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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:WRN-ADAM9 (FusionGDB2 ID:HG7486TG8754) |
Fusion Gene Summary for WRN-ADAM9 |
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Fusion gene information | Fusion gene name: WRN-ADAM9 | Fusion gene ID: hg7486tg8754 | Hgene | Tgene | Gene symbol | WRN | ADAM9 | Gene ID | 7486 | 8754 |
Gene name | WRN RecQ like helicase | ADAM metallopeptidase domain 9 | |
Synonyms | RECQ3|RECQL2|RECQL3 | CORD9|MCMP|MDC9|Mltng | |
Cytomap | ('WRN')('ADAM9') 8p12 | 8p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2 | disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000298139, | ||
Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 12 X 12 X 8=1152 |
# samples | 8 | 13 | |
** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1152*10)=-3.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: WRN [Title/Abstract] AND ADAM9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | WRN(30982516)-ADAM9(38871484), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WRN-ADAM9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. WRN-ADAM9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | WRN | GO:0000731 | DNA synthesis involved in DNA repair | 17563354 |
Hgene | WRN | GO:0006259 | DNA metabolic process | 16622405 |
Hgene | WRN | GO:0006284 | base-excision repair | 17611195 |
Hgene | WRN | GO:0006974 | cellular response to DNA damage stimulus | 18203716 |
Hgene | WRN | GO:0006979 | response to oxidative stress | 17611195 |
Hgene | WRN | GO:0009267 | cellular response to starvation | 11420665 |
Hgene | WRN | GO:0010225 | response to UV-C | 17563354 |
Hgene | WRN | GO:0031297 | replication fork processing | 17115688 |
Hgene | WRN | GO:0032508 | DNA duplex unwinding | 11735402|26420422 |
Hgene | WRN | GO:0044806 | G-quadruplex DNA unwinding | 11735402 |
Hgene | WRN | GO:0051345 | positive regulation of hydrolase activity | 17611195 |
Hgene | WRN | GO:0061820 | telomeric D-loop disassembly | 15200954|19734539|26420422 |
Hgene | WRN | GO:0071480 | cellular response to gamma radiation | 21639834 |
Hgene | WRN | GO:0098530 | positive regulation of strand invasion | 26420422 |
Hgene | WRN | GO:1902570 | protein localization to nucleolus | 11420665 |
Tgene | ADAM9 | GO:0000186 | activation of MAPKK activity | 17704059 |
Tgene | ADAM9 | GO:0006509 | membrane protein ectodomain proteolysis | 9920899 |
Tgene | ADAM9 | GO:0034612 | response to tumor necrosis factor | 11831872 |
Tgene | ADAM9 | GO:0050714 | positive regulation of protein secretion | 17704059 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-B6-A0I1-01A | WRN | chr8 | 30982516 | - | ADAM9 | chr8 | 38871484 | + |
ChimerDB4 | BRCA | TCGA-B6-A0I1-01A | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + |
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Fusion Gene ORF analysis for WRN-ADAM9 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000298139 | ENST00000484143 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + |
Frame-shift | ENST00000298139 | ENST00000481513 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + |
In-frame | ENST00000298139 | ENST00000466936 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + |
In-frame | ENST00000298139 | ENST00000487273 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000298139 | WRN | chr8 | 30982516 | + | ENST00000487273 | ADAM9 | chr8 | 38871484 | + | 6581 | 3074 | 249 | 5279 | 1676 |
ENST00000298139 | WRN | chr8 | 30982516 | + | ENST00000466936 | ADAM9 | chr8 | 38871484 | + | 4678 | 3074 | 249 | 3263 | 1004 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000298139 | ENST00000487273 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + | 9.57E-05 | 0.9999043 |
ENST00000298139 | ENST00000466936 | WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871484 | + | 8.70E-05 | 0.999913 |
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Fusion Genomic Features for WRN-ADAM9 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871483 | + | 0.000213238 | 0.9997868 |
WRN | chr8 | 30982516 | + | ADAM9 | chr8 | 38871483 | + | 0.000213238 | 0.9997868 |
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Fusion Protein Features for WRN-ADAM9 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:30982516/chr8:38871484) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 507_510 | 941 | 1433.0 | Compositional bias | Note=Poly-Glu |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 558_724 | 941 | 1433.0 | Domain | Helicase ATP-binding |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 60_228 | 941 | 1433.0 | Domain | Note=3'-5' exonuclease |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 749_899 | 941 | 1433.0 | Domain | Helicase C-terminal |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 668_671 | 941 | 1433.0 | Motif | Note=DEAH box |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 571_578 | 941 | 1433.0 | Nucleotide binding | ATP |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 424_477 | 941 | 1433.0 | Region | Note=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 424_450 | 941 | 1433.0 | Repeat | 1 |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 451_477 | 941 | 1433.0 | Repeat | 2 |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 505_634 | 84 | 820.0 | Compositional bias | Note=Cys-rich | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 790_795 | 84 | 820.0 | Compositional bias | Note=Poly-Pro | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 212_406 | 84 | 820.0 | Domain | Peptidase M12B | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 414_501 | 84 | 820.0 | Domain | Disintegrin | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 644_698 | 84 | 820.0 | Domain | EGF-like | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 719_819 | 84 | 820.0 | Topological domain | Cytoplasmic | |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 698_718 | 84 | 820.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 1150_1229 | 941 | 1433.0 | Domain | HRDC |
Tgene | ADAM9 | chr8:30982516 | chr8:38871484 | ENST00000487273 | 2 | 22 | 29_697 | 84 | 820.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for WRN-ADAM9 |
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>99398_99398_1_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000466936_length(transcript)=4678nt_BP=3074nt GGAGCTGATGTGTACTGTGTGCGCCGGGGAGGCGCCGGCTTGTACTCGGCAGCGCGGGAATAAAGTTTGCTGATTTGGTGTCTAGCCTGG ATGCCTGGGTTGCAGGCCCTGCTTGTGGTGGCGCTCCACAGTCATCCGGCTGAAGAAGACCTGTTGGACTGGATCTTCTCGGGTTTTCTT TCAGATATTGTTTTGTATTTACCCATGAAGACATTGTTTTTTGGACTCTGCAAATAGGACATTTCAAAGATGAGTGAAAAAAAATTGGAA ACAACTGCACAGCAGCGGAAATGTCCTGAATGGATGAATGTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAG AGTGTTTTTGAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACGATGCTAGTGATTGCTCTTTCCTGTCAGAA GATATTAGCATGAGTCTATCAGATGGGGATGTGGTGGGATTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTT GCACTAATTCAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGTCAGTTTTTCCCCAGGGATTAAAAATGTTG CTTGAAAATAAAGCAGTTAAAAAGGCAGGTGTAGGAATTGAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAAT TTTGTGGAGTTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTAACAGTCTGGTTAAACACCTCTTAGGTAAA CAGCTCCTGAAAGACAAGTCTATCCGCTGTAGCAATTGGAGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCT TATGCTGGTTTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTGCTATAAATAAAGAGGAAGAAATCCTACTT AGCGACATGAACAAACAGTTGACTTCAATCTCTGAGGAAGTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAAC CCACGGAGGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGACT GAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAA GTTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGTG GAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATT ACAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCCC AATGATAATGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAAT GAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTA GAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAAT GAAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCC AGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAG AGTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTA CAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGG ATTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTG GATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTT CCAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGT ACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACA AGTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTG AATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGT GTCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCA TATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGG CACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGA TGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGAT AATTGCAGGTCCAGAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATA CAGAGGTGTGGTCCTCTCTGCATCAGAGAACAGAGTACTCCTGGGGACAGAGCTGGCCAGAATACCCAAAATAATTGGCAGATGTCAAAT TTGGCTTTCTGTGTTTATTACTAGAGCATAAACATTTCTAGTTTTGTTTGAGTGTTTTACAGTCCTTTTTGGCAGTTAGGTATTATACCT TTTTTTCTTTTGCAATGGTTTTCATGAGAAATCTTTATTCCCATTACATGTGTATGTTTTATTTTTCTTCTGAACTTTGTAATACTTTGC TATGTTGAATTGTTTCTGTTGGTAGCGCACTTTTGCAGCATTCTTCAAATAGGAGGCAAAAAAATCTTTAGATTAATTATTAGTACTTAC AAAAACCAAGGAAATGCTGACTTAGGCCTATCTTCTGGTCCACTATCTGATTTCTTTATCTTAGTGTGTTGTTGGTCCATTGTTTAATAG AAAATTAGTAGAGGAGTTTGAATTTACCTTACAGCATAAACCAGATAGAAAATAACGCATTCATCCAGTCATGCATCCAATGATTACCAA GGCAGAAGGCCAAACACCACATAATTTGTGTCACTTGACAAAAGCAGTAATGTTAAAAGGCATTTTTTTCCTCATAGAGGTTTCTTGGCA TACTTTCTTCAGACATACACTGTTTGGGCTTGAGTTTTGACTCATTATTTGCTGATGAAGCTACTTTAATCTGTTTGTGCCTTGGTATCT TCGCTTTAAAATGTAATAATAGTTACCACTTTATGGATATACTGGGAAACTTAACTGAGTTAATACTTACAAGATGCTTAGAACAGTCTG ACAATTTTTAACTCAACGAATGTTATTATTTGTTGCTATTATTGACAGCGTATGTTCTTAAAACTGCCAAAAATTGATTTAATTATATAG AAACTTATGTAACTATTATCTTATATAATACTTAAGTATCATAAGTATGATAGAGTTATGCTTTTCTGGGTGTTTGAAAAATGTCAACTA AGACAGATGGTGTCTCACTTATTTCTTGGTTATTTAATATTGTTCAGTTAGATGAAAGTGTGATTGTAGATTTGAAATACAAAATAAAAC TTGGATACTGTGATTTTTTTAACATGGCCAGACTGTCATGTATTATAATGACATATACTTTTGTCCATAAAATGAAATTAAGTTTCACTG AAAAATTTACATACTTTCCCCTGGGGATTCTATTGCTTCAGATTAAAGTTTATAAAGTATCATTAGTGTCTTCCACAGGGTCATTTTACA CAAACACAGTTTTAGTGAGATGTCAACTGGCTTTTGTTGGTTGTTGGATTGACTGTGATTTAAAATGTTAAAGATGATATAATGCATCTT GTTCTGCTTCTAGGCTGAAAGGTCACTGAGGCAGAGCTGTTTGTACCTTGTATCCCCTGGAATTTTGCCTAAACATTTGTGTACTCATAG >99398_99398_1_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000466936_length(amino acids)=1004AA_BP=940 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYN RGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPH AFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLK HLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTD IKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRF VRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRDLLPEDFVVYTYNKEGTLITDHPNIQRCGPLCIREQSTPGDRAGQNTQ -------------------------------------------------------------- >99398_99398_2_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000487273_length(transcript)=6581nt_BP=3074nt GGAGCTGATGTGTACTGTGTGCGCCGGGGAGGCGCCGGCTTGTACTCGGCAGCGCGGGAATAAAGTTTGCTGATTTGGTGTCTAGCCTGG ATGCCTGGGTTGCAGGCCCTGCTTGTGGTGGCGCTCCACAGTCATCCGGCTGAAGAAGACCTGTTGGACTGGATCTTCTCGGGTTTTCTT TCAGATATTGTTTTGTATTTACCCATGAAGACATTGTTTTTTGGACTCTGCAAATAGGACATTTCAAAGATGAGTGAAAAAAAATTGGAA ACAACTGCACAGCAGCGGAAATGTCCTGAATGGATGAATGTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAG AGTGTTTTTGAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACGATGCTAGTGATTGCTCTTTCCTGTCAGAA GATATTAGCATGAGTCTATCAGATGGGGATGTGGTGGGATTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTT GCACTAATTCAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGTCAGTTTTTCCCCAGGGATTAAAAATGTTG CTTGAAAATAAAGCAGTTAAAAAGGCAGGTGTAGGAATTGAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAAT TTTGTGGAGTTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTAACAGTCTGGTTAAACACCTCTTAGGTAAA CAGCTCCTGAAAGACAAGTCTATCCGCTGTAGCAATTGGAGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCT TATGCTGGTTTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTGCTATAAATAAAGAGGAAGAAATCCTACTT AGCGACATGAACAAACAGTTGACTTCAATCTCTGAGGAAGTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAAC CCACGGAGGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGACT GAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAA GTTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGTG GAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATT ACAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCCC AATGATAATGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAAT GAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTA GAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAAT GAAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCC AGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAG AGTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTA CAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGG ATTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTG GATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTT CCAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGT ACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACA AGTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTG AATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGT GTCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCA TATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGG CACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGA TGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGAT AATTGCAGGTCCAGAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATA CAGAATCATTGTCATTATCGGGGCTATGTGGAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGGATTGCTG CATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCTACAAA GAGCCTCTGAAATGTGGAGTTTCCAACAAGGATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTA CTTCGAAGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGGAAAGGTATGACATGATGGGAAGA AATCAGACTGCTGTGAGAGAAGAGATGATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTT GGACTGGAGATTTGGACCAATGGAAACCTGATCAACATAGTTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAG TTTCTTATCACACGTCGGAGACATGACAGTGCACAGCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACA GTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTGTTTGGACAAATCACTGTGGAGACATTTGCTTCCATTGTTGCTCATGAATTGGGT CATAATCTTGGAATGAATCACGATGATGGGAGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATCGGGTTCCAGA AACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAACTGCCTTCTTAATATTCCAAAGCCTGATGAA GCCTATAGTGCTCCCTCCTGTGGTAATAAGTTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAATGTGAATTGGACCCT TGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGTTGTAAAGACTGTCGGTTCCTTCCAGGAGGT ACTTTATGCCGAGGAAAAACCAGTGAGTGTGATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAG AATGGATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTATGATGCTCAATGTCAAGTCATCTTTGGCTCA AAAGCCAAGGCTGCCCCCAAAGATTGTTTCATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATAC AAGAAGTGTGCCACTGGGAATGCTTTGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAGATACCTGTATTTGGAATTGTGCCTGCTATT ATTCAAACGCCTAGTCGAGGCACCAAATGTTGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGC ACAAAATGTGGTGCTGGAAAGATCTGTAGAAACTTCCAGTGTGTAGATGCTTCTGTTCTGAATTATGACTGTGATGTTCAGAAAAAGTGT CATGGACATGGGGTATGTAATAGCAATAAGAATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGA AGTGTGGACAGTGGACCTACATACAATGAAATGAATACTGCATTGAGGGACGGACTTCTGGTCTTCTTCTTCCTAATTGTTCCCCTTATT GTCTGTGCTATTTTTATCTTCATCAAGAGGGATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAGTCAGATGGC AAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTGACACCTCCCAGAGAAGTTCCTATATATGCA AACAGATTTGCAGTACCAACCTATGCAGCCAAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAG GGAAACTTAATTCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGATTTTTTTAACCTTCTTTTTGCAAATGTCTT CAGGGAACTGAGCTAATACTTTTTTTTTTTCTTGATGTTTTCTTGAAAAGCCTTTCTGTTGCAACTATGAATGAAAACAAAACACCACAA AACAGACTTCACTAACACAGAAAAACAGAAACTGAGTGTGAGAGTTGTGAAATACAAGGAAATGCAGTAAAGCCAGGGAATTTACAATAA CATTTCCGTTTCCATCATTGAATAAGTCTTATTCAGTCATCGGTGAGGTTAATGCACTAATCATGGATTTTTTGAACATGTTATTGCAGT GATTCTCAAATTAACTGTATTGGTGTAAGAGTTTTGTCATTAAGTGTTTAAGTGTTATTCTGAATTTTCTACCTTAGTTATCATTAATGT AGTTCCTCATTGAACATGTGATAATCTAATACCTGTGAAAACTGACTAATCAGCTGCCAATAATATCTAATATTTTTCATCATGCACGAA TTAATAATCATCATACTCTAGAATCTTGTCTGTCACTCACTACATGAATAAGCAAATATTGTCTTCAAAAGAATGCACAAGAACCACAAT TAAGATGTCATATTATTTTGAAAGTACAAAATATACTAAAAGAGTGTGTGTGTATTCACGCAGTTACTCGCTTCCATTTTTATGACCTTT CAACTATAGGTAATAACTCTTAGAGAAATTAATTTAATATTAGAATTTCTATTATGAATCATGTGAAAGCATGACATTCGTTCACAATAG CACTATTTTAAATAAATTATAAGCTTTAAGGTACGAAGTATTTAATAGATCTAATCAAATATGTTGATTCATGGCTATAATAAAGCAGGA GCAATTATAAAATCTTCAATCAATTGAACTTTTACAAAACCACTTGAGAATTTCATGAGCACTTTAAAATCTGAACTTTCAAAGCTTGCT ATTAAATCATTTAGAATGTTTACATTTACTAAGGTGTGCTGGGTCATGTAAAATATTAGACACTAATATTTTCATAGAAATTAGGCTGGA GAAAGAAGGAAGAAATGGTTTTCTTAAATACCTACAAAAAAGTTACTGTGGTATCTATGAGTTATCATCTTAGCTGTGTTAAAAATGAAT TTTTACTATGGCAGATATGGTATGGATCGTAAAATTTTAAGCACTAAAAATTTTTTCATAACCTTTCATAATAAAGTTTAATAATAGGTT TATTAACTGAATTTCATTAGTTTTTTAAAAGTGTTTTTGGTTTGTGTATATATACATATACAAATACAACATTTACAATAAATAAAATAC >99398_99398_2_WRN-ADAM9_WRN_chr8_30982516_ENST00000298139_ADAM9_chr8_38871484_ENST00000487273_length(amino acids)=1676AA_BP=940 MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYN RGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPH AFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLK HLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTD IKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRF VRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDC FGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKE RYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTA GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLL NIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFC QPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPV FGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNC ETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for WRN-ADAM9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 2_277 | 941.6666666666666 | 1433.0 | WRNIP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | WRN | chr8:30982516 | chr8:38871484 | ENST00000298139 | + | 23 | 35 | 987_993 | 941.6666666666666 | 1433.0 | DNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for WRN-ADAM9 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for WRN-ADAM9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | WRN | C0043119 | Werner Syndrome | 12 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | WRN | C0231341 | Premature aging syndrome | 1 | CTD_human |
Hgene | WRN | C0268134 | DNA Repair-Deficiency | 1 | CTD_human |
Hgene | WRN | C1563696 | DNA Repair-Deficiency Disorders | 1 | CTD_human |
Hgene | WRN | C1563697 | Chromosome Instability Syndromes | 1 | CTD_human |
Tgene | C0015397 | Disorder of eye | 1 | GENOMICS_ENGLAND | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C1423873 | CONE-ROD DYSTROPHY 9 | 1 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C3489532 | Cone-Rod Dystrophy 2 | 1 | ORPHANET |