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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EDC3-SLC6A11 (FusionGDB2 ID:HG80153TG6538)

Fusion Gene Summary for EDC3-SLC6A11

check button Fusion gene summary
Fusion gene informationFusion gene name: EDC3-SLC6A11
Fusion gene ID: hg80153tg6538
HgeneTgene
Gene symbol

EDC3

SLC6A11

Gene ID

80153

6538

Gene nameenhancer of mRNA decapping 3solute carrier family 6 member 11
SynonymsLSM16|MRT50|YJDC|YJEFN2|hYjeF_N2-15q23GAT-3|GAT3|GAT4
Cytomap('EDC3')('SLC6A11')

15q24.1

3p25.3

Type of geneprotein-codingprotein-coding
Descriptionenhancer of mRNA-decapping protein 3LSM16 homolog (EDC3, S. cerevisiae)enhancer of mRNA decapping 3 homologyjeF N-terminal domain-containing protein 2yjeF domain containingyjeF domain-containing protein 1sodium- and chloride-dependent GABA transporter 3GABA transporter 3solute carrier family 6 (neurotransmitter transporter), member 11solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315127, ENST00000426797, 
ENST00000568176, ENST00000562047, 
Fusion gene scores* DoF score10 X 9 X 6=5403 X 4 X 3=36
# samples 124
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EDC3 [Title/Abstract] AND SLC6A11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEDC3(74948074)-SLC6A11(10967690), # samples:3
Anticipated loss of major functional domain due to fusion event.EDC3-SLC6A11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EDC3-SLC6A11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EDC3-SLC6A11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EDC3-SLC6A11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EDC3-SLC6A11 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EDC3-SLC6A11 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EDC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SLC6A11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-2G-AAGA-01AEDC3chr15

74948074

-SLC6A11chr3

10967690

+
ChimerDB4TGCTTCGA-2G-AAGAEDC3chr15

74948073

-SLC6A11chr3

10967689

+
ChimerDB4TGCTTCGA-2G-AAGAEDC3chr15

74948074

-SLC6A11chr3

10967690

+


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Fusion Gene ORF analysis for EDC3-SLC6A11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000315127ENST00000454147EDC3chr15

74948074

-SLC6A11chr3

10967690

+
5CDS-intronENST00000315127ENST00000454147EDC3chr15

74948073

-SLC6A11chr3

10967689

+
5CDS-intronENST00000426797ENST00000454147EDC3chr15

74948074

-SLC6A11chr3

10967690

+
5CDS-intronENST00000426797ENST00000454147EDC3chr15

74948073

-SLC6A11chr3

10967689

+
5CDS-intronENST00000568176ENST00000454147EDC3chr15

74948074

-SLC6A11chr3

10967690

+
5CDS-intronENST00000568176ENST00000454147EDC3chr15

74948073

-SLC6A11chr3

10967689

+
Frame-shiftENST00000315127ENST00000254488EDC3chr15

74948074

-SLC6A11chr3

10967690

+
Frame-shiftENST00000315127ENST00000254488EDC3chr15

74948073

-SLC6A11chr3

10967689

+
Frame-shiftENST00000568176ENST00000254488EDC3chr15

74948074

-SLC6A11chr3

10967690

+
Frame-shiftENST00000568176ENST00000254488EDC3chr15

74948073

-SLC6A11chr3

10967689

+
In-frameENST00000426797ENST00000254488EDC3chr15

74948074

-SLC6A11chr3

10967690

+
In-frameENST00000426797ENST00000254488EDC3chr15

74948073

-SLC6A11chr3

10967689

+
intron-3CDSENST00000562047ENST00000254488EDC3chr15

74948074

-SLC6A11chr3

10967690

+
intron-3CDSENST00000562047ENST00000254488EDC3chr15

74948073

-SLC6A11chr3

10967689

+
intron-intronENST00000562047ENST00000454147EDC3chr15

74948074

-SLC6A11chr3

10967690

+
intron-intronENST00000562047ENST00000454147EDC3chr15

74948073

-SLC6A11chr3

10967689

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000426797EDC3chr1574948074-ENST00000254488SLC6A11chr310967690+439312834632061532
ENST00000426797EDC3chr1574948073-ENST00000254488SLC6A11chr310967689+439312834632061532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426797ENST00000254488EDC3chr1574948074-SLC6A11chr310967690+0.0009409130.99905914
ENST00000426797ENST00000254488EDC3chr1574948073-SLC6A11chr310967689+0.0009409130.99905914

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Fusion Genomic Features for EDC3-SLC6A11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EDC3chr1574948073-SLC6A11chr310967689+2.53E-121
EDC3chr1574948073-SLC6A11chr310967689+2.53E-121
EDC3chr1574948073-SLC6A11chr310967689+2.53E-121
EDC3chr1574948073-SLC6A11chr310967689+2.53E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EDC3-SLC6A11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:74948074/chr3:10967690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEDC3chr15:74948073chr3:10967689ENST00000315127-47192_228273509.0DomainDFDF
HgeneEDC3chr15:74948073chr3:10967689ENST00000426797-710192_228273509.0DomainDFDF
HgeneEDC3chr15:74948073chr3:10967689ENST00000568176-58192_228273509.0DomainDFDF
HgeneEDC3chr15:74948074chr3:10967690ENST00000315127-47192_228273509.0DomainDFDF
HgeneEDC3chr15:74948074chr3:10967690ENST00000426797-710192_228273509.0DomainDFDF
HgeneEDC3chr15:74948074chr3:10967690ENST00000568176-58192_228273509.0DomainDFDF
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714572_632373633.0Topological domainCytoplasmic
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714572_632373633.0Topological domainCytoplasmic
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714389_408373633.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714438_456373633.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714473_493373633.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714514_533373633.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714553_571373633.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714389_408373633.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714438_456373633.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714473_493373633.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714514_533373633.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714553_571373633.0TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEDC3chr15:74948073chr3:10967689ENST00000315127-47283_487273509.0DomainYjeF N-terminal
HgeneEDC3chr15:74948073chr3:10967689ENST00000426797-710283_487273509.0DomainYjeF N-terminal
HgeneEDC3chr15:74948073chr3:10967689ENST00000568176-58283_487273509.0DomainYjeF N-terminal
HgeneEDC3chr15:74948074chr3:10967690ENST00000315127-47283_487273509.0DomainYjeF N-terminal
HgeneEDC3chr15:74948074chr3:10967690ENST00000426797-710283_487273509.0DomainYjeF N-terminal
HgeneEDC3chr15:74948074chr3:10967690ENST00000568176-58283_487273509.0DomainYjeF N-terminal
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714152_225373633.0Topological domainExtracellular
TgeneSLC6A11chr15:74948073chr3:10967689ENST000002544887141_58373633.0Topological domainCytoplasmic
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714152_225373633.0Topological domainExtracellular
TgeneSLC6A11chr15:74948074chr3:10967690ENST000002544887141_58373633.0Topological domainCytoplasmic
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714131_151373633.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714226_244373633.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714253_270373633.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714306_323373633.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A11chr15:74948073chr3:10967689ENST00000254488714335_356373633.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A11chr15:74948073chr3:10967689ENST0000025448871459_79373633.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A11chr15:74948073chr3:10967689ENST0000025448871487_106373633.0TransmembraneHelical%3B Name%3D2
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714131_151373633.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714226_244373633.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714253_270373633.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714306_323373633.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A11chr15:74948074chr3:10967690ENST00000254488714335_356373633.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A11chr15:74948074chr3:10967690ENST0000025448871459_79373633.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A11chr15:74948074chr3:10967690ENST0000025448871487_106373633.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for EDC3-SLC6A11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24947_24947_1_EDC3-SLC6A11_EDC3_chr15_74948073_ENST00000426797_SLC6A11_chr3_10967689_ENST00000254488_length(transcript)=4393nt_BP=1283nt
GGGCGCTTCCGGCAGCGGCGGCGGTGGTGAAGGCCGATGCTGTGGGGGTGGGCGTGGAGAGAATTCTTCTGTGGGTCCTCTGGTGTTGAG
TGGTCGGCTTGGTGTGGTGTGCGGAGGAGCTCCAGGCCCGTCGGCGCGGAGGCTTTCAGGTATAGGCTGGGTCACTAGTCTTAAAACATT
TCTTCTTGAGAATGTCTAAAAGACTGTGGAATCTGTTAGATCTTATATACTTTTAAGTTGGCACCTGAAACTTTTCATCCTAGATTTACA
TAGTGGTCTTGCTGTGTTGCCCAGCCTGGTCTTGAATTCCTGGACTCAAGTGATGCTCCTGCCTTGGCTTCCCAAACTCCTGGAATTACA
ACTCAATGAATGACGGTTTTTGTTGCTCCACATCCTCGTCAGCATTTGGTGTTGTCAGTGTTTTGGATTTCGGCCATTCTGACAGTGGTC
TCACGTGTGAAACATGGCTACAGATTGGCTGGGAAGTATTGTGTCCATCAATTGTGGAGATAGCTTGGGTGTCTATCAGGGAAGAGTGTC
AGCTGTGGATCAGGTCAGCCAGACCATTTCTCTCACCCGGCCTTTCCATAATGGAGTGAAGTGTCTTGTTCCAGAAGTCACCTTCAGGGC
AGGTGACATTACGGAGTTAAAAATTCTGGAGATACCAGGACCTGGAGACAACCAACATTTTGGAGACCTTCATCAAACAGAATTAGGCCC
CTCTGGTGCTGGCTGCCAAGTGGGCATCAATCAGAATGGCACAGGCAAGTTTGTCAAGAAGCCAGCCTCTTCCAGCAGTGCCCCTCAGAA
TATCCCTAAGAGGACAGATGTGAAGAGCCAGGATGTTGCCGTTTCCCCGCAGCAGCAACAGTGCTCAAAGAGCTATGTCGACAGGCACAT
GGAATCCTTGAGTCAGTCCAAAAGTTTCCGTCGTCGGCACAACTCCTGGTCATCTAGTAGCAGGCACCCAAATCAGGCAACTCCCAAGAA
AAGTGGTTTAAAGAATGGCCAGATGAAGAATAAAGATGACGAGTGCTTCGGGGATGATATTGAGGAGATCCCAGACACAGATTTTGATTT
TGAAGGGAACCTGGCTCTTTTTGACAAGGCAGCTGTGTTTGAGGAGATTGATACCTATGAAAGGAGAAGTGGTACCCGTTCCCGGGGCAT
CCCAAATGAAAGGCCCACTCGGTACCGCCATGATGAGAACATCTTGGAGTCCGAGCCCATTGTCTATCGACGGATCATAGTGCCCCACAA
CGTGAGCAAGGAGTTCTGCACGGGCCCCGGCCTGGCCTTTATTGCGTACCCCAAGGCGGTCACCATGATGCCTCTCTCCCCGCTGTGGGC
CACCTTGTTCTTCATGATGCTCATCTTCCTGGGCCTGGACAGCCAGTTTGTGTGTGTGGAAAGCCTGGTGACCGCCGTGGTGGACATGTA
