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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Fusion gene:DYNC2H1-GTPBP4 (FusionGDB2 ID:HG79659TG23560)

Fusion Gene Summary for DYNC2H1-GTPBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC2H1-GTPBP4
Fusion gene ID: hg79659tg23560
HgeneTgene
Gene symbol

DYNC2H1

GTPBP4

Gene ID

79659

23560

Gene namedynein cytoplasmic 2 heavy chain 1GTP binding protein 4
SynonymsATD3|DHC1b|DHC2|DNCH2|DYH1B|SRPS2B|SRTD3|hdhc11CRFG|NGB|NOG1
Cytomap('DYNC2H1')('GTPBP4')

11q22.3

10p15.3

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 2 heavy chain 1dynein cytoplasmic heavy chain 2dynein heavy chain 11dynein heavy chain, isotype 1Bdynein, cytoplasmic, heavy polypeptide 2nucleolar GTP-binding protein 1G protein-binding protein CRFGGTP-binding protein NGBchronic renal failure gene protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375735, ENST00000398093, 
ENST00000334267, 
Fusion gene scores* DoF score15 X 13 X 9=17555 X 5 X 2=50
# samples 155
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: DYNC2H1 [Title/Abstract] AND GTPBP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNC2H1(103178560)-GTPBP4(1051757), # samples:1
Anticipated loss of major functional domain due to fusion event.DYNC2H1-GTPBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNC2H1-GTPBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNC2H1-GTPBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNC2H1-GTPBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYNC2H1

GO:0007030

Golgi organization

8666668

TgeneGTPBP4

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

17210637

TgeneGTPBP4

GO:0022408

negative regulation of cell-cell adhesion

17210637

TgeneGTPBP4

GO:0030336

negative regulation of cell migration

17210637

TgeneGTPBP4

GO:0031397

negative regulation of protein ubiquitination

17210637

TgeneGTPBP4

GO:0050821

protein stabilization

17210637


check buttonFusion gene breakpoints across DYNC2H1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GTPBP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J4DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+


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Fusion Gene ORF analysis for DYNC2H1-GTPBP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000375735ENST00000491635DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
5CDS-3UTRENST00000375735ENST00000538293DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
5CDS-3UTRENST00000375735ENST00000545048DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
5CDS-3UTRENST00000398093ENST00000491635DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
5CDS-3UTRENST00000398093ENST00000538293DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
5CDS-3UTRENST00000398093ENST00000545048DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
In-frameENST00000375735ENST00000360803DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
In-frameENST00000398093ENST00000360803DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
intron-3CDSENST00000334267ENST00000360803DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
intron-3UTRENST00000334267ENST00000491635DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
intron-3UTRENST00000334267ENST00000538293DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+
intron-3UTRENST00000334267ENST00000545048DYNC2H1chr11

103178560

+GTPBP4chr10

1051757

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375735DYNC2H1chr11103178560+ENST00000360803GTPBP4chr101051757+1533911637144126294161
ENST00000398093DYNC2H1chr11103178560+ENST00000360803GTPBP4chr101051757+15216115140125064168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375735ENST00000360803DYNC2H1chr11103178560+GTPBP4chr101051757+9.47E-050.99990535
ENST00000398093ENST00000360803DYNC2H1chr11103178560+GTPBP4chr101051757+8.38E-050.9999162

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Fusion Genomic Features for DYNC2H1-GTPBP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DYNC2H1chr11103178560+GTPBP4chr101051757+6.49E-050.99993503
DYNC2H1chr11103178560+GTPBP4chr101051757+6.49E-050.99993503

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DYNC2H1-GTPBP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:103178560/chr10:1051757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891074_110338314308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892897_298238314308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78893109_320038314308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78893408_344238314308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901074_110338384315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902897_298238384315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79903109_320038384315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79903408_344238384315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+7889145_15238314308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891689_169638314308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891979_198638314308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892291_229838314308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892655_266238314308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+7990145_15238384315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901689_169638384315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901979_198638384315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902291_229838384315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902655_266238384315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891651_187538314308.0RegionAAA 1
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891938_216138314308.0RegionAAA 2
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78891_165038314308.0RegionStem
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892251_250538314308.0RegionAAA 3
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892617_286338314308.0RegionAAA 4
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78892881_316938314308.0RegionStalk
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78893244_347338314308.0RegionAAA 5
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901651_187538384315.0RegionAAA 1
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901938_216138384315.0RegionAAA 2
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79901_165038384315.0RegionStem
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902251_250538384315.0RegionAAA 3
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902617_286338384315.0RegionAAA 4
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79902881_316938384315.0RegionStalk
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79903244_347338384315.0RegionAAA 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201074_11030921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202897_29820921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1203109_32000921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1203408_34420921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+120145_1520921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201689_16960921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201979_19860921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202291_22980921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202655_26620921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201651_18750921.0RegionAAA 1
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201938_21610921.0RegionAAA 2
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1201_16500921.0RegionStem
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202251_25050921.0RegionAAA 3
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202617_28630921.0RegionAAA 4
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1202881_31690921.0RegionStalk
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1203244_34730921.0RegionAAA 5
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000334267+1203690_39050921.0RegionAAA 6
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000375735+78893690_390538314308.0RegionAAA 6
HgeneDYNC2H1chr11:103178560chr10:1051757ENST00000398093+79903690_390538384315.0RegionAAA 6
TgeneGTPBP4chr11:103178560chr10:1051757ENST00000360803717169_340304635.0DomainOBG-type G
TgeneGTPBP4chr11:103178560chr10:1051757ENST00000360803717175_182304635.0Nucleotide bindingGTP
TgeneGTPBP4chr11:103178560chr10:1051757ENST00000360803717221_225304635.0Nucleotide bindingGTP
TgeneGTPBP4chr11:103178560chr10:1051757ENST00000360803717289_292304635.0Nucleotide bindingGTP


