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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C7orf26-CLCN7 (FusionGDB2 ID:HG79034TG1186)

Fusion Gene Summary for C7orf26-CLCN7

check button Fusion gene summary
Fusion gene informationFusion gene name: C7orf26-CLCN7
Fusion gene ID: hg79034tg1186
HgeneTgene
Gene symbol

C7orf26

CLCN7

Gene ID

79034

1186

Gene namechromosome 7 open reading frame 26chloride voltage-gated channel 7
Synonyms-CLC-7|CLC7|HOD|OPTA2|OPTB4|PPP1R63
Cytomap('C7orf26')('CLCN7')

7p22.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C7orf26H(+)/Cl(-) exchange transporter 7chloride channel 7 alpha subunitchloride channel protein 7chloride channel, voltage-sensitive 7protein phosphatase 1, regulatory subunit 63
Modification date2020031320200315
UniProtAcc

Q96N11

P51798

Ensembl transtripts involved in fusion geneENST00000344417, ENST00000359073, 
ENST00000472693, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 5 X 6=240
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C7orf26 [Title/Abstract] AND CLCN7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC7orf26(6630106)-CLCN7(1499328), # samples:1
Anticipated loss of major functional domain due to fusion event.C7orf26-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C7orf26-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C7orf26-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C7orf26-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C7orf26 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLCN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AC7orf26chr7

6630106

+CLCN7chr16

1499328

-


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Fusion Gene ORF analysis for C7orf26-CLCN7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344417ENST00000566812C7orf26chr7

6630106

+CLCN7chr16

1499328

-
5CDS-intronENST00000359073ENST00000566812C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000344417ENST00000262318C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000344417ENST00000382745C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000344417ENST00000448525C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000359073ENST00000262318C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000359073ENST00000382745C7orf26chr7

6630106

+CLCN7chr16

1499328

-
In-frameENST00000359073ENST00000448525C7orf26chr7

6630106

+CLCN7chr16

1499328

-
intron-3CDSENST00000472693ENST00000262318C7orf26chr7

6630106

+CLCN7chr16

1499328

-
intron-3CDSENST00000472693ENST00000382745C7orf26chr7

6630106

+CLCN7chr16

1499328

-
intron-3CDSENST00000472693ENST00000448525C7orf26chr7

6630106

+CLCN7chr16

1499328

-
intron-intronENST00000472693ENST00000566812C7orf26chr7

6630106

+CLCN7chr16

1499328

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000344417C7orf26chr76630106+ENST00000448525CLCN7chr161499328-29574592671259330
ENST00000344417C7orf26chr76630106+ENST00000382745CLCN7chr161499328-29564592671259330
ENST00000344417C7orf26chr76630106+ENST00000262318CLCN7chr161499328-25484592671619450
ENST00000359073C7orf26chr76630106+ENST00000448525CLCN7chr161499328-28303321401132330
ENST00000359073C7orf26chr76630106+ENST00000382745CLCN7chr161499328-28293321401132330
ENST00000359073C7orf26chr76630106+ENST00000262318CLCN7chr161499328-24213321401492450

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344417ENST00000448525C7orf26chr76630106+CLCN7chr161499328-0.0062555340.99374443
ENST00000344417ENST00000382745C7orf26chr76630106+CLCN7chr161499328-0.0062705080.9937295
ENST00000344417ENST00000262318C7orf26chr76630106+CLCN7chr161499328-0.153260920.8467391
ENST00000359073ENST00000448525C7orf26chr76630106+CLCN7chr161499328-0.0057869950.99421304
ENST00000359073ENST00000382745C7orf26chr76630106+CLCN7chr161499328-0.0058060210.994194
ENST00000359073ENST00000262318C7orf26chr76630106+CLCN7chr161499328-0.142535270.8574647

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Fusion Genomic Features for C7orf26-CLCN7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C7orf26-CLCN7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6630106/chr16:1499328)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C7orf26

Q96N11

CLCN7

P51798

FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625631_695539806.0DomainCBS 1
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625741_799539806.0DomainCBS 2
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524631_695515782.0DomainCBS 1
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524741_799515782.0DomainCBS 2
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625545_559539806.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625560_562539806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625563_574539806.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625575_578539806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524545_559515782.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524560_562515782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524563_574515782.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524575_578515782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524512_516515782.0MotifSelectivity filter part_3
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625658_660539806.0Nucleotide bindingATP
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625783_786539806.0Nucleotide bindingATP
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524658_660515782.0Nucleotide bindingATP
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524783_786515782.0Nucleotide bindingATP
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625598_805539806.0Topological domainCytoplasmic
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524598_805515782.0Topological domainCytoplasmic
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625579_597539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524512_535515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524579_597515782.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625206_213539806.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625288_300539806.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625304_312539806.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524206_213515782.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524288_300515782.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524304_312515782.0IntramembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625203_207539806.0MotifSelectivity filter part_1
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625245_249539806.0MotifSelectivity filter part_2
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625512_516539806.0MotifSelectivity filter part_3
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524203_207515782.0MotifSelectivity filter part_1
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524245_249515782.0MotifSelectivity filter part_2
TgeneCLCN7chr7:6630106chr16:1499328ENST0000038274516251_126539806.0Topological domainCytoplasmic
TgeneCLCN7chr7:6630106chr16:1499328ENST0000044852515241_126515782.0Topological domainCytoplasmic
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625127_159539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625174_197539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625223_241539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625247_264539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625322_341539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625375_405539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625410_432539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625487_507539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000003827451625512_535539806.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524127_159515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524174_197515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524223_241515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524247_264515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524322_341515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524375_405515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524410_432515782.0TransmembraneHelical
TgeneCLCN7chr7:6630106chr16:1499328ENST000004485251524487_507515782.0TransmembraneHelical


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Fusion Gene Sequence for C7orf26-CLCN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12007_12007_1_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000262318_length(transcript)=2548nt_BP=459nt
CGGCATTCGGCCGCTGTTCGGCTGCGCGGCGGCAGCTCCCGGCGGCTCCTGGCGGCGCCGCAGTCGGACCTTCGGGCGCCTGCTGGCCGG
CGGCAGCAGCGATGGCCCCCTGAGCAGGCAGGGAGCAGGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCG
CCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGCCCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATG
AGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGCTGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAG
CTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCCCCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCG
CAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTG
ACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTC
TTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACT
GCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCC
AATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTT
CTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCG
CGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTAC
ACGGTGCCCCAGGCATGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAA
TCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTG
AGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACC
ATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTG
TTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAG
CTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGA
GACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTT
GGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGG
CTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGG
CCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCT
GCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGC
CCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGC
CACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCAC
CGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCC
CTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTAT
TTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGG

>12007_12007_1_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000262318_length(amino acids)=450AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP
YTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQEGPRQVPPGKERLGGALAGPDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQ
TMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLGASLRRPSLHSPRLGFFTSRDQLCVCDLPTGLSASWEPAAGPAPACLCPCA

--------------------------------------------------------------
>12007_12007_2_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000382745_length(transcript)=2956nt_BP=459nt
CGGCATTCGGCCGCTGTTCGGCTGCGCGGCGGCAGCTCCCGGCGGCTCCTGGCGGCGCCGCAGTCGGACCTTCGGGCGCCTGCTGGCCGG
CGGCAGCAGCGATGGCCCCCTGAGCAGGCAGGGAGCAGGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCG
CCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGCCCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATG
AGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGCTGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAG
CTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCCCCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCG
CAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTG
ACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTC
TTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACT
GCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCC
AATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTT
CTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCG
CGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTAC
ACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAAT
CAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGA
GGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCA
TGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGT
TGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGC
TGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAG
ACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTG
GGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGC
TGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGC
CCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTG
CCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCC
CTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCC
ACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACC
GGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCC
TCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATT
TCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGT
CTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTTGCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACT
TTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGAAAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCT
TCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCCTGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGG
GCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAACTCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGG

>12007_12007_2_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000382745_length(amino acids)=330AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP

--------------------------------------------------------------
>12007_12007_3_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000448525_length(transcript)=2957nt_BP=459nt
CGGCATTCGGCCGCTGTTCGGCTGCGCGGCGGCAGCTCCCGGCGGCTCCTGGCGGCGCCGCAGTCGGACCTTCGGGCGCCTGCTGGCCGG
CGGCAGCAGCGATGGCCCCCTGAGCAGGCAGGGAGCAGGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCG
CCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGCCCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATG
AGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGCTGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAG
CTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCCCCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCG
CAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTG
ACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTC
TTCATTGAGGGCCTGTACGACATGCACATTCAGCTGCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACT
GCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCC
AATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTT
CTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCG
CGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTAC
ACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAAT
CAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGA
GGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCACCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCA
TGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGCTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGT
TGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCGCAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGC
TGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTCTTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAG
ACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGCCCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTG
GGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACGGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGC
TGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCACAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGC
CCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTGATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTG
CCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGCCCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCC
CTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAGCACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCC
ACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCGGCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACC
GGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCCCTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCC
TCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTAGAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATT
TCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACGCCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGT
CTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTTTGCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACT
TTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAGAAAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCT
TCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTCCTGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGG
GCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAACTCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGG

>12007_12007_3_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000344417_CLCN7_chr16_1499328_ENST00000448525_length(amino acids)=330AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP

--------------------------------------------------------------
>12007_12007_4_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000262318_length(transcript)=2421nt_BP=332nt
GGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCGCCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGC
CCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATGAGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGC
TGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAGCTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCC
CCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCGCAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCC
TGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCT
ACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGC
AGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGA
GGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATG
ACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACC
TGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGG
ACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGCATGCGTCGCTCCCACGGGTGTTC
AAGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCC
AGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGC
ACCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAG
CTGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGC
GCAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCT
CTTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTG
CCCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGAC
GGCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCC
ACAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGT
GATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGG
CCCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTA
GCACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCC
GGCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCC
CCTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTT
AGAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGAC

>12007_12007_4_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000262318_length(amino acids)=450AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP
YTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQEGPRQVPPGKERLGGALAGPDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQ
TMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLGASLRRPSLHSPRLGFFTSRDQLCVCDLPTGLSASWEPAAGPAPACLCPCA

--------------------------------------------------------------
>12007_12007_5_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000382745_length(transcript)=2829nt_BP=332nt
GGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCGCCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGC
CCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATGAGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGC
TGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAGCTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCC
CCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCGCAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCC
TGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCT
ACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGC
AGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGA
GGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATG
ACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACC
TGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGG
ACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCA
AGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCA
GGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCA
CCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGC
TGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCG
CAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTC
TTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGC
CCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACG
GCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCA
CAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTG
ATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGC
CCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAG
CACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCG
GCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCC
CTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTA
GAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACG
CCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTT
TGCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAG
AAAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTC
CTGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAA
CTCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTT

>12007_12007_5_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000382745_length(amino acids)=330AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP

--------------------------------------------------------------
>12007_12007_6_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000448525_length(transcript)=2830nt_BP=332nt
GGCGGCGGCAGGCGGGCAAGCGGGCGGGTGCCGCAGCCCAGGCCCGGGTCGCGCCTCTTTGTTTCCACGGGTAGCGGCGCAGTCCCGGGC
CCCGGGCGGAAGTGAGACGCGCTCGGCGCGGGGGCCGCGGCGGCCGCACCATGAGCGACATCCGCCACTCGCTGCTGCGCCGCGATGCGC
TGAGCGCCGCCAAGGAGGTGTTGTACCACCTGGACATCTACTTCAGCAGCCAGCTGCAGAGCGCGCCGCTGCCCATCGTGGACAAGGGCC
CCGTGGAGCTGCTGGAGGAGTTCGTGTTCCAGGTGCCCAAGGAGCGCAGCGCGCAGCCCAAGATCTGGGCGGACCCCGGCAAATACGCCC
TGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCT
ACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCAGCTGC
AGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGA
GGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATG
ACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACC
TGGGCCTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATCCACGTGTCCCAGG
ACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCA
AGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCA
GGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACGTGAGGCCCAGCCCTGCCCATAATGGGCACTGGCGCTGGCA
CCCCGGCCCTTCTGCATTTCCTCCCGGAGTCACTGGTTTCTCGGCCCAAACCATGCTCCCCAGCAGTGGCAATGGCGAGCACCCTGCAGC
TGGGCGGGCAGGCGGCAGGCGCGGAACTGACCCTCTCGCGGGACTGACCCTGTTGTGGGCAGTGGTCTCCCCCCTTGGCGCCTCCTTGCG
CAGGCCCAGCCTCCACTCTCCTCGTCTAGGTTTCTTTACCTCCAGGGATCAGCTGTGTGTGTGTGACCTCCCTACCGGGCTATCGGCCTC
TTGGGAGCCAGCGGCAGGGCCGGCACCTGCGTGCCTGTGCCCGTGTGCGTGAGACAGAGCCCTTGCCCCTGCTGCTGCCCCGAGGGCTGC
CCTGCCCTGGAAGGGCCCCTCTGCCTCCACACCAGTGGAGTCTTCGAGACTTGGGAGCTGCTTGGCCTCATTTTCAGCCATGAGCAGACG
GCCTGTGGTCCCTGGGCCTGAGGCACGGACTCGTAGCACCAGGGTTTGGAGGCTGCGACCGCCCCGGAGAGCAGCTTCACACTGGCGCCA
CAGAGGAGCCCCACGTGCACTCCCCGGCCTGCATCCGGCTTGGGTACACAGGCCCAGAGGACTGGGGTGACTCACGGGCCCTGTGCTGTG
ATGTTGAGAGCTGAGAAAAACCTCCAAGGCCCTGAGCCCCATGCCCAGCCCTGCCTTGGTCCCCCAACCCCCAGAGCTTGGAGTCTGGGC
CCCACACCCAGCCCTGCCTTGGTCCCTGAGCCTCAGAGCGTGGAATTGCTGCCCTGTGGACACTGGCTGGGAAGGCAGGTCTTCCCCTAG
CACATGGGGACCCCGGCCTCGAGGGTGACCTCCCTACCCCGCCCCTGCCAGCCACCAAGCGCAGGTGCAGCGGGGGCCAGACTCCTGCCG
GCCTCAGAGGACACCTGGCCCAGCACAGGCAGCTAGAAGGGCCGGTGGGCACCGGGGCCGGGAAGCCCCCACCTCACCACCTGAGGGCCC
CTGGGAGGCTCCTCTGGCCTGGCTGGGCTGGGTCTGGGGCCGCCACAGGCCCCTCACGGGGCGGCAGAGGCAACTTCAGTGTCCCTGTTA
GAGCAACACGGGTCCCTCCGTGGGGGGCTGGGTGCGGCCCCCTGCCGTGTATTTCCTCCCCAGGGAGTGGGGCCTCCCCGGGAGCTGACG
CCACCACCCTGCTTAGCCCTCACAGGGCCCCAAGGTGTCCGAGTGTGTTGGGTCTGAACGCGAAATAAAGAAATCCTCTCAGCCCGCCTT
TGCCAGCGTCGTCCCTCCCACCCCACCCAGACCACGTCCAACAGCCTGGGACTTTCGGGACCCTGGGGTCGGGGCACCGTGTGGAGTGAG
AAAGGCGTGAAAGACAGCGGCTGCGGCCACCCAGGGCACCAGCCACATCCTCTTCCTCGTCCCCGCCCCTCAGCCTCCCTCCTCTGGCTC
CTGGCTGGTGGGTCTGGGGGCAAGGCAGAGGCGCTCCAGGTGGAGGGGGGCGGGCCGGGGTGCCCACGCTGGGGTGACGCAAGAAGAAAA
CTCCCGGGCCTCAGAGTCGGCGCCGGAAACCTAGGTCTGGGTTTCCCTCGTGGTGGTTGTGTACTGAGGACCTGGAAGTGATCATATTTT

>12007_12007_6_C7orf26-CLCN7_C7orf26_chr7_6630106_ENST00000359073_CLCN7_chr16_1499328_ENST00000448525_length(amino acids)=330AA_BP=62
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKIWADPGKYALMGAAAQLGGIVRMTLS
LTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTA
SNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C7orf26-CLCN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C7orf26-CLCN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C7orf26-CLCN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1969106Osteopetrosis, Autosomal Recessive 47CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC3179239Osteopetrosis Autosomal Dominant Type 25CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1318518Infantile malignant osteopetrosis3ORPHANET
TgeneC0432261Osteopetrosis - intermediate type1ORPHANET
TgeneC1969093Osteopetrosis, Autosomal Recessive 61ORPHANET