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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARMC7-CYB561 (FusionGDB2 ID:HG79637TG1534)

Fusion Gene Summary for ARMC7-CYB561

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMC7-CYB561
Fusion gene ID: hg79637tg1534
HgeneTgene
Gene symbol

ARMC7

CYB561

Gene ID

79637

1534

Gene namearmadillo repeat containing 7cytochrome b561
Synonyms-CYB561A1|FRRS2|ORTHYP2
Cytomap('ARMC7')('CYB561')

17q25.1

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing protein 7cytochrome b561cytochrome b-561cytochrome b561 family, member A1ferric-chelate reductase 2
Modification date2020032720200313
UniProtAcc

Q9H6L4

P49447

Ensembl transtripts involved in fusion geneENST00000245543, ENST00000582136, 
ENST00000584947, ENST00000579096, 
ENST00000581078, 
Fusion gene scores* DoF score9 X 3 X 5=1354 X 5 X 3=60
# samples 94
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARMC7 [Title/Abstract] AND CYB561 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARMC7(73106701)-CYB561(61514921), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7146-01AARMC7chr17

73106701

+CYB561chr17

61514921

-


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Fusion Gene ORF analysis for ARMC7-CYB561

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000245543ENST00000360793ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000392975ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000392976ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000448884ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000581573ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000582297ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000245543ENST00000584031ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000360793ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000392975ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000392976ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000448884ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000581573ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000582297ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000582136ENST00000584031ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000360793ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000392975ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000392976ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000448884ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000581573ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000582297ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-5UTRENST00000584947ENST00000584031ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000245543ENST00000542042ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000245543ENST00000581163ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000245543ENST00000582034ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000245543ENST00000582997ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000582136ENST00000542042ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000582136ENST00000581163ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000582136ENST00000582034ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000582136ENST00000582997ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000584947ENST00000542042ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000584947ENST00000581163ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000584947ENST00000582034ARMC7chr17

73106701

+CYB561chr17

61514921

-
5CDS-intronENST00000584947ENST00000582997ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000360793ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000392975ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000392976ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000448884ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000581573ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000582297ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000579096ENST00000584031ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000360793ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000392975ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000392976ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000448884ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000581573ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000582297ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-5UTRENST00000581078ENST00000584031ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000579096ENST00000542042ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000579096ENST00000581163ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000579096ENST00000582034ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000579096ENST00000582997ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000581078ENST00000542042ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000581078ENST00000581163ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000581078ENST00000582034ARMC7chr17

73106701

+CYB561chr17

61514921

-
intron-intronENST00000581078ENST00000582997ARMC7chr17

73106701

+CYB561chr17

61514921

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARMC7-CYB561


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ARMC7-CYB561


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:73106701/:61514921)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMC7

Q9H6L4

CYB561

P49447

FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes. {ECO:0000250|UniProtKB:P10897}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARMC7-CYB561


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARMC7-CYB561


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARMC7-CYB561


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARMC7-CYB561


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4748569ORTHOSTATIC HYPOTENSION 21UNIPROT