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Fusion Gene Sequence for DYNC2H1-GTPBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24638_24638_1_DYNC2H1-GTPBP4_DYNC2H1_chr11_103178560_ENST00000375735_GTPBP4_chr10_1051757_ENST00000360803_length(transcript)=15339nt_BP=11637nt
GACTACCCCTGGCAACCGCGAAGCTCTGCGGTCCCGCGGTCGGGCTACGGGTTTGAGCAAAGCTCCTCTCTTCCCTTCACTTCCCTCCGG
ACTGGTTTCTTCTTCCTTCCCCCTTCCCCCAACTTCCCTCCACCCCTTCCAATCATGGCGAACGGGACTGCGGACGTTCGGAAGCTCTTC
ATCTTCACTACTACCCAGAATTACTTCGGGTTGATGTCTGAACTCTGGGATCAGCCACTGTTGTGCAACTGTCTTGAAATCAACAACTTC
TTGGATGACGGCAACCAGATGCTCCTCAGGGTGCAGCGATCCGACGCAGGAATCTCCTTTTCCAACACGATTGAGTTTGGTGACACAAAA
GATAAAGTGCTGGTGTTTTTCAAGCTGCGACCTGAAGTAATTACTGATGAGAATCTACATGATAACATTCTTGTTTCATCTATGTTAGAG
TCACCTATTAGTTCTCTTTACCAAGCAGTACGGCAAGTATTCGCACCAATGTTGTTAAAGGATCAGGAATGGAGCAGAAACTTTGATCCC
AAACTTCAGAATCTTTTGAGTGAACTAGAAGCTGGGTTGGGTATAGTTCTACGAAGATCAGACACTAACTTAACAAAATTGAAATTTAAG
GAAGATGACACACGAGGTATCCTTACACCAAGCGATGAGTTCCAGTTTTGGATAGAACAAGCTCACCGTGGAAATAAACAGATTAGTAAA
GAAAGAGCCAATTATTTTAAAGAATTATTTGAAACAATTGCAAGAGAGTTTTATAACTTGGACAGTCTATCCTTACTAGAAGTTGTTGAC
TTGGTGGAGACTACTCAGGATGTTGTAGATGATGTGTGGAGACAAACAGAACATGATCATTATCCTGAGTCACGAATGTTGCATCTCTTA
GACATCATAGGTGGTTCATTTGGAAGGTTTGTTCAGAAAAAGTTGGGAACTTTGAACCTGTGGGAAGATCCTTATTATCTTGTGAAAGAA
AGTCTGAAAGCTGGTATTTCAATTTGTGAACAGTGGGTGATAGTCTGTAATCATCTAACAGGTCAGGTGTGGCAGCGCTATGTTCCTCAT
CCATGGAAAAATGAAAAATATTTTCCAGAAACACTTGACAAACTTGGCAAACGCCTTGAAGAGGTCTTGGCTATTAGAACAATTCATGAG
AAGTTTCTCTATTTTCTACCTGCCAGTGAAGAGAAAATCATATGCCTCACTCGAGTATTTGAACCTTTTACTGGCCTGAATCCTGTGCAA
TATAATCCATATACTGAGCCCTTGTGGAAAGCTGCGGTGTCTCAATATGAAAAGATTATTGCACCTGCGGAACAAAAAATAGCAGGAAAA
TTGAAAAATTATATTTCAGAAATTCAAGACAGTCCACAGCAGCTTCTTCAAGCATTCCTGAAATATAAAGAGTTGGTAAAGCGTCCAACT
ATAAGCAAAGAATTGATGTTAGAAAGAGAAACTTTACTGGCAAGACTTGTGGACTCAATTAAAGATTTTCGATTAGACTTTGAGAATCGG
TGCCGAGGAATTCCTGGTGATGCATCTGGACCACTTTCTGGCAAAAATCTTTCAGAAGTTGTCAACAGTATAGTTTGGGTTCGCCAGTTG
GAATTGAAGGTAGATGATACTATCAAGATTGCAGAGGCTCTTTTATCTGACTTGCCAGGATTTCGATGTTTCCATCAAAGTGCCAAAGAT
CTCTTAGACCAGCTTAAACTATATGAACAGGAACAATTTGATGATTGGTCCAGGGATATTCAATCAGGTTTATCTGATTCCAGATCTGGT
TTGTGTATTGAGGCTAGTAGTCGAATTATGGAATTGGATTCTAATGATGGATTACTAAAAGTGCATTATTCAGATCGTTTGGTGATTCTT
CTGAGAGAAGTTCGTCAGCTCTCTGCACTTGGCTTTGTTATTCCTGCCAAAATACAGCAAGTTGCAAACATTGCACAGAAATTCTGCAAG
CAAGCAATTATTCTTAAACAAGTGGCACATTTTTATAATTCTATTGATCAACAAATGATTCAAAGTCAGAGGCCAATGATGTTACAATCT
GCCTTAGCATTTGAACAGATAATTAAGAATTCAAAAGCAGGAAGTGGAGGGAAATCACAGATAACTTGGGATAATCCTAAAGAATTAGAA
GGCTATATCCAAAAACTCCAAAATGCTGCTGAACGGCTTGCCACTGAAAATAGAAAACTGAGAAAATGGCACACTACATTTTGTGAAAAG
GTGGTTGTTCTTATGAATATTGATCTGCTTCGGCAGCAACAGCGCTGGAAAGATGGATTACAAGAATTGAGAACTGGCTTAGCAACTGTA
GAAGCACAGGGATTCCAAGCAAGTGACATGCATGCATGGAAACAACACTGGAATCATCAACTGTACAAAGCTCTGGAGCATCAGTACCAG
ATGGGCTTAGAAGCACTTAATGAGAATTTGCCAGAAATAAATATAGACTTAACTTACAAACAGGGACGATTACAATTCAGGCCCCCTTTT
GAAGAAATCCGGGCTAAATATTATAGAGAAATGAAGAGATTCATCGGCATTCCAAATCAGTTTAAGGGAGTGGGTGAGGCAGGAGATGAA
TCTATTTTTTCTATTATGATTGATAGAAATGCAAGTGGATTTTTGACGATTTTCAGCAAAGCAGAAGATCTGTTTAGAAGATTGTCAGCT
GTTTTACACCAACATAAGGAATGGATTGTAATTGGGCAAGTTGATATGGAAGCTCTGGTGGAAAAGCATCTTTTTACTGTACATGATTGG
GAGAAAAATTTTAAAGCATTAAAAATAAAGGGGAAAGAAGTAGAACGACTTCCAAGTGCTGTCAAGGTAGATTGTTTAAATATTAATTGC
AACCCTGTGAAGACTGTGATTGATGATCTCATCCAGAAGTTATTTGATCTGCTTGTTCTTTCTTTGAAGAAGTCCATACAGGCTCATTTA
CATGAAATTGATACATTTGTTACTGAGGCTATGGAAGTCTTAACAATTATGCCCCAGTCTGTGGAAGAAATTGGTGATGCAAATCTACAA
TATAGTAAGTTACAAGAACGGAAGCCAGAGATTTTGCCCTTATTTCAAGAAGCTGAAGACAAAAACAGACTTTTACGAACTGTGGCTGGT
GGAGGTTTAGAAACAATTAGTAATTTGAAAGCCAAGTGGGATAAATTTGAGTTAATGATGGAAAGTCACCAACTTATGATTAAAGACCAG
ATTGAAGTGATGAAAGGAAATGTGAAATCACGTCTTCAGATCTATTATCAAGAACTGGAAAAATTTAAAGCTCGTTGGGACCAACTAAAG
CCTGGTGATGATGTTATTGAAACTGGCCAACATAATACTCTTGATAAAAGTGCAAAGTTAATAAAAGAGAAAAAAATTGAGTTTGATGAT
CTTGAAGTCACAAGAAAAAAGCTGGTTGATGATTGCCATCATTTTAGACTGGAAGAGCCTAATTTCTCCCTGGCAAGTAGTATCTCTAAA
GATATCGAGAGCTGTGCCCAAATTTGGGCCTTTTATGAAGAGTTTCAACAAGGATTTCAGGAAATGGCCAATGAAGACTGGATCACTTTT
CGGACTAAGACATACCTGTTTGAGGAATTTTTGATGAACTGGCATGACAGATTAAGGAAGGTTGAAGAACATTCAGTGATGACAGTGAAA
TTACAATCAGAGGTTGACAAATATAAAATCGTAATTCCTATCTTGAAATATGTGAGAGGGGAGCATCTTTCTCCAGATCACTGGCTTGAC
CTTTTTCGTCTCCTTGGACTTCCTAGGGGGACTAGTCTAGAGAAACTACTGTTTGGTGATTTGCTCAGAGTAGCTGATACAATTGTAGCC
AAAGCTGCCGACCTTAAAGATTTAAATAGTCGGGCACAAGGTGAAGTTACAATCAGAGAAGCTTTACGTGAACTTGATCTTTGGGGAGTT
GGAGCAGTGTTTACATTAATTGATTATGAAGACAGCCAAAGTCGAACTATGAAGCTGATTAAAGACTGGAAAGATATAGTAAATCAGGTT
GGAGATAATAGATGCCTTCTCCAATCCTTAAAGGATTCTCCTTATTATAAAGGATTTGAAGATAAAGTATCAATTTGGGAAAGAAAACTT
GCAGAGTTAGATGAATACCTGCAGAATTTAAATCATATTCAGAGAAAGTGGGTGTATTTGGAACCCATTTTCGGCCGTGGAGCATTGCCA
AAAGAACAGACACGCTTCAACAGAGTTGATGAAGATTTTAGATCAATAATGACTGATATCAAGAAAGACAATAGAGTCACAACATTAACT
ACTCATGCTGGAATAAGAAATTCTCTACTAACAATACTTGATCAGCTTCAAAGATGTCAGAAATCATTAAATGAATTTTTGGAGGAAAAA
CGCTCAGCATTCCCAAGATTTTATTTTATTGGTGATGATGACTTATTAGAAATATTGGGCCAGTCTACCAACCCATCAGTGATTCAGTCT
CACCTGAAGAAGCTTTTTGCTGGTATTAACAGTGTTTGCTTTGATGAGAAATCAAAACATATAACTGCAATGAAATCTTTAGAGGGAGAA
GTTGTACCTTTTAAAAATAAAGTTCCTCTATCAAATAATGTAGAGACATGGTTGAATGATTTGGCCTTAGAAATGAAGAAAACTTTGGAA
CAGTTGTTGAAGGAATGTGTTACTACTGGGCGAAGTTCTCAAGGTGCAGTTGACCCATCTCTGTTCCCTTCACAGATTTTATGCTTGGCG
GAGCAGATTAAATTCACTGAAGATGTAGAAAATGCTATTAAAGATCATAGTCTTCATCAGATTGAAACACAACTGGTGAATAAGTTAGAG
CAATATACTAACATTGATACAAGTTCTGAGGATCCAGGGAATACTGAATCGGGCATCCTGGAGCTTAAACTTAAAGCCCTAATTCTTGAC
ATTATCCATAATATTGATGTGGTAAAGCAGTTAAACCAAATTCAGGTTCATACAACTGAAGACTGGGCTTGGAAAAAACAACTTAGATTC
TATATGAAAAGTGATCATACATGTTGTGTTCAAATGGTGGATTCTGAATTTCAGTATACTTATGAATATCAGGGTAATGCTTCCAAACTG
GTTTATACTCCACTGACAGACAAGTGCTACTTAACTCTCACTCAAGCCATGAAGATGGGACTTGGAGGAAATCCTTATGGACCAGCTGGA
ACTGGGAAAACGGAATCAGTAAAGGCTTTAGGTGGACTTCTTGGAAGACAAGTTTTAGTCTTTAATTGTGATGAGGGCATCGATGTGAAG
TCAATGGGACGAATATTTGTTGGTTTGGTGAAGTGTGGGGCCTGGGGTTGTTTTGATGAATTTAATAGGCTGGAAGAATCTGTACTGTCA
GCAGTTTCTATGCAAATCCAGACAATTCAAGATGCTTTGAAGAATCATAGAACTGTATGTGAACTGCTTGGCAAGGAGGTAGAAGTAAAT
TCTAATTCTGGAATTTTTATCACTATGAATCCTGCTGGAAAAGGTTATGGAGGAAGACAAAAACTGCCTGATAATCTTAAACAGCTTTTC
AGGCCCGTAGCTATGTCTCATCCAGACAATGAGCTTATTGCAGAAGTTATTCTCTATTCGGAAGGCTTTAAAGACGCTAAAGTATTGAGC
AGAAAATTGGTAGCTATTTTCAATCTATCTAGGGAACTTTTGACACCTCAGCAACATTATGATTGGGGTTTGAGAGCTTTGAAGACAGTT
CTGAGAGGAAGTGGAAATCTCCTTAGACAGCTAAACAAAAGTGGCACTACACAGAATGCTAATGAAAGTCATATTGTGGTACAAGCACTG
AGGCTTAATACCATGTCAAAGTTTACGTTTACTGATTGCACCCGGTTTGATGCACTGATAAAAGATGTCTTTCCGGGAATTGAATTGAAA
GAAGTGGAATATGATGAACTAAGTGCTGCATTAAAGCAGGTCTTTGAAGAGGCCAATTATGAAATTATACCCAATCAGATCAAAAAGGCT
TTAGAATTGTATGAACAGTTATGCCAGAGGATGGGAGTTGTTATTGTTGGTCCAAGTGGTGCTGGAAAATCAACGCTTTGGAGAATGTTA
AGGGCTGCGCTTTGTAAAACTGGCAAAGTAGTGAAACAATATACTATGAATCCCAAAGCTATGCCTCGATATCAATTATTAGGCCATATT
GACATGGACACAAGAGAATGGTCTGATGGTGTTTTGACAAATAGTGCTCGTCAAGTGGTTCGGGAACCTCAAGATGTCAGCTCATGGATA
ATCTGTGATGGTGATATTGACCCTGAATGGATAGAATCTCTGAATTCTGTTCTGGATGATAATCGACTGCTGACTATGCCCAGTGGAGAA
AGGATTCAGTTTGGCCCAAATGTTAACTTTGTATTTGAAACTCATGATTTAAGTTGTGCATCACCAGCCACAATATCTAGAATGGGAATG
ATCTTTCTTAGTGATGAAGAGACAGATCTTAATTCTCTGATAAAATCTTGGTTGAGGAATCAGCCTGCTGAATATAGAAATAATCTTGAA
AATTGGATTGGAGATTATTTTGAAAAGGCTTTACAATGGGTTCTAAAGCAGAATGACTATGTGGTAGAAACAAGTTTGGTTGGGACTGTG
ATGAATGGTTTGTCACATCTACATGGTTGCAGAGATCATGACGAATTCATTATTAATCTCATAAGGGGACTTGGTGGAAATCTGAATATG
AAGTCACGTTTGGAATTTACCAAAGAGGTTTTTCATTGGGCACGAGAATCTCCTCCAGACTTTCACAAACCTATGGATACCTACTATGAC
TCTACTAGGGGTCGATTAGCAACATATGTGCTTAAGAAGCCAGAAGACTTGACTGCTGATGATTTCAGTAACGGCTTAACTCTTCCAGTC
ATTCAGACTCCTGACATGCAACGAGGTCTAGATTATTTCAAACCATGGTTAAGTTCTGATACTAAACAGCCCTTTATTCTGGTAGGACCA
GAAGGATGTGGCAAAGGGATGCTGCTCAGGTACGCATTTTCACAACTCCGGTCCACTCAAATTGCTACAGTTCACTGTAGTGCACAAACC
ACTTCTCGACATCTCCTGCAGAAACTGAGCCAGACTTGCATGGTAATCAGTACTAATACTGGTCGTGTATACAGACCAAAAGACTGTGAA
AGACTTGTTCTGTACTTAAAAGATATCAACCTACCTAAACTTGATAAATGGGGGACCAGTACTTTGGTAGCATTCCTACAACAGGTATTG
ACGTATCAAGGATTTTATGATGAAAATTTGGAATGGGTTGGTCTAGAAAATATTCAAATTGTGGCTTCTATGTCAGCTGGAGGAAGACTG
GGAAGACATAAACTTACTACCAGATTTACTTCCATCGTTCGTCTTTGTTCTATAGATTACCCAGAAAGAGAGCAGTTACAAACGATTTAT
GGAGCATATTTGGAACCAGTTCTACATAAAAATCTGAAGAATCATTCTATTTGGGGTTCTTCATCAAAAATTTATCTTTTAGCAGGATCT
ATGGTACAAGTGTATGAACAGGTGCGAGCCAAATTTACAGTTGATGATTATAGTCACTATTTCTTTACTCCTTGCATTCTTACCCAATGG
GTTCTTGGCTTATTTAGATATGATTTAGAAGGAGGATCCTCAAACCATCCACTAGATTATGTGTTAGAAATTGTAGCATATGAGGCACGG
CGCTTATTTCGTGACAAAATTGTTGGTGCAAAGGAACTTCATTTATTTGACATCATTTTAACATCAGTGTTTCAAGGAGATTGGGGCTCA
GACATATTAGACAATATGTCAGATAGTTTCTACGTTACATGGGGAGCTCGGCATAATTCAGGAGCAAGGGCAGCCCCAGGACAACCATTA
CCTCCACATGGAAAACCACTTGGAAAACTAAACTCTACTGATCTCAAGGATGTTATTAAAAAGGGTCTTATTCATTATGGACGAGATAAC
CAGAATTTAGACATTTTACTTTTCCACGAAGTCTTGGAGTATATGTCTAGGATAGATAGAGTGCTGAGTTTCCCTGGAGGTTCACTTCTA
TTAGCAGGACGCAGTGGTGTAGGTCGTCGGACCATCACTTCTTTAGTCAGTCACATGCATGGAGCGGTCCTGTTTTCTCCAAAGATTTCC
AGAGGATATGAACTGAAGCAGTTCAAAAATGATCTCAAACATGTGCTGCAACTTGCAGGAATTGAAGCACAACAGGTAGTTTTACTTCTT
GAGGATTACCAGTTTGTACATCCTACATTTTTGGAGATGATCAATAGCCTTTTGTCTTCAGGTGAAGTTCCTGGACTCTATACTCTTGAA
GAATTAGAGCCCTTGCTGTTACCACTTAAGGATCAAGCTTCACAAGATGGTTTTTTTGGACCAGTCTTCAATTACTTCACATATAGAATT
CAGCAAAACTTGCATATTGTCTTGATAATGGATTCTGCAAATTCAAACTTCATGATAAACTGTGAGAGTAATCCAGCTTTGCATAAGAAA
TGCCAGGTGTTGTGGATGGAGGGTTGGTCCAATAGCAGTATGAAGAAAATACCTGAAATGTTATTCAGTGAAACAGGTGGTGGAGAAAAA
TACAATGATAAAAAACGAAAAGAAGAAAAGAAAAAAAATTCAGTTGATCCTGATTTTCTAAAATCATTTTTATTAATCCATGAATCTTGT
AAAGCATATGGTGCTACACCAAGCCGATACATGACCTTTTTACATGTGTATTCTGCCATTAGTAGTAGCAAGAAAAAGGAATTATTAAAA
AGACAAAGTCATTTGCAGGCTGGTGTATCTAAACTAAATGAAGCTAAAGCTCTTGTGGATGAACTGAACAGAAAAGCTGGAGAACAAAGT
GTGTTACTTAAAACGAAGCAAGATGAAGCAGATGCTGCCCTTCAAATGATCACAGTGTCAATGCAGGATGCTAGTGAGCAAAAAACAGAA
CTTGAAAGACTGAAGCACAGAATAGCAGAAGAAGTTGTTAAAATTGAAGAAAGAAAAAATAAAATTGATGATGAATTAAAAGAAGTACAA
CCTTTAGTCAATGAAGCTAAACTAGCAGTTGGAAACATTAAGCCCGAATCACTTTCAGAAATTCGCTCACTACGCATGCCACCTGATGTA
ATTAGAGATATTCTTGAAGGAGTTTTAAGGTTGATGGGTATCTTTGATACATCTTGGGTGAGCATGAAAAGTTTCCTTGCAAAAAGAGGT
GTAAGAGAAGACATAGCAACCTTTGATGCCCGAAATATTTCAAAGGAAATAAGAGAGAGTGTTGAAGAACTTCTTTTTAAAAATAAAGGC
TCTTTTGATCCAAAGAATGCTAAGCGTGCCAGTACTGCAGCTGCACCTTTGGCTGCCTGGGTGAAAGCCAATATTCAGTATTCCCATGTC
TTGGAACGAATTCATCCTTTGGAAACTGAACAGGCAGGATTAGAATCGAATCTGAAGAAAACTGAAGACAGAAAAAGGAAACTAGAGGAG
CTTCTTAATTCTGTTGGTCAAAAGGTATCAGAACTCAAAGAAAAATTTCAGAGCAGGACTTCAGAAGCTGCCAAACTTGAGGCTGAAGTA
AGCAAGGCACAAGAAACAATCAAAGCTGCAGAAGTCTTAATTAATCAGCTTGACAGAGAACATAAGAGATGGAATGCACAGGTTGTAGAG
ATAACAGAGGAATTAGCTACTCTTCCTAAAAGAGCTCAACTTGCTGCTGCATTTATTACATATCTTTCTGCTGCTCCTGAATCTCTGAGA
AAAACCTGTTTGGAAGAATGGACCAAGTCAGCTGGTCTTGAGAAATTTGATCTGAGGAGATTTCTTTGTACTGAAAGTGAGCAGTTAATT
TGGAAAAGTGAAGGCCTACCATCAGATGACCTTTCCATAGAAAATGCTCTTGTAATATTACAGAGTCGAGTGTGCCCATTTCTTATAGAT
CCTTCTTCCCAAGCTACAGAGTGGTTAAAAACACATTTGAAAGACTCACGTTTAGAAGTTATCAATCAGCAGGATAGTAACTTTATCACA
GCTCTTGAATTAGCAGTACGTTTTGGGAAAACCCTTATTATACAAGAGATGGATGGTGTAGAACCTGTTCTTTATCCATTATTGAGACGA
GATCTGGTTGCTCAAGGACCACGTTATGTGGTACAAATAGGTGACAAAATTATTGACTACAATGAAGAATTCCGCCTCTTTTTGTCAACA
AGAAACCCAAATCCTTTTATTCCACCGGATGCAGCTTCCATTGTTACTGAGGTTAACTTTACTACAACAAGAAGTGGATTACGAGGGCAG
CTTTTAGCTTTAACCATTCAGCATGAGAAACCTGATTTAGAAGAACAGAAAACAAAACTATTACAACAGGAAGAAGATAAGAAAATACAG
CTAGCCAAGCTCGAAGAATCTCTTCTAGAGACACTTGCCACATCTCAAGGCAATATTTTGGAAAATAAGGATTTGATTGAGTCTTTGAAT
CAGACAAAAGCAAGCAGTGCACTTATTCAAGAGTCACTTAAAGAATCTTACAAACTCCAAATTTCCCTTGATCAAGAACGGGATGCCTAT
CTCCCCCTGGCTGAGAGTGCCAGCAAGATGTACTTCATTATTTCTGATTTGTCCAAAATTAATAACATGTACCGTTTTAGTTTGGCTGCT
TTTCTCCGACTTTTCCAACGAGCTCTACAAAACAAACAGGATTCTGAAAATACAGAACAGAGAATCCAGTCACTTATCAGCTCATTACAA
CATATGGTATATGAATATATATGTCGTTGTCTATTTAAGGCTGATCAGTTGATGTTCGCTTTGCATTTTGTTCGAGGCATGCATCCTGAA
CTTTTTCAAGAAAATGAATGGGATACGTTTACAGGTGTGGTTGTTGGAGACATGTTACGGAAAGCTGACTCTCAACAAAAAATACGTGAT
CAGCTTCCGTCTTGGATAGATCAGGAACGAAGCTGGGCCGTGGCAACATTAAAGATTGCTCTCCCCAGTCTTTATCAGACCCTCTGCTTT
GAAGATGCAGCTCTGTGGCGTACTTATTATAATAATTCAATGTGTGAGCAAGAGTTTCCATCTATCCTTGCAAAGAAAGTTTCCTTATTT
CAGCAGATTCTTGTAGTACAGGCGCTAAGACCGGACAGATTGCAAAGTGCCATGGCTCTTTTTGCATGTAAAACTCTGGGACTGAAAGAG
GTGTCCCCACTGCCTCTAAATCTCAAACGTTTATACAAAGAGACACTGGAAATTGAACCCATCTTGATAATTATTTCTCCGGGTGCTGAT
CCTTCTCAGGAACTTCAAGAACTAGCTAATGCTGAAAGAAGCGGAGAGTGTTATCACCAGGTTGCCATGGGTCAAGGTCAAGCTGATTTA
GCAATTCAAATGCTAAAAGAATGTGCCCGCAATGGAGACTGGCTCTGTTTGAAGAACTTACATCTTGTGGTATCTTGGCTGCCAGTTCTG
GAAAAGGAATTGAATACTCTTCAACCTAAAGATACCTTTCGTCTTTGGCTCACTGCAGAAGTTCATCCCAACTTTACTCCTATTTTACTA
CAGTCAAGTCTGAAGATAACATATGAGAAAATATTTACAGATTTGCAGTCTGAAGGATTCCCTGTAATAGAGACCAGCACCCTGACTGAG
GAAGGTGTTATTAAAGTTAAAACAGAGGCTTGCGATAGGCTTTTGGCTCATCGAGTGGAAACCAAAATGAAGGGAAATAAAGTGAATGAG
GTGCTGAATAGACTGCACCTGGCTATCCCAACCAGGAGGGACGATAAGGAGAGGCCCCCTTTCATCCCTGAAGGAGTGGTGGCTCGCAGG
AAGAGGATGGAAACTGAGGAGTCCAGGAAGAAGAGGGAACGAGATCTTGAGCTGGAAATGGGAGATGATTATATTTTGGATCTTCAGAAG
TACTGGGATTTAATGAATTTGTCTGAAAAACATGATAAGATACCAGAAATCTGGGAAGGCCATAATATAGCTGATTATATTGATCCAGCC
ATCATGAAGAAATTGGAAGAATTAGAAAAAGAAGAAGAGCTGAGAACAGCTGCTGGAGAGTATGACAGTGTATCTGAGAGTGAAGACGAA
GAGATGCTGGAAATCCGACAGCTGGCAAAGCAAATTCGAGAGAAAAAGAAGTTGAAAATTCTGGAGTCCAAAGAAAAGAATACACAGGGA
CCCAGGATGCCGCGAACTGCTAAGAAGGTTCAGAGGACAGTTTTGGAGAAGGAGATGCGTAGTCTTGGTGTTGACATGGACGATAAAGAC
GATGCCCATTACGCAGTCCAGGCAAGAAGATCCCGGAGCATCACTAGGAAAAGAAAGCGGGAAGACTCTGCTCCCCCGTCCTCTGTGGCC
CGGAGTGGGAGTTGCTCTCGAACTCCACGTGACGTTTCTGGTCTTAGGGATGTCAAGATGGTGAAGAAAGCCAAGACTATGATGAAGAAT
GCTCAGAAGAAGATGAATCGGTTGGGGAAGAAAGGGGAGGCGGATAGACACGTGTTTGATATGAAGCCCAAGCACTTGCTGTCTGGGAAG
AGGAAAGCTGGTAAAAAGGACAGGAGATAGTATCCGTTTGGTTGGCGTGGCTTCGCTAGAGTGTTGCTGTTTATTTCCTGGTTTGGCACA
GTATGGTTTCATGAAATTGGAGCTCTGTATAAACTGAAAAAGACAAAATAAGTAAAGCACTTGTTGCTTTGCTGAAAACTATGGTTAACC
CTATATAGGTGTGGGAAATTTTTGTCACTGCATAATATTACAAATATTTTGAGTAGACAGTGTTTCCACATTTAATGGAGTATCAGTTGC
TTCAGATTTTCAGAACTGGGAAGATTTACTGGTTTAACTAGGTTGTTTTTGATGGAGAAAAACCTTATTTTCTTTTGTAAGAGCTGGGAG
CAAACACGTTTATGAGTGTGTCGGAATCCCGTGCTTAAAATACGCTCTTAAATTATTTTCTAGTCTTATTTTACAATGTCTCATTGTAGT
CTGTCTTCAACTATTTTATCCAAAATAAACCTCCAGAAGAAAGTAGTTTTCATTTACTTAGCTCATGTTTTGGTTTAGTTATAGTCGCTA
TGGATTTGGCCAAATAAAAAGGCAAACAACATGACATTTCTATTTTGTTTTAAAGCAAAAATACTTTTGGGGGAGTAAAATGTTGCTGGA
GGCATTAGGCAATTAAATATGGGCATTCTCCTATTTCTGTGGCCCGTCCCTGAAGTTACATGTTCAGTAAAACACAAAAACACCGCCAAT
GCCACCTCAAAAGCACCTGCTGGGGAGCGTTGGGGTGAAGAGCTGTGGGGTCGGAGGGACCTGCCCAGGGGTCCGTGTGCTCCTGGAGCT
CCAAAGACACACAGGGGTCCAAGAGCCACCACGGATAAGTTATCAAGTCACACAATCAACATTATAGCTGAGGAAAGGACTTTAGTTAAT
CACACTTCTGGATTACATGTGGCAATTTTAAAAATTTACCAGGGCTGGGCTGGGCGCAGGGGCTCAAGCCTGTAGTTCCAGCACTTTGGG
AGGCCGAGGTGGGCAGATCAGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATT
AGCCATGCGTGGTGGTGGGCATCTGTAATCCTAGCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAGCCCAGAGGCGGAGGTTGCAGT
GAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGAGAGACTCCGTGTGAAAAAAAAAAAAAAAATACCAGGTCTGGTTTTTG
AAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGTTAAACAACAACAGTATGGCCGGGCGCGGCAGCTCATG
CCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGT
CTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAGTCCCAACTACTTGGGAGGCTGAGGCAGGAGAATGGCTTG
AACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGTCGACAGCGAGACTCCATCTCAAAAAAAAAAAA
AAAATACCAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGTTAAACAACAACAGTA
TGTTTTAAAGCAAGTATGTCTTTATTTGTAAGCATATTACTGAAACGATCAAATGAACAGAAGTGGATAAACGTCGAGTCACTTGGCTGA
GACCATACGCATCTTCCGTACTGCTTGTATTAGGATGCAAGATTGAATGTGTCTTTTTTTTAAAAATGCAGCCTTGTGTTGCACTCTGAA
ATAAGTGATTTAAAAAGAAAAACATGATACAGAGATCCCATCCTGACCTTGGAGGCTTGGATAAAGCTGTGGGGAGACAGCCTCATGGTC
CAGCCAGGCTAGTCCGCCTGCTTCAGGACTCTCAAGATCTCCCCAAGACTTTCAGGATCAGCTGCTGTTAATCAAACAAGTGCTTATAAA
ATGGAAATTGGGACAAAGGAAATGTTAAATTTCCTCCCTGCAACCAGGCAGATGAGAAATATGGAAATAAGGAAAAGGGAAAATGAAGAT
ATGACAAAGTTGATGAAAAGGTTGAAATAGTGATTTATACATGATGGGCAATCAAGTGCCCCTTTTGCCCTGTTTTTTGGAGAGGGTGTA
TCATTGCCTCAATGGTGCGTCTGCCTGCACTGAGGGCATTACACATGGCTGACTCGACCTCCCTGCCTCTCACACTCTGTGTATTTTGTG
AAGCTCCACAAACGGGGTCACGTCATCCAGGTGAGGCCACCACCGGTACAGAAACCTCTCGGCAATGGTTCTTAGCCAGGGGGTGACTTT
GACTTCACCCCTCGCCTCCCTCTCCAGCAGCTCCCACAGCTCCTCCTGGGACAGGTAGAGGATGCTTTTCGTTTCACTGGGATCCGGGTT
CAGAGTGACGTTTTTCCTCACAAGCAGAAGGTAACAAATTTCATGCTCTCCCCAAATTCTGTCTGATTTTGCCTTGTGGTGATAGATTGT
CATGAACACAATGTCCTCTGGAGAAATCTATTGACAGAAATTGGTGCAGTGTTAACAACGCTAATGTAAAACACAGAATTTACAGAAAAA

>24638_24638_1_DYNC2H1-GTPBP4_DYNC2H1_chr11_103178560_ENST00000375735_GTPBP4_chr10_1051757_ENST00000360803_length(amino acids)=4161AA_BP=3831
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDEN
LHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL
NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTR
VFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVD
SIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSR
DIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQ
MIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTFCEKVVVLMNIDLLRQQQRWKD
GLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIP
NQFKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLP
SAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEA
EDKNRLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIETGQHNTLDKSA
KLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLASSISKDIESCAQIWAFYEEFQQGFQEMANEDWITFRTKTYLFEEFLMNWHDRL
RKVEEHSVMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTI
REALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWV
YLEPIFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEI
LGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVD
PSLFPSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHT
TEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQV
LVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGG
RQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQ
NANESHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGP
SGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVL
DDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQWVLKQN
DYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIRGLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLT
ADDFSNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIATVHCSAQTTSRHLLQKLSQTCMVIST
NTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSI
DYPEREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPL
DYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDV
IKKGLIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQL
AGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFM
INCESNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYGATPSRYMTFLHVYS
AISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEER
KNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIR
ESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQS
RTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTKSAGLEKFDL
RRFLCTESEQLIWKSEGLPSDDLSIENALVILQSRVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMD
GVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKT
KLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLS
KINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDM
LRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQALRPDRLQSAM
ALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLK
NLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYEKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHR
VETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIW
EGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKE
MRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKKGEADRHV

--------------------------------------------------------------
>24638_24638_2_DYNC2H1-GTPBP4_DYNC2H1_chr11_103178560_ENST00000398093_GTPBP4_chr10_1051757_ENST00000360803_length(transcript)=15216nt_BP=11514nt
ATGGCGAACGGGACTGCGGACGTTCGGAAGCTCTTCATCTTCACTACTACCCAGAATTACTTCGGGTTGATGTCTGAACTCTGGGATCAG
CCACTGTTGTGCAACTGTCTTGAAATCAACAACTTCTTGGATGACGGCAACCAGATGCTCCTCAGGGTGCAGCGATCCGACGCAGGAATC
TCCTTTTCCAACACGATTGAGTTTGGTGACACAAAAGATAAAGTGCTGGTGTTTTTCAAGCTGCGACCTGAAGTAATTACTGATGAGAAT
CTACATGATAACATTCTTGTTTCATCTATGTTAGAGTCACCTATTAGTTCTCTTTACCAAGCAGTACGGCAAGTATTCGCACCAATGTTG
TTAAAGGATCAGGAATGGAGCAGAAACTTTGATCCCAAACTTCAGAATCTTTTGAGTGAACTAGAAGCTGGGTTGGGTATAGTTCTACGA
AGATCAGACACTAACTTAACAAAATTGAAATTTAAGGAAGATGACACACGAGGTATCCTTACACCAAGCGATGAGTTCCAGTTTTGGATA
GAACAAGCTCACCGTGGAAATAAACAGATTAGTAAAGAAAGAGCCAATTATTTTAAAGAATTATTTGAAACAATTGCAAGAGAGTTTTAT
AACTTGGACAGTCTATCCTTACTAGAAGTTGTTGACTTGGTGGAGACTACTCAGGATGTTGTAGATGATGTGTGGAGACAAACAGAACAT
GATCATTATCCTGAGTCACGAATGTTGCATCTCTTAGACATCATAGGTGGTTCATTTGGAAGGTTTGTTCAGAAAAAGTTGGGAACTTTG
AACCTGTGGGAAGATCCTTATTATCTTGTGAAAGAAAGTCTGAAAGCTGGTATTTCAATTTGTGAACAGTGGGTGATAGTCTGTAATCAT
CTAACAGGTCAGGTGTGGCAGCGCTATGTTCCTCATCCATGGAAAAATGAAAAATATTTTCCAGAAACACTTGACAAACTTGGCAAACGC
CTTGAAGAGGTCTTGGCTATTAGAACAATTCATGAGAAGTTTCTCTATTTTCTACCTGCCAGTGAAGAGAAAATCATATGCCTCACTCGA
GTATTTGAACCTTTTACTGGCCTGAATCCTGTGCAATATAATCCATATACTGAGCCCTTGTGGAAAGCTGCGGTGTCTCAATATGAAAAG
ATTATTGCACCTGCGGAACAAAAAATAGCAGGAAAATTGAAAAATTATATTTCAGAAATTCAAGACAGTCCACAGCAGCTTCTTCAAGCA
TTCCTGAAATATAAAGAGTTGGTAAAGCGTCCAACTATAAGCAAAGAATTGATGTTAGAAAGAGAAACTTTACTGGCAAGACTTGTGGAC
TCAATTAAAGATTTTCGATTAGACTTTGAGAATCGGTGCCGAGGAATTCCTGGTGATGCATCTGGACCACTTTCTGGCAAAAATCTTTCA
GAAGTTGTCAACAGTATAGTTTGGGTTCGCCAGTTGGAATTGAAGGTAGATGATACTATCAAGATTGCAGAGGCTCTTTTATCTGACTTG
CCAGGATTTCGATGTTTCCATCAAAGTGCCAAAGATCTCTTAGACCAGCTTAAACTATATGAACAGGAACAATTTGATGATTGGTCCAGG
GATATTCAATCAGGTTTATCTGATTCCAGATCTGGTTTGTGTATTGAGGCTAGTAGTCGAATTATGGAATTGGATTCTAATGATGGATTA
CTAAAAGTGCATTATTCAGATCGTTTGGTGATTCTTCTGAGAGAAGTTCGTCAGCTCTCTGCACTTGGCTTTGTTATTCCTGCCAAAATA
CAGCAAGTTGCAAACATTGCACAGAAATTCTGCAAGCAAGCAATTATTCTTAAACAAGTGGCACATTTTTATAATTCTATTGATCAACAA
ATGATTCAAAGTCAGAGGCCAATGATGTTACAATCTGCCTTAGCATTTGAACAGATAATTAAGAATTCAAAAGCAGGAAGTGGAGGGAAA
TCACAGATAACTTGGGATAATCCTAAAGAATTAGAAGGCTATATCCAAAAACTCCAAAATGCTGCTGAACGGCTTGCCACTGAAAATAGA
AAACTGAGAAAATGGCACACTACATTTTGTGAAAAGGTGGTTGTTCTTATGAATATTGATCTGCTTCGGCAGCAACAGCGCTGGAAAGAT
GGATTACAAGAATTGAGAACTGGCTTAGCAACTGTAGAAGCACAGGGATTCCAAGCAAGTGACATGCATGCATGGAAACAACACTGGAAT
CATCAACTGTACAAAGCTCTGGAGCATCAGTACCAGATGGGCTTAGAAGCACTTAATGAGAATTTGCCAGAAATAAATATAGACTTAACT
TACAAACAGGGACGATTACAATTCAGGCCCCCTTTTGAAGAAATCCGGGCTAAATATTATAGAGAAATGAAGAGATTCATCGGCATTCCA
AATCAGTTTAAGGGAGTGGGTGAGGCAGGAGATGAATCTATTTTTTCTATTATGATTGATAGAAATGCAAGTGGATTTTTGACGATTTTC
AGCAAAGCAGAAGATCTGTTTAGAAGATTGTCAGCTGTTTTACACCAACATAAGGAATGGATTGTAATTGGGCAAGTTGATATGGAAGCT
CTGGTGGAAAAGCATCTTTTTACTGTACATGATTGGGAGAAAAATTTTAAAGCATTAAAAATAAAGGGGAAAGAAGTAGAACGACTTCCA
AGTGCTGTCAAGGTAGATTGTTTAAATATTAATTGCAACCCTGTGAAGACTGTGATTGATGATCTCATCCAGAAGTTATTTGATCTGCTT
GTTCTTTCTTTGAAGAAGTCCATACAGGCTCATTTACATGAAATTGATACATTTGTTACTGAGGCTATGGAAGTCTTAACAATTATGCCC
CAGTCTGTGGAAGAAATTGGTGATGCAAATCTACAATATAGTAAGTTACAAGAACGGAAGCCAGAGATTTTGCCCTTATTTCAAGAAGCT
GAAGACAAAAACAGACTTTTACGAACTGTGGCTGGTGGAGGTTTAGAAACAATTAGTAATTTGAAAGCCAAGTGGGATAAATTTGAGTTA
ATGATGGAAAGTCACCAACTTATGATTAAAGACCAGATTGAAGTGATGAAAGGAAATGTGAAATCACGTCTTCAGATCTATTATCAAGAA
CTGGAAAAATTTAAAGCTCGTTGGGACCAACTAAAGCCTGGTGATGATGTTATTGAAACTGGCCAACATAATACTCTTGATAAAAGTGCA
AAGTTAATAAAAGAGAAAAAAATTGAGTTTGATGATCTTGAAGTCACAAGAAAAAAGCTGGTTGATGATTGCCATCATTTTAGACTGGAA
GAGCCTAATTTCTCCCTGGCAAGTAGTATCTCTAAAGATATCGAGAGCTGTGCCCAAATTTGGGCCTTTTATGAAGAGTTTCAACAAGGA
TTTCAGGAAATGGCCAATGAAGACTGGATCACTTTTCGGACTAAGACATACCTGTTTGAGGAATTTTTGATGAACTGGCATGACAGATTA
AGGAAGGTTGAAGAACATTCAGTGATGACAGTGAAATTACAATCAGAGGTTGACAAATATAAAATCGTAATTCCTATCTTGAAATATGTG
AGAGGGGAGCATCTTTCTCCAGATCACTGGCTTGACCTTTTTCGTCTCCTTGGACTTCCTAGGGGGACTAGTCTAGAGAAACTACTGTTT
GGTGATTTGCTCAGAGTAGCTGATACAATTGTAGCCAAAGCTGCCGACCTTAAAGATTTAAATAGTCGGGCACAAGGTGAAGTTACAATC
AGAGAAGCTTTACGTGAACTTGATCTTTGGGGAGTTGGAGCAGTGTTTACATTAATTGATTATGAAGACAGCCAAAGTCGAACTATGAAG
CTGATTAAAGACTGGAAAGATATAGTAAATCAGGTTGGAGATAATAGATGCCTTCTCCAATCCTTAAAGGATTCTCCTTATTATAAAGGA
TTTGAAGATAAAGTATCAATTTGGGAAAGAAAACTTGCAGAGTTAGATGAATACCTGCAGAATTTAAATCATATTCAGAGAAAGTGGGTG
TATTTGGAACCCATTTTCGGCCGTGGAGCATTGCCAAAAGAACAGACACGCTTCAACAGAGTTGATGAAGATTTTAGATCAATAATGACT
GATATCAAGAAAGACAATAGAGTCACAACATTAACTACTCATGCTGGAATAAGAAATTCTCTACTAACAATACTTGATCAGCTTCAAAGA
TGTCAGAAATCATTAAATGAATTTTTGGAGGAAAAACGCTCAGCATTCCCAAGATTTTATTTTATTGGTGATGATGACTTATTAGAAATA
TTGGGCCAGTCTACCAACCCATCAGTGATTCAGTCTCACCTGAAGAAGCTTTTTGCTGGTATTAACAGTGTTTGCTTTGATGAGAAATCA
AAACATATAACTGCAATGAAATCTTTAGAGGGAGAAGTTGTACCTTTTAAAAATAAAGTTCCTCTATCAAATAATGTAGAGACATGGTTG
AATGATTTGGCCTTAGAAATGAAGAAAACTTTGGAACAGTTGTTGAAGGAATGTGTTACTACTGGGCGAAGTTCTCAAGGTGCAGTTGAC
CCATCTCTGTTCCCTTCACAGATTTTATGCTTGGCGGAGCAGATTAAATTCACTGAAGATGTAGAAAATGCTATTAAAGATCATAGTCTT
CATCAGATTGAAACACAACTGGTGAATAAGTTAGAGCAATATACTAACATTGATACAAGTTCTGAGGATCCAGGGAATACTGAATCGGGC
ATCCTGGAGCTTAAACTTAAAGCCCTAATTCTTGACATTATCCATAATATTGATGTGGTAAAGCAGTTAAACCAAATTCAGGTTCATACA
ACTGAAGACTGGGCTTGGAAAAAACAACTTAGATTCTATATGAAAAGTGATCATACATGTTGTGTTCAAATGGTGGATTCTGAATTTCAG
TATACTTATGAATATCAGGGTAATGCTTCCAAACTGGTTTATACTCCACTGACAGACAAGTGCTACTTAACTCTCACTCAAGCCATGAAG
ATGGGACTTGGAGGAAATCCTTATGGACCAGCTGGAACTGGGAAAACGGAATCAGTAAAGGCTTTAGGTGGACTTCTTGGAAGACAAGTT
TTAGTCTTTAATTGTGATGAGGGCATCGATGTGAAGTCAATGGGACGAATATTTGTTGGTTTGGTGAAGTGTGGGGCCTGGGGTTGTTTT
GATGAATTTAATAGGCTGGAAGAATCTGTACTGTCAGCAGTTTCTATGCAAATCCAGACAATTCAAGATGCTTTGAAGAATCATAGAACT
GTATGTGAACTGCTTGGCAAGGAGGTAGAAGTAAATTCTAATTCTGGAATTTTTATCACTATGAATCCTGCTGGAAAAGGTTATGGAGGA
AGACAAAAACTGCCTGATAATCTTAAACAGCTTTTCAGGCCCGTAGCTATGTCTCATCCAGACAATGAGCTTATTGCAGAAGTTATTCTC
TATTCGGAAGGCTTTAAAGACGCTAAAGTATTGAGCAGAAAATTGGTAGCTATTTTCAATCTATCTAGGGAACTTTTGACACCTCAGCAA
CATTATGATTGGGGTTTGAGAGCTTTGAAGACAGTTCTGAGAGGAAGTGGAAATCTCCTTAGACAGCTAAACAAAAGTGGCACTACACAG
AATGCTAATGAAAGTCATATTGTGGTACAAGCACTGAGGCTTAATACCATGTCAAAGTTTACGTTTACTGATTGCACCCGGTTTGATGCA
CTGATAAAAGATGTCTTTCCGGGAATTGAATTGAAAGAAGTGGAATATGATGAACTAAGTGCTGCATTAAAGCAGGTCTTTGAAGAGGCC
AATTATGAAATTATACCCAATCAGATCAAAAAGGCTTTAGAATTGTATGAACAGTTATGCCAGAGGATGGGAGTTGTTATTGTTGGTCCA
AGTGGTGCTGGAAAATCAACGCTTTGGAGAATGTTAAGGGCTGCGCTTTGTAAAACTGGCAAAGTAGTGAAACAATATACTATGAATCCC
AAAGCTATGCCTCGATATCAATTATTAGGCCATATTGACATGGACACAAGAGAATGGTCTGATGGTGTTTTGACAAATAGTGCTCGTCAA
GTGGTTCGGGAACCTCAAGATGTCAGCTCATGGATAATCTGTGATGGTGATATTGACCCTGAATGGATAGAATCTCTGAATTCTGTTCTG
GATGATAATCGACTGCTGACTATGCCCAGTGGAGAAAGGATTCAGTTTGGCCCAAATGTTAACTTTGTATTTGAAACTCATGATTTAAGT
TGTGCATCACCAGCCACAATATCTAGAATGGGAATGATCTTTCTTAGTGATGAAGAGACAGATCTTAATTCTCTGATAAAATCTTGGTTG
AGGAATCAGCCTGCTGAATATAGAAATAATCTTGAAAATTGGATTGGAGATTATTTTGAAAAGGCTTTACAATGGGTTCTAAAGCAGAAT
GACTATGTGGTAGAAACAAGTTTGGTTGGGACTGTGATGAATGGTTTGTCACATCTACATGGTTGCAGAGATCATGACGAATTCATTATT
AATCTCATAAGGGGACTTGGTGGAAATCTGAATATGAAGTCACGTTTGGAATTTACCAAAGAGGTTTTTCATTGGGCACGAGAATCTCCT
CCAGACTTTCACAAACCTATGGATACCTACTATGACTCTACTAGGGGTCGATTAGCAACATATGTGCTTAAGAAGCCAGAAGACTTGACT
GCTGATGATTTCAGTAACGGCTTAACTCTTCCAGTCATTCAGACTCCTGACATGCAACGAGGTCTAGATTATTTCAAACCATGGTTAAGT
TCTGATACTAAACAGCCCTTTATTCTGGTAGGACCAGAAGGATGTGGCAAAGGGATGCTGCTCAGGTACGCATTTTCACAACTCCGGTCC
ACTCAAATTGCTACAGTTCACTGTAGTGCACAAACCACTTCTCGACATCTCCTGCAGAAACTGAGCCAGACTTGCATGGTAATCAGTACT
AATACTGGTCGTGTATACAGACCAAAAGACTGTGAAAGACTTGTTCTGTACTTAAAAGATATCAACCTACCTAAACTTGATAAATGGGGG
ACCAGTACTTTGGTAGCATTCCTACAACAGGTATTGACGTATCAAGGATTTTATGATGAAAATTTGGAATGGGTTGGTCTAGAAAATATT
CAAATTGTGGCTTCTATGTCAGCTGGAGGAAGACTGGGAAGACATAAACTTACTACCAGATTTACTTCCATCGTTCGTCTTTGTTCTATA
GATTACCCAGAAAGAGAGCAGTTACAAACGATTTATGGAGCATATTTGGAACCAGTTCTACATAAAAATCTGAAGAATCATTCTATTTGG
GGTTCTTCATCAAAAATTTATCTTTTAGCAGGATCTATGGTACAAGTGTATGAACAGGTGCGAGCCAAATTTACAGTTGATGATTATAGT
CACTATTTCTTTACTCCTTGCATTCTTACCCAATGGGTTCTTGGCTTATTTAGATATGATTTAGAAGGAGGATCCTCAAACCATCCACTA
GATTATGTGTTAGAAATTGTAGCATATGAGGCACGGCGCTTATTTCGTGACAAAATTGTTGGTGCAAAGGAACTTCATTTATTTGACATC
ATTTTAACATCAGTGTTTCAAGGAGATTGGGGCTCAGACATATTAGACAATATGTCAGATAGTTTCTACGTTACATGGGGAGCTCGGCAT
AATTCAGGAGCAAGGGCAGCCCCAGGACAACCATTACCTCCACATGGAAAACCACTTGGAAAACTAAACTCTACTGATCTCAAGGATGTT
ATTAAAAAGGGTCTTATTCATTATGGACGAGATAACCAGAATTTAGACATTTTACTTTTCCACGAAGTCTTGGAGTATATGTCTAGGATA
GATAGAGTGCTGAGTTTCCCTGGAGGTTCACTTCTATTAGCAGGACGCAGTGGTGTAGGTCGTCGGACCATCACTTCTTTAGTCAGTCAC
ATGCATGGAGCGGTCCTGTTTTCTCCAAAGATTTCCAGAGGATATGAACTGAAGCAGTTCAAAAATGATCTCAAACATGTGCTGCAACTT
GCAGGAATTGAAGCACAACAGGTAGTTTTACTTCTTGAGGATTACCAGTTTGTACATCCTACATTTTTGGAGATGATCAATAGCCTTTTG
TCTTCAGGTGAAGTTCCTGGACTCTATACTCTTGAAGAATTAGAGCCCTTGCTGTTACCACTTAAGGATCAAGCTTCACAAGATGGTTTT
TTTGGACCAGTCTTCAATTACTTCACATATAGAATTCAGCAAAACTTGCATATTGTCTTGATAATGGATTCTGCAAATTCAAACTTCATG
ATAAACTGTGAGAGTAATCCAGCTTTGCATAAGAAATGCCAGGTGTTGTGGATGGAGGGTTGGTCCAATAGCAGTATGAAGAAAATACCT
GAAATGTTATTCAGTGAAACAGGTGGTGGAGAAAAATACAATGATAAAAAACGAAAAGAAGAAAAGAAAAAAAATTCAGTTGATCCTGAT
TTTCTAAAATCATTTTTATTAATCCATGAATCTTGTAAAGCATATGGTGCTACACCAAGCCGATACATGACCTTTTTACATGTGTATTCT
GCCATTAGTAGTAGCAAGAAAAAGGAATTATTAAAAAGACAAAGTCATTTGCAGGCTGGTGTATCTAAACTAAATGAAGCTAAAGCTCTT
GTGGATGAACTGAACAGAAAAGCTGGAGAACAAAGTGTGTTACTTAAAACGAAGCAAGATGAAGCAGATGCTGCCCTTCAAATGATCACA
GTGTCAATGCAGGATGCTAGTGAGCAAAAAACAGAACTTGAAAGACTGAAGCACAGAATAGCAGAAGAAGTTGTTAAAATTGAAGAAAGA
AAAAATAAAATTGATGATGAATTAAAAGAAGTACAACCTTTAGTCAATGAAGCTAAACTAGCAGTTGGAAACATTAAGCCCGAATCACTT
TCAGAAATTCGCTCACTACGCATGCCACCTGATGTAATTAGAGATATTCTTGAAGGAGTTTTAAGGTTGATGGGTATCTTTGATACATCT
TGGGTGAGCATGAAAAGTTTCCTTGCAAAAAGAGGTGTAAGAGAAGACATAGCAACCTTTGATGCCCGAAATATTTCAAAGGAAATAAGA
GAGAGTGTTGAAGAACTTCTTTTTAAAAATAAAGGCTCTTTTGATCCAAAGAATGCTAAGCGTGCCAGTACTGCAGCTGCACCTTTGGCT
GCCTGGGTGAAAGCCAATATTCAGTATTCCCATGTCTTGGAACGAATTCATCCTTTGGAAACTGAACAGGCAGGATTAGAATCGAATCTG
AAGAAAACTGAAGACAGAAAAAGGAAACTAGAGGAGCTTCTTAATTCTGTTGGTCAAAAGGTATCAGAACTCAAAGAAAAATTTCAGAGC
AGGACTTCAGAAGCTGCCAAACTTGAGGCTGAAGTAAGCAAGGCACAAGAAACAATCAAAGCTGCAGAAGTCTTAATTAATCAGCTTGAC
AGAGAACATAAGAGATGGAATGCACAGGTTGTAGAGATAACAGAGGAATTAGCTACTCTTCCTAAAAGAGCTCAACTTGCTGCTGCATTT
ATTACATATCTTTCTGCTGCTCCTGAATCTCTGAGAAAAACCTGTTTGGAAGAATGGACCAAGTCAGCTGGTCTTGAGAAATTTGATCTG
AGGAGATTTCTTTGTACTGAAAGTGAGCAGTTAATTTGGAAAAGTGAAGGCCTACCATCAGATGACCTTTCCATAGAAAATGCTCTTGTA
ATATTACAGATCATTGGTTTGAAATCATGGAGTCGAGTGTGCCCATTTCTTATAGATCCTTCTTCCCAAGCTACAGAGTGGTTAAAAACA
CATTTGAAAGACTCACGTTTAGAAGTTATCAATCAGCAGGATAGTAACTTTATCACAGCTCTTGAATTAGCAGTACGTTTTGGGAAAACC
CTTATTATACAAGAGATGGATGGTGTAGAACCTGTTCTTTATCCATTATTGAGACGAGATCTGGTTGCTCAAGGACCACGTTATGTGGTA
CAAATAGGTGACAAAATTATTGACTACAATGAAGAATTCCGCCTCTTTTTGTCAACAAGAAACCCAAATCCTTTTATTCCACCGGATGCA
GCTTCCATTGTTACTGAGGTTAACTTTACTACAACAAGAAGTGGATTACGAGGGCAGCTTTTAGCTTTAACCATTCAGCATGAGAAACCT
GATTTAGAAGAACAGAAAACAAAACTATTACAACAGGAAGAAGATAAGAAAATACAGCTAGCCAAGCTCGAAGAATCTCTTCTAGAGACA
CTTGCCACATCTCAAGGCAATATTTTGGAAAATAAGGATTTGATTGAGTCTTTGAATCAGACAAAAGCAAGCAGTGCACTTATTCAAGAG
TCACTTAAAGAATCTTACAAACTCCAAATTTCCCTTGATCAAGAACGGGATGCCTATCTCCCCCTGGCTGAGAGTGCCAGCAAGATGTAC
TTCATTATTTCTGATTTGTCCAAAATTAATAACATGTACCGTTTTAGTTTGGCTGCTTTTCTCCGACTTTTCCAACGAGCTCTACAAAAC
AAACAGGATTCTGAAAATACAGAACAGAGAATCCAGTCACTTATCAGCTCATTACAACATATGGTATATGAATATATATGTCGTTGTCTA
TTTAAGGCTGATCAGTTGATGTTCGCTTTGCATTTTGTTCGAGGCATGCATCCTGAACTTTTTCAAGAAAATGAATGGGATACGTTTACA
GGTGTGGTTGTTGGAGACATGTTACGGAAAGCTGACTCTCAACAAAAAATACGTGATCAGCTTCCGTCTTGGATAGATCAGGAACGAAGC
TGGGCCGTGGCAACATTAAAGATTGCTCTCCCCAGTCTTTATCAGACCCTCTGCTTTGAAGATGCAGCTCTGTGGCGTACTTATTATAAT
AATTCAATGTGTGAGCAAGAGTTTCCATCTATCCTTGCAAAGAAAGTTTCCTTATTTCAGCAGATTCTTGTAGTACAGGCGCTAAGACCG
GACAGATTGCAAAGTGCCATGGCTCTTTTTGCATGTAAAACTCTGGGACTGAAAGAGGTGTCCCCACTGCCTCTAAATCTCAAACGTTTA
TACAAAGAGACACTGGAAATTGAACCCATCTTGATAATTATTTCTCCGGGTGCTGATCCTTCTCAGGAACTTCAAGAACTAGCTAATGCT
GAAAGAAGCGGAGAGTGTTATCACCAGGTTGCCATGGGTCAAGGTCAAGCTGATTTAGCAATTCAAATGCTAAAAGAATGTGCCCGCAAT
GGAGACTGGCTCTGTTTGAAGAACTTACATCTTGTGGTATCTTGGCTGCCAGTTCTGGAAAAGGAATTGAATACTCTTCAACCTAAAGAT
ACCTTTCGTCTTTGGCTCACTGCAGAAGTTCATCCCAACTTTACTCCTATTTTACTACAGTCAAGTCTGAAGATAACATATGAGAAAATA
TTTACAGATTTGCAGTCTGAAGGATTCCCTGTAATAGAGACCAGCACCCTGACTGAGGAAGGTGTTATTAAAGTTAAAACAGAGGCTTGC
GATAGGCTTTTGGCTCATCGAGTGGAAACCAAAATGAAGGGAAATAAAGTGAATGAGGTGCTGAATAGACTGCACCTGGCTATCCCAACC
AGGAGGGACGATAAGGAGAGGCCCCCTTTCATCCCTGAAGGAGTGGTGGCTCGCAGGAAGAGGATGGAAACTGAGGAGTCCAGGAAGAAG
AGGGAACGAGATCTTGAGCTGGAAATGGGAGATGATTATATTTTGGATCTTCAGAAGTACTGGGATTTAATGAATTTGTCTGAAAAACAT
GATAAGATACCAGAAATCTGGGAAGGCCATAATATAGCTGATTATATTGATCCAGCCATCATGAAGAAATTGGAAGAATTAGAAAAAGAA
GAAGAGCTGAGAACAGCTGCTGGAGAGTATGACAGTGTATCTGAGAGTGAAGACGAAGAGATGCTGGAAATCCGACAGCTGGCAAAGCAA
ATTCGAGAGAAAAAGAAGTTGAAAATTCTGGAGTCCAAAGAAAAGAATACACAGGGACCCAGGATGCCGCGAACTGCTAAGAAGGTTCAG
AGGACAGTTTTGGAGAAGGAGATGCGTAGTCTTGGTGTTGACATGGACGATAAAGACGATGCCCATTACGCAGTCCAGGCAAGAAGATCC
CGGAGCATCACTAGGAAAAGAAAGCGGGAAGACTCTGCTCCCCCGTCCTCTGTGGCCCGGAGTGGGAGTTGCTCTCGAACTCCACGTGAC
GTTTCTGGTCTTAGGGATGTCAAGATGGTGAAGAAAGCCAAGACTATGATGAAGAATGCTCAGAAGAAGATGAATCGGTTGGGGAAGAAA
GGGGAGGCGGATAGACACGTGTTTGATATGAAGCCCAAGCACTTGCTGTCTGGGAAGAGGAAAGCTGGTAAAAAGGACAGGAGATAGTAT
CCGTTTGGTTGGCGTGGCTTCGCTAGAGTGTTGCTGTTTATTTCCTGGTTTGGCACAGTATGGTTTCATGAAATTGGAGCTCTGTATAAA
CTGAAAAAGACAAAATAAGTAAAGCACTTGTTGCTTTGCTGAAAACTATGGTTAACCCTATATAGGTGTGGGAAATTTTTGTCACTGCAT
AATATTACAAATATTTTGAGTAGACAGTGTTTCCACATTTAATGGAGTATCAGTTGCTTCAGATTTTCAGAACTGGGAAGATTTACTGGT
TTAACTAGGTTGTTTTTGATGGAGAAAAACCTTATTTTCTTTTGTAAGAGCTGGGAGCAAACACGTTTATGAGTGTGTCGGAATCCCGTG
CTTAAAATACGCTCTTAAATTATTTTCTAGTCTTATTTTACAATGTCTCATTGTAGTCTGTCTTCAACTATTTTATCCAAAATAAACCTC
CAGAAGAAAGTAGTTTTCATTTACTTAGCTCATGTTTTGGTTTAGTTATAGTCGCTATGGATTTGGCCAAATAAAAAGGCAAACAACATG
ACATTTCTATTTTGTTTTAAAGCAAAAATACTTTTGGGGGAGTAAAATGTTGCTGGAGGCATTAGGCAATTAAATATGGGCATTCTCCTA
TTTCTGTGGCCCGTCCCTGAAGTTACATGTTCAGTAAAACACAAAAACACCGCCAATGCCACCTCAAAAGCACCTGCTGGGGAGCGTTGG
GGTGAAGAGCTGTGGGGTCGGAGGGACCTGCCCAGGGGTCCGTGTGCTCCTGGAGCTCCAAAGACACACAGGGGTCCAAGAGCCACCACG
GATAAGTTATCAAGTCACACAATCAACATTATAGCTGAGGAAAGGACTTTAGTTAATCACACTTCTGGATTACATGTGGCAATTTTAAAA
ATTTACCAGGGCTGGGCTGGGCGCAGGGGCTCAAGCCTGTAGTTCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCAGGAGGTCAGGAGT
TCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCATGCGTGGTGGTGGGCATCTGTAATCCTA
GCTGCTCGGGAGGCTAAGGCAGGAGAATTGCTTGAGCCCAGAGGCGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGG
GTGACAGAGAGAGACTCCGTGTGAAAAAAAAAAAAAAAATACCAGGTCTGGTTTTTGAAATTCTTTCTCCGTATTAAACACCAAAACTTA
ACATATAGTTTACTTTGTGTTAAACAACAACAGTATGGCCGGGCGCGGCAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCA
GGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGT
GGTGGCGGGCGCCTGTAGTCCCAACTACTTGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGA
TCGCACCACTGCACTCCAGCCTGGTCGACAGCGAGACTCCATCTCAAAAAAAAAAAAAAAATACCAGGTCTGGTTTTTGAAATTCTTTCT
CCGTATTAAACACCAAAACTTAACATATAGTTTACTTTGTGTTAAACAACAACAGTATGTTTTAAAGCAAGTATGTCTTTATTTGTAAGC
ATATTACTGAAACGATCAAATGAACAGAAGTGGATAAACGTCGAGTCACTTGGCTGAGACCATACGCATCTTCCGTACTGCTTGTATTAG
GATGCAAGATTGAATGTGTCTTTTTTTTAAAAATGCAGCCTTGTGTTGCACTCTGAAATAAGTGATTTAAAAAGAAAAACATGATACAGA
GATCCCATCCTGACCTTGGAGGCTTGGATAAAGCTGTGGGGAGACAGCCTCATGGTCCAGCCAGGCTAGTCCGCCTGCTTCAGGACTCTC
AAGATCTCCCCAAGACTTTCAGGATCAGCTGCTGTTAATCAAACAAGTGCTTATAAAATGGAAATTGGGACAAAGGAAATGTTAAATTTC
CTCCCTGCAACCAGGCAGATGAGAAATATGGAAATAAGGAAAAGGGAAAATGAAGATATGACAAAGTTGATGAAAAGGTTGAAATAGTGA
TTTATACATGATGGGCAATCAAGTGCCCCTTTTGCCCTGTTTTTTGGAGAGGGTGTATCATTGCCTCAATGGTGCGTCTGCCTGCACTGA
GGGCATTACACATGGCTGACTCGACCTCCCTGCCTCTCACACTCTGTGTATTTTGTGAAGCTCCACAAACGGGGTCACGTCATCCAGGTG
AGGCCACCACCGGTACAGAAACCTCTCGGCAATGGTTCTTAGCCAGGGGGTGACTTTGACTTCACCCCTCGCCTCCCTCTCCAGCAGCTC
CCACAGCTCCTCCTGGGACAGGTAGAGGATGCTTTTCGTTTCACTGGGATCCGGGTTCAGAGTGACGTTTTTCCTCACAAGCAGAAGGTA
ACAAATTTCATGCTCTCCCCAAATTCTGTCTGATTTTGCCTTGTGGTGATAGATTGTCATGAACACAATGTCCTCTGGAGAAATCTATTG
ACAGAAATTGGTGCAGTGTTAACAACGCTAATGTAAAACACAGAATTTACAGAAAAATAGAGAAAATAAACACATTTGTTTTCCTCAGAA

>24638_24638_2_DYNC2H1-GTPBP4_DYNC2H1_chr11_103178560_ENST00000398093_GTPBP4_chr10_1051757_ENST00000360803_length(amino acids)=4168AA_BP=3838
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDEN
LHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL
NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTR
VFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVD
SIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSR
DIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQ
MIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTFCEKVVVLMNIDLLRQQQRWKD
GLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIP
NQFKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLP
SAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEA
EDKNRLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIETGQHNTLDKSA
KLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLASSISKDIESCAQIWAFYEEFQQGFQEMANEDWITFRTKTYLFEEFLMNWHDRL
RKVEEHSVMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTI
REALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWV
YLEPIFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEI
LGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVD
PSLFPSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHT
TEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQV
LVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGG
RQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQ
NANESHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGP
SGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVL
DDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQWVLKQN
DYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIRGLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLT
ADDFSNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIATVHCSAQTTSRHLLQKLSQTCMVIST
NTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSI
DYPEREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPL
DYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDV
IKKGLIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQL
AGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFM
INCESNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYGATPSRYMTFLHVYS
AISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEER
KNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIR
ESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQS
RTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTKSAGLEKFDL
RRFLCTESEQLIWKSEGLPSDDLSIENALVILQIIGLKSWSRVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKT
LIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKP
DLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMY
FIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFT
GVVVGDMLRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQALRP
DRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARN
GDWLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYEKIFTDLQSEGFPVIETSTLTEEGVIKVKTEAC
DRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKH
DKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQ
RTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKMNRLGKK

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Fusion Gene PPI Analysis for DYNC2H1-GTPBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYNC2H1-GTPBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYNC2H1-GTPBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDYNC2H1C0036069Saldino-Noonan Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDYNC2H1C0024507Majewski Syndrome3CTD_human;ORPHANET
HgeneDYNC2H1C0265275Jeune thoracic dystrophy2GENOMICS_ENGLAND;ORPHANET
HgeneDYNC2H1C0432197Short rib-polydactyly syndrome, Verma-Naumoff type2CTD_human;ORPHANET
HgeneDYNC2H1C0006142Malignant neoplasm of breast1CTD_human
HgeneDYNC2H1C0036996Short Rib-Polydactyly Syndrome1CTD_human
HgeneDYNC2H1C0152427Polydactyly1GENOMICS_ENGLAND
HgeneDYNC2H1C0678222Breast Carcinoma1CTD_human
HgeneDYNC2H1C1257931Mammary Neoplasms, Human1CTD_human
HgeneDYNC2H1C1458155Mammary Neoplasms1CTD_human
HgeneDYNC2H1C4704874Mammary Carcinoma, Human1CTD_human