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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KCNAB1-LRTM1 (FusionGDB2 ID:HG7881TG57408)

Fusion Gene Summary for KCNAB1-LRTM1

Fusion gene summary

Fusion gene information	Fusion gene name: KCNAB1-LRTM1
	Fusion gene ID: hg7881tg57408
		Hgene	Tgene
	Gene symbol	KCNAB1	LRTM1
	Gene ID	7881	57408
	Gene name	potassium voltage-gated channel subfamily A member regulatory beta subunit 1	leucine rich repeats and transmembrane domains 1
	Synonyms	AKR6A3\|KCNA1B\|KV-BETA-1\|Kvb1.3\|hKvBeta3\|hKvb3	HT017
	Cytomap	('KCNAB1')('LRTM1') 3q25.31	3p14.3
	Type of gene	protein-coding	protein-coding
	Description	voltage-gated potassium channel subunit beta-1K(+) channel subunit beta-1K+ channel Beta1a chainpotassium channel beta 3 chainpotassium channel beta3 subunitpotassium channel shaker chain beta 1apotassium channel, voltage gated subfamily A regulator	leucine-rich repeat and transmembrane domain-containing protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000497291, ENST00000302490, ENST00000389634, ENST00000389636, ENST00000471742, ENST00000490337,
Fusion gene scores	* DoF score	14 X 14 X 3=588	3 X 2 X 3=18
	# samples	14	4
	** MAII score	log2(14/588*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KCNAB1 [Title/Abstract] AND LRTM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KCNAB1(156233009)-LRTM1(54952919), # samples:1 KCNAB1(156233009)-LRTM1(54959242), # samples:1
Anticipated loss of major functional domain due to fusion event.	KCNAB1-LRTM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KCNAB1-LRTM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KCNAB1	GO:1901379	regulation of potassium ion transmembrane transport	7890032

Fusion gene breakpoints across KCNAB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QT-A5XO-01A	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
ChimerDB4	PCPG	TCGA-QT-A5XO-01A	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-

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Fusion Gene ORF analysis for KCNAB1-LRTM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000497291	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
3UTR-3CDS	ENST00000497291	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
3UTR-3CDS	ENST00000497291	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
3UTR-5UTR	ENST00000497291	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
5CDS-5UTR	ENST00000302490	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
5CDS-5UTR	ENST00000389634	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
5CDS-5UTR	ENST00000389636	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
5CDS-5UTR	ENST00000471742	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
5CDS-5UTR	ENST00000490337	ENST00000493075	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
Frame-shift	ENST00000302490	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000302490	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000389634	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000389634	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000389636	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000389636	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000471742	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000471742	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000490337	ENST00000273286	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
Frame-shift	ENST00000490337	ENST00000493075	KCNAB1	chr3	156233009	+	LRTM1	chr3	54952919	-
In-frame	ENST00000302490	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
In-frame	ENST00000389634	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
In-frame	ENST00000389636	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
In-frame	ENST00000471742	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-
In-frame	ENST00000490337	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000490337	KCNAB1	chr3	156233009	-	ENST00000273286	LRTM1	chr3	54959242	-	2182	929	64	1959	631
ENST00000389636	KCNAB1	chr3	156233009	-	ENST00000273286	LRTM1	chr3	54959242	-	2065	812	34	1842	602
ENST00000471742	KCNAB1	chr3	156233009	-	ENST00000273286	LRTM1	chr3	54959242	-	2302	1049	217	2079	620
ENST00000302490	KCNAB1	chr3	156233009	-	ENST00000273286	LRTM1	chr3	54959242	-	2935	1682	820	2712	630
ENST00000389634	KCNAB1	chr3	156233009	-	ENST00000273286	LRTM1	chr3	54959242	-	1977	724	0	1754	584

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000490337	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-	0.00912302	0.990877
ENST00000389636	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-	0.012769613	0.98723036
ENST00000471742	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-	0.008130875	0.9918691
ENST00000302490	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-	0.015036717	0.98496324
ENST00000389634	ENST00000273286	KCNAB1	chr3	156233009	-	LRTM1	chr3	54959242	-	0.013663016	0.986337

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Fusion Genomic Features for KCNAB1-LRTM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for KCNAB1-LRTM1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:156233009/chr3:54952919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000302490

108_109

270

402.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000302490

240_241

270

402.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000471742

108_109

277

409.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000471742

240_241

277

409.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000490337

108_109

288

420.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000490337

240_241

288

420.0

Nucleotide binding

NADP

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

180_234

346.0

Domain

Note=LRRCT

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

28_50

346.0

Domain

Note=LRRNT

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

180_234

270.0

Domain

Note=LRRCT

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

28_50

270.0

Domain

Note=LRRNT

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

123_144

346.0

Repeat

Note=LRR 4

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

147_168

346.0

Repeat

Note=LRR 5

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

51_72

346.0

Repeat

Note=LRR 1

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

75_96

346.0

Repeat

Note=LRR 2

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

99_120

346.0

Repeat

Note=LRR 3

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

123_144

270.0

Repeat

Note=LRR 4

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

147_168

270.0

Repeat

Note=LRR 5

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

51_72

270.0

Repeat

Note=LRR 1

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

75_96

270.0

Repeat

Note=LRR 2

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

99_120

270.0

Repeat

Note=LRR 3

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

28_288

346.0

Topological domain

Extracellular

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

310_345

346.0

Topological domain

Cytoplasmic

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

28_288

270.0

Topological domain

Extracellular

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

310_345

270.0

Topological domain

Cytoplasmic

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000273286

289_309

346.0

Transmembrane

Helical

Tgene

LRTM1

chr3:156233009

chr3:54959242

ENST00000493075

289_309

270.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000302490

295_300

270

402.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000302490

375_381

270

402.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000471742

295_300

277

409.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000471742

375_381

277

409.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000490337

295_300

288

420.0

Nucleotide binding

NADP

Hgene

KCNAB1

chr3:156233009

chr3:54959242

ENST00000490337

375_381

288

420.0

Nucleotide binding

NADP

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Fusion Gene Sequence for KCNAB1-LRTM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41346_41346_1_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000302490_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2935nt_BP=1682nt
AGTTCCAACTGTTGTGCTGCAGCAGATTTGGTCTGAGTCTGGGCAGAGCCCCTTTTTATGGAGCAACCCTCCCGATTTGTTACAGCAAGA
GCCTGGTGCAAGTGATCTTTGCCTTCCCATCGCACACAAAGGCAAAGAGCTCCTTAAAGGGACCTGCCTGCTCCTCCGTGCAGCTGCAAA
CCCGTGTCGGTGCAGGCTCAGCAACCCAGGCTTTCGCTCGAGAATGAGTGGGGAGGGGTCTTGAGGAGCCCCCACGTCCTCCCGGAGCGG
AGGCGGGAGGGAGCTGACAGCCGGAGTGGATGGAGACCACCAGTCCGAGGGGACCCGCTTGCGATTAGCTGCTTCTTGGGATGCTCCGCG
CGCCAGTTGAGCATCCTGCCTGTGGTCCAGGGGATGCTGGCGGCGCATCTTGCGGTAAGCCTGCGCTGATTTGAGCCATCGCCCAGAAGC
GAGCCCGCATTCAGACACCGCGGACCGGCTCCGCGAAGGGCTGCGTGCAGTCACCATGAATGCTCAGCTCTAGGCTTCTGTAAAAACCTC
CCCCACTGCATGGATTTGGCTGTTTAATCAGCCGAGATTACAGCCCGGGAAGATTTGCAAACCTGATTCTCCCTCCAGCTGCTGTGACAA
CTTCGGGGCCGTCTGTTTACTTCTCTGGGTCCCCGGGGACTCTTTCCTGCATCGCAGCCCCTTGTGCCACTTTGTGGGCTTGGCTCGAAA
GTCAGCCGCCAGGACTCCTCTGACGGCATCCCCAGGAAGGGGGAGCAAGGAGGGCTTAAAAGAAAAGCAGAAATCCCCGCAACTGCTCAA
CCTCTCGTGACTGCCTGTGTTCTGGGGTTCTGAGAGGGACCGTGCGCTGCCTGGGGAAGCAATGCAAGTCTCCATAGCCTGCACAGAGCA
CAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCCAATGTGGTGAACGCAGCCCGGGCCAAATT
CCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCTCTCAAAGAGTCCACCGCAAAGCAGACTGG
CATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGA
TGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGA
AGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGA
AACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTT
TGCAAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGG
CACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGA
GTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGAT
TGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGC
CGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTC
AGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGT
TTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAA
CAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGA
TCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAA
ACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCT
TAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGG
TGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCT
GCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCAC
CTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAG
CTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTA
GTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAG

>41346_41346_1_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000302490_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=630AA_BP=287
MPVFWGSERDRALPGEAMQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKY
RNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETER
GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHL
FQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPW
LMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRAL
LESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVL
RPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSPA

--------------------------------------------------------------
>41346_41346_2_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389634_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=1977nt_BP=724nt
ATGCAAGTCTCCATAGCCTGCACAGAGCACAATTTGAAGAGTCGGAATGGTGAGGACCGACTTCTGAGCAAGCAGAGCTCCACCGCCCCC
AATGTGGTGAACGCAGCCCGGGCCAAATTCCGCACGGTCGCTATCATCGCGCGCAGCCTGGGGACGTTCACGCCTCAGCATCACATTTCT
CTCAAAGAGTCCACCGCAAAGCAGACTGGCATGAAATATAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACA
TGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACT
GCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACA
ACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACAT
GTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTC
AATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAA
ATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACA
AATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAG
ATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCT
GGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTC
CCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTT
GCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTC
TGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAA
TCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCC
TCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGC
GAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTC
ATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCT
GGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATA
GTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAA

>41346_41346_2_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389634_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=584AA_BP=241
MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGT
WVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEEIVRAMTH
VINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSST
NFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSL
PQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICE
SPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCL

--------------------------------------------------------------
>41346_41346_3_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389636_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2065nt_BP=812nt
AGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGCGGGGAGTCAGATCTCAGAGGAGAACACCAA
GTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTCAGAAAACGCTAAAGACAGCAGCCTTAGTCC
CTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAACTGGTACCTAAAGCTCTGCGACCTGTCCAG
CGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATG
GGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGC
CGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAAC
CAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGAAATTGTCCGAGCCATGACACATGT
GATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAA
TATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAAT
AGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAA
TTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGAT
ACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGG
AGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCC
TCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGC
GGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTG
GAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATC
ACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTC
GCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGA
GCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCAT
GATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGG
GAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGT
GTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAA

>41346_41346_3_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000389636_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=602AA_BP=259
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGELLLFSSVIV
LLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVL
NLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKL
WLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGERELLECELKPKPRPANLR

--------------------------------------------------------------
>41346_41346_4_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000471742_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2302nt_BP=1049nt
ATGCACAGGCCTGGGCAGGGACACACAACCAACAGCTCTGTCGGGAACTTAGGAGCCTGCTCGCCTACAAAAATGATAAGAGAGATCTAA
AGAAAACAAGCTAAACCTTTTGAGGGACATACTGAAGCCAGATAACCCAAGGTATTCACAGCAAGATACAGTGAGTCTTAAAGTTAAGCA
CCGTGCAATTAGCTTTGCTTCCTTGGGTTTTTGAAACATGCATCTGTATAAACCTGCCTGTGCAGACATCCCGAGCCCCAAGCTGGGTCT
GCCAAAATCCAGTGAATCGGCTCTAAAATGTAGATGGCACCTAGCAGTGACCAAGACTCAGCCTCAGGCGGCCTGCAAACCTGTGAGGCC
CAGTGGAGCAGCCGAACAGAAATATGTGGAAAAGTTTCTACGTGTTCATGGAATTTCGTTGCAGGAAACCACCAGAGCAGAGACGGGCAT
GGCATACAGGAATCTTGGAAAATCAGGACTCAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGA
GGTTGCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGT
GATTCTGGGGAGCATCATCAAGAAGAAAGGCTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAAC
AGAAAGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGC
AAATCGACCGGACAGTAACACTCCCATGGAAGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCAC
CTCGAGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTA
CCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGT
CCTGCTCCAGGTGGTATGCAGCTGCCCGGACAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGA
AATCCCTTCCCATTTACCTCCTCAGACTCGAACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGT
GCCATGGCTCATGACCTTAAACTTGTCCAACAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTT
AAATCTAACCCAGAATTCACTCCTTTCCCTGGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAA
CATAAGCCACCTTCCCACATCCTTGGGAGAGACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCG
AGCGCTCCTGGAATCCATGCCCAGTGTGAGGCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACT
CTGGCTGGAGAAATTTGTCTATAAAGGGGGACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAG
GATCCCTCATGAGCTGTACCAGCCCTGCCCTCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGT
GGTCCTGAGGCCTCCTGAGAACCACAACGCGGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCG
TCATGCCATTGCCACTGTCATCATCACTGGCGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTA
TGCGGCAATCACAGCCCAGTACCATGGGGGACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTC
ACCAGCCTGAGAGCTTTTGTCTCAAATAGGATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTC
TGATTTTGCTTTTGCCAAAAGACAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAGGAA

>41346_41346_4_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000471742_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=620AA_BP=277
MHLYKPACADIPSPKLGLPKSSESALKCRWHLAVTKTQPQAACKPVRPSGAAEQKYVEKFLRVHGISLQETTRAETGMAYRNLGKSGLRV
SCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEG
LKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQL
PELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNS
LSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLL
LLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVVLRPPENHNAGE

--------------------------------------------------------------
>41346_41346_5_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000490337_LRTM1_chr3_54959242_ENST00000273286_length(transcript)=2182nt_BP=929nt
AGAAAAATCAATTCAGATTACTTTGATGACAGTGACTTCCAGTCTTCTCTGAAAGATCTCCACGATGCTGGCAGCCCGGACAGGGGCAGC
GGGGAGTCAGATCTCAGAGGAGAACACCAAGTTAAGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTC
AGAAAACGCTAAAGACAGCAGCCTTAGTCCCTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTGGCTCTGCTGCGCGAAGTGGAGATGAA
CTGGTACCTAAAGCTCTGCGACCTGTCCAGCGAGCACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACT
CAGAGTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTTGCTGAACGGCTGATGACCATCGCCTA
TGAAAGTGGTGTTAACCTCTTTGATACTGCCGAAGTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGG
CTGGAGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAAAGAGGGCTGTCAAGAAAGCATATTAT
TGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAGCTCGAGTATGTGGATGTGGTCTTTGCAAATCGACCGGACAGTAACACTCCCATGGA
AGAAATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCGAGATGGAGTGCTATGGAGATCATGGA
AGCCTATTCTGTAGCAAGACAGTTCAATATGATCCCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGT
CCAGCTGCCAGAGCTCTACCACAAAATAGGTGAACTGCTCCTGTTTTCCAGTGTGATTGTCCTGCTCCAGGTGGTATGCAGCTGCCCGGA
CAAGTGTTACTGTCAGTCATCTACAAATTTTGTAGACTGCAGCCAGCAGGGTCTGGCCGAAATCCCTTCCCATTTACCTCCTCAGACTCG
AACGCTGCATTTACAAGATAATCAGATACACCATCTTCCTGCTTTTGCATTTAGGTCAGTGCCATGGCTCATGACCTTAAACTTGTCCAA
CAATTCCCTTTCAAATCTGGCCCCTGGAGCTTTCCATGGGCTTCAGCACTTGCAGGTTTTAAATCTAACCCAGAATTCACTCCTTTCCCT
GGAAAGCAGACTTTTCCATTCCCTCCCTCAGCTGAGGGAGCTTGATTTGTCATCAAACAACATAAGCCACCTTCCCACATCCTTGGGAGA
GACTTGGGAGAACCTAACTATACTTGCGGTTCAACAAAACCAGCTTCAGCAGCTTGATCGAGCGCTCCTGGAATCCATGCCCAGTGTGAG
GCTTTTACTTCTCAAGGACAACCTCTGGAAATGCAATTGCCACTTGCTCGGTCTTAAACTCTGGCTGGAGAAATTTGTCTATAAAGGGGG
ACTAACAGACGGCATCATCTGTGAATCACCAGACACCTGGAAGGGAAAGGACCTCCTTAGGATCCCTCATGAGCTGTACCAGCCCTGCCC
TCTTCCTGCTCCTGATCCAGTGTCCTCGCAGGCTCAGTGGCCCGGCTCTGCCCACGGTGTGGTCCTGAGGCCTCCTGAGAACCACAACGC
GGGGGAGCGAGAACTCTTGGAGTGCGAGCTCAAACCCAAGCCAAGGCCGGCCAACCTGCGTCATGCCATTGCCACTGTCATCATCACTGG
CGTTGTGTGTGGGATTGTGTGTCTCATGATGTTGGCAGCTGCCATCTATGGCTGCACCTATGCGGCAATCACAGCCCAGTACCATGGGGG
ACCCTTGGCTCAAACCAATGATCCTGGGAAGGTGGAAGAAAAAGAGCGATTTGACAGCTCACCAGCCTGAGAGCTTTTGTCTCAAATAGG
ATTGGTCATTGCAGGCCAGAAGATAGTGTCTGAGTAGGGCTGATGTGTTTCCTGTTAGTCTGATTTTGCTTTTGCCAAAAGACAAAAAAA
AAAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGTCTGTAAAAAATATTTCTGGGGAGGAATTTATGTTGCGATTTTTAAAATACTATAGG

>41346_41346_5_KCNAB1-LRTM1_KCNAB1_chr3_156233009_ENST00000490337_LRTM1_chr3_54959242_ENST00000273286_length(amino acids)=631AA_BP=288
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMP
HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE
RGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYH
LFQREKVEVQLPELYHKIGELLLFSSVIVLLQVVCSCPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVP
WLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDRA
LLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLPAPDPVSSQAQWPGSAHGVV
LRPPENHNAGERELLECELKPKPRPANLRHAIATVIITGVVCGIVCLMMLAAAIYGCTYAAITAQYHGGPLAQTNDPGKVEEKERFDSSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KCNAB1-LRTM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KCNAB1-LRTM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KCNAB1-LRTM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Fusion Gene Studies in Kim Lab

Fusion gene:KCNAB1-LRTM1 (FusionGDB2 ID:HG7881TG57408)

Fusion Gene Summary for KCNAB1-LRTM1

Fusion Gene ORF analysis for KCNAB1-LRTM1

Fusion Genomic Features for KCNAB1-LRTM1

Fusion Protein Features for KCNAB1-LRTM1

Fusion Gene Sequence for KCNAB1-LRTM1

Fusion Gene PPI Analysis for KCNAB1-LRTM1

Related Drugs for KCNAB1-LRTM1

Related Diseases for KCNAB1-LRTM1

Fusion Gene Studies
in Kim Lab