CCCCAAGGTTTTCCGGAGGGGTTACCGGCGGGAGCTGCTCATCCTAGCCTTGTCTGTTATCTCCTATTTTCTGGGCCTCGTGATGTTAAC
AGAGGGTGGCATGTACATCTTCCAGCTCTTTGACTCCTATGCCGCCAGTGGGATGTGCCTTCTCTTCGTGGCCATCTTTGAGTGCATCTG
CATCGGCTGGGTGTATGGAAGCAACCGGTTCTATGATAACATTGAAGACATGATTGGCTACCGGCCACCGTCGCTCATTAAGTGGTGCTG
GATGATCATGACCCCTGGGATCTGCGCGGGGATCTTCATCTTCTTCTTGATCAAGTACAAGCCACTCAAGTACAACAACATCTACACCTA
CCCAGCCTGGGGCTATGGCATTGGCTGGCTCATGGCCCTGTCCTCCATGCTCTGCATCCCGCTCTGGATCTGCATCACAGTGTGGAAGAC
GGAGGGGACACTGCCCGAGAAACTCCAGAAGTTGACGACCCCCAGCACAGATCTGAAAATGCGGGGCAAGCTTGGGGTGAGCCCACGGAT
GGTGACAGTTAATGACTGTGATGCCAAACTCAAGAGTGACGGGACCATCGCAGCCATCACAGAGAAGGAGACGCACTTCTGAGCGGCCAC
CAGCCATCTGGGGCTCTTCTTCCTTTCTTCCCCCCGTGTATGTAAATGAATTCCTGAACCCCATACTTCACCTAATGGTAGGGGCTTGCT
TGTTTTGCACAGGATTAATTAACAAGTTAATTTTAAGGTGGCCACTGTACACTGCTCTAAAGTCATATCCCCTCCCCGCCCCCAGTCATC
ATGGAAGTAACCACTACAAAGAGATAACACTGTACGGGGACTGCCAGATCTTCTGTCCTAGGGCAGTTTTAATCAATGTTTTCTAGGGAT
TAGGAAGAAGTGTATAATATTGTAAAACTTTTTTTACTGGGGTTGTGGGCCAGGTGGGGTGGGGAGTGATGGCTGTCCTCCTCTGTCGGC
CTTTTAATGACCGTTCTGTGTCCCATGTATGTCTCTGACCATCCACAGCCGCCCCTCCTCCATACCCCAGGGATAATTTTTCCTTCAAAC
CTTCCCTTTCCAAGGGACACTGGGTTTGCAGACAGCAAGGCTATGTGGCAGAGAAGAAAAAGTCCAGCAGACTCAGGACTCCTGGGCTGC
AGGCCCCCCTCTGCCCTGATCCCATGAAGTGACCTTGGGCACTCCCTTTCCCTCCCTGGGCCTCAGTTTCCCCATCTCCCAAATGGGAGG
AGGAGCCGGATTGGGTTATTTCTTAGGGATTCTCTTTGTGTGCCTTGCTGGCTTCCAGACCTGCCGTGGACCTTGGCTTCCTCTGAAGAC
TTGCAGGCAATAATCTCCGCCCTCCCAGTTGTACCTCCTCCCCACCTGCTTATTTAAAATCAAGTTTATTGTAGAAATGGTGTGGTGTTG
ATGTGTGTTTTCCCTAAAACTCTAATTTCATCTCATCTGTGGGCAGCCCTGCTCTCTGGACACCAGTGGGTCCTCAGCCCCCATGGCAGG
GGCTCCTCTGTCTGGCCTGCCTTTTTTTCCTGGTCAGCTGCTCTTAGCGCCGGCTCTGCCTCTCCACCCTTGGCAGGGCTGGCTGGAGTT
GCTGTGGGGACTGATTTTCTGGGTGGGGAAGCAGCCATCTATTCTTGCAGCCATCTCAGCCAGGGTCTATGTCTTAGGACCTTCCTCCGG
CCTTCCATGAGAAGCAGCCACAGGGGGCCTGGTTTCCTCCTAAGGCCCTTCTCTGTCCCAGGCCACCTCTTCTCCCTCCTCCTGTCCCCT
AACCTCCACCTACCACCATCCTCCCTCTCAGTTCTCTCCCATCCTTGCCCCTGGTTCAGGAGCCATTCTACCTGCCTCAGTGGCCAGGCG
CAAGGCTACAGGTGCAGTCACCTGTTCCCGGCCACCTTCCCTCCCATCTTTGGCAGACAGAAGTCTCAGCTCTCACTAGAGGGAAGACCT
GGGCATCCTGCTGGCTCCTCTCTCCGTGGGGCCTGGAGTCTGGTGCTGTTCCCCAGCCAGCCTGGCTGCAGACCTCTCTGGCTGATACCG
CTCTTCTTCTTTAATTGGACTTCATATCAAGCCTCTGCCTTGGTTTCTGAGCTATATGAGGGTGGGGAAGGCACACTCTTTTTTCCTTTT
TCCTTAGGTTCCCAATATTATTTGGTGGAAACGTGGGCTTTCTCCAAACCAAGGCCTGAGTTTCCTGTAAGGGTCCTCTGTTTTTGATTC
ACCCAAAAGTCTGCAAACCCCCAGCATCTCTGCTCTGGCCAGCCCTGATCTGAAGCCTGTGTCTACTAAGAGGGATGCCCAGTGCCCCAC
TGGGCAGGACGGGAAGCCTAGCCTGGGCCCCCTCTGTGCACACAGTTCAGGCCTGCCCAGCTTCTTATGGGCAAGCCACCATCCCACTCT
CGTCTCCCTGAGCTGTCTGGTTCTGCGGACCCAGGAAGGGCCAGGCTGGGGCCCTGCTTGTGTTTATCCTCGGCTGCTGTCTTCCCAGCA
GGCCCCAGGCAAGGAGGCTTCCCATTGCTGCTGCTACCGGTTCTCCACAGATCCCTGTGGTCCGCCATCGCCGACACACACACACGTCGT
AATGTGGCTAACGCTTGACTCACTTAACACTACTCATGGGGCAGGGCGGAGGGTGGATTGTTGCTTTTTGTTTTTTGTAATTTCCTACTA
GTATTTGGGTAACTTTGGGGGTGGGGAGGGCAATGTGGGGGCAGGGGAACATGTCATTGTGATGACTTTTTTGATATTCATTAGAAACAA
TACATCCTTTCTGAGATATTTACAGTATTATTAAAAAATGAAAAAGGTTGTACTGTTTTGCATAATGAACATTTTTATTGGGCATTCAAA

>24947_24947_1_EDC3-SLC6A11_EDC3_chr15_74948073_ENST00000426797_SLC6A11_chr3_10967689_ENST00000254488_length(amino acids)=532AA_BP=273
MATDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGDNQHFGDLHQTELGPSGAG
CQVGINQNGTGKFVKKPASSSSAPQNIPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKSFRRRHNSWSSSSRHPNQATPKKSGLK
NGQMKNKDDECFGDDIEEIPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGIPNERPTRYRHDENILESEPIVYRRIIVPHNVSKE
FCTGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGM
YIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWG

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>24947_24947_2_EDC3-SLC6A11_EDC3_chr15_74948074_ENST00000426797_SLC6A11_chr3_10967690_ENST00000254488_length(transcript)=4393nt_BP=1283nt
GGGCGCTTCCGGCAGCGGCGGCGGTGGTGAAGGCCGATGCTGTGGGGGTGGGCGTGGAGAGAATTCTTCTGTGGGTCCTCTGGTGTTGAG
TGGTCGGCTTGGTGTGGTGTGCGGAGGAGCTCCAGGCCCGTCGGCGCGGAGGCTTTCAGGTATAGGCTGGGTCACTAGTCTTAAAACATT
TCTTCTTGAGAATGTCTAAAAGACTGTGGAATCTGTTAGATCTTATATACTTTTAAGTTGGCACCTGAAACTTTTCATCCTAGATTTACA
TAGTGGTCTTGCTGTGTTGCCCAGCCTGGTCTTGAATTCCTGGACTCAAGTGATGCTCCTGCCTTGGCTTCCCAAACTCCTGGAATTACA
ACTCAATGAATGACGGTTTTTGTTGCTCCACATCCTCGTCAGCATTTGGTGTTGTCAGTGTTTTGGATTTCGGCCATTCTGACAGTGGTC
TCACGTGTGAAACATGGCTACAGATTGGCTGGGAAGTATTGTGTCCATCAATTGTGGAGATAGCTTGGGTGTCTATCAGGGAAGAGTGTC
AGCTGTGGATCAGGTCAGCCAGACCATTTCTCTCACCCGGCCTTTCCATAATGGAGTGAAGTGTCTTGTTCCAGAAGTCACCTTCAGGGC
AGGTGACATTACGGAGTTAAAAATTCTGGAGATACCAGGACCTGGAGACAACCAACATTTTGGAGACCTTCATCAAACAGAATTAGGCCC
CTCTGGTGCTGGCTGCCAAGTGGGCATCAATCAGAATGGCACAGGCAAGTTTGTCAAGAAGCCAGCCTCTTCCAGCAGTGCCCCTCAGAA
TATCCCTAAGAGGACAGATGTGAAGAGCCAGGATGTTGCCGTTTCCCCGCAGCAGCAACAGTGCTCAAAGAGCTATGTCGACAGGCACAT
GGAATCCTTGAGTCAGTCCAAAAGTTTCCGTCGTCGGCACAACTCCTGGTCATCTAGTAGCAGGCACCCAAATCAGGCAACTCCCAAGAA
AAGTGGTTTAAAGAATGGCCAGATGAAGAATAAAGATGACGAGTGCTTCGGGGATGATATTGAGGAGATCCCAGACACAGATTTTGATTT
TGAAGGGAACCTGGCTCTTTTTGACAAGGCAGCTGTGTTTGAGGAGATTGATACCTATGAAAGGAGAAGTGGTACCCGTTCCCGGGGCAT
CCCAAATGAAAGGCCCACTCGGTACCGCCATGATGAGAACATCTTGGAGTCCGAGCCCATTGTCTATCGACGGATCATAGTGCCCCACAA
