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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C16orf70-GNAO1 (FusionGDB2 ID:HG80262TG2775)

Fusion Gene Summary for C16orf70-GNAO1

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf70-GNAO1
Fusion gene ID: hg80262tg2775
HgeneTgene
Gene symbol

C16orf70

GNAO1

Gene ID

80262

2775

Gene namechromosome 16 open reading frame 70G protein subunit alpha o1
SynonymsC16orf6|LIN10|lin-10EIEE17|G-ALPHA-o|GNAO|HLA-DQB1|NEDIM
Cytomap('C16orf70')('GNAO1')

16q22.1

16q13

Type of geneprotein-codingprotein-coding
DescriptionUPF0183 protein C16orf70lin-10 homologguanine nucleotide-binding protein G(o) subunit alphaGO2-q chimeric G-proteinguanine nucleotide binding protein (G protein), alpha activating activity polypeptide Oguanine nucleotide-binding regulatory protein 2
Modification date2020031320200313
UniProtAcc.

P09471

Ensembl transtripts involved in fusion geneENST00000569683, ENST00000219139, 
ENST00000569600, 
Fusion gene scores* DoF score10 X 8 X 8=6407 X 8 X 4=224
# samples 128
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C16orf70 [Title/Abstract] AND GNAO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC16orf70(67159945)-GNAO1(56362543), # samples:3
Anticipated loss of major functional domain due to fusion event.C16orf70-GNAO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C16orf70-GNAO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C16orf70-GNAO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C16orf70-GNAO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C16orf70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GNAO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-PD-A5DF-01AC16orf70chr16

67159945

-GNAO1chr16

56362543

+
ChimerDB4LIHCTCGA-PD-A5DF-01AC16orf70chr16

67159945

+GNAO1chr16

56362543

+


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Fusion Gene ORF analysis for C16orf70-GNAO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000569683ENST00000262493C16orf70chr16

67159945

+GNAO1chr16

56362543

+
3UTR-3CDSENST00000569683ENST00000262494C16orf70chr16

67159945

+GNAO1chr16

56362543

+
3UTR-intronENST00000569683ENST00000569295C16orf70chr16

67159945

+GNAO1chr16

56362543

+
5CDS-intronENST00000219139ENST00000569295C16orf70chr16

67159945

+GNAO1chr16

56362543

+
5CDS-intronENST00000569600ENST00000569295C16orf70chr16

67159945

+GNAO1chr16

56362543

+
In-frameENST00000219139ENST00000262493C16orf70chr16

67159945

+GNAO1chr16

56362543

+
In-frameENST00000219139ENST00000262494C16orf70chr16

67159945

+GNAO1chr16

56362543

+
In-frameENST00000569600ENST00000262493C16orf70chr16

67159945

+GNAO1chr16

56362543

+
In-frameENST00000569600ENST00000262494C16orf70chr16

67159945

+GNAO1chr16

56362543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569600C16orf70chr1667159945+ENST00000262493GNAO1chr1656362543+244731501076358
ENST00000569600C16orf70chr1667159945+ENST00000262494GNAO1chr1656362543+532631501076358
ENST00000219139C16orf70chr1667159945+ENST00000262493GNAO1chr1656362543+25514191431180345
ENST00000219139C16orf70chr1667159945+ENST00000262494GNAO1chr1656362543+54304191431180345

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569600ENST00000262493C16orf70chr1667159945+GNAO1chr1656362543+0.0008040880.9991959
ENST00000569600ENST00000262494C16orf70chr1667159945+GNAO1chr1656362543+0.0080205480.9919795
ENST00000219139ENST00000262493C16orf70chr1667159945+GNAO1chr1656362543+0.0007136260.99928635
ENST00000219139ENST00000262494C16orf70chr1667159945+GNAO1chr1656362543+0.0073271720.99267286

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Fusion Genomic Features for C16orf70-GNAO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C16orf70chr1667159945+GNAO1chr1656362542+6.01E-070.9999994
C16orf70chr1667159945+GNAO1chr1656362542+6.01E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C16orf70-GNAO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67159945/chr16:56362543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GNAO1

P09471

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329176_182101481.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329201_205101481.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329270_273101481.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428176_182101355.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428201_205101355.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428270_273101355.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329174_182101481.0RegionG2 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329197_206101481.0RegionG3 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329266_273101481.0RegionG4 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249329324_329101481.0RegionG5 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428174_182101355.0RegionG2 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428197_206101355.0RegionG3 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428266_273101355.0RegionG4 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST0000026249428324_329101355.0RegionG5 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624932932_354101481.0DomainG-alpha
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624942832_354101355.0DomainG-alpha
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624932940_47101481.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624942840_47101355.0Nucleotide bindingGTP
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624932935_48101481.0RegionG1 motif
TgeneGNAO1chr16:67159945chr16:56362543ENST000002624942835_48101355.0RegionG1 motif


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Fusion Gene Sequence for C16orf70-GNAO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11022_11022_1_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000219139_GNAO1_chr16_56362543_ENST00000262493_length(transcript)=2551nt_BP=419nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGG
CAGTAGCCATTCTTCAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTC
TTAACCTGACTCAGGACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGCTGACGCCAAGATGGTGTGTGATGTGGTGA
GTCGGATGGAAGACACCGAGCCCTTCTCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCA
ACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTGGATCGGATTGGGGCCGCCGACTACCAGCCCACCG
AGCAGGACATCCTCCGAACCAGGGTCAAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTTGACG
TCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCTGTGTCGCGCTCAGCGGCTATG
ACCAGGTGCTCCACGAAGACGAAACCACGAACCGCATGCACGAGTCTCTCATGCTCTTCGACTCCATCTGTAACAACAAGTTCTTCATCG
ATACCTCCATCATTCTCTTCCTCAACAAGAAAGATCTCTTTGGCGAGAAGATCAAGAAGTCACCTTTGACCATCTGCTTTCCTGAATACA
CAGGCCCCAATACCTATGAAGACGCAGCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATATTGTC
ACATGACTTGTGCCACAGACACGAATAACATCCAGGTGGTGTTCGACGCCGTCACCGACATCATCATTGCCAACAACCTCCGGGGCTGCG
GCTTGTACTGACCTCTTGTCCTGTATAGCAACCTATTTGACTGCTTCACGGACTCTTTGCTGTTGACGTTGATCTCCTGGTAGCATGACC
TTTTGGCCTTTGTAAGACACACAGCCTTTCTGTATCAAGCCCCTGTCTAACCTACGACCCCAGAGTGACTGACGGCTGTGTATTTCTGTA
GAATGCTGTAGAATCCGGTTTTAGTTGAGTCTTCACATTTAGAATTTGAAAGGAAAAACAGAACATTTCTCATGTGCTTTGTAGCTTAAA
AAAAGGAAAACTCACCATTTCATCCATATTTCTTTTTCTTGCAAAACAAACATACCCATCTGCACCGACGCCTGCCCCCGTCCCACCTCG
CGGCGCAGCCCCTGGAGCTCCTGCTGGGGGGCAGGGCCCATCTGCCGCCTGGGGCTCCGGTGCGGTGCACTGGTCCGAGGAGTGTGCTCA
GGCCGGGCTTTCCAGAAGGCCACAGGCCACTGCAAACCCTGCTGCCTGCCGGCCGCCCAGACACCACAGACGCCACCTGGCGGCCCTAAG
CCACTCCCGCCACACGCTCACTCCAGGTTCGTATAGAAAAAGCACAGCTCTCACTGGCCAGTAGCTGCCAAAAAGAACACCCATCGTATA
AGGAAATCCAGCCCCATAGAAAACAATCTGCCCACCGACCCCCTTTCTAAGGATAGCCTTTGTAGGGGTTTTTTGGTTCCTTTTTTTTTT
TTTTCAGTTTTTGTTTTTACTTTTGTCCCGCCGAGTACTATGTATTACCAGCCCCCCACCCCACAGATCAGTTTTCCTAGTCTTTGGGAA
ACGGGTTGTGTTTTTTTTCCTTTGCCGTGTTGGATTTCCGGTCCCGGCTGACACCTCCCTTCGTGTGTGCGCCCCTCCCCACCCCTGCCT
TTGTTTCGGTGCCCTGTGTCCGCTCTCTCATGTGGGGATGTTTGTGCTGCAGACAAAAAGAACAAAAAAAAATTTTTAAATACCACAAGA
TGGAAAAAAAAAACAAAAAAATTTAAAAAGATGGAATGTAGTGTTTACATTAAAGCCGCCGTTTTCATGACCAATCCTATGTCATTTCTA
CTTTGACTAATACCCAAACCCTAAACCTCTTCACGGTTTCACTTTTAAGACTTAATCTTTGCTGAAGAAGACCAGTCACAGCCATTTCAA
ATAAAGAGGAGGCAAAAAGACAAAACACACAAAAAATTAAAAAAAAAAACTTAAAAAAAAAAGGAAAAAAGAAAAAAAAGCCCACGGGTC
TTTGTAAGCCTTTCTATTCCCAATCGGTGAGGTTTCTGTGATATCTTACACACTGCCAGTCTACTTCTCTGACTAATGGAAAATTCCTGT
GTAGCTCAATAAAAGAGAATGTTTGTCTGTA

