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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:COQ8B-AKAP8 (FusionGDB2 ID:HG79934TG10270) |
Fusion Gene Summary for COQ8B-AKAP8 |
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Fusion gene information | Fusion gene name: COQ8B-AKAP8 | Fusion gene ID: hg79934tg10270 | Hgene | Tgene | Gene symbol | COQ8B | AKAP8 | Gene ID | 79934 | 10270 |
Gene name | coenzyme Q8B | A-kinase anchoring protein 8 | |
Synonyms | ADCK4|NPHS9 | AKAP 95|AKAP-8|AKAP-95|AKAP95 | |
Cytomap | ('ADCK4','COQ8B')('AKAP8','AKAP8') 19q13.2 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | atypical kinase COQ8B, mitochondrialaarF domain containing kinase 4aarF domain-containing protein kinase 4coenzyme Q protein 8B | A-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDa | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000324464, ENST00000450541, ENST00000243583, | ||
Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 4 X 5 X 4=80 |
# samples | 2 | 7 | |
** MAII score | log2(2/2*10)=3.32192809488736 | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COQ8B [Title/Abstract] AND AKAP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADCK4(41201894)-AKAP8(15469873), # samples:2 COQ8B(41201894)-AKAP8(15469873), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ADCK4-AKAP8 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COQ8B | GO:0006468 | protein phosphorylation | 27499294 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-49-4486-01A | ADCK4 | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - |
ChimerDB4 | LUAD | TCGA-49-4486 | ADCK4 | chr19 | 41201893 | - | AKAP8 | chr19 | 15469873 | - |
ChimerDB4 | LUAD | TCGA-49-4486-01A | COQ8B | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - |
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Fusion Gene ORF analysis for COQ8B-AKAP8 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000324464 | ENST00000269701 | ADCK4 | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - |
Frame-shift | ENST00000324464 | ENST00000269701 | ADCK4 | chr19 | 41201893 | - | AKAP8 | chr19 | 15469873 | - |
Frame-shift | ENST00000450541 | ENST00000269701 | ADCK4 | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - |
Frame-shift | ENST00000450541 | ENST00000269701 | ADCK4 | chr19 | 41201893 | - | AKAP8 | chr19 | 15469873 | - |
In-frame | ENST00000243583 | ENST00000269701 | ADCK4 | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - |
In-frame | ENST00000243583 | ENST00000269701 | ADCK4 | chr19 | 41201893 | - | AKAP8 | chr19 | 15469873 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000243583 | ADCK4 | chr19 | 41201893 | - | ENST00000269701 | AKAP8 | chr19 | 15469873 | - | 3192 | 1110 | 24 | 1661 | 545 |
ENST00000243583 | ADCK4 | chr19 | 41201894 | - | ENST00000269701 | AKAP8 | chr19 | 15469873 | - | 3192 | 1110 | 24 | 1661 | 545 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000243583 | ENST00000269701 | ADCK4 | chr19 | 41201893 | - | AKAP8 | chr19 | 15469873 | - | 0.005244244 | 0.99475574 |
ENST00000243583 | ENST00000269701 | ADCK4 | chr19 | 41201894 | - | AKAP8 | chr19 | 15469873 | - | 0.005244244 | 0.99475574 |
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Fusion Genomic Features for COQ8B-AKAP8 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for COQ8B-AKAP8 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41201894/:15469873) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 155_158 | 362 | 504.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 216_219 | 362 | 504.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 155_158 | 403 | 545.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 216_219 | 403 | 545.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 155_158 | 362 | 504.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 216_219 | 362 | 504.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 155_158 | 362 | 504.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 216_219 | 362 | 504.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 155_158 | 403 | 545.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 216_219 | 403 | 545.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 155_158 | 362 | 504.0 | Motif | KxGQ motif |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 216_219 | 362 | 504.0 | Motif | AAAS motif |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 324_327 | 362 | 504.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 324_327 | 403 | 545.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 324_327 | 362 | 504.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 324_327 | 362 | 504.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 324_327 | 403 | 545.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 324_327 | 362 | 504.0 | Nucleotide binding | ATP |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 92_108 | 362 | 504.0 | Transmembrane | Helical |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 92_108 | 403 | 545.0 | Transmembrane | Helical |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 92_108 | 362 | 504.0 | Transmembrane | Helical |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 92_108 | 362 | 504.0 | Transmembrane | Helical |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 92_108 | 403 | 545.0 | Transmembrane | Helical |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 92_108 | 362 | 504.0 | Transmembrane | Helical |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 525_569 | 509 | 693.0 | Region | Involved in condensin complex recruitment | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 