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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf57-ELAVL3 (FusionGDB2 ID:HG79173TG1995)

Fusion Gene Summary for C19orf57-ELAVL3

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf57-ELAVL3
Fusion gene ID: hg79173tg1995
HgeneTgene
Gene symbol

C19orf57

ELAVL3

Gene ID

79173

1995

Gene namechromosome 19 open reading frame 57ELAV like RNA binding protein 3
Synonyms-HUC|HUCL|PLE21
Cytomap('C19orf57')('ELAVL3')

19p13.12

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C19orf57pre-T/NK cell associated protein (3B3)ELAV-like protein 3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)ELAV like neuron-specific RNA binding protein 3Hu antigen Chu-antigen Cparaneoplastic cerebellar degeneration-associated antigenparaneoplastic limbic enceph
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000346736, ENST00000454313, 
ENST00000586783, ENST00000591586, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 5=180
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf57 [Title/Abstract] AND ELAVL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf57(14000000)-ELAVL3(11577642), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf57-ELAVL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf57-ELAVL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C19orf57 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ELAVL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-A5NZC19orf57chr19

14000000

-ELAVL3chr19

11577642

-


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Fusion Gene ORF analysis for C19orf57-ELAVL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346736ENST00000592218C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
5CDS-intronENST00000454313ENST00000592218C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
5CDS-intronENST00000586783ENST00000592218C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
Frame-shiftENST00000346736ENST00000359227C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
Frame-shiftENST00000346736ENST00000438662C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
Frame-shiftENST00000454313ENST00000359227C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
Frame-shiftENST00000454313ENST00000438662C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
In-frameENST00000586783ENST00000359227C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
In-frameENST00000586783ENST00000438662C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
intron-3CDSENST00000591586ENST00000359227C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
intron-3CDSENST00000591586ENST00000438662C19orf57chr19

14000000

-ELAVL3chr19

11577642

-
intron-intronENST00000591586ENST00000592218C19orf57chr19

14000000

-ELAVL3chr19

11577642

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000586783C19orf57chr1914000000-ENST00000359227ELAVL3chr1911577642-5963166802762920
ENST00000586783C19orf57chr1914000000-ENST00000438662ELAVL3chr1911577642-2865166802741913

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000586783ENST00000359227C19orf57chr1914000000-ELAVL3chr1911577642-0.0004880510.99951196
ENST00000586783ENST00000438662C19orf57chr1914000000-ELAVL3chr1911577642-0.0045147810.9954853

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Fusion Genomic Features for C19orf57-ELAVL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C19orf57-ELAVL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14000000/chr19:11577642)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneELAVL3chr19:14000000chr19:11577642ENST0000035922707125_2053368.0DomainRRM 2
TgeneELAVL3chr19:14000000chr19:11577642ENST0000035922707284_3623368.0DomainRRM 3
TgeneELAVL3chr19:14000000chr19:11577642ENST000003592270739_1173368.0DomainRRM 1
TgeneELAVL3chr19:14000000chr19:11577642ENST0000043866207125_2053361.0DomainRRM 2
TgeneELAVL3chr19:14000000chr19:11577642ENST0000043866207284_3623361.0DomainRRM 3
TgeneELAVL3chr19:14000000chr19:11577642ENST000004386620739_1173361.0DomainRRM 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C19orf57-ELAVL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11238_11238_1_C19orf57-ELAVL3_C19orf57_chr19_14000000_ENST00000586783_ELAVL3_chr19_11577642_ENST00000359227_length(transcript)=5963nt_BP=1668nt
ATGACTAAGAGGAAGAAGCTGCGGACCTCAGGAGAGGGACTCTGTCCTCCAAAACCCCTAAAGAACCCAAGGCTAGGAGACTTCTATGGG
GACCCCCAGAGTTCCATGTTGGGCTGTTTACATCACCCTGAGGAGCCAGAGGGCAAATTGGGACCTGTTCCCTCTACACAGCAGCACGGG
GAGGAACCAGGAAAGGCCGTCTCCAGCTCCCCTGATGAGGAAACAGGATCTCCCTGCCGGCTCCTCCGTCAACCAGAAAAGGAGCCAGCT
CCCCTTCCTCCTTCCCAGAACTCATTCGGGAGGTTTGTTCCCCAGTTTGCAAAATCCAGGAAGACAGTGACAAGAAAAGAAGAGATGAAG
GATGAGGACCGTGGGAGTGGGGCCTTTAGCCTGGAAACAATCGCAGAGTCCAGCGCCCAGAGTCCAGGATGCCAGCTGCTAGTGGAGACC
CTGGGGGTCCCCCTCCAGGAGGCCACGGAGCTGGGGGACCCAACGCAGGCAGACAGTGCCCGCCCTGAGCAGAGCAGCCAGAGCCCTGTG
CAGGCGGTGCCCGGCAGTGGGGATTCTCAGCCTGATGACCCTCCAGACAGGGGGACGGGGTTGTCCGCCTCACAGAGGGCCAGCCAAGAC
CACCTGTCAGAACAAGGGGCCGATGACAGCAAGCCTGAGACAGACAGGGTTCCAGGTGACGGTGGCCAAAAGGAACACCTACCAAGCATT
GATTCTGAAGGGGAGAAGCCAGACAGAGGAGCCCCCCAGGAGGGAGGGGCCCAAAGGACAGCAGGGGCTGGCCTGCCTGGAGGGCCCCAG
GAGGAGGGAGACGGTGTCCCCTGTACCCCAGCATCAGCTCCTACCTCAGGCCCTGCTCCAGGACTGGGCCCTGCCTCTTGGTGCCTGGAA
CCCGGGTCTGTGGCCCAGGGCTCCCCTGACCCCCAGCAGACCCCCAGCAGGATGGGTAGGGAAGGGGAAGGGACTCATAGCAGCCTGGGA
TGCTCCTCCCTCGGGATGGTTGTCATCGCAGACCTGAGCACAGACCCCACTGAGCTGGAAGAGAGGGCTCTGGAGGTGGCTGGGCCCGAT
GGGCAGGCCAGTGCCATATCACCTGCCTCTCCCAGGAGGAAGGCCGCTGATGGAGGCCACAGGAGGGCCTTGCCAGGCTGCACCTCGCTC
ACTGGGGAAACCACAGGAGAAAGTGGGGAGGCAGGGCAGGATGGCAAGCCCCCCGGCGATGTCCTAGTGGGCCCTACAGCCTCCCTGGCT
CTGGCACCTGGGAGCGGAGAGTCCATGATGGGTGCTGGAGATTCCGGTCATGCATCCCCGGACACAGGTCCATGTGTCAATCAGAAGCAG
GAGCCAGGTCCTGCTCAAGAGGAAGCCGAGTTAGGTGGCCAGAACCTCGAACGAGACCTCGAGGGGTTCCGTGTGTCCCCGCAAGCCTCT
GTTGTGCTGGAACACAGAGAAATAGCAGACGACCCTCTCCAGGAGCCCGGGGCTCAGCAGGGCATTCCAGACACCACCTCAGAGCTGGCA
GGGCAGCGAGACCACCTGCCTCATTCTGCAGACCAGGGCACCTGGGCAGACTCTTTAGCTGTGGAACTCGACTTCCTGCTGGACAGCCAG
ATACAGGATGCCCTGGACGCCTCTGACTTCGAAGCCCCACCTGAGCAGCAGATACTGGGGGCCATGGAGTCTCAGGTGGGGGGGGGCCCG
GCCGGCCCGGCCCTGCCCAACGGGCCACTCCTTGGTACAAATGGAGCCACTGACGACAGCAAGACCAACCTCATCGTCAACTACCTGCCC
CAGAACATGACCCAGGATGAGTTCAAGAGTCTCTTCGGCAGCATTGGCGACATCGAGTCCTGCAAGTTGGTTCGGGACAAGATCACAGGG
CAGAGCCTTGGCTACGGGTTTGTGAACTATTCTGACCCCAATGATGCAGACAAAGCCATCAACACCCTCAACGGCCTCAAATTACAGACG
AAGACCATCAAGGTGTCCTATGCCAGACCCAGTTCAGCATCCATCCGGGATGCTAACCTGTACGTCAGCGGGCTCCCCAAGACCATGAGC
CAGAAAGAGATGGAGCAGCTCTTCTCCCAGTACGGCCGCATCATCACGTCCCGCATCCTGGTGGACCAGGTCACAGGTGTCTCTCGGGGT
GTGGGATTCATCCGCTTTGACAAGAGGATTGAGGCCGAAGAGGCTATCAAAGGACTGAATGGGCAGAAGCCGCTGGGCGCAGCTGAGCCC
ATCACAGTCAAGTTCGCGAACAACCCAAGTCAGAAGACGGGGCAGGCGCTGCTCACCCACCTCTACCAGTCATCCGCCCGGCGCTACGCA
GGCCCCCTACACCATCAGACCCAGCGTTTCCGGCTGGACAATTTGCTCAACATGGCCTACGGCGTCAAGAGTCCCCTGTCGCTCATCGCC
AGGTTCTCGCCGATCGCCATCGATGGTATGAGCGGCCTGGCGGGCGTGGGCCTGTCGGGGGGCGCGGCGGGCGCCGGCTGGTGCATCTTC
GTGTACAACCTGTCACCGGAGGCAGACGAGAGCGTGCTGTGGCAGCTGTTCGGGCCTTTTGGGGCAGTCACCAACGTCAAGGTCATCCGT
GATTTCACCACCAACAAGTGCAAGGGTTTCGGCTTCGTGACCATGACCAACTATGACGAGGCGGCCATGGCCATCGCCAGCCTGAACGGC
TATCGCCTGGGCGAGCGCGTGCTGCAGGTCTCCTTCAAGACCAGCAAACAGCACAAGGCGTGAGCCCACCCCGCCTGCCCTCCCACCCCC
TCCCCGGGCAGCAGAGAGAGAGAGAGAGAAAGAGAGAGAGAGAGAGAGAAGGGGCCCAAGAGAGACAGCACAGGCAGCCCCACGGACGAC
GCGAGGGCCCCACGTCCCTGCGGAAGCCACAGGGTGAGCACTCTGGGGTGGGAGGGTCTGCAGGGAATTGGGGGGGTGCCCGGGGATCCC
CCGCCCCATCCTCCTGCCCCCACCCCAGGCTGGGCTGTTCACTCTCTCGTCTTGGTTTGGTTCATGGTGAAGGTTTTTGTTTCTTTTTTC
GGCTAAAAAGAATGCAGAGATGTGCCCCCACCCCCACCCTCGACCACCCCCGATGGGATGGCTTGGGGGGCTCCAGGGGGTGCCCTCCCA
GACCCCCTTGCCCAGGCCTCCCCAGCACCTAGGTGGGGCCTGGGGTAGGAGGAACAGGTTTAAAAATCCCCAAAAAAGCGAACCGTGAGG
AGGGGTGTGGGCACCCCCGGCCCAGTGCCCCCTGGTGGAATGCGGGGGAGCAGGCAGTGGGGCTGGAAGCAGAAACAAAATGAAAAAAAA
AGGGGGGTGGGAGGGGAAGAAAAACTCTATTTTTGTAAAAAGGGAAAAAGACCTCGTGGAGAATTTTTACTGGGGATTCTTGAACTTGAA
AAAAAAAAACACAAAAAAAGACAAAAAAAAAAAAAGAAAATATTTTGGCAGGTTATGTTTACCAACTGGGGCGGGGGTGGGGGGGGCCCA
GGGAGCAGGGCTTAGGGGCTAGCAGCCCACGGGGCCACACAGAGAAACAACCACGCAGACAGTCACACCACGGGGACACACGGACAGACG
CAGACGGACACAGCGACATGCCCCAGACACGTTAAGGGACTGGTTGGCCAAACTCAGACACGTGGACAGGGATAGACAGAAAGAGACAGA
AGCTGGGGCTACGTCCATGTGGACACAGACCACAGATGTGGGCACACGAATCCATCCACCTGTCCACGTGCACACGTGAATGTAGCGATA
GATATTTGGACATCAAATTTGGACACCAGGTCACGGAGAAACACAAACACCACCCAGGAACACGCAGACATATGCCCATAGCATCCCACA
GGCCCAGGCAGGAGGTCCCACCCCAGACCCTGCCCCAGACGCTCCCTCACCCTCTCGGCCCCCTCGCCCTGGCCCCCAGGTTCTCTGCAG
AGATCTCTCCTGGACCCCCAGCGGTCTCCTTGGCGCCCACGAACACAGGCGTGCACACGCAGCGCACATGCATTGAGACACACGATACCT
CGTTCCACCTTGGCGTCACGGTGGGCTGGAGGCAGCCCCCCCCCCCACAACACTTGAGGCCAAAGGACACCCCTGTCCCCGGGGCTCAGC
CTCCCCCTGGGCCGAGGCCTTGGCCCACACAGCTGAGGGAGAGGCCCAGCCCTGAGCCTCCCCCACCAGGACTGGGCCTCCCCGGCAGCA
AGACCCCGGCACTCCCCGCCAGGCCCAGGGTGGGGTGGATGGGCCCAAAGGCCCAGCCCCACACTCCTTTCCCGTCCACTTGTCACCTAC
CTATCCCCTTTCGGTTTGTTGGGTTTTTCGTCTTTCCAGATTGCAGTGGACACAGCCCCCGATCTCGAGCCCCGGCCCCCGGCTTCTGTC
TGGACATTGCATCGCCCTAGTTTTCTTTCTTTAAAAAAAAAAAATTCCAACAGAAGCCACAGGCCGGAGCCCCTGGGAGCCCTCGCACCG
CTCCCCACCCCACTCAGCGGCCCCATCGGAACTGAGAATTGCAAAACCCCCGACTTTAGCTATAGTTAAGTTGCCTTCCCCCGGTGTCCC
CACGTTTGGTGTCTGGCTATGGCGCCCCCATCTGACTGTCCAGCTCTCTCTCCCCCACCCCTCCCGGTGTTGTTATTAAACGTCTGTGGA
GCTTCTGCTGCAAGGAACAAAAAAGAAAAAAATCAAAAAAGCGACAAAAAAACACAAACAGAAGAGGAAAAAAAAGCAACAAAAAAAGAA
AACACACAGAAGAGATTTAAAAAAAAAAAAGGAAAAAAAAAAAAGACATAAACTGGCACCAGTTAACTTTCTTGTACTTTTTTGCTGAAT
TTAGCTTCTTGTAGTTTTAACTTATTGCTATGTTAACTATTTATTCTCCTCGTTGCCCTGTAAGGACATCCGTGTATATTTCTGTTACTT
CATCCGGTTTGCAAGTTAAAGGAACGACAATGTTCTCTTTGTTTCTTTAAGTTTTGCCGAGACATGGTTATGCCTAATTTATTTATAAAA
GGGGAAGTGGAATCATTAAAGTAATAATAATTATTAATAACAGTAATGGTAGCCGAGTGGCACGCGGGGGCGTGTGCTCTGCGGGACAGT
CCCCACGGCCAGCGACGTCCAGGTCACCAATGGGATTCTTTTTGCTCTTGTCTTGAGAATTTTTTCAGTCCTATTTAGCTGGTGAAATCC
CTAGCTTGTTCTTGATACACGAACCTATTTATTCTCGTGGTTTTAAGTCCTCCCTGCCCTCTCTCCTCTCCCCTGCAGCAGGGCAGGGAC
CCCTCTCCCCTGCTGTCTCTTGGGGCTCTCTCCCCTCCGCCCTCTGCATTCGGGAACACGCACGTCCGCGTGGGAAGCTTGCAGCAGGGC
GTCCGAGCAATAAGGGCTGGGTTTGTCCCCCACCCTGGGGGGGGCCAGGCTCCAGAGAGGGGGCACCTCCCCACACACCCCCCCCCCACC
GAGGCCTAGGCCCCTGCCACCCCCAAGACTGGGAGGGGACTTCTTTTTCTAAAACACAAAACTCAGCCCAGCCAGGCCCCCTCCCTGGAG
GCCAGCCCCTCCCCGCAGGGGGCCAGGCCGGGGCTCCCAGGCGAGGGGGACTTGGGGCTTCCACGTCCCTGGGGGGCAGGGGCCAGGCCA
GGGGGGAGGGGGCTCAGCCCCTCCACCCCTCCCTTCATCCTGTTATTTATTCGGAAGGTTTCAAATCACGACAGAGTCCATGTTGGAGGT
GATAAAAAACTGTAAAAAAAAAAAAAAAAAAAAAGACAAAACAAAAGACAAAAAAAAAAAAAAAACCCAACAAGAACACTTCGCGTTGCG
TTTAGACTATTTATTACCGGGATCACAGGCCTGGCCGCGGTAACAGACTTTTACATGGAATTGTTTAATTATTTGTACTTTTCATGCCAG

>11238_11238_1_C19orf57-ELAVL3_C19orf57_chr19_14000000_ENST00000586783_ELAVL3_chr19_11577642_ENST00000359227_length(amino acids)=920AA_BP=555
MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPA
PLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPV
QAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQ
EEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPD
GQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQ
EPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQ
IQDALDASDFEAPPEQQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITG
QSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRG
VGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIA
RFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNG

--------------------------------------------------------------
>11238_11238_2_C19orf57-ELAVL3_C19orf57_chr19_14000000_ENST00000586783_ELAVL3_chr19_11577642_ENST00000438662_length(transcript)=2865nt_BP=1668nt
ATGACTAAGAGGAAGAAGCTGCGGACCTCAGGAGAGGGACTCTGTCCTCCAAAACCCCTAAAGAACCCAAGGCTAGGAGACTTCTATGGG
GACCCCCAGAGTTCCATGTTGGGCTGTTTACATCACCCTGAGGAGCCAGAGGGCAAATTGGGACCTGTTCCCTCTACACAGCAGCACGGG
GAGGAACCAGGAAAGGCCGTCTCCAGCTCCCCTGATGAGGAAACAGGATCTCCCTGCCGGCTCCTCCGTCAACCAGAAAAGGAGCCAGCT
CCCCTTCCTCCTTCCCAGAACTCATTCGGGAGGTTTGTTCCCCAGTTTGCAAAATCCAGGAAGACAGTGACAAGAAAAGAAGAGATGAAG
GATGAGGACCGTGGGAGTGGGGCCTTTAGCCTGGAAACAATCGCAGAGTCCAGCGCCCAGAGTCCAGGATGCCAGCTGCTAGTGGAGACC
CTGGGGGTCCCCCTCCAGGAGGCCACGGAGCTGGGGGACCCAACGCAGGCAGACAGTGCCCGCCCTGAGCAGAGCAGCCAGAGCCCTGTG
CAGGCGGTGCCCGGCAGTGGGGATTCTCAGCCTGATGACCCTCCAGACAGGGGGACGGGGTTGTCCGCCTCACAGAGGGCCAGCCAAGAC
CACCTGTCAGAACAAGGGGCCGATGACAGCAAGCCTGAGACAGACAGGGTTCCAGGTGACGGTGGCCAAAAGGAACACCTACCAAGCATT
GATTCTGAAGGGGAGAAGCCAGACAGAGGAGCCCCCCAGGAGGGAGGGGCCCAAAGGACAGCAGGGGCTGGCCTGCCTGGAGGGCCCCAG
GAGGAGGGAGACGGTGTCCCCTGTACCCCAGCATCAGCTCCTACCTCAGGCCCTGCTCCAGGACTGGGCCCTGCCTCTTGGTGCCTGGAA
CCCGGGTCTGTGGCCCAGGGCTCCCCTGACCCCCAGCAGACCCCCAGCAGGATGGGTAGGGAAGGGGAAGGGACTCATAGCAGCCTGGGA
TGCTCCTCCCTCGGGATGGTTGTCATCGCAGACCTGAGCACAGACCCCACTGAGCTGGAAGAGAGGGCTCTGGAGGTGGCTGGGCCCGAT
GGGCAGGCCAGTGCCATATCACCTGCCTCTCCCAGGAGGAAGGCCGCTGATGGAGGCCACAGGAGGGCCTTGCCAGGCTGCACCTCGCTC
ACTGGGGAAACCACAGGAGAAAGTGGGGAGGCAGGGCAGGATGGCAAGCCCCCCGGCGATGTCCTAGTGGGCCCTACAGCCTCCCTGGCT
CTGGCACCTGGGAGCGGAGAGTCCATGATGGGTGCTGGAGATTCCGGTCATGCATCCCCGGACACAGGTCCATGTGTCAATCAGAAGCAG
GAGCCAGGTCCTGCTCAAGAGGAAGCCGAGTTAGGTGGCCAGAACCTCGAACGAGACCTCGAGGGGTTCCGTGTGTCCCCGCAAGCCTCT
GTTGTGCTGGAACACAGAGAAATAGCAGACGACCCTCTCCAGGAGCCCGGGGCTCAGCAGGGCATTCCAGACACCACCTCAGAGCTGGCA
GGGCAGCGAGACCACCTGCCTCATTCTGCAGACCAGGGCACCTGGGCAGACTCTTTAGCTGTGGAACTCGACTTCCTGCTGGACAGCCAG
ATACAGGATGCCCTGGACGCCTCTGACTTCGAAGCCCCACCTGAGCAGCAGATACTGGGGGCCATGGAGTCTCAGGTGGGGGGGGGCCCG
GCCGGCCCGGCCCTGCCCAACGGGCCACTCCTTGGTACAAATGGAGCCACTGACGACAGCAAGACCAACCTCATCGTCAACTACCTGCCC
CAGAACATGACCCAGGATGAGTTCAAGAGTCTCTTCGGCAGCATTGGCGACATCGAGTCCTGCAAGTTGGTTCGGGACAAGATCACAGGG
CAGAGCCTTGGCTACGGGTTTGTGAACTATTCTGACCCCAATGATGCAGACAAAGCCATCAACACCCTCAACGGCCTCAAATTACAGACG
AAGACCATCAAGGTGTCCTATGCCAGACCCAGTTCAGCATCCATCCGGGATGCTAACCTGTACGTCAGCGGGCTCCCCAAGACCATGAGC
CAGAAAGAGATGGAGCAGCTCTTCTCCCAGTACGGCCGCATCATCACGTCCCGCATCCTGGTGGACCAGGTCACAGGTGTCTCTCGGGGT
GTGGGATTCATCCGCTTTGACAAGAGGATTGAGGCCGAAGAGGCTATCAAAGGACTGAATGGGCAGAAGCCGCTGGGCGCAGCTGAGCCC
ATCACAGTCAAGTTCGCGAACAACCCAAGTCAGAAGACGGGGCAGGCGCTGCTCACCCACCTCTACCAGTCATCCGCCCGGCGCTACGCA
GGCCCCCTACACCATCAGACCCAGCGTTTCCGGCTGGACAATTTGCTCAACATGGCCTACGGCGTCAAGAGGTTCTCGCCGATCGCCATC
GATGGTATGAGCGGCCTGGCGGGCGTGGGCCTGTCGGGGGGCGCGGCGGGCGCCGGCTGGTGCATCTTCGTGTACAACCTGTCACCGGAG
GCAGACGAGAGCGTGCTGTGGCAGCTGTTCGGGCCTTTTGGGGCAGTCACCAACGTCAAGGTCATCCGTGATTTCACCACCAACAAGTGC
AAGGGTTTCGGCTTCGTGACCATGACCAACTATGACGAGGCGGCCATGGCCATCGCCAGCCTGAACGGCTATCGCCTGGGCGAGCGCGTG
CTGCAGGTCTCCTTCAAGACCAGCAAACAGCACAAGGCGTGAGCCCACCCCGCCTGCCCTCCCACCCCCTCCCCGGGCAGCAGAGAGAGA

>11238_11238_2_C19orf57-ELAVL3_C19orf57_chr19_14000000_ENST00000586783_ELAVL3_chr19_11577642_ENST00000438662_length(amino acids)=913AA_BP=555
MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPA
PLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPV
QAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQ
EEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPD
GQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQ
EPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQ
IQDALDASDFEAPPEQQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITG
QSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRG
VGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKRFSPIAI
DGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERV

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Fusion Gene PPI Analysis for C19orf57-ELAVL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf57-ELAVL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf57-ELAVL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human