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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALG9-CRYAB (FusionGDB2 ID:HG79796TG1410)

Fusion Gene Summary for ALG9-CRYAB

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG9-CRYAB
Fusion gene ID: hg79796tg1410
HgeneTgene
Gene symbol

ALG9

CRYAB

Gene ID

79796

1410

Gene nameALG9 alpha-1,2-mannosyltransferasecrystallin alpha B
SynonymsCDG1L|DIBD1|GIKANIS|LOH11CR1JCMD1II|CRYA2|CTPP2|CTRCT16|HEL-S-101|HSPB5|MFM2
Cytomap('ALG9')('CRYAB')

11q23.1

11q23.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-1,2-mannosyltransferase ALG9asparagine-linked glycosylation 9 alpha-12-mannosyltransferase-like proteinasparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)asparagine-linked glycosylation 9 homolog (yeast, alphalpha-crystallin B chainepididymis secretory protein Li 101heat shock protein beta-5heat-shock 20 kD like-proteinrenal carcinoma antigen NY-REN-27rosenthal fiber component
Modification date2020031320200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000524880, ENST00000398006, 
ENST00000527228, ENST00000527377, 
ENST00000531154, 
Fusion gene scores* DoF score6 X 6 X 5=1807 X 5 X 3=105
# samples 76
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALG9 [Title/Abstract] AND CRYAB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALG9(111749685)-CRYAB(111782646), # samples:1
ALG9(111749280)-CRYAB(111782646), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRYAB

GO:0031333

negative regulation of protein complex assembly

23106396

TgeneCRYAB

GO:0032387

negative regulation of intracellular transport

14752512

TgeneCRYAB

GO:0043066

negative regulation of apoptotic process

14752512

TgeneCRYAB

GO:0045892

negative regulation of transcription, DNA-templated

20587334

TgeneCRYAB

GO:1905907

negative regulation of amyloid fibril formation

23106396



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1740-01AALG9chr11

111749280

-CRYABchr11

111782646

-
ChimerDB4OVTCGA-61-1740-01AALG9chr11

111749685

-CRYABchr11

111782646

-


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Fusion Gene ORF analysis for ALG9-CRYAB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000524880ENST00000526180ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000526180ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000527950ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000527950ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000531198ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000531198ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000533475ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-5UTRENST00000524880ENST00000533475ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000227251ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000227251ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000525823ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000525823ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000533280ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000533280ALG9chr11

111749685

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000533971ALG9chr11

111749280

-CRYABchr11

111782646

-
5CDS-intronENST00000524880ENST00000533971ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000526180ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000526180ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000527950ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000527950ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000531198ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000531198ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000533475ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000398006ENST00000533475ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000526180ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000526180ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000527950ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000527950ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000531198ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000531198ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000533475ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527228ENST00000533475ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000526180ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000526180ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000527950ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000527950ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000531198ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000531198ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000533475ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000527377ENST00000533475ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000526180ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000526180ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000527950ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000527950ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000531198ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000531198ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000533475ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-5UTRENST00000531154ENST00000533475ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000227251ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000227251ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000525823ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000525823ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000533280ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000533280ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000533971ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000398006ENST00000533971ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000227251ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000227251ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000525823ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000525823ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000533280ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000533280ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000533971ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527228ENST00000533971ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000227251ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000227251ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000525823ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000525823ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000533280ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000533280ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000533971ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000527377ENST00000533971ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000227251ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000227251ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000525823ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000525823ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000533280ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000533280ALG9chr11

111749685

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000533971ALG9chr11

111749280

-CRYABchr11

111782646

-
intron-intronENST00000531154ENST00000533971ALG9chr11

111749685

-CRYABchr11

111782646

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ALG9-CRYAB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ALG9chr11111749279-CRYABchr11111782642-0.999903449.65E-05
ALG9chr11111749684-CRYABchr11111782642-0.98342220.016577778
ALG9chr11111749279-CRYABchr11111782642-0.999903449.65E-05
ALG9chr11111749684-CRYABchr11111782642-0.98342220.016577778


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ALG9-CRYAB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111749685/:111782646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ALG9-CRYAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ALG9-CRYAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALG9-CRYAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALG9-CRYAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALG9C2931006Congenital disorder of glycosylation type 1L5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneALG9C1849762Polycystic Kidney Disease, Potter Type I, with Microbrachycephaly, Hypertelorism, and Brachymelia2CTD_human;GENOMICS_ENGLAND
HgeneALG9C0085413Polycystic Kidney, Autosomal Dominant1GENOMICS_ENGLAND
HgeneALG9C0158683Polycystic liver disease1GENOMICS_ENGLAND
HgeneALG9C1691228Cystic Kidney Diseases1GENOMICS_ENGLAND
HgeneALG9C4551631Cystic liver disease1GENOMICS_ENGLAND
TgeneC1837317Alpha-B Crystallinopathy6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0392557Nuclear cataract3ORPHANET
TgeneC1112705Nuclear non-senile cataract3ORPHANET
TgeneC0340427Familial dilated cardiomyopathy2ORPHANET
TgeneC0858617Posterior subcapsular cataract2ORPHANET
TgeneC3554649CARDIOMYOPATHY, DILATED, 1II2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC3808377CATARACT 16, MULTIPLE TYPES2CTD_human;GENOMICS_ENGLAND
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0040411Tongue Neoplasms1CTD_human
TgeneC0086543Cataract1CTD_human
TgeneC0153349Malignant neoplasm of tongue1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0524524Pseudoaphakia1CTD_human
TgeneC0524851Neurodegenerative Disorders1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1510497Lens Opacities1CTD_human
TgeneC2678065Myofibrillar Myopathy1GENOMICS_ENGLAND
TgeneC3151236MYOPATHY, MYOFIBRILLAR, FATAL INFANTILE HYPERTONIC, ALPHA-B CRYSTALLIN-RELATED1CTD_human;GENOMICS_ENGLAND;ORPHANET