572_589 | 509 | 693.0 | Region | RII-binding | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 525_569 | 509 | 693.0 | Region | Involved in condensin complex recruitment | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 572_589 | 509 | 693.0 | Region | RII-binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 191_423 | 362 | 504.0 | Domain | Note=Protein kinase |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 191_423 | 403 | 545.0 | Domain | Note=Protein kinase |
Hgene | ADCK4 | chr19:41201893 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 191_423 | 362 | 504.0 | Domain | Note=Protein kinase |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000243583 | - | 12 | 14 | 191_423 | 362 | 504.0 | Domain | Note=Protein kinase |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000324464 | - | 13 | 15 | 191_423 | 403 | 545.0 | Domain | Note=Protein kinase |
Hgene | ADCK4 | chr19:41201894 | chr19:15469873 | ENST00000450541 | - | 12 | 14 | 191_423 | 362 | 504.0 | Domain | Note=Protein kinase |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 107_118 | 509 | 693.0 | Compositional bias | Note=Poly-Gly | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 107_118 | 509 | 693.0 | Compositional bias | Note=Poly-Gly | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 289_306 | 509 | 693.0 | Motif | Bipartite nuclear localization signal | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 289_306 | 509 | 693.0 | Motif | Bipartite nuclear localization signal | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 387_450 | 509 | 693.0 | Region | Involved in chromatin-binding | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 387_450 | 509 | 693.0 | Region | Involved in chromatin-binding | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 392_414 | 509 | 693.0 | Zinc finger | C2H2 AKAP95-type 1 | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 481_504 | 509 | 693.0 | Zinc finger | C2H2 AKAP95-type 2 | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 392_414 | 509 | 693.0 | Zinc finger | C2H2 AKAP95-type 1 | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 481_504 | 509 | 693.0 | Zinc finger | C2H2 AKAP95-type 2 |
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Fusion Gene Sequence for COQ8B-AKAP8 |
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>2198_2198_1_ADCK4-AKAP8_ADCK4_chr19_41201893_ENST00000243583_AKAP8_chr19_15469873_ENST00000269701_length(transcript)=3192nt_BP=1110nt CTCGGAGGCTGAGAGCAGTGGGCAATGTGGCTGAAGGTGGGGGGCCTACTTCGGGGGACCGGTGGACAGCTGGGCCAGACTGTTGGTTGG CCTTGTGGGGCCCTGGGGCCTGGGCCCCACCGCTGGGGACCATGTGGAGGTTCTTGGGCCCAAAAGTTTTACCAGGATGGGCCTGGGAGA GGCCTGGGTGAGGAGGACATTCGCAGGGCACGGGAGGCCCGTCCCAGGAAGACACCCCGGCCCCAGCTGAGTGACCGCTCTCGAGAACGC AAGGTGCCTGCCTCCCGCATCAGCCGCTTGGCCAACTTTGGGGGACTGGCTGTGGGCTTGGGGCTAGGAGTACTGGCCGAGATGGCTAAG AAGTCCATGCCAGGAGGTCGTCTGCAGTCAGACAACAGCTTCATCAGCCCTCAGCTGCAGCACATCTTTGAGCGGGTCCGCCAGAGCGCC GACTTCATGCCCCGCTGGCAGATGCTGAGAGTTCTTGAAGAGGAGCTCGGCAGGGACTGGCAGGCCAAGGTGGCCTCCTTGGAGGAGGTG CCCTTTGCCGCTGCCTCAATTGGGCAGGTGCACCAGGGCCTGCTGAGGGACGGGACGGAGGTGGCCGTGAAGATCCAGTACCCCGGCATA GCCCAGAGCATTCAGAGCGATGTCCAGAACCTGCTGGCGGTACTCAAGATGAGCGCGGCCCTGCCCGCGGGCCTGTTTGCCGAGCAGAGC CTGCAGGCCTTGCAGCAGGAGCTGGCTTGGGAGTGTGACTACCGTCGTGAGGCGGCTTGTGCCCAGAATTTCAGGCAGCTGCTGGCAAAT GACCCCTTCTTCCGGGTCCCAGCCGTGGTTAAGGAGCTGTGCACGACACGGGTGCTGGGCATGGAGCTGGCTGGAGGGGTCCCCCTGGAC CAGTGCCAGGGCCTAAGCCAGGACCTGCGGAACCAGATTTGCTTCCAGCTCCTGACGCTGTGTCTGCGGGAGCTGTTTGAGTTCCGATTC ATGCAGACTGACCCCAACTGGGCCAACTTCCTGTATGATGCCTCCAGCCACCAGGTGACCCTGCTGGACTTTGGTGCAAGCCGGGAGTTT GGGACAGAGTTCACAGACCATTACATCGAGTTGGCTGCTGAACAGTTCAAGAAAACCAGTCTCCATGTGGCTAAGAGTGTTTTGAACAAC AGACATATAGTGAAGATGCTGGAAAAATACCTCAAGGGTGAGGACCCTTTCACCAGTGAAACTGTTGATCCAGAAATGGAAGGAGATGAC AATTTAGGAGGTGAGGATAAGAAAGAGACACCTGAGGAGGTGGCCGCGGACGTCTTAGCAGAGGTGATTACAGCAGCAGTGAGGGCCGTA GATGGGGAAGGAGCGCCCGCTCCAGAGAGCAGCGGGGAGCCGGCTGAGGACGAAGGCCCCACGGACACAGCGGAGGCCGGTAGTGATCCT CAAGCCGAACAGCTGCTGGAAGAGCAGGTGCCCTGTGGAACGGCACATGAGAAGGGCGTCCCCAAGGCCAGAAGTGAGGCTGCAGAGGCT GGAAATGGCGCCGAGACAATGGCAGCAGAGGCAGAAAGTGCCCAAACCAGAGTTGCTCCTGCCCCAGCTGCCGCGGATGCTGAAGTGGAA CAAACTGATGCAGAGTCTAAAGACGCTGTTCCCACAGAATGATGCTCATTTCCCTGTTCCAGGGAAGGCGTTGGGATGATGGATGCGTTG GTCTTTCTCCCTTGGTTTGTAAGCAGTACAAGGGCGTGTGCTCCCAGAATATGCTGTAATCTAATTTTGGTGAAGAGACCCAGCGTTTCC TCCTGAGCAGTGCCTCTCACGGCTTGTCTCATGCAGTCGTGTGGCTTCTTGCCCAGGTTTCAAAGCTGAAGTACATTGTCCTTAGCGGCT GTAACATGTCTCTTGACAGTAGTGCACTTGGAATAATAAAGGTTGGGTGATTATATCTTGATGATACATTACTTGTTCAATACAGCCACT GATGGAATGCTTCCTTTTTTATTTTTTTCCTTAATTTTTTTTTTTATTTGGTTGGGAACAGCTGAATACTAGGAATATATCTTGCTCTAT AGAGGATTTTTTTTTGTATGTTTCAAGCTTCAGCCTTTAACCTATACCTTTGTAGTGCACCATATGGTGTGTGACTTTCACAGGACTTCG CAGCACCTGGTTCACATGTGGCACTGACCGCGTCACATCCACGCACTCCCAAAGGCCAGAAGTATCTGACCGACCTACGCCACTGGAAAC ACACCCACCGCAACCTCAAGAACCAGACTGTGCAGAGGGCATTGCGTCCCAATCTTTAGTCCTTGCTGAATCAGTTCTCTAATATTTTAC CTCATTTGTGTTCCACCTCTAGATTACTTCAGGTTTTTTTCCTTTAAAATTAGTTACTACCACTCAAATGTATTTACAAAGAGAATTTGG CCAGGCACGGTGATGCATACCTATAATCCCAGCACTTCGGGAGGCCGTGGTGAGAGGATAGCTTAAGCCCAGGAGTTCAAGACCAACCTG GACAACATAGCAAGACCCCATCTCTTAAAAAAAAAGGAAAGAAAACTTGATGTGATTGCCATAGGTGGAATAATCCAACATAAATTGCCA TAGATAGAAGGTATCTGTAATATATATATATATATATAAAATGAAATATATGTTTCATTTTAGAGAAATAACTATTACTTTAGATCTTTC CAAATCTGAGAAAGGGAGGCTAGCATGTGTTCAAGGTTAGCACGCAACAGAATTTCCTAAAATCAGAAGAATTGGAAGATCCTCCCCTTT TGAAATGGCCCTGCTGTGTCAGTTTCCCTGTGGCCTTTTGAACTGTACATCTCACATGTTGGGAAACGCTGGCCACTGGGAAATCATTAG AAAGGAGGCTGTAGAATATTTGCCGAGCCTCTACTGTATACCAGGGGCTAACTCACCAAGCACATTCTAGGAATTGGGCCCTGCTCATGA GGAGCCTTAGTGGAGATTCCAGGTGAATATTTATGAAAAAGTCAACATTAGAACTGAAAATGGAAATAAACTGCTTGAAAAGACGATGGT GCCTCTGGGTCATTTCTGCTCAGCATCCGTTTGTGTTGTGTAGATGCGTCTTAATCGCAGGGTGAGCATGCCTTTTAAGCTTGTTCTCTT >2198_2198_1_ADCK4-AKAP8_ADCK4_chr19_41201893_ENST00000243583_AKAP8_chr19_15469873_ENST00000269701_length(amino acids)=545AA_BP=362 MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRIS RLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIG QVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPA VVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHY IELAAEQFKKTSLHVAKSVLNNRHIVKMLEKYLKGEDPFTSETVDPEMEGDDNLGGEDKKETPEEVAADVLAEVITAAVRAVDGEGAPAP ESSGEPAEDEGPTDTAEAGSDPQAEQLLEEQVPCGTAHEKGVPKARSEAAEAGNGAETMAAEAESAQTRVAPAPAAADAEVEQTDAESKD -------------------------------------------------------------- >2198_2198_2_ADCK4-AKAP8_ADCK4_chr19_41201894_ENST00000243583_AKAP8_chr19_15469873_ENST00000269701_length(transcript)=3192nt_BP=1110nt CTCGGAGGCTGAGAGCAGTGGGCAATGTGGCTGAAGGTGGGGGGCCTACTTCGGGGGACCGGTGGACAGCTGGGCCAGACTGTTGGTTGG CCTTGTGGGGCCCTGGGGCCTGGGCCCCACCGCTGGGGACCATGTGGAGGTTCTTGGGCCCAAAAGTTTTACCAGGATGGGCCTGGGAGA GGCCTGGGTGAGGAGGACATTCGCAGGGCACGGGAGGCCCGTCCCAGGAAGACACCCCGGCCCCAGCTGAGTGACCGCTCTCGAGAACGC AAGGTGCCTGCCTCCCGCATCAGCCGCTTGGCCAACTTTGGGGGACTGGCTGTGGGCTTGGGGCTAGGAGTACTGGCCGAGATGGCTAAG AAGTCCATGCCAGGAGGTCGTCTGCAGTCAGACAACAGCTTCATCAGCCCTCAGCTGCAGCACATCTTTGAGCGGGTCCGCCAGAGCGCC GACTTCATGCCCCGCTGGCAGATGCTGAGAGTTCTTGAAGAGGAGCTCGGCAGGGACTGGCAGGCCAAGGTGGCCTCCTTGGAGGAGGTG CCCTTTGCCGCTGCCTCAATTGGGCAGGTGCACCAGGGCCTGCTGAGGGACGGGACGGAGGTGGCCGTGAAGATCCAGTACCCCGGCATA GCCCAGAGCATTCAGAGCGATGTCCAGAACCTGCTGGCGGTACTCAAGATGAGCGCGGCCCTGCCCGCGGGCCTGTTTGCCGAGCAGAGC CTGCAGGCCTTGCAGCAGGAGCTGGCTTGGGAGTGTGACTACCGTCGTGAGGCGGCTTGTGCCCAGAATTTCAGGCAGCTGCTGGCAAAT GACCCCTTCTTCCGGGTCCCAGCCGTGGTTAAGGAGCTGTGCACGACACGGGTGCTGGGCATGGAGCTGGCTGGAGGGGTCCCCCTGGAC CAGTGCCAGGGCCTAAGCCAGGACCTGCGGAACCAGATTTGCTTCCAGCTCCTGACGCTGTGTCTGCGGGAGCTGTTTGAGTTCCGATTC ATGCAGACTGACCCCAACTGGGCCAACTTCCTGTATGATGCCTCCAGCCACCAGGTGACCCTGCTGGACTTTGGTGCAAGCCGGGAGTTT GGGACAGAGTTCACAGACCATTACATCGAGTTGGCTGCTGAACAGTTCAAGAAAACCAGTCTCCATGTGGCTAAGAGTGTTTTGAACAAC AGACATATAGTGAAGATGCTGGAAAAATACCTCAAGGGTGAGGACCCTTTCACCAGTGAAACTGTTGATCCAGAAATGGAAGGAGATGAC AATTTAGGAGGTGAGGATAAGAAAGAGACACCTGAGGAGGTGGCCGCGGACGTCTTAGCAGAGGTGATTACAGCAGCAGTGAGGGCCGTA GATGGGGAAGGAGCGCCCGCTCCAGAGAGCAGCGGGGAGCCGGCTGAGGACGAAGGCCCCACGGACACAGCGGAGGCCGGTAGTGATCCT CAAGCCGAACAGCTGCTGGAAGAGCAGGTGCCCTGTGGAACGGCACATGAGAAGGGCGTCCCCAAGGCCAGAAGTGAGGCTGCAGAGGCT GGAAATGGCGCCGAGACAATGGCAGCAGAGGCAGAAAGTGCCCAAACCAGAGTTGCTCCTGCCCCAGCTGCCGCGGATGCTGAAGTGGAA CAAACTGATGCAGAGTCTAAAGACGCTGTTCCCACAGAATGATGCTCATTTCCCTGTTCCAGGGAAGGCGTTGGGATGATGGATGCGTTG GTCTTTCTCCCTTGGTTTGTAAGCAGTACAAGGGCGTGTGCTCCCAGAATATGCTGTAATCTAATTTTGGTGAAGAGACCCAGCGTTTCC TCCTGAGCAGTGCCTCTCACGGCTTGTCTCATGCAGTCGTGTGGCTTCTTGCCCAGGTTTCAAAGCTGAAGTACATTGTCCTTAGCGGCT GTAACATGTCTCTTGACAGTAGTGCACTTGGAATAATAAAGGTTGGGTGATTATATCTTGATGATACATTACTTGTTCAATACAGCCACT GATGGAATGCTTCCTTTTTTATTTTTTTCCTTAATTTTTTTTTTTATTTGGTTGGGAACAGCTGAATACTAGGAATATATCTTGCTCTAT AGAGGATTTTTTTTTGTATGTTTCAAGCTTCAGCCTTTAACCTATACCTTTGTAGTGCACCATATGGTGTGTGACTTTCACAGGACTTCG CAGCACCTGGTTCACATGTGGCACTGACCGCGTCACATCCACGCACTCCCAAAGGCCAGAAGTATCTGACCGACCTACGCCACTGGAAAC ACACCCACCGCAACCTCAAGAACCAGACTGTGCAGAGGGCATTGCGTCCCAATCTTTAGTCCTTGCTGAATCAGTTCTCTAATATTTTAC CTCATTTGTGTTCCACCTCTAGATTACTTCAGGTTTTTTTCCTTTAAAATTAGTTACTACCACTCAAATGTATTTACAAAGAGAATTTGG CCAGGCACGGTGATGCATACCTATAATCCCAGCACTTCGGGAGGCCGTGGTGAGAGGATAGCTTAAGCCCAGGAGTTCAAGACCAACCTG GACAACATAGCAAGACCCCATCTCTTAAAAAAAAAGGAAAGAAAACTTGATGTGATTGCCATAGGTGGAATAATCCAACATAAATTGCCA TAGATAGAAGGTATCTGTAATATATATATATATATATAAAATGAAATATATGTTTCATTTTAGAGAAATAACTATTACTTTAGATCTTTC CAAATCTGAGAAAGGGAGGCTAGCATGTGTTCAAGGTTAGCACGCAACAGAATTTCCTAAAATCAGAAGAATTGGAAGATCCTCCCCTTT TGAAATGGCCCTGCTGTGTCAGTTTCCCTGTGGCCTTTTGAACTGTACATCTCACATGTTGGGAAACGCTGGCCACTGGGAAATCATTAG AAAGGAGGCTGTAGAATATTTGCCGAGCCTCTACTGTATACCAGGGGCTAACTCACCAAGCACATTCTAGGAATTGGGCCCTGCTCATGA GGAGCCTTAGTGGAGATTCCAGGTGAATATTTATGAAAAAGTCAACATTAGAACTGAAAATGGAAATAAACTGCTTGAAAAGACGATGGT GCCTCTGGGTCATTTCTGCTCAGCATCCGTTTGTGTTGTGTAGATGCGTCTTAATCGCAGGGTGAGCATGCCTTTTAAGCTTGTTCTCTT >2198_2198_2_ADCK4-AKAP8_ADCK4_chr19_41201894_ENST00000243583_AKAP8_chr19_15469873_ENST00000269701_length(amino acids)=545AA_BP=362 MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRIS RLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIG QVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPA VVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHY IELAAEQFKKTSLHVAKSVLNNRHIVKMLEKYLKGEDPFTSETVDPEMEGDDNLGGEDKKETPEEVAADVLAEVITAAVRAVDGEGAPAP ESSGEPAEDEGPTDTAEAGSDPQAEQLLEEQVPCGTAHEKGVPKARSEAAEAGNGAETMAAEAESAQTRVAPAPAAADAEVEQTDAESKD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for COQ8B-AKAP8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 109_201 | 509.0 | 693.0 | DDX5 | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 109_201 | 509.0 | 693.0 | DDX5 | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 1_210 | 509.0 | 693.0 | DPY30 | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 1_210 | 509.0 | 693.0 | DPY30 | |
Tgene | AKAP8 | chr19:41201893 | chr19:15469873 | ENST00000269701 | 11 | 14 | 1_195 | 509.0 | 693.0 | MCM2 | |
Tgene | AKAP8 | chr19:41201894 | chr19:15469873 | ENST00000269701 | 11 | 14 | 1_195 | 509.0 | 693.0 | MCM2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COQ8B-AKAP8 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COQ8B-AKAP8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COQ8B | C3809965 | NEPHROTIC SYNDROME, TYPE 9 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | COQ8B | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | ORPHANET |
Tgene | C0041696 | Unipolar Depression | 1 | PSYGENET | |
Tgene | C1269683 | Major Depressive Disorder | 1 | PSYGENET |