAGATGAAAGTGAGGATCAACTACTTTGAGGATTGTACAACTTTGTAAATTGCACAAATATGACGGCATATTTATA
TCTGCCTGCATTTGTGAAAACAAACTTGTCAAGGAGCTTATTTCTGGAAAGGGTCAATGATTCTAGAAAAAAAAAAAAGATAAATATGAG

>28113_28113_1_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000366522_length(amino acids)=175AA_BP=
MHTSTNQPSPHSSLHSQTLKNPSPKLLREMDLTFPPISSFGGPTMKPLSLLQPYASAYSLSGPIQRWTHRGYRGWPSLLCFTDPTQDHTT

--------------------------------------------------------------
>28113_28113_2_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000366523_length(transcript)=1037nt_BP=181nt
GGACCCGCCCCGCCGGGGCTTTTGGGAGCGCGGGCAGCGAGCGCACTCGGCGGACGCAAGGGCGGCGGGGAGCACACGGAGCACTGCAGG
CGCCGGGTTGGGACAGCGTCTTCGCTGCTGCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACC
AAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTGCAGAGGTAGAGGAAGAAGAAC
CCACTGGATACATTCGATTCGAAAAATTTCTTCCGGTGATGACAGAAATACTACTAGAAAGAAAATACAGACCAATTCCAGAAGATGTCC
TTCTTCGAGCTTTTGAGGTTTTAGATTCAGCTAAACGTGGGTTTCTTACTAAGGACGAGCTGATCAAGTATATGACTGAAGAAGGTGAGC
CTTTTTCTCAAGAGGAAATGGAAGAAATGTTGTCTGCTGCAATTGATCCAGAATCAAATTCAATTAATTACAAGGACTATATAACAATGA
TGGTGATAGATGAAAATTAAATGTTCTAAAGATAATTTCTGATTGAAAGAACAATTTTAGAAATTGCTTGTTCTTGTTAATTTCACATCT
TATCTTAGGATTCCTATATGTGATATTTAATACCTTGTGACATAACTATTTTAAGACACTTTGTTTTTAAAGATGATCGTAACACTTTAA
ACCAAATTTAGTATGTCTAGCCTTACAGAATGATAAATTACTATTTATTTAAAAACTATTCTTAAAACATTTTAACATTAGAATGGATTG
TTGTTTATTTTCTACAATAAAACTCAGGTCACCTTCGAATTAATTAAGCTGACAAAATGAAAATGACTTAATTACCCAAGGTTTGGCATG
TAAAGATCTTAAGAGGGGGCAGAACGAACCACTCGAAAACGAGTAGCAGTGTAATGAAGGCTTCTTTTTTAAACAATAACAAATGCTTCA

>28113_28113_2_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000366523_length(amino acids)=142AA_BP=1
MISSSLVRNPRLAESKTSKARRRTSSGIGLYFLSSSISVITGRNFSNRMYPVGSSSSTSAIRSCSSPSVGQHPNDLIIVPISWFRHFRFL

--------------------------------------------------------------
>28113_28113_3_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000447569_length(transcript)=506nt_BP=181nt
GGACCCGCCCCGCCGGGGCTTTTGGGAGCGCGGGCAGCGAGCGCACTCGGCGGACGCAAGGGCGGCGGGGAGCACACGGAGCACTGCAGG
CGCCGGGTTGGGACAGCGTCTTCGCTGCTGCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACC
AAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTGCAGAGGTAGAGGAAGAAGAAC
CCACTGGATACATTCGATTCGAAAAATTTCTTCCGGTGATGACAGAAATACTACTAGAAAGAAAATACAGACCAATTCCAGAAGATGTCC
TTCTTCGAGCTTTTGAGGTTTTAGATTCAGCTAAACGTGGGTTTCTTACTAAGGACGAGCTGATCAAGTATATGACTGAAGAAGATGGAG

>28113_28113_3_EZR-EFCAB2_EZR_chr6_159239114_ENST00000367075_EFCAB2_chr1_245222688_ENST00000447569_length(amino acids)=142AA_BP=1
MISSSLVRNPRLAESKTSKARRRTSSGIGLYFLSSSISVITGRNFSNRMYPVGSSSSTSAIRSCSSPSVGQHPNDLIIVPISWFRHFRFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EZR-EFCAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159239114chr1:245222688ENST00000337147-113244_5864.0587.0SCYL3
HgeneEZRchr6:159239114chr1:245222688ENST00000367075-214244_5864.0587.0SCYL3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EZR-EFCAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EZR-EFCAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEZRC0033578Prostatic Neoplasms3CTD_human
HgeneEZRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEZRC0007097Carcinoma1CTD_human
HgeneEZRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneEZRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEZRC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneEZRC0027627Neoplasm Metastasis1CTD_human
HgeneEZRC0029408Degenerative polyarthritis1CTD_human
HgeneEZRC0086743Osteoarthrosis Deformans1CTD_human
HgeneEZRC0205696Anaplastic carcinoma1CTD_human
HgeneEZRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEZRC0205698Undifferentiated carcinoma1CTD_human
HgeneEZRC0205699Carcinomatosis1CTD_human
HgeneEZRC1257925Mammary Carcinoma, Animal1CTD_human