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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C11orf49-MAEA (FusionGDB2 ID:HG79096TG10296)

Fusion Gene Summary for C11orf49-MAEA

check button Fusion gene summary
Fusion gene informationFusion gene name: C11orf49-MAEA
Fusion gene ID: hg79096tg10296
HgeneTgene
Gene symbol

C11orf49

MAEA

Gene ID

79096

10296

Gene namechromosome 11 open reading frame 49macrophage erythroblast attacher, E3 ubiquitin ligase
Synonyms-EMLP|EMP|GID9|HLC-10|P44EMLP|PIG5
Cytomap('C11orf49')('MAEA')

11p11.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0705 protein C11orf49E3 ubiquitin-protein transferase MAEAGID complex subunit 9, FYV10 homologcell proliferation-inducing gene 5 proteinerythroblast macrophage proteinhuman lung cancer oncogene 10 proteinlung cancer-related protein 10macrophage erythroblast attacher
Modification date2020031320200314
UniProtAcc

Q9H6J7

.
Ensembl transtripts involved in fusion geneENST00000278460, ENST00000378615, 
ENST00000378618, ENST00000395460, 
ENST00000536126, ENST00000543718, 
ENST00000527268, 
Fusion gene scores* DoF score26 X 14 X 9=32768 X 9 X 5=360
# samples 2711
** MAII scorelog2(27/3276*10)=-3.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C11orf49 [Title/Abstract] AND MAEA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC11orf49(46958402)-MAEA(1330648), # samples:1
Anticipated loss of major functional domain due to fusion event.C11orf49-MAEA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-MAEA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-MAEA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-MAEA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-MAEA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAEA

GO:0007155

cell adhesion

9763581

TgeneMAEA

GO:0033033

negative regulation of myeloid cell apoptotic process

9763581


check buttonFusion gene breakpoints across C11orf49 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MAEA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A0IUC11orf49chr11

46958402

+MAEAchr4

1330648

+


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Fusion Gene ORF analysis for C11orf49-MAEA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000278460ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
5CDS-3UTRENST00000378615ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
5CDS-3UTRENST00000378618ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
5CDS-3UTRENST00000395460ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000536126ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3CDSENST00000543718ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3UTRENST00000536126ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
5UTR-3UTRENST00000543718ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000278460ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378615ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000378618ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
Frame-shiftENST00000395460ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
In-frameENST00000278460ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
In-frameENST00000378615ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
In-frameENST00000378618ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
In-frameENST00000395460ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000264750C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000303400C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000452175C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000505177C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000505839C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000510794C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3CDSENST00000527268ENST00000514708C11orf49chr11

46958402

+MAEAchr4

1330648

+
intron-3UTRENST00000527268ENST00000512289C11orf49chr11

46958402

+MAEAchr4

1330648

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378618C11orf49chr1146958402+ENST00000514708MAEAchr41330648+14599852519155
ENST00000278460C11orf49chr1146958402+ENST00000514708MAEAchr41330648+146610559526155
ENST00000395460C11orf49chr1146958402+ENST00000514708MAEAchr41330648+14458438505155
ENST00000378615C11orf49chr1146958402+ENST00000514708MAEAchr41330648+14357428495155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378618ENST00000514708C11orf49chr1146958402+MAEAchr41330648+0.0099175510.99008244
ENST00000278460ENST00000514708C11orf49chr1146958402+MAEAchr41330648+0.0112585390.98874146
ENST00000395460ENST00000514708C11orf49chr1146958402+MAEAchr41330648+0.0108090620.98919094
ENST00000378615ENST00000514708C11orf49chr1146958402+MAEAchr41330648+0.0103107660.98968923

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Fusion Genomic Features for C11orf49-MAEA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C11orf49chr1146958402+MAEAchr41330648+2.66E-121
C11orf49chr1146958402+MAEAchr41330648+2.66E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C11orf49-MAEA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46958402/chr4:1330648)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C11orf49

Q9H6J7

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAEAchr11:46958402chr4:1330648ENST0000026475048314_381214356.0Zinc fingerRING-Gid-type
TgeneMAEAchr11:46958402chr4:1330648ENST0000030340059314_381255397.0Zinc fingerRING-Gid-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAEAchr11:46958402chr4:1330648ENST0000026475048121_153214356.0DomainLisH
TgeneMAEAchr11:46958402chr4:1330648ENST0000026475048159_216214356.0DomainCTLH
TgeneMAEAchr11:46958402chr4:1330648ENST0000030340059121_153255397.0DomainLisH
TgeneMAEAchr11:46958402chr4:1330648ENST0000030340059159_216255397.0DomainCTLH
TgeneMAEAchr11:46958402chr4:1330648ENST00000264750481_124214356.0RegionExtracellular and involved in cell to cell contact
TgeneMAEAchr11:46958402chr4:1330648ENST00000303400591_124255397.0RegionExtracellular and involved in cell to cell contact


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Fusion Gene Sequence for C11orf49-MAEA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10722_10722_1_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000278460_MAEA_chr4_1330648_ENST00000514708_length(transcript)=1466nt_BP=105nt
CGGCAACCTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGG
ACTACGAGTATCTGGGACCTTCTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTG
GGAAACAATTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCTGCTACAAGGAGGACGGCAGCTCCAAGAGCC
CTGACTGCCCTGTGTGCAGCCGCTCCCTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGA
TTTCTGGCGACGTGATGAACGAGAACAATCCGCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTC
AAGATGATAAAGTCGTGTGCCCGAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAGGCCCCACGTCGTG
AAGCGCACGCCTCGGGGACGGGCTGCAGTGGGCGGGGAGGCCACGCCTTCCTCCTGTCCCACGCTCCAGCCTGCCGCGGCGTTTCTGTTT
CTTGCGACCAAAGATCCGTGAGCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACATTTGGAT
TGGTAGGATTTTGTAACACGTCAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTGCGAAGGAAACTCTTCTTTAAAGACTGACCTAA
ACACCGAGGGAAACTTAAGAACGTTTAAAATATAGGAGTCCGTGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACT
TGGAGAACGGGCTGGTCCTTCACCACTTCCTGTTGGCCCTGGCCTGGCCGGGGAAGGTGGCAGCGGCACCGGACTGACCTGCAGTGACCC
GCGATGCCGCGCCACGAGGGACACTTATGGCTTCATTCGAGAGCTGCTGCCAAAACGCCTGGCGCCGCCACCGTCGGGGGCTGGCTTCGA
GGACGCCCGCCTGCCTCGCGGGTCGTGTCCGCGGGACTGTGTTCGTACGTGCATAGTTTCGATATCACATCGCGGGGCTGTGTTCGTAGC
TGCGTCGTTTCGATATCACACCCTCTGTGTGCCGCCTTACTTCCTGCTTCGAGAATGTATAACGTGGAAATCCACGGGACCAAATTTCTG
CAGAGGCCTTGCCGGATGGTTCCATAACTGTAGAGTCTAATTGCTATCCATTACAGAAATTAATCGTTCAGTTGAAAGAAGTACTGATGA
CTTTTCAAAACAAATGAACCACCGTAGCTGACAGAGAACCGTATCGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGAC

>10722_10722_1_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000278460_MAEA_chr4_1330648_ENST00000514708_length(amino acids)=155AA_BP=15
MLSPERLALPDYEYLGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDTCYKEDGSSKSPDCPVCSRSLNKLAQPLPMA

