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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BIRC7-ZNF200 (FusionGDB2 ID:HG79444TG7752)

Fusion Gene Summary for BIRC7-ZNF200

check button Fusion gene summary
Fusion gene informationFusion gene name: BIRC7-ZNF200
Fusion gene ID: hg79444tg7752
HgeneTgene
Gene symbol

BIRC7

ZNF200

Gene ID

79444

7752

Gene namebaculoviral IAP repeat containing 7zinc finger protein 200
SynonymsKIAP|LIVIN|ML-IAP|MLIAP|RNF50-
Cytomap('BIRC7')('ZNF200')

20q13.33

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionbaculoviral IAP repeat-containing protein 7RING finger protein 50RING-type E3 ubiquitin transferase BIRC7kidney inhibitor of apoptosis proteinlivin inhibitor of apoptosismelanoma inhibitor of apoptosis proteinzinc finger protein 200
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000217169, ENST00000342412, 
ENST00000395306, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 1 X 2=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: BIRC7 [Title/Abstract] AND ZNF200 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBIRC7(61870962)-ZNF200(3285360), # samples:3
Anticipated loss of major functional domain due to fusion event.BIRC7-ZNF200 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BIRC7-ZNF200 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBIRC7

GO:0016567

protein ubiquitination

16729033

HgeneBIRC7

GO:0042127

regulation of cell proliferation

21617971

HgeneBIRC7

GO:0070247

regulation of natural killer cell apoptotic process

18034418



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2GK-06ABIRC7chr20

61870962

-ZNF200chr16

3285360

-
ChimerDB4SKCMTCGA-EE-A2GK-06ABIRC7chr20

61870962

+ZNF200chr16

3285360

-


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Fusion Gene ORF analysis for BIRC7-ZNF200

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000217169ENST00000396868BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-3CDSENST00000342412ENST00000396868BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-5UTRENST00000217169ENST00000396871BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-5UTRENST00000217169ENST00000414144BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-5UTRENST00000342412ENST00000396871BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-5UTRENST00000342412ENST00000414144BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000217169ENST00000396870BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000217169ENST00000431561BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000217169ENST00000575948BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000342412ENST00000396870BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000342412ENST00000431561BIRC7chr20

61870962

+ZNF200chr16

3285360

-
3UTR-intronENST00000342412ENST00000575948BIRC7chr20

61870962

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000395306ENST00000396871BIRC7chr20

61870962

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000395306ENST00000414144BIRC7chr20

61870962

+ZNF200chr16

3285360

-
5CDS-intronENST00000395306ENST00000396870BIRC7chr20

61870962

+ZNF200chr16

3285360

-
5CDS-intronENST00000395306ENST00000431561BIRC7chr20

61870962

+ZNF200chr16

3285360

-
5CDS-intronENST00000395306ENST00000575948BIRC7chr20

61870962

+ZNF200chr16

3285360

-
Frame-shiftENST00000395306ENST00000396868BIRC7chr20

61870962

+ZNF200chr16

3285360

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BIRC7-ZNF200


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for BIRC7-ZNF200


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61870962/:3285360)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BIRC7-ZNF200


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BIRC7-ZNF200


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BIRC7-ZNF200


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BIRC7-ZNF200


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBIRC7C0007134Renal Cell Carcinoma2CTD_human
HgeneBIRC7C0279702Conventional (Clear Cell) Renal Cell Carcinoma2CTD_human
HgeneBIRC7C1266042Chromophobe Renal Cell Carcinoma2CTD_human
HgeneBIRC7C1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
HgeneBIRC7C1266044Collecting Duct Carcinoma of the Kidney2CTD_human
HgeneBIRC7C1306837Papillary Renal Cell Carcinoma2CTD_human