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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C11orf49-LARS (FusionGDB2 ID:HG79096TG51520)

Fusion Gene Summary for C11orf49-LARS

check button Fusion gene summary
Fusion gene informationFusion gene name: C11orf49-LARS
Fusion gene ID: hg79096tg51520
HgeneTgene
Gene symbol

C11orf49

LARS

Gene ID

79096

51520

Gene namechromosome 11 open reading frame 49leucyl-tRNA synthetase 1
Synonyms-HSPC192|ILFS1|LARS|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025Cl
Cytomap('C11orf49')('LARS')

11p11.2

5q32

Type of geneprotein-codingprotein-coding
DescriptionUPF0705 protein C11orf49leucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44
Modification date2020031320200313
UniProtAcc

Q9H6J7

.
Ensembl transtripts involved in fusion geneENST00000278460, ENST00000378615, 
ENST00000378618, ENST00000395460, 
ENST00000536126, ENST00000543718, 
ENST00000527268, 
Fusion gene scores* DoF score26 X 14 X 9=327610 X 8 X 6=480
# samples 2710
** MAII scorelog2(27/3276*10)=-3.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C11orf49 [Title/Abstract] AND LARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC11orf49(46958402)-LARS(145493874), # samples:1
Anticipated loss of major functional domain due to fusion event.C11orf49-LARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-LARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C11orf49-LARS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLARS

GO:0006425

glutaminyl-tRNA aminoacylation

26869582


check buttonFusion gene breakpoints across C11orf49 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4343-01AC11orf49chr11

46958402

+LARSchr5

145493874

-


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Fusion Gene ORF analysis for C11orf49-LARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000278460ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
5CDS-intronENST00000378615ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
5CDS-intronENST00000378618ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
5CDS-intronENST00000395460ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000536126ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000536126ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000536126ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000536126ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000543718ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000543718ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000543718ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-3CDSENST00000543718ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-intronENST00000536126ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
5UTR-intronENST00000543718ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000278460ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000278460ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000378615ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000378615ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000378618ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000378618ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000395460ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
Frame-shiftENST00000395460ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000278460ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000278460ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000378615ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000378615ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000378618ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000378618ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000395460ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
In-frameENST00000395460ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
intron-3CDSENST00000527268ENST00000274562C11orf49chr11

46958402

+LARSchr5

145493874

-
intron-3CDSENST00000527268ENST00000394434C11orf49chr11

46958402

+LARSchr5

145493874

-
intron-3CDSENST00000527268ENST00000510191C11orf49chr11

46958402

+LARSchr5

145493874

-
intron-3CDSENST00000527268ENST00000545646C11orf49chr11

46958402

+LARSchr5

145493874

-
intron-intronENST00000527268ENST00000511505C11orf49chr11

46958402

+LARSchr5

145493874

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000378618C11orf49chr1146958402+ENST00000394434LARSchr5145493874-1372985230383
ENST00000378618C11orf49chr1146958402+ENST00000545646LARSchr5145493874-567985230383
ENST00000278460C11orf49chr1146958402+ENST00000394434LARSchr5145493874-13791055931083
ENST00000278460C11orf49chr1146958402+ENST00000545646LARSchr5145493874-5741055931083
ENST00000395460C11orf49chr1146958402+ENST00000394434LARSchr5145493874-1358843828983
ENST00000395460C11orf49chr1146958402+ENST00000545646LARSchr5145493874-553843828983
ENST00000378615C11orf49chr1146958402+ENST00000394434LARSchr5145493874-1348742827983
ENST00000378615C11orf49chr1146958402+ENST00000545646LARSchr5145493874-543742827983

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378618ENST00000394434C11orf49chr1146958402+LARSchr5145493874-0.27386620.72613376
ENST00000378618ENST00000545646C11orf49chr1146958402+LARSchr5145493874-0.084793650.9152063
ENST00000278460ENST00000394434C11orf49chr1146958402+LARSchr5145493874-0.145995070.854005
ENST00000278460ENST00000545646C11orf49chr1146958402+LARSchr5145493874-0.071323760.92867625
ENST00000395460ENST00000394434C11orf49chr1146958402+LARSchr5145493874-0.2118950.788105
ENST00000395460ENST00000545646C11orf49chr1146958402+LARSchr5145493874-0.116196150.88380384
ENST00000378615ENST00000394434C11orf49chr1146958402+LARSchr5145493874-0.178698120.8213019
ENST00000378615ENST00000545646C11orf49chr1146958402+LARSchr5145493874-0.097377480.9026225

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Fusion Genomic Features for C11orf49-LARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C11orf49-LARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46958402/chr5:145493874)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C11orf49

Q9H6J7

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLARSchr11:46958402chr5:145493874ENST00000394434303253_6311081177.0MotifNote='HIGH' region
TgeneLARSchr11:46958402chr5:145493874ENST000003944343032716_72011081177.0MotifNote='KMSKS' region
TgeneLARSchr11:46958402chr5:145493874ENST000003944343032260_50911081177.0RegionNote=Editing domain


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Fusion Gene Sequence for C11orf49-LARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10717_10717_1_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000278460_LARS_chr5_145493874_ENST00000394434_length(transcript)=1379nt_BP=105nt
CGGCAACCTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGG
ACTACGAGTATCTGGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGG
AGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAA
GGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACT
CTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTC
ATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAAC
TCTTTTTAAAAAACAAATTGTTGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGT
GTACTTTATACTTTGATGAAGGCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAA
AGAAAAGTAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACT
TCAATTACTAAGTATTTTGTATAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATA
ATGGCTTCTTCAAGGCTAATATCAATAGTTTATAAGCAGTATATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTT
CCCCCCCAGAAATCTGCATTTACTAAATTTGTCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATA
ATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTA
CTAAAAATACAAAAATTAGCTTGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTG
GGAGACCGAGGTTGCAGTGAGCTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCTGTCTCAATCAATCCATCAAT

>10717_10717_1_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000278460_LARS_chr5_145493874_ENST00000394434_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_2_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000278460_LARS_chr5_145493874_ENST00000545646_length(transcript)=574nt_BP=105nt
CGGCAACCTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGG
ACTACGAGTATCTGGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGG
AGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAA
GGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACT
CTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTC
ATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAAC

>10717_10717_2_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000278460_LARS_chr5_145493874_ENST00000545646_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_3_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378615_LARS_chr5_145493874_ENST00000394434_length(transcript)=1348nt_BP=74nt
GGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGACCTTTCCAAAGTGAA
ACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCA
TGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCT
GGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAAC
CTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGG
ACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGTTGCTATTTCC
TAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTGTACTTTATACTTTGATGAAGGCTAAGGTGT
ACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAAAGAAAAGTAGTAAATTAGCAGCTTTTTTTTT
TAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACTTCAATTACTAAGTATTTTGTATAAAGAACAA
ATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATAATGGCTTCTTCAAGGCTAATATCAATAGTTT
ATAAGCAGTATATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCCCCCAGAAATCTGCATTTACTAAATTTG
TCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCAAGGTGGGCA
GTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTTGGCATGGTG
GCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAGACCGAGGTTGCAGTGAGCTGAAACCGT

>10717_10717_3_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378615_LARS_chr5_145493874_ENST00000394434_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_4_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378615_LARS_chr5_145493874_ENST00000545646_length(transcript)=543nt_BP=74nt
GGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGACCTTTCCAAAGTGAA
ACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCA
TGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCT
GGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAAC
CTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGG
ACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGTTGCTATTTCC

>10717_10717_4_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378615_LARS_chr5_145493874_ENST00000545646_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_5_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378618_LARS_chr5_145493874_ENST00000394434_length(transcript)=1372nt_BP=98nt
CTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGA
GTATCTGGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACAC
CGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGA
TATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTG
TGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTC
TATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTT
AAAAAACAAATTGTTGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTGTACTTT
ATACTTTGATGAAGGCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAAAGAAAAG
TAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACTTCAATTA
CTAAGTATTTTGTATAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATAATGGCTT
CTTCAAGGCTAATATCAATAGTTTATAAGCAGTATATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCCCCC
AGAAATCTGCATTTACTAAATTTGTCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCCCAG
CACTTTGGGAGGCCAAGGTGGGCAGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAA
TACAAAAATTAGCTTGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAGACC
GAGGTTGCAGTGAGCTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCTGTCTCAATCAATCCATCAATCAATCAA

>10717_10717_5_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378618_LARS_chr5_145493874_ENST00000394434_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_6_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378618_LARS_chr5_145493874_ENST00000545646_length(transcript)=567nt_BP=98nt
CTGGGTTCCGGAAGCCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGA
GTATCTGGACCTTTCCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACAC
CGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGA
TATTGGCGATACAATAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTG
TGTCTACTGATTGGCTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTC
TATCAAGTCATCTTTGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTT

>10717_10717_6_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000378618_LARS_chr5_145493874_ENST00000545646_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_7_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000395460_LARS_chr5_145493874_ENST00000394434_length(transcript)=1358nt_BP=84nt
CCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGACCTTT
CCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCA
TTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAA
TAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGG
CTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTT
TGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGT
TGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTGTACTTTATACTTTGATGAAG
GCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAAAGAAAAGTAGTAAATTAGCAG
CTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACTTCAATTACTAAGTATTTTGTA
TAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATAATGGCTTCTTCAAGGCTAATA
TCAATAGTTTATAAGCAGTATATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCCCCCAGAAATCTGCATTT
ACTAAATTTGTCTTAAGTCCAATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCC
AAGGTGGGCAGTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCT
TGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAGACCGAGGTTGCAGTGAG
CTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCTGTCTCAATCAATCCATCAATCAATCAATAAAATAGAGGTCA

>10717_10717_7_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000395460_LARS_chr5_145493874_ENST00000394434_length(amino acids)=83AA_BP=15

--------------------------------------------------------------
>10717_10717_8_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000395460_LARS_chr5_145493874_ENST00000545646_length(transcript)=553nt_BP=84nt
CCGGAGAGCTGGAGCTTTGAAGCCACCCCGGTCAAAGGATGCTGAGTCCGGAGCGCCTAGCCCTACCGGACTACGAGTATCTGGACCTTT
CCAAAGTGAAACTGATGAGATTTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCA
TTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAA
TAATCTATCTGGTTCATTAAACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGG
CTATCAGAACCTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTT
TGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGT

>10717_10717_8_C11orf49-LARS_C11orf49_chr11_46958402_ENST00000395460_LARS_chr5_145493874_ENST00000545646_length(amino acids)=83AA_BP=15

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C11orf49-LARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C11orf49-LARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C11orf49-LARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource