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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:THSD4-ADAM10 (FusionGDB2 ID:HG79875TG102) |
Fusion Gene Summary for THSD4-ADAM10 |
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Fusion gene information | Fusion gene name: THSD4-ADAM10 | Fusion gene ID: hg79875tg102 | Hgene | Tgene | Gene symbol | THSD4 | ADAM10 | Gene ID | 79875 | 102 |
Gene name | thrombospondin type 1 domain containing 4 | ADAM metallopeptidase domain 10 | |
Synonyms | ADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005 | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | |
Cytomap | ('THSD4')('ADAM10') 15q23 | 15q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | thrombospondin type-1 domain-containing protein 4A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6thrombospondin, type I, domain containing 4 | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000261862, ENST00000355327, ENST00000357769, ENST00000567838, | ||
Fusion gene scores | * DoF score | 21 X 27 X 8=4536 | 12 X 10 X 8=960 |
# samples | 31 | 13 | |
** MAII score | log2(31/4536*10)=-3.87108051966799 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/960*10)=-2.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: THSD4 [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | THSD4(71549054)-ADAM10(58957396), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | THSD4-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. THSD4-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. THSD4-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. THSD4-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
Tgene | ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
Tgene | ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
Tgene | ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-CG-4444-01A | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
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Fusion Gene ORF analysis for THSD4-ADAM10 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000261862 | ENST00000558733 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-5UTR | ENST00000355327 | ENST00000558733 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000261862 | ENST00000396140 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000261862 | ENST00000402627 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000261862 | ENST00000561288 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000355327 | ENST00000396140 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000355327 | ENST00000402627 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
5CDS-intron | ENST00000355327 | ENST00000561288 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
In-frame | ENST00000261862 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
In-frame | ENST00000355327 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-3CDS | ENST00000357769 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-3CDS | ENST00000567838 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-5UTR | ENST00000357769 | ENST00000558733 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-5UTR | ENST00000567838 | ENST00000558733 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000357769 | ENST00000396140 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000357769 | ENST00000402627 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000357769 | ENST00000561288 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000567838 | ENST00000396140 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000567838 | ENST00000402627 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
intron-intron | ENST00000567838 | ENST00000561288 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000355327 | THSD4 | chr15 | 71549054 | - | ENST00000260408 | ADAM10 | chr15 | 58957396 | - | 5255 | 1149 | 134 | 2911 | 925 |
ENST00000261862 | THSD4 | chr15 | 71549054 | - | ENST00000260408 | ADAM10 | chr15 | 58957396 | - | 5200 | 1094 | 79 | 2856 | 925 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000355327 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - | 0.000255937 | 0.999744 |
ENST00000261862 | ENST00000260408 | THSD4 | chr15 | 71549054 | - | ADAM10 | chr15 | 58957396 | - | 0.000243133 | 0.9997569 |
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Fusion Genomic Features for THSD4-ADAM10 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for THSD4-ADAM10 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:71549054/chr15:58957396) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 53_307 | 338 | 1019.0 | Domain | TSP type-1 1 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 53_307 | 338 | 1019.0 | Domain | TSP type-1 1 |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 555_673 | 161 | 749.0 | Compositional bias | Cys-rich | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 220_456 | 161 | 749.0 | Domain | Peptidase M12B | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 457_551 | 161 | 749.0 | Domain | Disintegrin | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 171_178 | 161 | 749.0 | Motif | Cysteine switch | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 708_715 | 161 | 749.0 | Motif | SH3-binding | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 722_728 | 161 | 749.0 | Motif | SH3-binding | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 694_748 | 161 | 749.0 | Topological domain | Cytoplasmic | |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 673_693 | 161 | 749.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 676_737 | 338 | 1019.0 | Domain | TSP type-1 2 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 739_792 | 338 | 1019.0 | Domain | TSP type-1 3 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 793_851 | 338 | 1019.0 | Domain | TSP type-1 4 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 852_911 | 338 | 1019.0 | Domain | TSP type-1 5 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 912_968 | 338 | 1019.0 | Domain | TSP type-1 6 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000261862 | - | 5 | 17 | 971_1008 | 338 | 1019.0 | Domain | PLAC |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 676_737 | 338 | 1019.0 | Domain | TSP type-1 2 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 739_792 | 338 | 1019.0 | Domain | TSP type-1 3 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 793_851 | 338 | 1019.0 | Domain | TSP type-1 4 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 852_911 | 338 | 1019.0 | Domain | TSP type-1 5 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 912_968 | 338 | 1019.0 | Domain | TSP type-1 6 |
Hgene | THSD4 | chr15:71549054 | chr15:58957396 | ENST00000355327 | - | 6 | 18 | 971_1008 | 338 | 1019.0 | Domain | PLAC |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 20_672 | 161 | 749.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for THSD4-ADAM10 |
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>90758_90758_1_THSD4-ADAM10_THSD4_chr15_71549054_ENST00000261862_ADAM10_chr15_58957396_ENST00000260408_length(transcript)=5200nt_BP=1094nt GACTTGAACGCAACTCCCAATTGCAGAAAATTGGCAACGTCTCTGAAGAGCCCTTGCTTTTGCCTGGACCCCCAGCATCATGGTTTCCCA TTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTCTGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAACACAGGAAGGT CCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGGACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGCCCCTGGTCGGC CTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGCAGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGCCAGCGGCCTGG CGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGTCGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAGACGCCAGCGCT GGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGGTGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTCACTGGGGACAG AAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCAAGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACAGACACTGCACA CACGCCACAGAGGCTCCGGAGACAGAAGCTCTCATCCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGCTACAGTTCACC AGCCCACCAGGTCCCCCAACATGGGCCTTTGTACCAAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCCCCCATCTACCA GCTACCTTTGACCCATGATCAAGGCTACCCTGCAGCTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGTGTGGGGACCCA TGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGATCTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTGTGCAACACCAA CGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGGTACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTTTATGAGTGGGA ACCATTTGCAGAAGACTATCCCCATAAATACGGTCCTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAATACCAGAT GACTGGTGTAGAGGAAGTAACACAGATACCTCAAGAAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGC TGAAAAAAATACTTGTCAGCTTTATATTCAGACTGATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCCCAGATATC CAGTCATGTTAAAGCGATTGATACAATTTACCAGACCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAAT CAATACAACTGCTGATGAGAAGGACCCTACAAATCCTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAATTCTGAGCA GAATCATGATGACTACTGTTTGGCCTATGTCTTCACAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTC AGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAACTCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACTGTTCAGAA CTATGGGTCTCATGTACCTCCCAAAGTCTCTCACATTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAAC AGAGTGCACACCAGGAGAATCTAAGAATTTGGGTCAAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGGGACAAACT TAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCA ACCTATTTGTGGAAATGGAATGGTAGAACAAGGTGAAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGCTTCGATGC AAATCAACCAGAGGGAAGAAAATGCAAACTGAAACCTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATT CAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAGACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCAGCATCTGA CCCTAAACCAAACTTCACAGACTGTAATAGGCATACACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTT AGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAGATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCATCAACTTG TGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACTTCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGG TTACTGTGATGTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCAGAGCTCTA TGAAAACATTGCTGAATGGATTGTGGCTCATTGGTGGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAA GATATGCAGTGTTCATACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGACCTCCACA GCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAGAGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCTTGGTTCTT CCTAGTGCCTACAATGGGAAAACTTCACTCCAAAGAGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAG AAAAAATGGCAAGAGATCATATCCTCAGACCAGGTGGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGGAGGTGGAA AAGGAACCCAATTTTCTTATGAACAGATATTTTTAACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCCCTGTTCTT CGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTGGCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTCAACTGCCA ATCAAGGCTAGGAGGCTCGACCACCTCAACATTGGAGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTATTTCTTACG TACACTGTACTTCTGTGTGCAATTGTAAACAGAAATTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAATTAAAAAT TACTGTTTAATTGACATACTCAGGATAACAGAGAATGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAAA TGAAAATCAATTTACCTTTCTGTTACGATGGAGTTGGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTA TACTGAAGAACACAGTTAAGTGTTGTGCAAACTGGACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGTTTCTGCTT ACGTCTTTTAAACTTTCTAATTCAATTCCATTTTTCAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCAATGAAATG ATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTTTCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGC TGTGTCTTTATCAAAATATTTAAACGGTTTTTTCAGCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGCTTAAGTAG TAGTTAAAATTGTAGATAGGCCTTCTGACATTTTTTTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCCCATTCCAA ATTTATTTTTGAAACAGATGTAAATAATTGGCATTTTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTATGCAGGAA ATAGAAGGGGCATTACAAAAATTGAAGCTTGTGACATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTAAAGCTATG ATTTTCCTGACTTCACATAGGAGGCAAATTTAGAGAAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTTTTTTTAAG AGTATAAGGTTTACACAATCATTCTCATAATGTGACGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCTTCCTTGTA AACTTGTACAGTATGTGGTGACTTTTTCAAAATACAGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCAGATAGACT ATAAATAATTCTAAACAAACAAGTAGGTAGATATGTATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGTGCAAAGGT TGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTTTATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGGAACATGTA AATTTTTTGCTTGTAATGTTATCCTGTGGTAGGATTTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAAATGTTTTC TGAAAAGAGATACATGCACTGAACTCTTTCCACTGCGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTAATACTACT GTCAGTTTTAATGTCCACTGTGTTTTATACAGTATCTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATAAAGTATTG TGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGCATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTGAACTCTGA GAACTATCACAAGAAGCTTCCCACAAGGCAGTGTTTTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCTTAATACTT >90758_90758_1_THSD4-ADAM10_THSD4_chr15_71549054_ENST00000261862_ADAM10_chr15_58957396_ENST00000260408_length(amino acids)=925AA_BP=338 MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGG QRPGAPARAFADHVVSAVRTSVPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEAPIYQLPLTHDQGYPAASSLFHSPETSNNHG VGTHGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEDYPHKYGPQGGCADHSVFERMR KYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVK RIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGII TVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFV ESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALC PASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCN DFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRR -------------------------------------------------------------- >90758_90758_2_THSD4-ADAM10_THSD4_chr15_71549054_ENST00000355327_ADAM10_chr15_58957396_ENST00000260408_length(transcript)=5255nt_BP=1149nt ATCAGACCAACGTGAATTGAATCACAGCAGTTCAGAAAGAGGAAACTGGATTCAGGACTTGAACGCAACTCCCAATTGCAGAAAATTGGC AACGTCTCTGAAGAGCCCTTGCTTTTGCCTGGACCCCCAGCATCATGGTTTCCCATTTCATGGGGTCTCTCAGTGTCCTGTGTTTCCTTC TGCTGCTTGGATTCCAGTTCGTCTGCCCACAGCCCTCCACTCAACACAGGAAGGTCCCGCAGCGGATGGCGGCGGAGGGCGCCCCCGAGG ACGACGGCGGCGGCGGCGCCCCGGGAGTGTGGGGCGCCTGGGGCCCCTGGTCGGCCTGCTCGCGTAGCTGCAGCGGCGGCGTGATGGAGC AGACGCGGCCCTGCCTGCCCCGCTCCTACCGCCTGCGCGGCGGCCAGCGGCCTGGCGCCCCTGCGCGCGCCTTCGCGGACCACGTGGTGT CGGCGGTGCGCACGTCGGTGCCACTGCACCGGAGCCGCGACGAGACGCCAGCGCTGGCCGGTACGGACGCCAGCCGCCAGGGCCCCACGG TGCTGCGAGGCAGCCGGCACCCACAGCCCCAGGGCCTCGAAGTCACTGGGGACAGAAGGAGCAGGACCCGTGGTACCATTGGCCCTGGCA AGTATGGCTATGGTAAGGCCCCATATATCTTACCACTGCAGACAGACACTGCACACACGCCACAGAGGCTCCGGAGACAGAAGCTCTCAT CCCGCCATTCCAGGTCCCAGGGAGCATCTTCTGCTAGGCATGGCTACAGTTCACCAGCCCACCAGGTCCCCCAACATGGGCCTTTGTACC AAAGTGACAGTGGCCCTCGCTCTGGACTGCAGGCTGCGGAGGCCCCCATCTACCAGCTACCTTTGACCCATGATCAAGGCTACCCTGCAG CTTCAAGTCTCTTTCACAGCCCAGAAACAAGCAACAACCACGGTGTGGGGACCCATGGGGCAACTCAGAGCTTCTCTCAGCCTGCCCGAT CTACAGCAATCTCATGCATCGGGGCCTATCGGCAGTACAAGCTGTGCAACACCAACGTATGTCCAGAAAGCAGTAGAAGTATCCGGGAGG TACAGTGTGCATCCTACAACAACAAGCCATTCATGGGCCGGTTTTATGAGTGGGAACCATTTGCAGAAGACTATCCCCATAAATACGGTC CTCAGGGGGGCTGTGCAGATCATTCAGTATTTGAAAGAATGAGGAAATACCAGATGACTGGTGTAGAGGAAGTAACACAGATACCTCAAG AAGAACATGCTGCTAATGGTCCAGAACTTCTGAGGAAAAAACGTACAACTTCAGCTGAAAAAAATACTTGTCAGCTTTATATTCAGACTG ATCATTTGTTCTTTAAATATTACGGAACACGAGAAGCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCGATTGATACAATTTACCAGA CCACAGACTTCTCCGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAATACAACTGCTGATGAGAAGGACCCTACAAATC CTTTCCGTTTCCCAAATATTGGTGTGGAGAAGTTTCTGGAATTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTATGTCTTCA CAGACCGAGATTTTGATGATGGCGTACTTGGTCTGGCTTGGGTTGGAGCACCTTCAGGAAGCTCTGGAGGAATATGTGAAAAAAGTAAAC TCTATTCAGATGGTAAGAAGAAGTCCTTAAACACTGGAATTATTACTGTTCAGAACTATGGGTCTCATGTACCTCCCAAAGTCTCTCACA TTACTTTTGCTCACGAAGTTGGACATAACTTTGGATCCCCACATGATTCTGGAACAGAGTGCACACCAGGAGAATCTAAGAATTTGGGTC AAAAAGAAAATGGCAATTACATCATGTATGCAAGAGCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAA ATATAAGCCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGTGGAAATGGAATGGTAGAACAAGGTG AAGAATGTGATTGTGGCTATAGTGACCAGTGTAAAGATGAATGCTGCTTCGATGCAAATCAACCAGAGGGAAGAAAATGCAAACTGAAAC CTGGGAAACAGTGCAGTCCAAGTCAAGGTCCTTGTTGTACAGCACAGTGTGCATTCAAGTCAAAGTCTGAGAAGTGTCGGGATGATTCAG ACTGTGCAAGGGAAGGAATATGTAATGGCTTCACAGCTCTCTGCCCAGCATCTGACCCTAAACCAAACTTCACAGACTGTAATAGGCATA CACAAGTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAATATGGCTTAGAGGAGTGTACGTGTGCCAGTTCTGATGGCAAAG ATGATAAAGAATTATGCCATGTATGCTGTATGAAGAAAATGGACCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAGTAGGCACT TCAGTGGTCGAACCATCACCCTGCAACCTGGATCCCCTTGCAACGATTTTAGAGGTTACTGTGATGTTTTCATGCGGTGCAGATTAGTAG ATGCTGATGGTCCTCTAGCTAGGCTTAAAAAAGCAATTTTTAGTCCAGAGCTCTATGAAAACATTGCTGAATGGATTGTGGCTCATTGGT GGGCAGTATTACTTATGGGAATTGCTCTGATCATGCTAATGGCTGGATTTATTAAGATATGCAGTGTTCATACTCCAAGTAGTAATCCAA AGTTGCCTCCTCCTAAACCACTTCCAGGCACTTTAAAGAGGAGGAGACCTCCACAGCCCATTCAGCAACCCCAGCGTCAGCGGCCCCGAG AGAGTTATCAAATGGGACACATGAGACGCTAACTGCAGCTTTTGCCTTGGTTCTTCCTAGTGCCTACAATGGGAAAACTTCACTCCAAAG AGAAACCTATTAAGTCATCATCTCCAAACTAAACCCTCACAAGTAACAGTTGAAGAAAAAATGGCAAGAGATCATATCCTCAGACCAGGT GGAATTACTTAAATTTTAAAGCCTGAAAATTCCAATTTGGGGGTGGGAGGTGGAAAAGGAACCCAATTTTCTTATGAACAGATATTTTTA ACTTAATGGCACAAAGTCTTAGAATATTATTATGTGCCCCGTGTTCCCTGTTCTTCGTTGCTGCATTTTCTTCACTTGCAGGCAAACTTG GCTCTCAATAAACTTTTACCACAAATTGAAATAAATATATTTTTTTCAACTGCCAATCAAGGCTAGGAGGCTCGACCACCTCAACATTGG AGACATCACTTGCCAATGTACATACCTTGTTATATGCAGACATGTATTTCTTACGTACACTGTACTTCTGTGTGCAATTGTAAACAGAAA TTGCAATATGGATGTTTCTTTGTATTATAAAATTTTTCCGCTCTTAATTAAAAATTACTGTTTAATTGACATACTCAGGATAACAGAGAA TGGTGGTATTCAGTGGTCCAGGATTCTGTAATGCTTTACACAGGCAGTTTTGAAATGAAAATCAATTTACCTTTCTGTTACGATGGAGTT GGTTTTGATACTCATTTTTTCTTTATCACATGGCTGCTACGGGCACAAGTGACTATACTGAAGAACACAGTTAAGTGTTGTGCAAACTGG ACATAGCAGCACATACTACTTCAGAGTTCATGATGTAGATGTCTGGTTTCTGCTTACGTCTTTTAAACTTTCTAATTCAATTCCATTTTT CAATTAATAGGTGAAATTTTATTCATGCTTTGATAGAAATTATGTCAATGAAATGATTCTTTTTATTTGTAGCCTACTTATTTGTGTTTT TCATATATCTGAAATATGCTAATTATGTTTTCTGTCTGATATGGAAAAGAAAAGCTGTGTCTTTATCAAAATATTTAAACGGTTTTTTCA GCATATCATCACTGATCATTGGTAACCACTAAAGATGAGTAATTTGCTTAAGTAGTAGTTAAAATTGTAGATAGGCCTTCTGACATTTTT TTTCCTAAAATTTTTAACAGCATTGAAGGTGAAACAGCACAATGTCCCATTCCAAATTTATTTTTGAAACAGATGTAAATAATTGGCATT TTAAAGAGAAAGCAAAAACATTTAATGTATTAACAGGCTTATTGCTATGCAGGAAATAGAAGGGGCATTACAAAAATTGAAGCTTGTGAC ATATTTATTGCTTCTGTTTTCCAACTACATCACTTCAACTAGAAGTAAAGCTATGATTTTCCTGACTTCACATAGGAGGCAAATTTAGAG AAAGTTGTAAAGATTTCTATGTTTTGGGTTTTTTTTTTTCCTTTTTTTTTTTAAGAGTATAAGGTTTACACAATCATTCTCATAATGTGA CGCAAGCCAGCAAGGCCAAAAATGCTAGAGAAAATAACGGGATCTCTTCCTTGTAAACTTGTACAGTATGTGGTGACTTTTTCAAAATAC AGCTTTTTGTACATGATTTAGAGACAAATTTTGTACATGAAACCCCAGATAGACTATAAATAATTCTAAACAAACAAGTAGGTAGATATG TATGTAATTGCTTTTAAATCATTTAAATGCCTTTGTTTTTGGACTGTGCAAAGGTTGGAAGTGGGTTTGCATTTCTAAAATGGTGACTTT TATTCTGCAAGAGTTCTTAGTAACTTCTTGAGTGTGGTAGACTTTGGAACATGTAAATTTTTTGCTTGTAATGTTATCCTGTGGTAGGAT TTTGGCAGGTACACACACTGCCCTATTTTATTTTGAGTCTAAGTTAAATGTTTTCTGAAAAGAGATACATGCACTGAACTCTTTCCACTG CGAATCAAGATGTGGTAATATAAAAGGATCAAGACAAATGAGATCTAATACTACTGTCAGTTTTAATGTCCACTGTGTTTTATACAGTAT CTTTTTTTGTTCACTTTGGAAATTTTTACTAAAAATTGCAAAAAATAAAGTATTGTGCAAAGATGTAAGGTTTTTTGAAACTTGAAATGC ATTAATAAATAGACGATTAAATCAACTTGAAGGTTCTATACTCTTTGAACTCTGAGAACTATCACAAGAAGCTTCCCACAAGGCAGTGTT TTCTTACAGTTGTCTCTTCCTACAAAAGTATAGATTATCTTTATTCTTAATACTTTGGAATCCATGTAGAAAATTTCCAGTTAGATACTC >90758_90758_2_THSD4-ADAM10_THSD4_chr15_71549054_ENST00000355327_ADAM10_chr15_58957396_ENST00000260408_length(amino acids)=925AA_BP=338 MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGG QRPGAPARAFADHVVSAVRTSVPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEAPIYQLPLTHDQGYPAASSLFHSPETSNNHG VGTHGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEDYPHKYGPQGGCADHSVFERMR KYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVK RIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGII TVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFV ESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALC PASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCN DFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for THSD4-ADAM10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | ADAM10 | chr15:71549054 | chr15:58957396 | ENST00000260408 | 3 | 16 | 734_748 | 161.33333333333334 | 749.0 | AP2A1%2C AP2A2 and AP2M1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for THSD4-ADAM10 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for THSD4-ADAM10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | THSD4 | C0013146 | Drug abuse | 1 | CTD_human |
Hgene | THSD4 | C0013170 | Drug habituation | 1 | CTD_human |
Hgene | THSD4 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Hgene | THSD4 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Hgene | THSD4 | C0038580 | Substance Dependence | 1 | CTD_human |
Hgene | THSD4 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Hgene | THSD4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | THSD4 | C0740858 | Substance abuse problem | 1 | CTD_human |
Hgene | THSD4 | C1510472 | Drug Dependence | 1 | CTD_human |
Hgene | THSD4 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
Tgene | C3810041 | ALZHEIMER DISEASE 18 | 2 | CTD_human;UNIPROT | |
Tgene | C0002395 | Alzheimer's Disease | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0011265 | Presenile dementia | 1 | CTD_human | |
Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human | |
Tgene | C0406811 | Reticulate acropigmentation of Kitamura | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human | |
Tgene | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human | |
Tgene | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |