Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATAD5-SIPA1L3 (FusionGDB2 ID:HG79915TG23094)

Fusion Gene Summary for ATAD5-SIPA1L3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD5-SIPA1L3
Fusion gene ID: hg79915tg23094
HgeneTgene
Gene symbol

ATAD5

SIPA1L3

Gene ID

79915

23094

Gene nameATPase family AAA domain containing 5signal induced proliferation associated 1 like 3
SynonymsC17orf41|ELG1|FRAG1CTRCT45|SPAL3|SPAR3
Cytomap('ATAD5')('SIPA1L3')

17q11.2

19q13.13-q13.2

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homologsignal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3spine-associated RapGAP 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000321990, 
Fusion gene scores* DoF score10 X 11 X 6=66030 X 26 X 13=10140
# samples 1135
** MAII scorelog2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(35/10140*10)=-4.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATAD5 [Title/Abstract] AND SIPA1L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD5(29185341)-SIPA1L3(38652893), # samples:2
Anticipated loss of major functional domain due to fusion event.ATAD5-SIPA1L3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD5-SIPA1L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIPA1L3

GO:0003382

epithelial cell morphogenesis

26231217

TgeneSIPA1L3

GO:0090162

establishment of epithelial cell polarity

26231217


check buttonFusion gene breakpoints across ATAD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SIPA1L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A2I6-01AATAD5chr17

29185341

-SIPA1L3chr19

38652893

+
ChimerDB4BLCATCGA-DK-A2I6-01AATAD5chr17

29185341

+SIPA1L3chr19

38652893

+


Top

Fusion Gene ORF analysis for ATAD5-SIPA1L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321990ENST00000476317ATAD5chr17

29185341

+SIPA1L3chr19

38652893

+
In-frameENST00000321990ENST00000222345ATAD5chr17

29185341

+SIPA1L3chr19

38652893

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000321990ATAD5chr1729185341+ENST00000222345SIPA1L3chr1938652893+7151333437850181546

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321990ENST00000222345ATAD5chr1729185341+SIPA1L3chr1938652893+0.0006365140.9993635

Top

Fusion Genomic Features for ATAD5-SIPA1L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATAD5chr1729185341+SIPA1L3chr1938652892+4.48E-101
ATAD5chr1729185341+SIPA1L3chr1938652892+4.48E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ATAD5-SIPA1L3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:29185341/chr19:38652893)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIPA1L3chr17:29185341chr19:38652893ENST0000022234512221720_177412201782.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD5chr17:29185341chr19:38652893ENST00000321990+9231589_15999851845.0Compositional biasNote=Poly-Ser
HgeneATAD5chr17:29185341chr19:38652893ENST00000321990+9231428_14329851845.0MotifNote=LXCXE motif
HgeneATAD5chr17:29185341chr19:38652893ENST00000321990+9231132_11399851845.0Nucleotide bindingATP
TgeneSIPA1L3chr17:29185341chr19:38652893ENST000002223451222611_82812201782.0DomainRap-GAP
TgeneSIPA1L3chr17:29185341chr19:38652893ENST000002223451222966_104212201782.0DomainPDZ


Top

Fusion Gene Sequence for ATAD5-SIPA1L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7382_7382_1_ATAD5-SIPA1L3_ATAD5_chr17_29185341_ENST00000321990_SIPA1L3_chr19_38652893_ENST00000222345_length(transcript)=7151nt_BP=3334nt
GCAGGACGGCGCGAAAACCCAATTGACAAGAATTCCCTCCGAAGCTCTGTGGTCCGATCTGCGGTCCGCTTGCTTTCCCTGCCCGGTCCC
GAGCGCTCAGCCTGAAGCGCCGCTTTCGAGGGCACCCTGCATACACTGGCCGCGCCTCAGGGATCTCATTGCCCGCGCTTTCTCATTGCC
TCTTTCCGTGTTCGATTCGGCTGATCTGGGCCCAGCCTCCGCTCCCGCTCTCTGTCGGTGGGCGCGGGGGAATCCGAAACGGCTCAGCAG
AATCCCAGCAGCTTGCTGCTACTGGAGCGGGCCGCCTCCATGGCCTCCAGGCAGGCCGGGCTGGACCGCGTGAGGTCCTAGGAGACGGGA
TTCCGGGAAGCGGGGAGTATGGTGGGGGTCCTGGCCATGGCGGCTGCAGCTGCTCCGCCTCCCGTGAAGGACTGCGAGATTGAGCCATGC
AAAAAGCGAAAGAAAGATGATGACACATCTACCTGCAAAACAATTACAAAATATTTATCACCACTAGGGAAGACTAGAGACAGGGTTTTT
GCTCCACCAAAACCTAGTAATATTCTGGATTATTTTAGAAAGACTTCACCCACAAATGAGAAGACACAATTAGGGAAAGAGTGCAAGATA
AAGTCACCTGAATCAGTACCTGTTGACAGCAACAAAGACTGTACGACACCTTTGGAAATGTTCTCAAATGTAGAGTTTAAGAAGAAAAGA
AAGAGGGTTAATTTATCTCATCAACTAAATAATATTAAAACTGAAAATGAAGCTCCAATTGAAATTAGTAGCGACGATAGCAAAGAAGAC
TATAGTTTAAATAATGATTTTGTGGAAAGTAGTACTTCTGTTTTACGTTACAAGAAACAAGTAGAGGTACTTGCAGAAAACATTCAAGAT
ACAAAAAGTCAACCAAATACTATGACCTCCCTGCAAAATTCTAAAAAAGTAAATCCTAAACAAGGGACCACAAAAAATGACTTCAAAAAG
TTGAGAAAAAGGAAATGCAGAGATGTAGTAGATCTATCTGAAAGCTTACCCTTGGCAGAGGAACTAAATTTGCTTAAAAAAGATGGTAAA
GATACTAAACAGATGGAGAATACTACAAGCCATGCAAACTCTAGAGATAACGTAACTGAAGCAGCCCAGTTAAATGATAGTATAATAACT
GTCTCATATGAGGAATTTTTAAAAAGTCACAAGGAAAATAAAGTGGAAGAGATACCAGACTCTACAATGTCAATTTGTGTTCCTTCTGAA
ACTGTCGACGAAATAGTCAAAAGTGGTTATATAAGTGAATCAGAAAACTCCGAAATTTCCCAGCAGGTACGCTTTAAGACAGTTACTGTT
CTTGCACAGGTTCACCCTATTCCGCCCAAAAAGACAGGGAAAATACCCCGAATTTTCTTGAAACAAAAGCAATTTGAAATGGAAAATAGT
TTATCTGATCCTGAGAATGAACAGACAGTTCAGAAAAGAAAATCTAATGTTGTTATACAGGAGGAAGAATTAGAATTGGCTGTTTTGGAA
GCTGGAAGTTCTGAAGCTGTGAAACCAAAATGCACTCTAGAAGAAAGACAGCAATTTATGAAAGCATTTAGGCAGCCAGCATCAGATGCA
CTTAAAAATGGAGTTAAAAAGTCTTCTGATAAGCAGAAAGACCTTAATGAAAAATGTCTATATGAAGTAGGAAGAGATGATAATTCTAAA
AAAATCATGGAAAATTCTGGTATCCAAATGGTTTCAAAAAATGGCAATTTACAGTTACACACTGATAAAGGAAGTTTTCTGAAGGAGAAA
AATAAAAAGCTAAAGAAGAAGAATAAGAAAACATTAGATACTGGGGCTATTCCAGGCAAAAACAGAGAGGGAAACACTCAAAAGAAAGAA
ACAACCTTTTTCTTAAAAGAGAAACAATATCAAAATAGAATGAGTTTAAGACAAAGGAAAACAGAGTTTTTCAAAAGCAGCACTTTATTT
AACAATGAAAGTCTTGTTTATGAAGATATAGCAAATGATGACCTTCTAAAGGTTTCCTCTCTGTGTAACAATAATAAATTGTCAAGAAAA
ACCAGCATACCAGTTAAAGATATTAAGCTTACACAGTCTAAAGCTGAATCTGAAGCCAGCTTGCTAAATGTTTCCACGCCCAAGTCAACT
AGAAGATCTGGAAGAATTAGCAGCACACCTACTACAGAAACCATTAGAGGTATTGATTCTGACGATGTACAAGATAATAGTCAACTAAAG
GCTTCCACTCAAAAAGCAGCCAACTTATCGGAAAAGCACAGCTTATATACAGCAGAATTAATAACAGTACCCTTTGATTCAGAGAGCCCT
ATTAGAATGAAATTCACCAGAATTAGTACTCCCAAAAAATCTAAGAAAAAATCTAACAAAAGATCTGAGAAATCTGAAGCAACTGATGGA
GGTTTTACTTCTCAGATTAGAAAGGCAAGCAATACTTCAAAAAACATATCAAAAGCAAAACAATTGATTGAAAAAGCAAAAGCTTTACAC
ATCAGTAGGTCAAAGGTGACTGAAGAAATAGCGATACCCTTAAGGCGCTCCTCTAGACATCAGACACTTCCTGAAAGGAAGAAATTGTCA
GAAACAGAAGATTCTGTTATAATAATAGATTCAAGTCCTACTGCTTTAAAGCATCCAGAGAAAAATCAGAAGAAACTTCAGTGTTTGAAT
GATGTGCTAGGAAAAAAACTTAACACATCCACTAAAAATGTACCTGGAAAAATGAAAGTCGCTCCTTTATTTCTTGTCAGAAAAGCACAA
AAAGCAGCTGATCCTGTCCCTAGTTTTGATGAAAGCAGTCAAGATACATCTGAAAAATCTCAGGATTGTGATGTTCAATGTAAAGCAAAG
CGTGACTTCCTAATGAGTGGTTTGCCAGATTTGTTGAAACGGCAAATTGCAAAGAAAGCTGCTGCGCTGGATGTGTACAATGCAGTGAGT
ACCAGTTTCCAGAGAGTCGTACATGTGCAACAAAAGGATGATGGGTGTTGTTTGTGGCATTTGAAACCACCCTCTTGTCCTCTCTTAACT
AAATTTAAAGAACTGAACACTAAAGTAATAGATCTCTCAAAATGTGGTATTGCTCTTGGTGAATTTTCAACATTGAATTCAAAGTTGAAA
AGCGGTAACTCTGCTGCTGTGTTCATGAGGACAAGGAAGGAATTTACTGAAGAAGTAAGAAATCTTTTGCTTGAGGAAATTAGGTGGTCA
AATCCTGAATTTTCATTGAAAAAATATTTTCCCTTACTCCTAAAAAAACAAATTGAGCACCAAGTACTTTCTTCCGAGTGTCATAGTAAA
CAAGAGCCTTTGTGGCATGTGCCTGCCCAGGCCAGGCTCTCAGCCATAGCCGGAAGCAGCGGGAACAAGCACCCGTCCAGGCAGGATGCA
GCAGGCAAAGATTCCCCCAACAGGCATTCCAAAGGAGAACCTCAATACTCAAGTCATTCCAGCAGCAACACCCTCTCCAGCAACGCATCC
AGCAGCCACAGCGACGACCGCTGGTTCGACCCCCTGGACCCCCTGGAGCCAGAGCAAGACCCCCTCTCCAAGGGTGGCTCTAGTGACAGC
GGCATCGACACCACCCTCTACACCTCCAGCCCTAGCTGCATGTCCCTGGCCAAGGCTCCACGGCCCGCCAAGCCACACAAGCCCCCTGGA
AGTATGGGCCTTTGTGGCGGGGGTCGCGAGGCCGCTGGGAGGTCCCACCACGCAGACAGGCGGCGGGAGGTCTCCCCTGCCCCCGCAGTT
GCCGGCCAAAGCAAGGGCTACCGACCGAAGCTGTACTCCTCCGGCTCCAGCACCCCCACGGGACTGGCGGGGGGCAGCCGAGACCCACCG
AGGCAGCCCAGTGACATGGGCTCGAGGGTTGGCTACCCCGCTCAGGTTTACAAAACTGCCAGTGCAGAGACTCCTCGGCCCTCCCAGCTG
GCCCAGCCCAGCCCCTTTCAGCTCTCCGCCTCCGTCCCCAAGTCCTTCTTCTCCAAGCAGCCTGTACGCAATAAGCACCCAACAGGGTGG
AAGAGAACGGAGGAGCCCCCACCACGGCCACTCCCCTTCAGTGACCCAAAGAAGCAGGTGGACACGAACACCAAAAATGTCTTTGGGCAA
CCGAGGTTGAGGGCATCCCTCCGAGACCTCCGGTCACCACGGAAGAACTACAAATCCACCATCGAGGATGACCTGAAGAAACTCATCATC
ATGGACAACCTGGGGCCAGAGCAGGAGAGAGACACGGGACAGTCACCGCAGAAGGGCCTGCAGCGGACGCTGTCGGACGAGAGCCTGTGC
AGCGGGCGCCGGGAGCCCAGCTTCGCCAGCCCCGCTGGCCTAGAGCCAGGGCTGCCCAGCGACGTGCTCTTCACCAGCACCTGCGCCTTC
CCGTCCAGCACGCTGCCTGCACGCCGCCAGCACCAGCACCCCCACCCGCCCGTCGGCCCCGGTGCCACCCCTGCCGCCGGCAGCGGCTTT
CCCGAGAAGAAATCCACCATCTCAGCCTCGGAGCTCTCGCTGGCTGATGGGCGGGACCGCCCCCTGCGGCGCCTGGACCCTGGGCTGATG
CCCCTGCCTGACACAGCTGCTGGCCTCGAGTGGTCCAGCCTGGTGAACGCAGCCAAGGCATACGAAGTGCAAAGAGCCGTCTCACTCTTC
TCTCTGAACGACCCGGCCCTGAGCCCGGACATCCCGCCTGCACACAGTCCTGTCCACAGCCACCTGAGCCTGGAGAGGGGACCCCCGACC
CCCAGGACCACCCCTACCATGAGCGAGGAGCCACCCCTGGATCTGACAGGCAAGGTGTACCAGCTGGAGGTGATGCTGAAACAGCTGCAC
ACTGACCTGCAGAAGGAGAAGCAGGACAAGGTGGTGCTCCAGTCAGAGGTGGCCAGCCTGCGGCAGAACAACCAGCGGCTGCAGGAGGAG
TCGCAGGCCGCCAGCGAGCAGCTGCGCAAGTTTGCGGAGATCTTCTGCAGGGAGAAGAAGGAGCTCTGAGGTGGGAGGCCGCCGCCCGCC
TTCGCTCCTTCCCCTCAGGCCGTGGCCCTGCTGCCTCTCTCCCTCCACTCAGCTCCCAGCTGCCGGTGTGACCAAGATGACCCATCCAGG
GCCCTCCCCATGGACACGGAAACTCCGATGGCCTCACTAGGGCTGTGAGTCAGGGTCAGCGCGCACAGCCCTCATGCCCCAGAGGGCGAA
GTGGTCTCAGGCCTCCCTCCAAGCTGCCCAGCTGTGGTCCCGGTGAGCTGGGCTGTGCTTACACCGCTCCCGGGCCTGCCCCGCTGTCCC
CATCTAGCCTCTTCCTGGGACCAGCCCTTCGAAGCTGATGGGGACGGAGAGAGGAGCCAGTCTCCAGACGCCTCGGCTCCAGGAGGTCAC
ACAGCAGGTTTCTGCACCACGCACAACAAAGTTGCGGCTTGTGGGGCCGAGGCCCCTGCATGAAAAGTACAGCGTGAAAGCAACCCTTTC
TTCCCCACACCCAGAGAGGTGAGGCCCGCGTGGACACAGACCAGGGCGCCTCGGTCCCTAGCACGTGAGCTCCAAAAAGCACGAACATGA
TCCCCTCCCTAACCCCCTCCTCCCAAAAAGCAGCCAGGAGCACTTTCTTAGAGTTTAAATTATTTTCTTGGGGGCCTGAGGATAGAGAGA
GGCAAGGCTAGCCTCCAGAGCCGATTTATTTGAGAGAGAAACTCTATTTGGATCTCCAGGACGGTTTATACGATCTTTTTCTATCAGCTC
CTCTTCCGCCAGAGGCCACTGCACCTGGGCTAGGGGTCCACAGGCCCCTCCACCTTCCAGCTAACCAGGCCAGGCCGGGGCGGTGGAGCC
ACCACACAGCCGACTCTCTCCTCCTCCTCCCGGCACGACCTGGCCCTGACCAGCAGCCTCGGCCTCTTCTGGGTTCCAGGAGGGGCTCCC
GAAGCCCTCAGGACAGGGCTGGAGGAGAACAGCCTTCATCTCCTCCTCTGGTTTTTTTTTCCTTTGCAAGTCTCCCAGCCCATCTCTCCG
AGCAGCGGCCACCAGACCCCCTCACCATGCTCCCCGGGGAGCACTGCACCCCGCGAACCCCACTGGACGCTGGTTCTCTAAAGGCAATAA
GGGGCGGCCATGCCGGTGTGGTACCACGCTGTTCCTCCAGGAAACCGTTTCTTTTTTTCCTTCTTTAAAAGCAAACAGAAAAAGATATAT
ATATATATATATATATATTTATTTTTTCATGTAGAGTTGGCGCCAGAACAAGCCTGTATGGCCACAGTCTGTGGATTCATCCCCCCAACC
TCAAGCTGAGGACCAAGGCGTGTCCCCTGTGGGCTGGGGGTCAGTGGGAGGACCAGAGGGATGAAGTCAGGGCAGGCCGGTGCCCTTTTT
GGGAGGCACCAGGCGGGGAGGAGTTGGCGGAGCAGGTCTGGCTGTGAGCCAGCACCAGGCAACCCGGCCCTTGTCCAGGGACCTCTGCTG
CCTTCTCTCTGGGGTCAGGAACCTCAGAGGAGGGGGCTCTGGGGACTGCATAGGACGCAGGCACTCGGAGGTGCCGGTGTGGATGGGTGG
GGGTGAGAGAAGAGGGTTCTTATCGCGTCTCCTGTGATCAGCCTCTGGCCCCCTGGAGGAGGAAACCTCAGCGCTGCCCCTGCCCCCACC
CTCACCCCCAACACCAAGAGTGAGGTGGGCGTGCCCCAGGCAGCGTCCTCAGCCCTGGCCAGCTACTGTGATGCCATCTTCTCCCCCATC
CCCTTCTCTGGGGGGCCCACCCGTCCCCCACCCCCACCCCTTAGACCCTCATCGGGTCCCTTTTTTTTTTTTTTTTTCAGTTGTCTCCTC
CCATCTTCAGATCATTCGAATCATTTTGGGGACTTAATCATGTACATGGACAAGTGTAAATTATGATTTTTGGTTTTGTTTTCTGTTATT
TTTTAAGGATTTCTGCAAAAACAGATCTATTTAATTTGAGGTTGATGTTCTATCCAATGGCCGAAGATAGCAGCAGGTTTTTTTTTTCAT
ATGTTGATTTGTTTCATTTGGATTTTTTTTTTATTATTCTTTATTGTCTTTTTTTTTTCCCCATCCCTGTCTTGAGATTTTCTGGCATGT

>7382_7382_1_ATAD5-SIPA1L3_ATAD5_chr17_29185341_ENST00000321990_SIPA1L3_chr19_38652893_ENST00000222345_length(amino acids)=1546AA_BP=985
MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESV
PVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPN
TMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEF
LKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPEN
EQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENS
GIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLV
YEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKA
ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKV
TEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPV
PSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELN
TKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQEPLWH
VPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTL
YTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDM
GSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRAS
LRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLP
ARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPA
LSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATAD5-SIPA1L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATAD5-SIPA1L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATAD5-SIPA1L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATAD5C4721610Carcinoma, Ovarian Epithelial1CTD_human
TgeneC0266539Congenital total cataract1ORPHANET