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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DEK-DEK (FusionGDB2 ID:HG7913TG7913) |
Fusion Gene Summary for DEK-DEK |
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Fusion gene information | Fusion gene name: DEK-DEK | Fusion gene ID: hg7913tg7913 | Hgene | Tgene | Gene symbol | DEK | DEK | Gene ID | 7913 | 7913 |
Gene name | DEK proto-oncogene | DEK proto-oncogene | |
Synonyms | D6S231E | D6S231E | |
Cytomap | ('DEK')('DEK') 6p22.3 | 6p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein DEKDEK oncogene (DNA binding) | protein DEKDEK oncogene (DNA binding) | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P35659 | P35659 | |
Ensembl transtripts involved in fusion gene | ENST00000244776, ENST00000397239, | ENST00000397239, ENST00000244776, | |
Fusion gene scores | * DoF score | 11 X 13 X 6=858 | 5 X 9 X 3=135 |
# samples | 15 | 9 | |
** MAII score | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/135*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DEK [Title/Abstract] AND DEK [Title/Abstract] AND fusion [Title/Abstract] Role of theĀ DEKĀ oncogene in the development of squamous cell carcinoma. (pmid: 32656741) | ||
Most frequent breakpoint | DEK(18224734)-DEK(18224836), # samples:1 DEK(18225161)-DEK(18225235), # samples:1 DEK(18224464)-DEK(18225752), # samples:1 DEK(18258274)-DEK(18258561), # samples:1 DEK(18258638)-DEK(18236683), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for DEK-DEK |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DEK-DEK |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DEK | chr6 | 18258636 | + | DEK | chr6 | 18236682 | + | 0.9999993 | 6.71E-07 |
DEK | chr6 | 18258636 | + | DEK | chr6 | 18236682 | + | 0.9999993 | 6.71E-07 |
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Fusion Protein Features for DEK-DEK |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:18224734/:18224836) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DEK | DEK |
FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. | FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DEK-DEK |
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Fusion Gene PPI Analysis for DEK-DEK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DEK-DEK |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DEK-DEK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DEK | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Hgene | DEK | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Hgene | DEK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | DEK | C0678222 | Breast Carcinoma | 1 | CTD_human |
Hgene | DEK | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Hgene | DEK | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | DEK | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Tgene | C0027626 | Neoplasm Invasiveness | 2 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0027627 | Neoplasm Metastasis | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |