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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM254-CREB3L3 (FusionGDB2 ID:HG80195TG84699)

Fusion Gene Summary for TMEM254-CREB3L3

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM254-CREB3L3
Fusion gene ID: hg80195tg84699
HgeneTgene
Gene symbol

TMEM254

CREB3L3

Gene ID

80195

84699

Gene nametransmembrane protein 254cAMP responsive element binding protein 3 like 3
SynonymsC10orf57|bA369J21.6CREB-H|CREBH|HYST1481
Cytomap('C10orf57','TMEM254')('CREB3L3','CREB3L3')

10q22.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 254transmembrane protein C10orf57cyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factorcAMP-responsive element-binding protein, hepatic-specific
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000467529, ENST00000372274, 
ENST00000372275, ENST00000372277, 
ENST00000372281, 
Fusion gene scores* DoF score4 X 3 X 3=366 X 7 X 6=252
# samples 47
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM254 [Title/Abstract] AND CREB3L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC10orf57(81841960)-CREB3L3(4170136), # samples:2
TMEM254(81841960)-CREB3L3(4170137), # samples:2
Anticipated loss of major functional domain due to fusion event.TMEM254-CREB3L3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM254-CREB3L3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM254-CREB3L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMEM254-CREB3L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREB3L3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

16469704


check buttonFusion gene breakpoints across TMEM254 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CREB3L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A106-01AC10orf57chr10

81841960

-CREB3L3chr19

4170137

+
ChimerDB4BRCATCGA-E2-A106C10orf57chr10

81841960

+CREB3L3chr19

4170136

+
ChimerDB4BRCATCGA-E2-A106-01ATMEM254chr10

81841960

+CREB3L3chr19

4170137

+


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Fusion Gene ORF analysis for TMEM254-CREB3L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000467529ENST00000078445TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
3UTR-intronENST00000467529ENST00000252587TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
3UTR-intronENST00000467529ENST00000595923TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
3UTR-intronENST00000467529ENST00000602147TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
3UTR-intronENST00000467529ENST00000602257TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372274ENST00000252587TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372274ENST00000595923TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372274ENST00000602147TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372274ENST00000602257TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372275ENST00000252587TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372275ENST00000595923TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372275ENST00000602147TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372275ENST00000602257TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372277ENST00000252587TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372277ENST00000595923TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372277ENST00000602147TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372277ENST00000602257TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372281ENST00000252587TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372281ENST00000595923TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372281ENST00000602147TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
5CDS-intronENST00000372281ENST00000602257TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
In-frameENST00000372274ENST00000078445TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
In-frameENST00000372275ENST00000078445TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
In-frameENST00000372277ENST00000078445TMEM254chr10

81841960

+CREB3L3chr19

4170137

+
In-frameENST00000372281ENST00000078445TMEM254chr10

81841960

+CREB3L3chr19

4170137

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000372277TMEM254chr1081841960+ENST00000078445CREB3L3chr194170137+19312811878913321
ENST00000372281TMEM254chr1081841960+ENST00000078445CREB3L3chr194170137+19312811878913321
ENST00000372275TMEM254chr1081841960+ENST00000078445CREB3L3chr194170137+19192691866901321
ENST00000372274TMEM254chr1081841960+ENST00000078445CREB3L3chr194170137+19092591856891321

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372277ENST00000078445TMEM254chr1081841960+CREB3L3chr194170137+0.160901440.8390986
ENST00000372281ENST00000078445TMEM254chr1081841960+CREB3L3chr194170137+0.160901440.8390986
ENST00000372275ENST00000078445TMEM254chr1081841960+CREB3L3chr194170137+0.1661130.833887
ENST00000372274ENST00000078445TMEM254chr1081841960+CREB3L3chr194170137+0.167786210.8322138

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Fusion Genomic Features for TMEM254-CREB3L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM254chr1081841960+CREB3L3chr194170136+2.07E-070.99999976
TMEM254chr1081841960+CREB3L3chr194170136+2.07E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM254-CREB3L3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:81841960/chr19:4170136)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372274+3615_3583119.66666666666667TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372274+3661_8183119.66666666666667TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372275+3515_3583229.66666666666666TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372275+3561_8183229.66666666666666TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372277+3515_3583104.0TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372277+3561_8183104.0TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372281+3415_3583124.0TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372281+3461_8183124.0TransmembraneHelical
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000078445510285_306273462.0RegionLeucine-zipper
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000595923510285_306272461.0RegionLeucine-zipper
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000078445510344_461273462.0Topological domainLumenal
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000595923510344_461272461.0Topological domainLumenal
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000078445510323_343273462.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000595923510323_343272461.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372274+3695_11583119.66666666666667TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372275+3595_11583229.66666666666666TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372277+3595_11583104.0TransmembraneHelical
HgeneTMEM254chr10:81841960chr19:4170137ENST00000372281+3495_11583124.0TransmembraneHelical
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000078445510243_306273462.0DomainbZIP
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000595923510243_306272461.0DomainbZIP
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000078445510245_274273462.0RegionBasic motif
TgeneCREB3L3chr10:81841960chr19:4170137ENST00000595923510245_274272461.0RegionBasic motif
TgeneCREB3L3chr10:81841960chr19:4170137ENST000000784455101_322273462.0Topological domainCytoplasmic
TgeneCREB3L3chr10:81841960chr19:4170137ENST000005959235101_322272461.0Topological domainCytoplasmic


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Fusion Gene Sequence for TMEM254-CREB3L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>92006_92006_1_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372274_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1909nt_BP=259nt
TTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTCATCACCCTCAGCTTTGGCTACT
ACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTGGACCACCATC
ACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGTGCAAGATGTCAGCTT
GCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGG
CCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATCATCCTCCCCT
CCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCACAACGATGCTG
CCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAGTCTCCAGGAA
GCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTCCTGAGGAATG
CAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTGGAGGCGGCGG
GAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCAGCTACCCACC
TGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGCCTGACTGAGG
CCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAAGCAAAGAGCA
GACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAACAGACCCAGA
CAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGATCCG
GACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTAGACAGACAGA
CACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACAGACAGACAGA
CACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAAGAGACCCAGA
CAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGACAGACGCACA
CACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGAGACTGCAGGG
AGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGCCTGATCCGAA

>92006_92006_1_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372274_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_2_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372275_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1919nt_BP=269nt
CGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTCATCACCCTCAGC
TTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACTCAGTACTTGGTG
GACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATAGTATTGTGCAAG
ATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAG
AAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCCTTTGCCCTCATC
ATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCCAGAACTTTGCAC
AACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACAACCCGAGAAGAG
TCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAACGCCACCCTGGTC
CTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGACGTGCAGGGCTG
GAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATGCTGCACTGGGCA
GCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCACACACCCAGGGC
CTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAGCCAGGAGCAGAA
GCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACACAGCCTGAAA
CAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCAGACACAGCCTGA
AACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACA
GACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCTA
GACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAACAGACCCGGACA
GACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGACGCAGCCTGAAA
GAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACCTGAACAGACAGA
CAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGAGGAAGCCGCCGA
GACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTTTTCTAAGACTGC

>92006_92006_2_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372275_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_3_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372277_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1931nt_BP=281nt
GAAGCGCGCTCCCGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTC
ATCACCCTCAGCTTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACT
CAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATA
GTATTGTGCAAGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTG
GAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCC
TTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCC
AGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACA
ACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAAC
GCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGA
CGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATG
CTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCA
CACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAG
CCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGA
CACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCA
GACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCG
GACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAA
CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGA
CGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACC
TGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGA
GGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTT

>92006_92006_3_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372277_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------
>92006_92006_4_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372281_CREB3L3_chr19_4170137_ENST00000078445_length(transcript)=1931nt_BP=281nt
GAAGCGCGCTCCCGGGGAGGTGTTGCAGCCATGGCTACGGCAGCCGGCGCGACCTACTTTCAGCGAGGCAGTCTGTTCTGGTTCACAGTC
ATCACCCTCAGCTTTGGCTACTACACATGGGTTGTCTTCTGGCCTCAGAGTATCCCTTATCAGAACCTTGGGCCCCTGGGCCCCTTCACT
CAGTACTTGGTGGACCACCATCACACCCTCCTGTGCAATGGGTATTGGCTTGCCTGGCTGATTCATGTGGGAGAGTCCTTGTATGCCATA
GTATTGTGCAAGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTG
GAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCAGTCCTGTTGCTGTCC
TTTGCCCTCATCATCCTCCCCTCCATCAGCCCTTTTGGCCCCAACAAAACCGAGAGCCCTGGGGACTTTGCGCCTGTACGAGTGTTCTCC
AGAACTTTGCACAACGATGCTGCCTCCCGCGTGGCTGCTGATGCTGTGCCAGGCTCCGAGGCCCCAGGACCCCGACCCGAGGCTGACACA
ACCCGAGAAGAGTCTCCAGGAAGCCCCGGGGCAGACTGGGGCTTCCAGGACACCGCGAACCTGACCAATTCGACGGAGGAGCTGGACAAC
GCCACCCTGGTCCTGAGGAATGCAACAGAGGGGCTGGGCCAGGTCGCCCTGCTGGACTGGGTGGCGCCTGGGCCGAGCACTGGCTCAGGA
CGTGCAGGGCTGGAGGCGGCGGGAGACGAGCTGTGAGCCCCGCCAGGACTATGCTCCCAGGCCCCTCTGCCCAGGGGTGCCTTGGGGATG
CTGCACTGGGCAGCTACCCACCTGGGGATGGGACGTGAGGCCAAGACCCCAGCAGAGATGCCAGAATGGGGGAGGCACAGCTCATAGCCA
CACACCCAGGGCCTGACTGAGGCCCACGCAGGAACCGACACTCAGACACAAGGCAAAGAGGGCCACAGGACCCGGGAAATACACACAGAG
CCAGGAGCAGAAGCAAAGAGCAGACACACATACAGCCTGAAACAGACCTGGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGA
CACAGCCTGAAACAGACCCAGACAAACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACAGCCTGAAACAGACCCA
GACACAGCCTGAAACAGATCCGGACAGACAGACAGAAACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCG
GACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCGGACAGACAGACAGACACAGCCT
GAAACAGACCTAGACAGACAGACACAGATTGAAACAGACCCAGACAAACAGACAGACACAGCCTGAAACAGACCCAGACACAGCCTGAAA
CAGACCCGGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACAGACACAGCCTGAAACAGACCCAGACAGACAGACCGA
CGCAGCCTGAAAGAGACCCAGACAGAGAGACAGGCAGACACAGCCTAAAACAGACCTGGACAGACAGGCAGACGTAGTCTGAAACAGACC
TGAACAGACAGACAGACGCACACACACAACAGATGCGCAGCAACTCCCCGCCCAGGGACCCCTCCCGGCCTCCCTCGCACACTGGGAGGA
GGAAGCCGCCGAGACTGCAGGGAGCCTGGCCCCGGAGCCCCGGGTGCGCCCTGGTCTTTGGAGCAGCCACGGCCCACAATCACCCCCCTT

>92006_92006_4_TMEM254-CREB3L3_TMEM254_chr10_81841960_ENST00000372281_CREB3L3_chr19_4170137_ENST00000078445_length(amino acids)=321AA_BP=88
MWAVAAPKTRAHPGLRGQAPCSLGGFLLPVCEGGREGSLGGELLRICCVCASVCLFRSVSDYVCLSVQVCFRLCLPVSLSGSLSGCVGLS
VWVCFRLCLSVCLGLFQAVSVCLSGSVSGCVWVCFRLCLSVCLGLFQSVSVCLGLFQAVSVCLSGSVSGCVCLSVRVCFRLCLSVCPGLF
QAVSVCLSGSVSGCFCLSVRICFRLCLGLFQAVCLSVWVCFRLCLSVCLSGSVSGCVCLSGSVSGCVCLSRSVSGCMCVCSLLLLLALCV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM254-CREB3L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM254-CREB3L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM254-CREB3L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource