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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ACSS3-CYP39A1 (FusionGDB2 ID:HG79611TG51302) |
Fusion Gene Summary for ACSS3-CYP39A1 |
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Fusion gene information | Fusion gene name: ACSS3-CYP39A1 | Fusion gene ID: hg79611tg51302 | Hgene | Tgene | Gene symbol | ACSS3 | CYP39A1 | Gene ID | 79611 | 51302 |
Gene name | acyl-CoA synthetase short chain family member 3 | cytochrome P450 family 39 subfamily A member 1 | |
Synonyms | - | - | |
Cytomap | ('ACSS3')('CYP39A1') 12q21.31 | 6p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | acyl-CoA synthetase short-chain family member 3, mitochondrialAMP-binding enzyme, 33217acetate--CoA ligase 3propionate--CoA ligase | 24-hydroxycholesterol 7-alpha-hydroxylasecytochrome P450, family 39, subfamily A, polypeptide 1cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9H6R3 | Q9NYL5 | |
Ensembl transtripts involved in fusion gene | ENST00000261206, ENST00000548058, ENST00000548324, | ||
Fusion gene scores | * DoF score | 9 X 7 X 2=126 | 4 X 4 X 4=64 |
# samples | 8 | 4 | |
** MAII score | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACSS3 [Title/Abstract] AND CYP39A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACSS3(81472210)-CYP39A1(46518174), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ACSS3-CYP39A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSS3-CYP39A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CYP39A1 | GO:0006699 | bile acid biosynthetic process | 10748047 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-A7EI-01A | ACSS3 | chr12 | 81472210 | - | CYP39A1 | chr6 | 46518174 | - |
ChimerDB4 | SARC | TCGA-DX-A7EI-01A | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
ChimerDB4 | SARC | TCGA-DX-A7EI | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
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Fusion Gene ORF analysis for ACSS3-CYP39A1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000261206 | ENST00000489657 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
5CDS-intron | ENST00000548058 | ENST00000489657 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
In-frame | ENST00000261206 | ENST00000275016 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
In-frame | ENST00000548058 | ENST00000275016 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
intron-3CDS | ENST00000548324 | ENST00000275016 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
intron-intron | ENST00000548324 | ENST00000489657 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000548058 | ACSS3 | chr12 | 81472210 | + | ENST00000275016 | CYP39A1 | chr6 | 46518174 | - | 1855 | 1221 | 739 | 1221 | 160 |
ENST00000261206 | ACSS3 | chr12 | 81472210 | + | ENST00000275016 | CYP39A1 | chr6 | 46518174 | - | 1006 | 372 | 64 | 609 | 181 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000548058 | ENST00000275016 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - | 0.9059892 | 0.09401075 |
ENST00000261206 | ENST00000275016 | ACSS3 | chr12 | 81472210 | + | CYP39A1 | chr6 | 46518174 | - | 0.6738256 | 0.32617438 |
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Fusion Genomic Features for ACSS3-CYP39A1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ACSS3-CYP39A1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:81472210/chr6:46518174) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ACSS3 | CYP39A1 |
FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:A0A0G2K047, ECO:0000269|PubMed:28003429}. | FUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047). {ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:25201972}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548058 | + | 1 | 16 | 425_427 | 103 | 687.0 | Nucleotide binding | ATP |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548058 | + | 1 | 16 | 446_451 | 103 | 687.0 | Nucleotide binding | ATP |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548324 | + | 1 | 11 | 425_427 | 0 | 369.0 | Nucleotide binding | ATP |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548324 | + | 1 | 11 | 446_451 | 0 | 369.0 | Nucleotide binding | ATP |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548058 | + | 1 | 16 | 227_230 | 103 | 687.0 | Region | Coenzyme A binding |
Hgene | ACSS3 | chr12:81472210 | chr6:46518174 | ENST00000548324 | + | 1 | 11 | 227_230 | 0 | 369.0 | Region | Coenzyme A binding |
Tgene | CYP39A1 | chr12:81472210 | chr6:46518174 | ENST00000275016 | 10 | 12 | 267_287 | 446 | 470.0 | Transmembrane | Helical | |
Tgene | CYP39A1 | chr12:81472210 | chr6:46518174 | ENST00000275016 | 10 | 12 | 352_372 | 446 | 470.0 | Transmembrane | Helical | |
Tgene | CYP39A1 | chr12:81472210 | chr6:46518174 | ENST00000275016 | 10 | 12 | 412_432 | 446 | 470.0 | Transmembrane | Helical |
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Fusion Gene Sequence for ACSS3-CYP39A1 |
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>1547_1547_1_ACSS3-CYP39A1_ACSS3_chr12_81472210_ENST00000261206_CYP39A1_chr6_46518174_ENST00000275016_length(transcript)=1006nt_BP=372nt GGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTGGCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCG TAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGCCCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGT CCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGGCAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTC GGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTACAAGCCCTGGACCAAAACGCTGGAGAACAAACACTC GCCCTCTACCAGAGTTATCTCCATTTGGTGGGTGTCCCCCAGCCGGAAGGGCAATGCCGAATTGAATATAAACAAAGAATATGACATCTG TTGGGCCTCACAAGGACCAGGGCCTTCTGGAGGAGTGGCACTACCCCACCTGGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCT TCACTTTGTTTTAGGACTTAGTTCAAGAACACATTCAAATGGTGCATGTGTTTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACT CTCAGTAATATAGAGACCGGAATACATGGTTTATAGGAAATGATCAAATGATCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTG ATTTCATGCATAACTGTATTAAAACATTAAATAGAAATAATGTCATTTGAATGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCA TACTTAAATTTTTATTTTGAAAAGTCTAAAAGGCTTAGATTTTTAAAATTTAATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTG ATTCTCAACTAGCAATTGGAACTCCTAGGCTCTATTAACATAATTCTTTATTGTAAACGTATCTAATGCTAAAAGTAATAAAATGGTAGT >1547_1547_1_ACSS3-CYP39A1_ACSS3_chr12_81472210_ENST00000261206_CYP39A1_chr6_46518174_ENST00000275016_length(amino acids)=181AA_BP=102 MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPW TKTLENKHSPSTRVISIWWVSPSRKGNAELNINKEYDICWASQGPGPSGGVALPHLAAPRPELYKNTLLHFVLGLSSRTHSNGACVWYLQ -------------------------------------------------------------- >1547_1547_2_ACSS3-CYP39A1_ACSS3_chr12_81472210_ENST00000548058_CYP39A1_chr6_46518174_ENST00000275016_length(transcript)=1855nt_BP=1221nt CTTTCTTTTTACATTTTCCCAGTTTCCTCTTTTGATTCATCTTTACTTACTTCCTATTTTTGTTTTTTGTTTATTTGTTTGTTTTGTTTT CTCATTAGAAAAGCCACAGAAACTCCAAGCAGGCAAATTAGAAGGGAGGCAATGCAACAAGTCCTATCTGTTCTCTGTCTAGATCACATG CGGAGTCTGGTCAGCAGGTGAATCCGCATCCCAGTGGGGTCACCTTCCCTGTGACCTGTCAATCACCCCAAGAAGCACTTCCCAATTTGT CTGGCACAACCTCCTTCCACTCCTCCTACCCTCTCAGTGGTCAGGAAATCCCGGAGCAGTCCTTGCCCTGGAGCTGCTTGTGTTTTTAGT AACCAGGGACTGAGCTGATTTTGAAAAATCAATCAATCAATAAATAACAATCAAAGAGCCTTGCCTCAACGCACCGAGTTGCTGGTTTCC TGCAGGTCAGAGGCGATGCCACCTCCACCAACGACCTTCCAAAGATTAAACCAGCCGTGTACAAACTGCTGGATTGAAAATTGAGAGATG GGCCGTTGGCCTCCTCCTAGGAGTACTTGTGTGTTGAAATCGGAAGGACGTTCTGGAGTTTGAGCGCGATTTTTCCCGGAAGGCTGCGGG GTTGGAAGTGCATGTTGGGGTTTGGATCTCGTGCAGCAGCGCAACTAACCTGCTGCAACGGCGCTGTGACACCCCTGTCCCGGGGCCCCC ACTTTAGCCTGTTGCTTCTCTGGTCGCTCCAGGTCGGTTTTTCCCGGCGACTCTAGTGTGGCTTCCAAACTTCTGGGCTCTGGGCTCACT TCGGAATTTGCCCCCGCCCCCTACTCCCTTCCCTCAGGCCCCAGGAAGTTGCAAGAGTACCATTTGTCGCACACTCGGGGACCGCGGGTG GCCGGAGGAGATGAAACCGTCTTGGCTGCAGTGTCGTAAAGTCACCAGCGCCGGGGGGCTCGGAGGGCCCTTGCCTGGGTCCTCTCCGGC CCGGGGAGCCGGTGCGGCCCTCAGGGCTTTAGTGGTCCCGGGCCCGCGGGGCGGTCTCGGGGGCCGGGGATGCAGGGCACTGTCCTCCGG CAGTGGCAGCGAGTACAAGACCCACTTCGCAGCCTCGGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCTGCCGAGCAGATCAGCTGGTA CAAGCCCTGGACCAAAACGCTGGAGAACAAACACTCGCCCTCTACCAGGTGAGTTATCTCCATTTGGTGGGTGTCCCCCAGCCGGAAGGG CAATGCCGAATTGAATATAAACAAAGAATATGACATCTGTTGGGCCTCACAAGGACCAGGGCCTTCTGGAGGAGTGGCACTACCCCACCT GGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCTTCACTTTGTTTTAGGACTTAGTTCAAGAACACATTCAAATGGTGCATGTGT TTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACTCTCAGTAATATAGAGACCGGAATACATGGTTTATAGGAAATGATCAAATGA TCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTGATTTCATGCATAACTGTATTAAAACATTAAATAGAAATAATGTCATTTGAA TGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCATACTTAAATTTTTATTTTGAAAAGTCTAAAAGGCTTAGATTTTTAAAATTT AATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTGATTCTCAACTAGCAATTGGAACTCCTAGGCTCTATTAACATAATTCTTTAT >1547_1547_2_ACSS3-CYP39A1_ACSS3_chr12_81472210_ENST00000548058_CYP39A1_chr6_46518174_ENST00000275016_length(amino acids)=160AA_BP= MVAPGRFFPATLVWLPNFWALGSLRNLPPPPTPFPQAPGSCKSTICRTLGDRGWPEEMKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACSS3-CYP39A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACSS3-CYP39A1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACSS3-CYP39A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human |