CGTGAGCAAGGAGTTCTGCACGGGCCCCGGCCTGGCCTTTATTGCGTACCCCAAGGCGGTCACCATGATGCCTCTCTCCCCGCTGTGGGC
CACCTTGTTCTTCATGATGCTCATCTTCCTGGGCCTGGACAGCCAGTTTGTGTGTGTGGAAAGCCTGGTGACCGCCGTGGTGGACATGTA
CCCCAAGGTTTTCCGGAGGGGTTACCGGCGGGAGCTGCTCATCCTAGCCTTGTCTGTTATCTCCTATTTTCTGGGCCTCGTGATGTTAAC
AGAGGGTGGCATGTACATCTTCCAGCTCTTTGACTCCTATGCCGCCAGTGGGATGTGCCTTCTCTTCGTGGCCATCTTTGAGTGCATCTG
CATCGGCTGGGTGTATGGAAGCAACCGGTTCTATGATAACATTGAAGACATGATTGGCTACCGGCCACCGTCGCTCATTAAGTGGTGCTG
GATGATCATGACCCCTGGGATCTGCGCGGGGATCTTCATCTTCTTCTTGATCAAGTACAAGCCACTCAAGTACAACAACATCTACACCTA
CCCAGCCTGGGGCTATGGCATTGGCTGGCTCATGGCCCTGTCCTCCATGCTCTGCATCCCGCTCTGGATCTGCATCACAGTGTGGAAGAC
GGAGGGGACACTGCCCGAGAAACTCCAGAAGTTGACGACCCCCAGCACAGATCTGAAAATGCGGGGCAAGCTTGGGGTGAGCCCACGGAT
GGTGACAGTTAATGACTGTGATGCCAAACTCAAGAGTGACGGGACCATCGCAGCCATCACAGAGAAGGAGACGCACTTCTGAGCGGCCAC
CAGCCATCTGGGGCTCTTCTTCCTTTCTTCCCCCCGTGTATGTAAATGAATTCCTGAACCCCATACTTCACCTAATGGTAGGGGCTTGCT
TGTTTTGCACAGGATTAATTAACAAGTTAATTTTAAGGTGGCCACTGTACACTGCTCTAAAGTCATATCCCCTCCCCGCCCCCAGTCATC
ATGGAAGTAACCACTACAAAGAGATAACACTGTACGGGGACTGCCAGATCTTCTGTCCTAGGGCAGTTTTAATCAATGTTTTCTAGGGAT
TAGGAAGAAGTGTATAATATTGTAAAACTTTTTTTACTGGGGTTGTGGGCCAGGTGGGGTGGGGAGTGATGGCTGTCCTCCTCTGTCGGC
CTTTTAATGACCGTTCTGTGTCCCATGTATGTCTCTGACCATCCACAGCCGCCCCTCCTCCATACCCCAGGGATAATTTTTCCTTCAAAC
CTTCCCTTTCCAAGGGACACTGGGTTTGCAGACAGCAAGGCTATGTGGCAGAGAAGAAAAAGTCCAGCAGACTCAGGACTCCTGGGCTGC
AGGCCCCCCTCTGCCCTGATCCCATGAAGTGACCTTGGGCACTCCCTTTCCCTCCCTGGGCCTCAGTTTCCCCATCTCCCAAATGGGAGG
AGGAGCCGGATTGGGTTATTTCTTAGGGATTCTCTTTGTGTGCCTTGCTGGCTTCCAGACCTGCCGTGGACCTTGGCTTCCTCTGAAGAC
TTGCAGGCAATAATCTCCGCCCTCCCAGTTGTACCTCCTCCCCACCTGCTTATTTAAAATCAAGTTTATTGTAGAAATGGTGTGGTGTTG
ATGTGTGTTTTCCCTAAAACTCTAATTTCATCTCATCTGTGGGCAGCCCTGCTCTCTGGACACCAGTGGGTCCTCAGCCCCCATGGCAGG
GGCTCCTCTGTCTGGCCTGCCTTTTTTTCCTGGTCAGCTGCTCTTAGCGCCGGCTCTGCCTCTCCACCCTTGGCAGGGCTGGCTGGAGTT
GCTGTGGGGACTGATTTTCTGGGTGGGGAAGCAGCCATCTATTCTTGCAGCCATCTCAGCCAGGGTCTATGTCTTAGGACCTTCCTCCGG
CCTTCCATGAGAAGCAGCCACAGGGGGCCTGGTTTCCTCCTAAGGCCCTTCTCTGTCCCAGGCCACCTCTTCTCCCTCCTCCTGTCCCCT
AACCTCCACCTACCACCATCCTCCCTCTCAGTTCTCTCCCATCCTTGCCCCTGGTTCAGGAGCCATTCTACCTGCCTCAGTGGCCAGGCG
CAAGGCTACAGGTGCAGTCACCTGTTCCCGGCCACCTTCCCTCCCATCTTTGGCAGACAGAAGTCTCAGCTCTCACTAGAGGGAAGACCT
GGGCATCCTGCTGGCTCCTCTCTCCGTGGGGCCTGGAGTCTGGTGCTGTTCCCCAGCCAGCCTGGCTGCAGACCTCTCTGGCTGATACCG
CTCTTCTTCTTTAATTGGACTTCATATCAAGCCTCTGCCTTGGTTTCTGAGCTATATGAGGGTGGGGAAGGCACACTCTTTTTTCCTTTT
TCCTTAGGTTCCCAATATTATTTGGTGGAAACGTGGGCTTTCTCCAAACCAAGGCCTGAGTTTCCTGTAAGGGTCCTCTGTTTTTGATTC
ACCCAAAAGTCTGCAAACCCCCAGCATCTCTGCTCTGGCCAGCCCTGATCTGAAGCCTGTGTCTACTAAGAGGGATGCCCAGTGCCCCAC
TGGGCAGGACGGGAAGCCTAGCCTGGGCCCCCTCTGTGCACACAGTTCAGGCCTGCCCAGCTTCTTATGGGCAAGCCACCATCCCACTCT
CGTCTCCCTGAGCTGTCTGGTTCTGCGGACCCAGGAAGGGCCAGGCTGGGGCCCTGCTTGTGTTTATCCTCGGCTGCTGTCTTCCCAGCA
GGCCCCAGGCAAGGAGGCTTCCCATTGCTGCTGCTACCGGTTCTCCACAGATCCCTGTGGTCCGCCATCGCCGACACACACACACGTCGT
AATGTGGCTAACGCTTGACTCACTTAACACTACTCATGGGGCAGGGCGGAGGGTGGATTGTTGCTTTTTGTTTTTTGTAATTTCCTACTA
GTATTTGGGTAACTTTGGGGGTGGGGAGGGCAATGTGGGGGCAGGGGAACATGTCATTGTGATGACTTTTTTGATATTCATTAGAAACAA
TACATCCTTTCTGAGATATTTACAGTATTATTAAAAAATGAAAAAGGTTGTACTGTTTTGCATAATGAACATTTTTATTGGGCATTCAAA

>24947_24947_2_EDC3-SLC6A11_EDC3_chr15_74948074_ENST00000426797_SLC6A11_chr3_10967690_ENST00000254488_length(amino acids)=532AA_BP=273
MATDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGDNQHFGDLHQTELGPSGAG
CQVGINQNGTGKFVKKPASSSSAPQNIPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKSFRRRHNSWSSSSRHPNQATPKKSGLK
NGQMKNKDDECFGDDIEEIPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGIPNERPTRYRHDENILESEPIVYRRIIVPHNVSKE
FCTGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGM
YIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWG

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Fusion Gene PPI Analysis for EDC3-SLC6A11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EDC3-SLC6A11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EDC3-SLC6A11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEDC3C4225319MENTAL RETARDATION, AUTOSOMAL RECESSIVE 501CTD_human;UNIPROT
TgeneC0025202melanoma1CTD_human
TgeneC0036341Schizophrenia1PSYGENET