--------------------------------------------------------------
>10722_10722_2_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000378615_MAEA_chr4_1330648_ENST00000514708_length(transcript)=1435nt_BP=74nt
GGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGGACCTTCTGGACCCTG
CACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACAATTCTGTGTTCACCCTCACCCTGC
AGGCTGGCCTCTCAGCCATCAAGACACCTGCTACAAGGAGGACGGCAGCTCCAAGAGCCCTGACTGCCCTGTGTGCAGCCGCTCCCTGAA
CAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGATTTCTGGCGACGTGATGAACGAGAACAATCC
GCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTGTGCCCGAGAACCAA
AGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAGGCCCCACGTCGTGAAGCGCACGCCTCGGGGACGGGCTGCAGTGG
GCGGGGAGGCCACGCCTTCCTCCTGTCCCACGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGACCAAAGATCCGTGAGCAACGATAA
ATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACATTTGGATTGGTAGGATTTTGTAACACGTCAACCATTTG
ATGCTTCTGAAAAGTACTTTCAACTTGCGAAGGAAACTCTTCTTTAAAGACTGACCTAAACACCGAGGGAAACTTAAGAACGTTTAAAAT
ATAGGAGTCCGTGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAACGGGCTGGTCCTTCACCACTTCCT
GTTGGCCCTGGCCTGGCCGGGGAAGGTGGCAGCGGCACCGGACTGACCTGCAGTGACCCGCGATGCCGCGCCACGAGGGACACTTATGGC
TTCATTCGAGAGCTGCTGCCAAAACGCCTGGCGCCGCCACCGTCGGGGGCTGGCTTCGAGGACGCCCGCCTGCCTCGCGGGTCGTGTCCG
CGGGACTGTGTTCGTACGTGCATAGTTTCGATATCACATCGCGGGGCTGTGTTCGTAGCTGCGTCGTTTCGATATCACACCCTCTGTGTG
CCGCCTTACTTCCTGCTTCGAGAATGTATAACGTGGAAATCCACGGGACCAAATTTCTGCAGAGGCCTTGCCGGATGGTTCCATAACTGT
AGAGTCTAATTGCTATCCATTACAGAAATTAATCGTTCAGTTGAAAGAAGTACTGATGACTTTTCAAAACAAATGAACCACCGTAGCTGA

>10722_10722_2_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000378615_MAEA_chr4_1330648_ENST00000514708_length(amino acids)=155AA_BP=15
MLSPERLALPDYEYLGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDTCYKEDGSSKSPDCPVCSRSLNKLAQPLPMA

--------------------------------------------------------------
>10722_10722_3_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000378618_MAEA_chr4_1330648_ENST00000514708_length(transcript)=1459nt_BP=98nt
CTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGA
GTATCTGGGACCTTCTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACA
ATTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCTGCTACAAGGAGGACGGCAGCTCCAAGAGCCCTGACTG
CCCTGTGTGCAGCCGCTCCCTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGATTTCTGG
CGACGTGATGAACGAGAACAATCCGCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGA
TAAAGTCGTGTGCCCGAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAGGCCCCACGTCGTGAAGCGCA
CGCCTCGGGGACGGGCTGCAGTGGGCGGGGAGGCCACGCCTTCCTCCTGTCCCACGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGA
CCAAAGATCCGTGAGCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACATTTGGATTGGTAGG
ATTTTGTAACACGTCAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTGCGAAGGAAACTCTTCTTTAAAGACTGACCTAAACACCGA
GGGAAACTTAAGAACGTTTAAAATATAGGAGTCCGTGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAA
CGGGCTGGTCCTTCACCACTTCCTGTTGGCCCTGGCCTGGCCGGGGAAGGTGGCAGCGGCACCGGACTGACCTGCAGTGACCCGCGATGC
CGCGCCACGAGGGACACTTATGGCTTCATTCGAGAGCTGCTGCCAAAACGCCTGGCGCCGCCACCGTCGGGGGCTGGCTTCGAGGACGCC
CGCCTGCCTCGCGGGTCGTGTCCGCGGGACTGTGTTCGTACGTGCATAGTTTCGATATCACATCGCGGGGCTGTGTTCGTAGCTGCGTCG
TTTCGATATCACACCCTCTGTGTGCCGCCTTACTTCCTGCTTCGAGAATGTATAACGTGGAAATCCACGGGACCAAATTTCTGCAGAGGC
CTTGCCGGATGGTTCCATAACTGTAGAGTCTAATTGCTATCCATTACAGAAATTAATCGTTCAGTTGAAAGAAGTACTGATGACTTTTCA
AAACAAATGAACCACCGTAGCTGACAGAGAACCGTATCGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGACTAGCTAA

>10722_10722_3_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000378618_MAEA_chr4_1330648_ENST00000514708_length(amino acids)=155AA_BP=15
MLSPERLALPDYEYLGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDTCYKEDGSSKSPDCPVCSRSLNKLAQPLPMA

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>10722_10722_4_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000395460_MAEA_chr4_1330648_ENST00000514708_length(transcript)=1445nt_BP=84nt
CCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGGACCTT
CTGGACCCTGCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTGGGAAACAATTCTGTGTTCACC
CTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCTGCTACAAGGAGGACGGCAGCTCCAAGAGCCCTGACTGCCCTGTGTGCAGCC
GCTCCCTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGCAAGATTTCTGGCGACGTGATGAACG
AGAACAATCCGCCCATGATGCTGCCCAACGGCTACGTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTGTGCC
CGAGAACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAGGCCCCACGTCGTGAAGCGCACGCCTCGGGGACGG
GCTGCAGTGGGCGGGGAGGCCACGCCTTCCTCCTGTCCCACGCTCCAGCCTGCCGCGGCGTTTCTGTTTCTTGCGACCAAAGATCCGTGA
GCAACGATAAATACTCTTAGGAAGAGAGAAAATAAGGTTTCATAAGTTTGTACTTGAAAACATTTGGATTGGTAGGATTTTGTAACACGT
CAACCATTTGATGCTTCTGAAAAGTACTTTCAACTTGCGAAGGAAACTCTTCTTTAAAGACTGACCTAAACACCGAGGGAAACTTAAGAA
CGTTTAAAATATAGGAGTCCGTGATTTCCCTGTGTTTTCAGTTTCTTTCCTTCTGTGAACGATGAGACTTGGAGAACGGGCTGGTCCTTC
ACCACTTCCTGTTGGCCCTGGCCTGGCCGGGGAAGGTGGCAGCGGCACCGGACTGACCTGCAGTGACCCGCGATGCCGCGCCACGAGGGA
CACTTATGGCTTCATTCGAGAGCTGCTGCCAAAACGCCTGGCGCCGCCACCGTCGGGGGCTGGCTTCGAGGACGCCCGCCTGCCTCGCGG
GTCGTGTCCGCGGGACTGTGTTCGTACGTGCATAGTTTCGATATCACATCGCGGGGCTGTGTTCGTAGCTGCGTCGTTTCGATATCACAC
CCTCTGTGTGCCGCCTTACTTCCTGCTTCGAGAATGTATAACGTGGAAATCCACGGGACCAAATTTCTGCAGAGGCCTTGCCGGATGGTT
CCATAACTGTAGAGTCTAATTGCTATCCATTACAGAAATTAATCGTTCAGTTGAAAGAAGTACTGATGACTTTTCAAAACAAATGAACCA
CCGTAGCTGACAGAGAACCGTATCGTAGAGGTTTGTAGTTAGTGCTTATTTTTGCATGTTGATGTTGACTAGCTAATAAACTGTAAATGT

>10722_10722_4_C11orf49-MAEA_C11orf49_chr11_46958402_ENST00000395460_MAEA_chr4_1330648_ENST00000514708_length(amino acids)=155AA_BP=15
MLSPERLALPDYEYLGPSGPCTVADADPAVPVRQLPTTPAGKQFCVHPHPAGWPLSHQDTCYKEDGSSKSPDCPVCSRSLNKLAQPLPMA

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Fusion Gene PPI Analysis for C11orf49-MAEA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C11orf49-MAEA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C11orf49-MAEA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human