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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:NUP85-ZDHHC18 (FusionGDB2 ID:HG79902TG84243)

Fusion Gene Summary for NUP85-ZDHHC18

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP85-ZDHHC18
Fusion gene ID: hg79902tg84243
HgeneTgene
Gene symbol

NUP85

ZDHHC18

Gene ID

79902

84243

Gene namenucleoporin 85zinc finger DHHC-type palmitoyltransferase 18
SynonymsFROUNT|NPHS17|Nup75DHHC-18|DHHC18
Cytomap('NUP85')('ZDHHC18')

17q25.1

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85palmitoyltransferase ZDHHC18zinc finger DHHC domain-containing protein 18zinc finger DHHC-type containing 18zinc finger, DHHC domain containing 18
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000245544, ENST00000447371, 
ENST00000540768, ENST00000541827, 
ENST00000579298, ENST00000579324, 
ENST00000449421, 
Fusion gene scores* DoF score7 X 5 X 6=2105 X 4 X 5=100
# samples 76
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP85 [Title/Abstract] AND ZDHHC18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP85(73229253)-ZDHHC18(27180217), # samples:3
Anticipated loss of major functional domain due to fusion event.NUP85-ZDHHC18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP85-ZDHHC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZDHHC18

GO:0018345

protein palmitoylation

23034182


check buttonFusion gene breakpoints across NUP85 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZDHHC18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A1HR-01ANUP85chr17

73229253

-ZDHHC18chr1

27180217

+
ChimerDB4BLCATCGA-CF-A1HR-01ANUP85chr17

73229253

+ZDHHC18chr1

27180217

+


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Fusion Gene ORF analysis for NUP85-ZDHHC18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000245544ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
5CDS-intronENST00000447371ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
5CDS-intronENST00000540768ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
5CDS-intronENST00000541827ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
5CDS-intronENST00000579298ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
5CDS-intronENST00000579324ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000245544ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000447371ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000540768ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000541827ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000579298ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
In-frameENST00000579324ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
intron-3CDSENST00000449421ENST00000374142NUP85chr17

73229253

+ZDHHC18chr1

27180217

+
intron-intronENST00000449421ENST00000478902NUP85chr17

73229253

+ZDHHC18chr1

27180217

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245544NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+55621686561690544
ENST00000541827NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+54521576991580493
ENST00000579324NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+54521576991580493
ENST00000579298NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+53981522271526499
ENST00000447371NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+541115353971539380
ENST00000540768NUP85chr1773229253+ENST00000374142ZDHHC18chr127180217+536814927801496238

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245544ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0028690490.99713093
ENST00000541827ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0047119610.995288
ENST00000579324ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0047119610.995288
ENST00000579298ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0030467620.99695325
ENST00000447371ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0108106560.9891894
ENST00000540768ENST00000374142NUP85chr1773229253+ZDHHC18chr127180217+0.0381617470.96183825

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Fusion Genomic Features for NUP85-ZDHHC18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUP85chr1773229253+ZDHHC18chr127180216+7.50E-060.9999925
NUP85chr1773229253+ZDHHC18chr127180216+7.50E-060.9999925

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NUP85-ZDHHC18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73229253/chr1:27180217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZDHHC18chr17:73229253chr1:27180217ENST000003741426811_46349389.0Compositional biasPro-rich
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268192_242349389.0DomainDHHC
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268112_119349389.0Topological domainLumenal
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268141_235349389.0Topological domainCytoplasmic
TgeneZDHHC18chr17:73229253chr1:27180217ENST00000374142681_90349389.0Topological domainCytoplasmic
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268257_277349389.0Topological domainLumenal
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268299_388349389.0Topological domainCytoplasmic
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268120_140349389.0TransmembraneHelical
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268236_256349389.0TransmembraneHelical
TgeneZDHHC18chr17:73229253chr1:27180217ENST0000037414268278_298349389.0TransmembraneHelical
TgeneZDHHC18chr17:73229253chr1:27180217ENST000003741426891_111349389.0TransmembraneHelical


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Fusion Gene Sequence for NUP85-ZDHHC18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61094_61094_1_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000245544_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5562nt_BP=1686nt
GCTCTGAGCGGGAGGCCTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCG
AGCCAACAGTCACTTTGATTCCAGGCGTGAATTCCAAGAAGAACCAAATGTATTTTGACTGGGGTCCAGGGGAGATGCTGGTATGTGAAA
CCTCCTTCAACAAAAAAGAAAAATCAGAGATGGTGCCAAGTTGCCCCTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAA
TCTTGAGAAAACTCTTCAATGAATCCCATGGAATCTTTCTGGGCCTCCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTC
AATTGGTTCGAGTGAGTAAAAACTACCGATCAGTCATCAGAGCATGTATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAG
CCAATGGCCGCCAGTTCAGCAGCCAGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGG
CCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCA
GTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCT
CCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGA
ACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCA
GCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATT
TCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGG
GAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCG
CCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCA
ACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACT
GCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCT
GTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCC
TCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTT
CTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGCCTAATTGACCGGAGGGGATTTGT
GCAGTCCGACACCGTGTTGCCCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAGCCTGATGCCAGCATGGTAGGAGGCCACCC
CTGACCACGGCTCAGTACTTGCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCGGGACCCTCCCTATTCCATCCAAGGGAAGC
AGAACTGCCAAAGACTCAAGTCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGAACTGTTCCGTGGCTGTGCCCTCTGCTCCC
CAAACCCAGGTTCCCACAGCCTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGACCAGAGCCTCTGGAGGCTACCCAGGGGAC
CACACCAAGTCCTTGCCTGTGCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGTGAGGCCTCCCAGGTGGGGGAACTGCTTGG
GCCTTGCTGAGCCAGGGTCCTCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAGCTGGCTGTGGAGAGGAAGCCTCCATGGGC
TGCTTTGGTCTGTGGGCTCCTTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATTTTTGGTGGGGTTTTCCCCCCTTTTTTATG
GAGTTGGCCAATAGGATTGAGTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGGGGGCAGCCTGTATCAGACAAAGGTAAATC
AGCCAGCCAGGCACCCACAGCCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTGGGAGCCTGGTCCTTCCCCTGCCCATGGAG
AGCTCTTTAAGGGATCCCAGCCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGGGTGGGTTATGCTCATGCTGGCAATACTTG
AAACGGGTTTATTAATGCTGGGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTCTTTTTTAAATGGAAGGAGAAAATGTCAGC
CACATTACTGTCTGTGTAGTGCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAAGTTTATTCCAAGAGACCTTCTGGCTGGAA
TGAGTGAGAGTGTGTGTGCATGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTGGCTCCCATATCCCCTGGGCTGCCCCCTGC
CCCATCCCCTTTGAGTGTCAGAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGGTCACGAGAAAACCCTGGGCTCCCACTGGG
GCTCAGCCCAGCCTCCTATCTTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGACTCTGCCACTCTACCCCCAGCCCTACCCA
CCAGCCCCCAGGTGAGGCTTCCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGTGGGTGGGGTGATGGCTCTGGGGAGCGGCT
GCCATCCTACAAGCCACACCCCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGCTGGAAGACAAGGTGTTTCTGCCAAACGGG
GACCTCCATCCAGAGAAAAGGAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGGCCTGAGTCTGGGCCGGAAACTCAGAGGAT
GTTTCTCCTCTGCTGGGAGCTGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCCTCCTTGGCCCTTCAAGTGGGCTGAAGCCC
TTGGAAAGTGACATAGGAAGTCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCACAGACAGCTGGGAATGGCAGCCACAGAGG
GTCCCCTCTGGGAGAAACAGCTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGGCCCTGGGAGGTGAGGAAGAAGCTGGCTAG
AGGAGGGGGCTCCCACCTACCTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAAAACTTCAGTTTATAAGAGTTGCTTTGCTT
TGGTTTGGTTTTTGTTTGCTTTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTTCAGACAAATTTGGTTCTTTCCTGGGGAGA
CTGTGAGAAGGCAGGCAGCCCAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCTGTCCGCTGGAGGAAGAGCAGAGAGGGCTG
CGGCTGAGCCCCCATGGGCACGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCACCTTCCCCTGCCTCAGGGGCTTGGAGACCC
CCAAATTCTTCTTCCCTACTGCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAAATGTTTGAGACAGTAGATTCCAGTTTGAG
AGCCGGAGCTTCCCTGGCTACCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCATAACACTGGCCCACCTCTCTGGTATCTCC
CTCAGGAGGACACCTGTCAGGATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGGCCTCTTTGCAGAGGGTTAGCTGGTAAGAC
CGTTTCTTCCCTGTCGGCCAGCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGCATGCCTCGCCAACCCCATGGAGCCCGTCC
ATCTGTCTGGTGTGTGGTGCGGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCCGCTAAGCAGAAGGATCGGGATATAGGGCA
AGGCTAAAAGCCCAGCCCCATTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCAGCTGGAAGAGGAGGTGGAGGGTGAGGCTG
GGGAGAGGATGGCGAACCTGCCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATGCAGGGGCCACCGGTCACTAACACTCTTAT
GTCCTGGCTTTCTGTCCCCGCTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCATTGCCTGCTGCCTAAGCCTTGGCCCTTCTC
TCGGGCAGAGGCAGGTGCTGTGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGCCTCCCTCCTCCCAGGCCTGCTAACCCTCT
CTCTTCTCCTTCTTTGCTGTCCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCTCCTGAGGACCGCTGCTCTCTGCCTCTCCA
GGAATGGCCTGGGGGGAGCCAGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCTGCCACCATCTGTGCCTACAGGGTCTGCCC
CCCAGCCTGCCCGGCCTGTGTGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTTTGCCCCATTCCCGCTCCATGCCGGCCAGA
GTGTAGAAAGCCATAACGCAGCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCCTCTCTCCTCCACTGACTTCCCCTTCCCGG
ATTTGTGAGGTGTCAAGACTAGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGATCAGGCATAGCCATAGTCAAGCCCAGCAGG
TTTCCTCAGGAGCTGTCTGGGGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGACTGTTCTAAGCACAACTGGCTTGATACTGT
TCCCACGGCCTGTCCACCTCCCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAGGGTGCGTGCCTCCTTTGCTCTAGGCACTG
AGGGACCAAGCTAGCCGTGCACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAGCCAAGGAAAATCAGCTGAGCCCAGGGCTG

>61094_61094_1_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000245544_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=544AA_BP=
MGFGAMEELDGEPTVTLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRI
DEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVC
EVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEEC
ERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEF
DIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLN
TEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRL

--------------------------------------------------------------
>61094_61094_2_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000447371_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5411nt_BP=1535nt
ATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTTTGATTCCAGGCGTG
AATTCCAAGAAGAACCAAATGTATTTTGACTGGGGTCCAGGGGAGATGCTGGTATGTGAAACCTCCTTCAACAAAAAAGAAAAATCAGAG
ATGGTGCCAAGTTGCCCCTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAATGAATCCCAT
GGAATCTTTCTGGGCCTCCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAAAACTACCGA
TCAGTCATCAGAGCATGTATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTC
TCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGGTGACCATCTTGGTGCTGCAGGG
CCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGAT
GAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCG
GTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCA
GAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTA
TGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACAT
CCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCT
CCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTG
GCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGA
GCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGC
CGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCT
CAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATT
CCTGGCCTAATTGACCGGAGGGGATTTGTGCAGTCCGACACCGTGTTGCCCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAG
CCTGATGCCAGCATGGTAGGAGGCCACCCCTGACCACGGCTCAGTACTTGCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCG
GGACCCTCCCTATTCCATCCAAGGGAAGCAGAACTGCCAAAGACTCAAGTCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGA
ACTGTTCCGTGGCTGTGCCCTCTGCTCCCCAAACCCAGGTTCCCACAGCCTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGA
CCAGAGCCTCTGGAGGCTACCCAGGGGACCACACCAAGTCCTTGCCTGTGCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGT
GAGGCCTCCCAGGTGGGGGAACTGCTTGGGCCTTGCTGAGCCAGGGTCCTCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAG
CTGGCTGTGGAGAGGAAGCCTCCATGGGCTGCTTTGGTCTGTGGGCTCCTTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATT
TTTGGTGGGGTTTTCCCCCCTTTTTTATGGAGTTGGCCAATAGGATTGAGTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGG
GGGCAGCCTGTATCAGACAAAGGTAAATCAGCCAGCCAGGCACCCACAGCCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTG
GGAGCCTGGTCCTTCCCCTGCCCATGGAGAGCTCTTTAAGGGATCCCAGCCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGG
GTGGGTTATGCTCATGCTGGCAATACTTGAAACGGGTTTATTAATGCTGGGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTC
TTTTTTAAATGGAAGGAGAAAATGTCAGCCACATTACTGTCTGTGTAGTGCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAA
GTTTATTCCAAGAGACCTTCTGGCTGGAATGAGTGAGAGTGTGTGTGCATGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTG
GCTCCCATATCCCCTGGGCTGCCCCCTGCCCCATCCCCTTTGAGTGTCAGAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGG
TCACGAGAAAACCCTGGGCTCCCACTGGGGCTCAGCCCAGCCTCCTATCTTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGA
CTCTGCCACTCTACCCCCAGCCCTACCCACCAGCCCCCAGGTGAGGCTTCCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGT
GGGTGGGGTGATGGCTCTGGGGAGCGGCTGCCATCCTACAAGCCACACCCCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGC
TGGAAGACAAGGTGTTTCTGCCAAACGGGGACCTCCATCCAGAGAAAAGGAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGG
CCTGAGTCTGGGCCGGAAACTCAGAGGATGTTTCTCCTCTGCTGGGAGCTGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCC
TCCTTGGCCCTTCAAGTGGGCTGAAGCCCTTGGAAAGTGACATAGGAAGTCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCA
CAGACAGCTGGGAATGGCAGCCACAGAGGGTCCCCTCTGGGAGAAACAGCTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGG
CCCTGGGAGGTGAGGAAGAAGCTGGCTAGAGGAGGGGGCTCCCACCTACCTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAA
AACTTCAGTTTATAAGAGTTGCTTTGCTTTGGTTTGGTTTTTGTTTGCTTTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTT
CAGACAAATTTGGTTCTTTCCTGGGGAGACTGTGAGAAGGCAGGCAGCCCAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCT
GTCCGCTGGAGGAAGAGCAGAGAGGGCTGCGGCTGAGCCCCCATGGGCACGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCAC
CTTCCCCTGCCTCAGGGGCTTGGAGACCCCCAAATTCTTCTTCCCTACTGCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAA
ATGTTTGAGACAGTAGATTCCAGTTTGAGAGCCGGAGCTTCCCTGGCTACCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCA
TAACACTGGCCCACCTCTCTGGTATCTCCCTCAGGAGGACACCTGTCAGGATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGG
CCTCTTTGCAGAGGGTTAGCTGGTAAGACCGTTTCTTCCCTGTCGGCCAGCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGC
ATGCCTCGCCAACCCCATGGAGCCCGTCCATCTGTCTGGTGTGTGGTGCGGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCC
GCTAAGCAGAAGGATCGGGATATAGGGCAAGGCTAAAAGCCCAGCCCCATTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCA
GCTGGAAGAGGAGGTGGAGGGTGAGGCTGGGGAGAGGATGGCGAACCTGCCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATG
CAGGGGCCACCGGTCACTAACACTCTTATGTCCTGGCTTTCTGTCCCCGCTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCAT
TGCCTGCTGCCTAAGCCTTGGCCCTTCTCTCGGGCAGAGGCAGGTGCTGTGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGC
CTCCCTCCTCCCAGGCCTGCTAACCCTCTCTCTTCTCCTTCTTTGCTGTCCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCT
CCTGAGGACCGCTGCTCTCTGCCTCTCCAGGAATGGCCTGGGGGGAGCCAGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCT
GCCACCATCTGTGCCTACAGGGTCTGCCCCCCAGCCTGCCCGGCCTGTGTGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTT
TGCCCCATTCCCGCTCCATGCCGGCCAGAGTGTAGAAAGCCATAACGCAGCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCC
TCTCTCCTCCACTGACTTCCCCTTCCCGGATTTGTGAGGTGTCAAGACTAGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGAT
CAGGCATAGCCATAGTCAAGCCCAGCAGGTTTCCTCAGGAGCTGTCTGGGGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGAC
TGTTCTAAGCACAACTGGCTTGATACTGTTCCCACGGCCTGTCCACCTCCCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAG
GGTGCGTGCCTCCTTTGCTCTAGGCACTGAGGGACCAAGCTAGCCGTGCACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAG
CCAAGGAAAATCAGCTGAGCCCAGGGCTGGGGGCTGCTTGTCTGCTATCCTGTACCTTTTTTTTTTTTAACCAAAATAAAGATTCCCCTC

>61094_61094_2_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000447371_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=380AA_BP=
MQLLLKIQPMAASSAARSPFCQQWSSSGTCVRFFLLKWPQVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQ
TLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGE
SSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPE
LGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDL

--------------------------------------------------------------
>61094_61094_3_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000540768_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5368nt_BP=1492nt
TTTAGGAATAAAACAGATTTGAGCAGAAGAAGTCTGTTGGATGCAGGGAGTATAAAAGGGGAAAGCATCCTGCTGTTTCCAGTGGCAGAA
GAGAAAGAGAAGTACCATGAAGAGGGGTGAACAACATCACTCTCGTGCCGGACACAGACAAGGAATGATTAGGCTTGCAGTCCCCCAGTC
TCAGCCTCTCTCCACTCTCACAAGCAGGAAGGGATCTGAGCTCTGTTAGTGGGAAATCTTGGAGTTTGCATTTCTCTGATCACGAGGCTA
CCTCCTATCCTGTTTTGAAAGAGGAACAGAAAAGCAGAGCTTGTCCCAGGAATTGTGAAATGGGCTGCAATGTCTTCAGAGGCAGTAGCA
GTTTTAGGAAGTGTGCCCTCCTGGCTCTGGGGAAAGGTTGAATTGGGGTCTTGTGGGCACTTGTTTTCTCATGGGATGTATCAGTCAGAC
CCATGCACAGTTCTGGGCGGCAGGGAAGTGTGTCTCTTTCTGGACTTGAGCCAGTGAGCTGTTGGCATGCCTTTTTAAAGGCATTAGAAA
AAAGGTTTCTTTCTTTTTTTTCCTTTCCTGTTCACACCACCTTCATATGAACATGGAGAAGGGAGGTTTCTAAGTGGGCCCCTGATTTAC
TCCTATGTCAATAATCGTGCCAGACCCTAAGGGGCAGAAAAGGCAGCCAGGGGATCCTGACTCAGAGGCTGTAGTTCGTCAGCCCTGCTA
AAGGGCCAGGGGTTTGTCTCTCAGTGCCTGGGTGGGCATGCTTGACTGCTAACCCCTTAGCTGAAAGGAGATGGCAGGAGTCCTCCACAG
GGTCCCTTCTTCCCTCCTGGCTTACAGCTTCCTCTGAAGACGGGCCAGTTCCTTGCTGTCTGGCAAGAGGAAACAGCTGGGGTGCACTTC
ACTGGGAGTTGGGCAAGATGTCGGCAGTTTCCTGGTGCCCTTCAAGTCCTCCAAAAGTATCGAGCTAAAAGCATCGCCCTGAGCAACTGG
TGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTC
CTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGC
CGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAG
ATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATC
CGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTC
ATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGCCTAATTGACCGGAGGGGATTTGTGCAGTCCGACACCG
TGTTGCCCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAGCCTGATGCCAGCATGGTAGGAGGCCACCCCTGACCACGGCTCA
GTACTTGCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCGGGACCCTCCCTATTCCATCCAAGGGAAGCAGAACTGCCAAAGA
CTCAAGTCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGAACTGTTCCGTGGCTGTGCCCTCTGCTCCCCAAACCCAGGTTCC
CACAGCCTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGACCAGAGCCTCTGGAGGCTACCCAGGGGACCACACCAAGTCCTT
GCCTGTGCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGTGAGGCCTCCCAGGTGGGGGAACTGCTTGGGCCTTGCTGAGCCA
GGGTCCTCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAGCTGGCTGTGGAGAGGAAGCCTCCATGGGCTGCTTTGGTCTGTG
GGCTCCTTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATTTTTGGTGGGGTTTTCCCCCCTTTTTTATGGAGTTGGCCAATAG
GATTGAGTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGGGGGCAGCCTGTATCAGACAAAGGTAAATCAGCCAGCCAGGCAC
CCACAGCCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTGGGAGCCTGGTCCTTCCCCTGCCCATGGAGAGCTCTTTAAGGGA
TCCCAGCCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGGGTGGGTTATGCTCATGCTGGCAATACTTGAAACGGGTTTATTA
ATGCTGGGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTCTTTTTTAAATGGAAGGAGAAAATGTCAGCCACATTACTGTCTG
TGTAGTGCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAAGTTTATTCCAAGAGACCTTCTGGCTGGAATGAGTGAGAGTGTG
TGTGCATGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTGGCTCCCATATCCCCTGGGCTGCCCCCTGCCCCATCCCCTTTGA
GTGTCAGAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGGTCACGAGAAAACCCTGGGCTCCCACTGGGGCTCAGCCCAGCCT
CCTATCTTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGACTCTGCCACTCTACCCCCAGCCCTACCCACCAGCCCCCAGGTG
AGGCTTCCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGTGGGTGGGGTGATGGCTCTGGGGAGCGGCTGCCATCCTACAAGC
CACACCCCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGCTGGAAGACAAGGTGTTTCTGCCAAACGGGGACCTCCATCCAGA
GAAAAGGAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGGCCTGAGTCTGGGCCGGAAACTCAGAGGATGTTTCTCCTCTGCT
GGGAGCTGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCCTCCTTGGCCCTTCAAGTGGGCTGAAGCCCTTGGAAAGTGACAT
AGGAAGTCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCACAGACAGCTGGGAATGGCAGCCACAGAGGGTCCCCTCTGGGAG
AAACAGCTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGGCCCTGGGAGGTGAGGAAGAAGCTGGCTAGAGGAGGGGGCTCCC
ACCTACCTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAAAACTTCAGTTTATAAGAGTTGCTTTGCTTTGGTTTGGTTTTTG
TTTGCTTTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTTCAGACAAATTTGGTTCTTTCCTGGGGAGACTGTGAGAAGGCAG
GCAGCCCAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCTGTCCGCTGGAGGAAGAGCAGAGAGGGCTGCGGCTGAGCCCCCA
TGGGCACGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCACCTTCCCCTGCCTCAGGGGCTTGGAGACCCCCAAATTCTTCTTC
CCTACTGCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAAATGTTTGAGACAGTAGATTCCAGTTTGAGAGCCGGAGCTTCCC
TGGCTACCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCATAACACTGGCCCACCTCTCTGGTATCTCCCTCAGGAGGACACC
TGTCAGGATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGGCCTCTTTGCAGAGGGTTAGCTGGTAAGACCGTTTCTTCCCTGT
CGGCCAGCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGCATGCCTCGCCAACCCCATGGAGCCCGTCCATCTGTCTGGTGTG
TGGTGCGGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCCGCTAAGCAGAAGGATCGGGATATAGGGCAAGGCTAAAAGCCCA
GCCCCATTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCAGCTGGAAGAGGAGGTGGAGGGTGAGGCTGGGGAGAGGATGGCG
AACCTGCCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATGCAGGGGCCACCGGTCACTAACACTCTTATGTCCTGGCTTTCTG
TCCCCGCTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCATTGCCTGCTGCCTAAGCCTTGGCCCTTCTCTCGGGCAGAGGCAG
GTGCTGTGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGCCTCCCTCCTCCCAGGCCTGCTAACCCTCTCTCTTCTCCTTCTT
TGCTGTCCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCTCCTGAGGACCGCTGCTCTCTGCCTCTCCAGGAATGGCCTGGGG
GGAGCCAGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCTGCCACCATCTGTGCCTACAGGGTCTGCCCCCCAGCCTGCCCGG
CCTGTGTGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTTTGCCCCATTCCCGCTCCATGCCGGCCAGAGTGTAGAAAGCCAT
AACGCAGCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCCTCTCTCCTCCACTGACTTCCCCTTCCCGGATTTGTGAGGTGTC
AAGACTAGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGATCAGGCATAGCCATAGTCAAGCCCAGCAGGTTTCCTCAGGAGCT
GTCTGGGGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGACTGTTCTAAGCACAACTGGCTTGATACTGTTCCCACGGCCTGTC
CACCTCCCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAGGGTGCGTGCCTCCTTTGCTCTAGGCACTGAGGGACCAAGCTAG
CCGTGCACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAGCCAAGGAAAATCAGCTGAGCCCAGGGCTGGGGGCTGCTTGTCT

>61094_61094_3_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000540768_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=238AA_BP=
MKGDGRSPPQGPFFPPGLQLPLKTGQFLAVWQEETAGVHFTGSWARCRQFPGALQVLQKYRAKSIALSNWWFVAHLTDLLDHCKLLQSHN
LYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNN

--------------------------------------------------------------
>61094_61094_4_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000541827_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5452nt_BP=1576nt
CTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTAA
AAATCAGAGATGGTGCCAAGTTGCCCCTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAAT
GAATCCCATGGAATCTTTCTGGGCCTCCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAA
AACTACCGATCAGTCATCAGAGCATGTATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGC
AGCCAGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTC
CTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACAT
GACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGC
CCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAG
CTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTC
TTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTG
TACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAA
CCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTT
GTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTG
CTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTC
TCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACT
GAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCT
AAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGAC
AACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGCCTAATTGACCGGAGGGGATTTGTGCAGTCCGACACCGTGTTGC
CCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAGCCTGATGCCAGCATGGTAGGAGGCCACCCCTGACCACGGCTCAGTACTT
GCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCGGGACCCTCCCTATTCCATCCAAGGGAAGCAGAACTGCCAAAGACTCAAG
TCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGAACTGTTCCGTGGCTGTGCCCTCTGCTCCCCAAACCCAGGTTCCCACAGC
CTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGACCAGAGCCTCTGGAGGCTACCCAGGGGACCACACCAAGTCCTTGCCTGT
GCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGTGAGGCCTCCCAGGTGGGGGAACTGCTTGGGCCTTGCTGAGCCAGGGTCC
TCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAGCTGGCTGTGGAGAGGAAGCCTCCATGGGCTGCTTTGGTCTGTGGGCTCC
TTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATTTTTGGTGGGGTTTTCCCCCCTTTTTTATGGAGTTGGCCAATAGGATTGA
GTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGGGGGCAGCCTGTATCAGACAAAGGTAAATCAGCCAGCCAGGCACCCACAG
CCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTGGGAGCCTGGTCCTTCCCCTGCCCATGGAGAGCTCTTTAAGGGATCCCAG
CCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGGGTGGGTTATGCTCATGCTGGCAATACTTGAAACGGGTTTATTAATGCTG
GGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTCTTTTTTAAATGGAAGGAGAAAATGTCAGCCACATTACTGTCTGTGTAGT
GCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAAGTTTATTCCAAGAGACCTTCTGGCTGGAATGAGTGAGAGTGTGTGTGCA
TGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTGGCTCCCATATCCCCTGGGCTGCCCCCTGCCCCATCCCCTTTGAGTGTCA
GAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGGTCACGAGAAAACCCTGGGCTCCCACTGGGGCTCAGCCCAGCCTCCTATC
TTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGACTCTGCCACTCTACCCCCAGCCCTACCCACCAGCCCCCAGGTGAGGCTT
CCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGTGGGTGGGGTGATGGCTCTGGGGAGCGGCTGCCATCCTACAAGCCACACC
CCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGCTGGAAGACAAGGTGTTTCTGCCAAACGGGGACCTCCATCCAGAGAAAAG
GAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGGCCTGAGTCTGGGCCGGAAACTCAGAGGATGTTTCTCCTCTGCTGGGAGC
TGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCCTCCTTGGCCCTTCAAGTGGGCTGAAGCCCTTGGAAAGTGACATAGGAAG
TCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCACAGACAGCTGGGAATGGCAGCCACAGAGGGTCCCCTCTGGGAGAAACAG
CTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGGCCCTGGGAGGTGAGGAAGAAGCTGGCTAGAGGAGGGGGCTCCCACCTAC
CTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAAAACTTCAGTTTATAAGAGTTGCTTTGCTTTGGTTTGGTTTTTGTTTGCT
TTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTTCAGACAAATTTGGTTCTTTCCTGGGGAGACTGTGAGAAGGCAGGCAGCC
CAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCTGTCCGCTGGAGGAAGAGCAGAGAGGGCTGCGGCTGAGCCCCCATGGGCA
CGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCACCTTCCCCTGCCTCAGGGGCTTGGAGACCCCCAAATTCTTCTTCCCTACT
GCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAAATGTTTGAGACAGTAGATTCCAGTTTGAGAGCCGGAGCTTCCCTGGCTA
CCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCATAACACTGGCCCACCTCTCTGGTATCTCCCTCAGGAGGACACCTGTCAG
GATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGGCCTCTTTGCAGAGGGTTAGCTGGTAAGACCGTTTCTTCCCTGTCGGCCA
GCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGCATGCCTCGCCAACCCCATGGAGCCCGTCCATCTGTCTGGTGTGTGGTGC
GGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCCGCTAAGCAGAAGGATCGGGATATAGGGCAAGGCTAAAAGCCCAGCCCCA
TTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCAGCTGGAAGAGGAGGTGGAGGGTGAGGCTGGGGAGAGGATGGCGAACCTG
CCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATGCAGGGGCCACCGGTCACTAACACTCTTATGTCCTGGCTTTCTGTCCCCG
CTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCATTGCCTGCTGCCTAAGCCTTGGCCCTTCTCTCGGGCAGAGGCAGGTGCTG
TGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGCCTCCCTCCTCCCAGGCCTGCTAACCCTCTCTCTTCTCCTTCTTTGCTGT
CCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCTCCTGAGGACCGCTGCTCTCTGCCTCTCCAGGAATGGCCTGGGGGGAGCC
AGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCTGCCACCATCTGTGCCTACAGGGTCTGCCCCCCAGCCTGCCCGGCCTGTG
TGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTTTGCCCCATTCCCGCTCCATGCCGGCCAGAGTGTAGAAAGCCATAACGCA
GCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCCTCTCTCCTCCACTGACTTCCCCTTCCCGGATTTGTGAGGTGTCAAGACT
AGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGATCAGGCATAGCCATAGTCAAGCCCAGCAGGTTTCCTCAGGAGCTGTCTGG
GGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGACTGTTCTAAGCACAACTGGCTTGATACTGTTCCCACGGCCTGTCCACCTC
CCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAGGGTGCGTGCCTCCTTTGCTCTAGGCACTGAGGGACCAAGCTAGCCGTGC
ACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAGCCAAGGAAAATCAGCTGAGCCCAGGGCTGGGGGCTGCTTGTCTGCTATC

>61094_61094_4_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000541827_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=493AA_BP=
MVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRIDEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQV
SILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPAS
AGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSN
PTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEY
ASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDA

--------------------------------------------------------------
>61094_61094_5_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000579298_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5398nt_BP=1522nt
ATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTTTGATTCCAGGCGTG
AATTCCAAGAAGAACCAAATGTATTTTGACTGGGGTCCAGGGGAGATGCTGGTATGTGAAACCTCCTTCAACAAAAAAGAAAAATCAGAG
ATGGTGCCAAGTTGCCCCTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAATGAATCCCAT
GGAATCTTTCTGGGCCTCCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAAAACTACCGA
TCAGTCATCAGAGCATGTATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTC
TCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTC
CTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTC
TGGAACTTGCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGAC
AGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTG
AGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGC
CTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATC
AAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAAC
CTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTC
GATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTG
AAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAAT
CGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGT
GAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGCCTAATTG
ACCGGAGGGGATTTGTGCAGTCCGACACCGTGTTGCCCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAGCCTGATGCCAGCA
TGGTAGGAGGCCACCCCTGACCACGGCTCAGTACTTGCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCGGGACCCTCCCTAT
TCCATCCAAGGGAAGCAGAACTGCCAAAGACTCAAGTCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGAACTGTTCCGTGGC
TGTGCCCTCTGCTCCCCAAACCCAGGTTCCCACAGCCTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGACCAGAGCCTCTGG
AGGCTACCCAGGGGACCACACCAAGTCCTTGCCTGTGCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGTGAGGCCTCCCAGG
TGGGGGAACTGCTTGGGCCTTGCTGAGCCAGGGTCCTCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAGCTGGCTGTGGAGA
GGAAGCCTCCATGGGCTGCTTTGGTCTGTGGGCTCCTTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATTTTTGGTGGGGTTT
TCCCCCCTTTTTTATGGAGTTGGCCAATAGGATTGAGTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGGGGGCAGCCTGTAT
CAGACAAAGGTAAATCAGCCAGCCAGGCACCCACAGCCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTGGGAGCCTGGTCCT
TCCCCTGCCCATGGAGAGCTCTTTAAGGGATCCCAGCCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGGGTGGGTTATGCTC
ATGCTGGCAATACTTGAAACGGGTTTATTAATGCTGGGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTCTTTTTTAAATGGA
AGGAGAAAATGTCAGCCACATTACTGTCTGTGTAGTGCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAAGTTTATTCCAAGA
GACCTTCTGGCTGGAATGAGTGAGAGTGTGTGTGCATGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTGGCTCCCATATCCC
CTGGGCTGCCCCCTGCCCCATCCCCTTTGAGTGTCAGAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGGTCACGAGAAAACC
CTGGGCTCCCACTGGGGCTCAGCCCAGCCTCCTATCTTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGACTCTGCCACTCTA
CCCCCAGCCCTACCCACCAGCCCCCAGGTGAGGCTTCCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGTGGGTGGGGTGATG
GCTCTGGGGAGCGGCTGCCATCCTACAAGCCACACCCCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGCTGGAAGACAAGGT
GTTTCTGCCAAACGGGGACCTCCATCCAGAGAAAAGGAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGGCCTGAGTCTGGGC
CGGAAACTCAGAGGATGTTTCTCCTCTGCTGGGAGCTGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCCTCCTTGGCCCTTC
AAGTGGGCTGAAGCCCTTGGAAAGTGACATAGGAAGTCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCACAGACAGCTGGGA
ATGGCAGCCACAGAGGGTCCCCTCTGGGAGAAACAGCTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGGCCCTGGGAGGTGA
GGAAGAAGCTGGCTAGAGGAGGGGGCTCCCACCTACCTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAAAACTTCAGTTTAT
AAGAGTTGCTTTGCTTTGGTTTGGTTTTTGTTTGCTTTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTTCAGACAAATTTGG
TTCTTTCCTGGGGAGACTGTGAGAAGGCAGGCAGCCCAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCTGTCCGCTGGAGGA
AGAGCAGAGAGGGCTGCGGCTGAGCCCCCATGGGCACGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCACCTTCCCCTGCCTC
AGGGGCTTGGAGACCCCCAAATTCTTCTTCCCTACTGCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAAATGTTTGAGACAG
TAGATTCCAGTTTGAGAGCCGGAGCTTCCCTGGCTACCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCATAACACTGGCCCA
CCTCTCTGGTATCTCCCTCAGGAGGACACCTGTCAGGATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGGCCTCTTTGCAGAG
GGTTAGCTGGTAAGACCGTTTCTTCCCTGTCGGCCAGCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGCATGCCTCGCCAAC
CCCATGGAGCCCGTCCATCTGTCTGGTGTGTGGTGCGGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCCGCTAAGCAGAAGG
ATCGGGATATAGGGCAAGGCTAAAAGCCCAGCCCCATTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCAGCTGGAAGAGGAG
GTGGAGGGTGAGGCTGGGGAGAGGATGGCGAACCTGCCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATGCAGGGGCCACCGG
TCACTAACACTCTTATGTCCTGGCTTTCTGTCCCCGCTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCATTGCCTGCTGCCTA
AGCCTTGGCCCTTCTCTCGGGCAGAGGCAGGTGCTGTGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGCCTCCCTCCTCCCA
GGCCTGCTAACCCTCTCTCTTCTCCTTCTTTGCTGTCCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCTCCTGAGGACCGCT
GCTCTCTGCCTCTCCAGGAATGGCCTGGGGGGAGCCAGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCTGCCACCATCTGTG
CCTACAGGGTCTGCCCCCCAGCCTGCCCGGCCTGTGTGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTTTGCCCCATTCCCG
CTCCATGCCGGCCAGAGTGTAGAAAGCCATAACGCAGCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCCTCTCTCCTCCACT
GACTTCCCCTTCCCGGATTTGTGAGGTGTCAAGACTAGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGATCAGGCATAGCCAT
AGTCAAGCCCAGCAGGTTTCCTCAGGAGCTGTCTGGGGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGACTGTTCTAAGCACA
ACTGGCTTGATACTGTTCCCACGGCCTGTCCACCTCCCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAGGGTGCGTGCCTCC
TTTGCTCTAGGCACTGAGGGACCAAGCTAGCCGTGCACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAGCCAAGGAAAATCA

>61094_61094_5_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000579298_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=499AA_BP=
MGFGAMEELDGEPTVTLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRI
DEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVC
EVDSLSADVLGSENPSKHDSFWNLPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVT
RLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMRE
FLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWS

--------------------------------------------------------------
>61094_61094_6_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000579324_ZDHHC18_chr1_27180217_ENST00000374142_length(transcript)=5452nt_BP=1576nt
CTGAGCGGGAAGCATTGGCGTCCGAGCGACTTCTAGGAGCCTGGGGTTCGGCGCTATGGAGGAGCTCGATGGCGAGCCAACAGTCACTAA
AAATCAGAGATGGTGCCAAGTTGCCCCTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAAT
GAATCCCATGGAATCTTTCTGGGCCTCCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAA
AACTACCGATCAGTCATCAGAGCATGTATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGC
AGCCAGGTCTCCATTTTGTCAGCAATGGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTC
CTCCATCTCCTTGACTGGGTCCGGCTCCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACAT
GACAGCTTCTGGAACTTGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGC
CCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAG
CTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTC
TTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTG
TACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAA
CCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTT
GTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTG
CTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTC
TCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACT
GAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCT
AAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGAC
AACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGCCTAATTGACCGGAGGGGATTTGTGCAGTCCGACACCGTGTTGC
CCTCACCCATCAGAAGCGATGAGCCAGCCTGCAGAGCCAAGCCTGATGCCAGCATGGTAGGAGGCCACCCCTGACCACGGCTCAGTACTT
GCCACCTGCTGGCCTGTCTGACCCTCCGCACTCACCTGCCGGGACCCTCCCTATTCCATCCAAGGGAAGCAGAACTGCCAAAGACTCAAG
TCTTTTCATATTTATTTCCCATCCTGCGTGGCTTTCCCTGAACTGTTCCGTGGCTGTGCCCTCTGCTCCCCAAACCCAGGTTCCCACAGC
CTTGGGCCCTAGGTACCCCAGCTGATCAGTGCCAGGAGAGACCAGAGCCTCTGGAGGCTACCCAGGGGACCACACCAAGTCCTTGCCTGT
GCCGGGCGAGCCCTGTGTGAGTGAGGCTGTGAACTGAGCGTGAGGCCTCCCAGGTGGGGGAACTGCTTGGGCCTTGCTGAGCCAGGGTCC
TCAGGGTGAAGCAGGACTGAGGAGTGGCCAGCTCTGGATAGCTGGCTGTGGAGAGGAAGCCTCCATGGGCTGCTTTGGTCTGTGGGCTCC
TTCATTCCCTTGGTGATAATTTCCCTTTATTCTGTGGGATTTTTGGTGGGGTTTTCCCCCCTTTTTTATGGAGTTGGCCAATAGGATTGA
GTTGGGGCTCCAGTAGAGAAGGCAGGGTTGGTGGTGGGTGGGGGCAGCCTGTATCAGACAAAGGTAAATCAGCCAGCCAGGCACCCACAG
CCTCAGCTCCTGTGCAGTTCCTGGGCAGCACAGTGGAAGTGGGAGCCTGGTCCTTCCCCTGCCCATGGAGAGCTCTTTAAGGGATCCCAG
CCTGCCCCTCCACTTCTCTCCCAAGCCAGGTCCCGGCATGGGTGGGTTATGCTCATGCTGGCAATACTTGAAACGGGTTTATTAATGCTG
GGTATTTTGCACAATTTTATAGACCTCTTTTCTACATAGTCTTTTTTAAATGGAAGGAGAAAATGTCAGCCACATTACTGTCTGTGTAGT
GCCAGGTGAAGGGTTATCAGAAGGCTGGTTGGTTTTAATAAGTTTATTCCAAGAGACCTTCTGGCTGGAATGAGTGAGAGTGTGTGTGCA
TGTGTGTGTGTGTTCATGTGTGCCCTGTATGAATGTGGCTGGCTCCCATATCCCCTGGGCTGCCCCCTGCCCCATCCCCTTTGAGTGTCA
GAAGCACTCTGAGCCAAGGGGACAGGGGGCACGTGCACTGGTCACGAGAAAACCCTGGGCTCCCACTGGGGCTCAGCCCAGCCTCCTATC
TTTCCTTCTTCTATGGACTTCAGACAGCCAGTGTCTGGGGACTCTGCCACTCTACCCCCAGCCCTACCCACCAGCCCCCAGGTGAGGCTT
CCAGCTGGGACCTGCCCAGACAGGCTGAGCCTGGGCGTGGTGGGTGGGGTGATGGCTCTGGGGAGCGGCTGCCATCCTACAAGCCACACC
CCCTCCTCTGAGCTCTGAATATGGGACCCAGTGCCAGGAGCTGGAAGACAAGGTGTTTCTGCCAAACGGGGACCTCCATCCAGAGAAAAG
GAAGAAGGTGCAGGGTGGGCCAAGAGGCAAGTGAAGGTTGGCCTGAGTCTGGGCCGGAAACTCAGAGGATGTTTCTCCTCTGCTGGGAGC
TGTAGTTTCTTATCAAAATAGATATTGTTCCACCATCCCCCTCCTTGGCCCTTCAAGTGGGCTGAAGCCCTTGGAAAGTGACATAGGAAG
TCCCCAGATCTTGCCCTTCTCACTCCAGAGGCTAGTGGTCACAGACAGCTGGGAATGGCAGCCACAGAGGGTCCCCTCTGGGAGAAACAG
CTTCACCCCAGCCTCAGGGCCCTGGGCCATCACTGCAGTGGCCCTGGGAGGTGAGGAAGAAGCTGGCTAGAGGAGGGGGCTCCCACCTAC
CTTTTATTTAAGCCAGTATTCTTTGTTCCTGCTTGTAATAAAACTTCAGTTTATAAGAGTTGCTTTGCTTTGGTTTGGTTTTTGTTTGCT
TTTCCTTTGCTGAGGCCCCAACTGGGAGCCCTCTGTTCTTTCAGACAAATTTGGTTCTTTCCTGGGGAGACTGTGAGAAGGCAGGCAGCC
CAGTGATCTGGCTACATTTTCCCTCACCTGGCTGGAGCTCTGTCCGCTGGAGGAAGAGCAGAGAGGGCTGCGGCTGAGCCCCCATGGGCA
CGTGAAAAGAGGCCATCCTGTCCCCTCTTTGTCCCCTCCACCTTCCCCTGCCTCAGGGGCTTGGAGACCCCCAAATTCTTCTTCCCTACT
GCCTTTCCACTCCGATCCCCAATGAGTGCCCAGCTAAGAAAATGTTTGAGACAGTAGATTCCAGTTTGAGAGCCGGAGCTTCCCTGGCTA
CCACCTCCAACCTGGGCACCAGGGCCCAGCCAGACAACTCATAACACTGGCCCACCTCTCTGGTATCTCCCTCAGGAGGACACCTGTCAG
GATTTTGCCATCTCCTGCACAGCCTGAGGGGAGCTAACAGGCCTCTTTGCAGAGGGTTAGCTGGTAAGACCGTTTCTTCCCTGTCGGCCA
GCACTGCCCGCTCCCCTCACACACCATCTCATCCTCATCGCATGCCTCGCCAACCCCATGGAGCCCGTCCATCTGTCTGGTGTGTGGTGC
GGTGTGTGTGCTGGTGGTGGTAGGGTCTCCAGGGACTCCCCGCTAAGCAGAAGGATCGGGATATAGGGCAAGGCTAAAAGCCCAGCCCCA
TTGTGGACTGAGGAAGTAGCTTCTCGCAGAGCAGCTCTCCAGCTGGAAGAGGAGGTGGAGGGTGAGGCTGGGGAGAGGATGGCGAACCTG
CCCTGAGGTGCTTGGGTCTGTGCTGGTGGGGTCCTGGTATGCAGGGGCCACCGGTCACTAACACTCTTATGTCCTGGCTTTCTGTCCCCG
CTGAGCTTTCTCTCACCCGCCCGTTTTCTCTCCTGCTTCATTGCCTGCTGCCTAAGCCTTGGCCCTTCTCTCGGGCAGAGGCAGGTGCTG
TGGCAGCACCTCTCCCCACCACCGGGGCCCCTGCAGGCCGCCTCCCTCCTCCCAGGCCTGCTAACCCTCTCTCTTCTCCTTCTTTGCTGT
CCTGCCGGGGATCTCCAGTGTGTGCGGGGGCTTAAGGACCTCCTGAGGACCGCTGCTCTCTGCCTCTCCAGGAATGGCCTGGGGGGAGCC
AGGCACCCGGCACCTCCACCTGCCTAACCTGTGGCCCATCTGCCACCATCTGTGCCTACAGGGTCTGCCCCCCAGCCTGCCCGGCCTGTG
TGCTCTCTAGGACCCCCATAGGGGGCAGGGGCTGGCCTCTTTGCCCCATTCCCGCTCCATGCCGGCCAGAGTGTAGAAAGCCATAACGCA
GCCATCAGCACAATAATGTGACTCTACGCTGATATGCTCCCTCTCTCCTCCACTGACTTCCCCTTCCCGGATTTGTGAGGTGTCAAGACT
AGGAATCTGGCCTTAGAGCCTGCCCCTCCACCCCCTCAGATCAGGCATAGCCATAGTCAAGCCCAGCAGGTTTCCTCAGGAGCTGTCTGG
GGTGTTGATGGTGGATGACGCTGCTGAACAAGTTTGGTGACTGTTCTAAGCACAACTGGCTTGATACTGTTCCCACGGCCTGTCCACCTC
CCACCCCCAACCCTCCACCAGAGTAGGTAGGATGTAGGGAGGGTGCGTGCCTCCTTTGCTCTAGGCACTGAGGGACCAAGCTAGCCGTGC
ACAGCCCCATACACTTCAGGGGACTAAAGGAAAGAGCTGAGCCAAGGAAAATCAGCTGAGCCCAGGGCTGGGGGCTGCTTGTCTGCTATC

>61094_61094_6_NUP85-ZDHHC18_NUP85_chr17_73229253_ENST00000579324_ZDHHC18_chr1_27180217_ENST00000374142_length(amino acids)=493AA_BP=
MVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRIDEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQV
SILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPAS
AGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSN
PTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEY
ASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUP85-ZDHHC18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUP85-ZDHHC18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUP85-ZDHHC18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP85C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneNUP85C4748545NEPHROTIC SYNDROME, TYPE 171GENOMICS_ENGLAND;UNIPROT