>11022_11022_1_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000219139_GNAO1_chr16_56362543_ENST00000262493_length(amino acids)=345AA_BP=92
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQR
LKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETH
FTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKI
KKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

--------------------------------------------------------------
>11022_11022_2_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000219139_GNAO1_chr16_56362543_ENST00000262494_length(transcript)=5430nt_BP=419nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGG
CAGTAGCCATTCTTCAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTC
TTAACCTGACTCAGGACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGCTGACGCCAAGATGGTGTGTGATGTGGTGA
GTCGGATGGAAGACACCGAGCCCTTCTCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCA
ACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTGGATCGGATTGGGGCCGCCGACTACCAGCCCACCG
AGCAGGACATCCTCCGAACCAGGGTCAAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTTGACG
TCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCTGTGTCGCGCTCAGCGGCTATG
ACCAGGTGCTCCACGAAGACGAAACCACGAACCGCATGCACGAATCCCTGAAGCTTTTTGACAGCATCTGCAACAACAAATGGTTCACAG
ACACGTCCATCATCCTGTTTCTTAACAAGAAGGACATATTTGAAGAGAAGATCAAGAAGTCCCCGCTCACCATCTGCTTTCCTGAATATA
CAGGCCCCAGCGCCTTCACAGAAGCCGTGGCTTACATCCAGGCCCAGTACGAGAGCAAGAACAAGTCAGCCCACAAAGAGATCTACACCC
ACGTCACCTGCGCCACGGACACCAACAACATCCAGTTTGTCTTTGATGCTGTGACGGACGTCATCATCGCCAAAAACCTGCGGGGCTGTG
GACTCTACTGAGCCCAGCCGCCCTGCCCGGCACCCTTGCCCTGCCTGGCCTGCCGCCCCCCCTCCCCTGGAACCAGGCTCCACCACTCTC
AGACCACTCTTTGCACTTGAGGAAGAAGACCTCAGAGGCTGGCACCAAGGGAGGGAGGAGGGAGCATCCTCCACCCGCACCCCCCAACAG
AACTTGTGGTAACGCAGGGGCGGGGCGGGGCTGCTGAGTGCATGCTGCAAGGCCAGGAGACTCCACGCTCACAGCCTCTGTGTCATCTCT
GAGTGCTTGATCGGGAAGCTGGGGGGACAGGGCAGGGCCCAGATGGGCACACCCTGCACCTGATGACTCACTGGAAGCCTCGGAGTGTCC
TCCTGTCATCTTGGGTGGTGCAGGGGCGCAGATGGCCCTGCAGCAGGGTGCTGGCAGGGTGGGGTCATAGGAGCCATCCTTCAGCTTTGC
CTGGGGTCTCTGGTGGAGGGCAGTTCCGTCAACAAAAGCCAGGGTGGGATCAGGCCAACTTGGTGTGGGTTGGAGGACTCAGGCCTTGGC
GATGGCCTCCGTCTCCCTGCTCCCTCCCCTGGGTCTCAGCCCTTCCTTCTCTGGGTCATCCTCCCTTGCCTTTGCTCTCCCAGAGAACTC
CCATCCCTGACTCCTCCGAGTTCTGGAAATGCTTCTTGAGACTGATTTATGGCTCAGATAGATGGTGGCGTGGAGCGGGGGGAGGGAGAG
ATGGGAGGTGCGGGGAAGGGAGGTGGAAGCTCCTGTGTCACCTGGGCTGGGGCCTCCCGCCCAGTCCTCGCAGGCCAAAGGGTGACCCAT
TTCTTTTTTCCAGTCACCAGGAGCTCGGATGGTCACTCTGAGGTGTGAATAGATATGTTTTTCCTTCAGTCCACACTGAATTCAACTCAA
ACCAGCAAAGGCCTTTGGGCTGGGGATTCTGTGGTTGCAGAGGTCTAGAGGGGGTGGACTTTTGCAGCCAGTGCCTCCGCCTCACCGTCT
TGGTGAAGAAATCAGCGAGTTTGTTCACAGCCGTTGGTGTCTTCCCAGCCCCTGGGGACAGAGGACAGCAGGGGGATGGAGCTGACACCC
TGGAGTATTTGGACCCAGGCCAGCACAAACACACCCCCCTGTCCCCAACTCTAAAGGGAGAGTCCTAGGACTCCTTAGAGGAGGCTTCAC
TGCGGAGATCCCTGAGCAGAAGGGGGCGGGGTAGCTTCTCCCGGTGACGGTGACGCAGGTCTGGCTGGCCTTGGGCAACCAACACACCTC
TCCCACTCCAAGATGCCTCCAGGTGGCTGAGGCCAACGCCCACACCCAGGCCAGTCGTGTGCTTGTACAGCAGGCTGTGCCTGGGGACCT
AGATGTGCCATGGGAGGGAGGAGGGTACCCACTGACAGGCCTCTGCCTCCCTCCTCAAGCCCTCTGTTCTCCCTGCCCCCACTCTGGACA
CTGCTTAGTCCCCAGCCAGGCAGGGCCCCTGGGTTTCCACTTGCAGCCCCCGGACTGCCCCAGAGCCGGGAAGCACCAGTGCCAACAGCT
CTGGACTTGTTGGACCCACAGGCACAGAGCTCTGAGTGGTGCCCAGGAGACCCAGGAACCTTCCCTAGTGCCAAATGCCTGCAGGGACCG
GTGCCTGGGGAGCCTCTGGCAGCCGGACTGCAGGAGCCACCCCATCAGCCCAAGTCCACCTCTGTTTTGTTCACCTCGGTCATGTTTTGG
ACCTTGCACCAGGTGCTGGGACGTGGCAGAGGACAGGCCCTGGGAACCAACAGTGTCCTACCATGGACAGCCAGGGCCAGCTAAGCTAAG
CCATCCCGCCCAACACAGAAGACATGGCAGTTATTTCTCAGCAGCACCACGCTGGGTGAGGCCAGTTGTTCCGCTTACTCTGCTCCGAAC
TGTAACCCCAGGCTCAGAAGCAGCCGGCAAAAGGGGGATGCTGGCCACGCCCCACCTCTAAGGCCATCACCCTGGAGGTGGAAGTCACTG
GGCTGGAGGGCTCTCCATGTCCCCCAGCAGCCGCCCTCAGAACACAGTGGCCAGAGCACCAGGCTGGGTCCAGGCCTCCAATCCAGGCCT
TCCCTGTCCCTAGAACTGGGGCTGGAGGAGTGGGTGCTCAGCCCTTCCTGCCCTCCATCCCCAGCCTGCCTTTCTCTTCCTTTGGATGCT
CCATCCTCCTTGGTTTCTTGCACTGCTCTCAATCCTCCCACCCTAGCCTGGGGGTGGTCCTTGGTCCTCAGGGGTATCCGGGGAGAAATT
CTCTCCCTGTGCATGACACCTGTCATCCATGTCGTAACCAGCGGCTCCATCTTGTGGGGTGGTGACTGAGGGTGACAAATGAGATTTGGC
TCCGTCGTGGATGTGGATGTGGGAGGAATGTTGCGAGTGACACGTGTGGGTTTCTAATCCACAGTGGTCCTGCGTGTGCCCTGAGGGGCC
ATGGTAACCTCTCCGATGGCTCGGATTTAGCAGGCCAAGCAGAAACTGATTTCTACGAAGAGCGTCTTTGCCAAACTCATGAAAATTGTG
CCTGCCACTTTCATGCCTATGGGCCAGTTTTGTGACCTGCGCCGCTGACCATCCTAAGAACCAGGTCTTGGCCTTCCCTCTGAGCACTGA
TAGAGGTCCCCAAGGCTCTCTGGCCTGAGGAGGGTGTGGGGTCTGCCCAGCCCCAAGCAGAGAGCACAGTCTGGGCCCCTGACCAACAGC
TTTGGCATTCTGGGTTCCATGGGGACCCTAGAGCTCAGGCACAAGAACAACACCATACCTGCTGCCAGGACGCAGCTGTCTCCCAGGCCC
TCCCCACAGCCCAGCTCCCACTGGCAGGAACTGGACACATCCCTGCCCTCCATGGTCTGCACTGGTCTTCTCTGAGTATTCTTAGGAGCA
GAGGCAGCCCCAAGTTCCAACTTGCAAGCCCTGTAACTAAGCTGTCTATAAACCCCAGCAGGGAAGGCCAAGGGATGGTCTCACCCATGC
CCTTCCCTTTGGCCAACATGAGTCCTGCAGTGGGGAGCTTAGCCCCTGCTCCCACCTAACACTCTACAGTTAGCACCCAGGGGTTGATTC
AGGAAGTTCTTCCTTTTTCTAGCCTGCATCCTTCCTGGCCACCCCCTTTATTTCTCAGTCTGACCTGGTGCACTCTTGGCAAGTGAGTCC
ATTGCAGTCCCAGGTGGATATTTAATGAGCACTCGGACTGTTTCCTCCAAGTCAGCTAGTGGCCTGCCCTCCTCCTTTTCAAGAAGTCTG
GGGCACAGAGCCTCCTCTGGCTGCCTCTTCTCTTCTCTGAGCCTCTGGGAGCCTTCAGGCAAAACCTGGCAGTTCTCAGGAACCCAGACC
TGAGGCTCCAGCTCCGCGGCCACCAGAGATTCAGTGTGCAGTGCCGAAGGCAGTCACCCCCAGGCAGTTCCTGCTGTCAGGCCGCAAGCC
TAGAGCGCAGGATCCCAGCAGCCCAGGGAACAGGGCCGGCGTGTGAGCTGCTGCCGTGGGGTCTGTGGTAGGGCTCCCCATCTCCCACCC
CTCAGCAAGAAGAGTCCTGACCCCTGACCCCACCCTGCCCAGAGAGGAGCTGGGGCCTCCAGACAGACCCCACTGCAGCCAGATGAAGGC
CCCTGTCAAAGAAGGGGCAGGCTGGGGGAAAAGCAGAAAGAATGGCCCCCAGTCCAAACTCCTGGATCCCCTCCATGAGAGAGGGGCTCC
CCCTGGAACAGAAGCTCTCATCCCCAGGCCCAGTGCACAAGACCACCAGCAGAGACCCACCGCCCTTCCTGGCAGAGCACCACTTCCTGG
CAGTGCAGCTCCGAGGCACCACTACTGTCCTCCCCTTCCCTCCCCACCCCTCCCCTCCCTTTCCCTCCTCTCCCCTCCCCTCCACACCTG
CCCTGTTACTCCCACAGCTCTGGGCAGCCAGGCCCTCCCCTCCTGCCTCCTGGTCTTCTCTACTCCGCTGGTTCTGACCCATCCCCTGGC
TCTGCCCGCCGTCCCCCACCCTGCCCCTGCTGAGTATCTTCTTCCTCCCCACGCACCCCCCTCCCCCATCTAGGCGAGGTGGGCTCGGGC
GTCCCAGGCCCTCCTTAGAAAAGCCGTCTCTCTCGAGTGCAGTGGTCCCACCTCCCAACCCCATCACTGCTGCCCACCCCATATTAACTG
TAATTTTGTAAGAAGAGTGACTTGTTGGTTTAATAAATCTCTAGTTATTGTAATAATTTATTGGCTGCCATAATGTATTTATTAGTCGCC
TACCGTTAATAAAAAGTGCCCGCTTTCCTA

>11022_11022_2_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000219139_GNAO1_chr16_56362543_ENST00000262494_length(amino acids)=345AA_BP=92
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQR
LKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETH
FTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSIILFLNKKDIFEEKI
KKSPLTICFPEYTGPSAFTEAVAYIQAQYESKNKSAHKEIYTHVTCATDTNNIQFVFDAVTDVIIAKNLRGCGLY

--------------------------------------------------------------
>11022_11022_3_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000569600_GNAO1_chr16_56362543_ENST00000262493_length(transcript)=2447nt_BP=315nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGGCAGTAGCCATTCTT
CAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTCTTAACCTGACTCAG
GACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGCTGACGCCAAGATGGTGTGTGATGTGGTGAGTCGGATGGAAGAC
ACCGAGCCCTTCTCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCAACCGGTCCCGGGAG
TATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTGGATCGGATTGGGGCCGCCGACTACCAGCCCACCGAGCAGGACATCCTC
CGAACCAGGGTCAAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTTGACGTCGGAGGCCAGCGA
TCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCTGTGTCGCGCTCAGCGGCTATGACCAGGTGCTCCAC
GAAGACGAAACCACGAACCGCATGCACGAGTCTCTCATGCTCTTCGACTCCATCTGTAACAACAAGTTCTTCATCGATACCTCCATCATT
CTCTTCCTCAACAAGAAAGATCTCTTTGGCGAGAAGATCAAGAAGTCACCTTTGACCATCTGCTTTCCTGAATACACAGGCCCCAATACC
TATGAAGACGCAGCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATATTGTCACATGACTTGTGCC
ACAGACACGAATAACATCCAGGTGGTGTTCGACGCCGTCACCGACATCATCATTGCCAACAACCTCCGGGGCTGCGGCTTGTACTGACCT
CTTGTCCTGTATAGCAACCTATTTGACTGCTTCACGGACTCTTTGCTGTTGACGTTGATCTCCTGGTAGCATGACCTTTTGGCCTTTGTA
AGACACACAGCCTTTCTGTATCAAGCCCCTGTCTAACCTACGACCCCAGAGTGACTGACGGCTGTGTATTTCTGTAGAATGCTGTAGAAT
CCGGTTTTAGTTGAGTCTTCACATTTAGAATTTGAAAGGAAAAACAGAACATTTCTCATGTGCTTTGTAGCTTAAAAAAAGGAAAACTCA
CCATTTCATCCATATTTCTTTTTCTTGCAAAACAAACATACCCATCTGCACCGACGCCTGCCCCCGTCCCACCTCGCGGCGCAGCCCCTG
GAGCTCCTGCTGGGGGGCAGGGCCCATCTGCCGCCTGGGGCTCCGGTGCGGTGCACTGGTCCGAGGAGTGTGCTCAGGCCGGGCTTTCCA
GAAGGCCACAGGCCACTGCAAACCCTGCTGCCTGCCGGCCGCCCAGACACCACAGACGCCACCTGGCGGCCCTAAGCCACTCCCGCCACA
CGCTCACTCCAGGTTCGTATAGAAAAAGCACAGCTCTCACTGGCCAGTAGCTGCCAAAAAGAACACCCATCGTATAAGGAAATCCAGCCC
CATAGAAAACAATCTGCCCACCGACCCCCTTTCTAAGGATAGCCTTTGTAGGGGTTTTTTGGTTCCTTTTTTTTTTTTTTCAGTTTTTGT
TTTTACTTTTGTCCCGCCGAGTACTATGTATTACCAGCCCCCCACCCCACAGATCAGTTTTCCTAGTCTTTGGGAAACGGGTTGTGTTTT
TTTTCCTTTGCCGTGTTGGATTTCCGGTCCCGGCTGACACCTCCCTTCGTGTGTGCGCCCCTCCCCACCCCTGCCTTTGTTTCGGTGCCC
TGTGTCCGCTCTCTCATGTGGGGATGTTTGTGCTGCAGACAAAAAGAACAAAAAAAAATTTTTAAATACCACAAGATGGAAAAAAAAAAC
AAAAAAATTTAAAAAGATGGAATGTAGTGTTTACATTAAAGCCGCCGTTTTCATGACCAATCCTATGTCATTTCTACTTTGACTAATACC
CAAACCCTAAACCTCTTCACGGTTTCACTTTTAAGACTTAATCTTTGCTGAAGAAGACCAGTCACAGCCATTTCAAATAAAGAGGAGGCA
AAAAGACAAAACACACAAAAAATTAAAAAAAAAAACTTAAAAAAAAAAGGAAAAAAGAAAAAAAAGCCCACGGGTCTTTGTAAGCCTTTC
TATTCCCAATCGGTGAGGTTTCTGTGATATCTTACACACTGCCAGTCTACTTCTCTGACTAATGGAAAATTCCTGTGTAGCTCAATAAAA
GAGAATGTTTGTCTGTA

>11022_11022_3_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000569600_GNAO1_chr16_56362543_ENST00000262493_length(amino acids)=358AA_BP=105
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQ
DGIKLMFDAFNQRLKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDIL
RTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSII
LFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

--------------------------------------------------------------
>11022_11022_4_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000569600_GNAO1_chr16_56362543_ENST00000262494_length(transcript)=5326nt_BP=315nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGGAATGCCTCTGGCTCAGGCAGTAGCCATTCTT
CAGAAGCACTGTCGCATCATCAAAAACGTCCAGGTTCTCTACAGTGAACAGTCTCCTCTAAGCCATGACCTCATTCTTAACCTGACTCAG
GACGGGATCAAACTAATGTTTGATGCTTTCAATCAGAGACTTAAGGCTGACGCCAAGATGGTGTGTGATGTGGTGAGTCGGATGGAAGAC
ACCGAGCCCTTCTCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGCTTCAACCGGTCCCGGGAG
TATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTGGATCGGATTGGGGCCGCCGACTACCAGCCCACCGAGCAGGACATCCTC
CGAACCAGGGTCAAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTTGACGTCGGAGGCCAGCGA
TCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACGGCCATCATTTTCTGTGTCGCGCTCAGCGGCTATGACCAGGTGCTCCAC
GAAGACGAAACCACGAACCGCATGCACGAATCCCTGAAGCTTTTTGACAGCATCTGCAACAACAAATGGTTCACAGACACGTCCATCATC
CTGTTTCTTAACAAGAAGGACATATTTGAAGAGAAGATCAAGAAGTCCCCGCTCACCATCTGCTTTCCTGAATATACAGGCCCCAGCGCC
TTCACAGAAGCCGTGGCTTACATCCAGGCCCAGTACGAGAGCAAGAACAAGTCAGCCCACAAAGAGATCTACACCCACGTCACCTGCGCC
ACGGACACCAACAACATCCAGTTTGTCTTTGATGCTGTGACGGACGTCATCATCGCCAAAAACCTGCGGGGCTGTGGACTCTACTGAGCC
CAGCCGCCCTGCCCGGCACCCTTGCCCTGCCTGGCCTGCCGCCCCCCCTCCCCTGGAACCAGGCTCCACCACTCTCAGACCACTCTTTGC
ACTTGAGGAAGAAGACCTCAGAGGCTGGCACCAAGGGAGGGAGGAGGGAGCATCCTCCACCCGCACCCCCCAACAGAACTTGTGGTAACG
CAGGGGCGGGGCGGGGCTGCTGAGTGCATGCTGCAAGGCCAGGAGACTCCACGCTCACAGCCTCTGTGTCATCTCTGAGTGCTTGATCGG
GAAGCTGGGGGGACAGGGCAGGGCCCAGATGGGCACACCCTGCACCTGATGACTCACTGGAAGCCTCGGAGTGTCCTCCTGTCATCTTGG
GTGGTGCAGGGGCGCAGATGGCCCTGCAGCAGGGTGCTGGCAGGGTGGGGTCATAGGAGCCATCCTTCAGCTTTGCCTGGGGTCTCTGGT
GGAGGGCAGTTCCGTCAACAAAAGCCAGGGTGGGATCAGGCCAACTTGGTGTGGGTTGGAGGACTCAGGCCTTGGCGATGGCCTCCGTCT
CCCTGCTCCCTCCCCTGGGTCTCAGCCCTTCCTTCTCTGGGTCATCCTCCCTTGCCTTTGCTCTCCCAGAGAACTCCCATCCCTGACTCC
TCCGAGTTCTGGAAATGCTTCTTGAGACTGATTTATGGCTCAGATAGATGGTGGCGTGGAGCGGGGGGAGGGAGAGATGGGAGGTGCGGG
GAAGGGAGGTGGAAGCTCCTGTGTCACCTGGGCTGGGGCCTCCCGCCCAGTCCTCGCAGGCCAAAGGGTGACCCATTTCTTTTTTCCAGT
CACCAGGAGCTCGGATGGTCACTCTGAGGTGTGAATAGATATGTTTTTCCTTCAGTCCACACTGAATTCAACTCAAACCAGCAAAGGCCT
TTGGGCTGGGGATTCTGTGGTTGCAGAGGTCTAGAGGGGGTGGACTTTTGCAGCCAGTGCCTCCGCCTCACCGTCTTGGTGAAGAAATCA
GCGAGTTTGTTCACAGCCGTTGGTGTCTTCCCAGCCCCTGGGGACAGAGGACAGCAGGGGGATGGAGCTGACACCCTGGAGTATTTGGAC
CCAGGCCAGCACAAACACACCCCCCTGTCCCCAACTCTAAAGGGAGAGTCCTAGGACTCCTTAGAGGAGGCTTCACTGCGGAGATCCCTG
AGCAGAAGGGGGCGGGGTAGCTTCTCCCGGTGACGGTGACGCAGGTCTGGCTGGCCTTGGGCAACCAACACACCTCTCCCACTCCAAGAT
GCCTCCAGGTGGCTGAGGCCAACGCCCACACCCAGGCCAGTCGTGTGCTTGTACAGCAGGCTGTGCCTGGGGACCTAGATGTGCCATGGG
AGGGAGGAGGGTACCCACTGACAGGCCTCTGCCTCCCTCCTCAAGCCCTCTGTTCTCCCTGCCCCCACTCTGGACACTGCTTAGTCCCCA
GCCAGGCAGGGCCCCTGGGTTTCCACTTGCAGCCCCCGGACTGCCCCAGAGCCGGGAAGCACCAGTGCCAACAGCTCTGGACTTGTTGGA
CCCACAGGCACAGAGCTCTGAGTGGTGCCCAGGAGACCCAGGAACCTTCCCTAGTGCCAAATGCCTGCAGGGACCGGTGCCTGGGGAGCC
TCTGGCAGCCGGACTGCAGGAGCCACCCCATCAGCCCAAGTCCACCTCTGTTTTGTTCACCTCGGTCATGTTTTGGACCTTGCACCAGGT
GCTGGGACGTGGCAGAGGACAGGCCCTGGGAACCAACAGTGTCCTACCATGGACAGCCAGGGCCAGCTAAGCTAAGCCATCCCGCCCAAC
ACAGAAGACATGGCAGTTATTTCTCAGCAGCACCACGCTGGGTGAGGCCAGTTGTTCCGCTTACTCTGCTCCGAACTGTAACCCCAGGCT
CAGAAGCAGCCGGCAAAAGGGGGATGCTGGCCACGCCCCACCTCTAAGGCCATCACCCTGGAGGTGGAAGTCACTGGGCTGGAGGGCTCT
CCATGTCCCCCAGCAGCCGCCCTCAGAACACAGTGGCCAGAGCACCAGGCTGGGTCCAGGCCTCCAATCCAGGCCTTCCCTGTCCCTAGA
ACTGGGGCTGGAGGAGTGGGTGCTCAGCCCTTCCTGCCCTCCATCCCCAGCCTGCCTTTCTCTTCCTTTGGATGCTCCATCCTCCTTGGT
TTCTTGCACTGCTCTCAATCCTCCCACCCTAGCCTGGGGGTGGTCCTTGGTCCTCAGGGGTATCCGGGGAGAAATTCTCTCCCTGTGCAT
GACACCTGTCATCCATGTCGTAACCAGCGGCTCCATCTTGTGGGGTGGTGACTGAGGGTGACAAATGAGATTTGGCTCCGTCGTGGATGT
GGATGTGGGAGGAATGTTGCGAGTGACACGTGTGGGTTTCTAATCCACAGTGGTCCTGCGTGTGCCCTGAGGGGCCATGGTAACCTCTCC
GATGGCTCGGATTTAGCAGGCCAAGCAGAAACTGATTTCTACGAAGAGCGTCTTTGCCAAACTCATGAAAATTGTGCCTGCCACTTTCAT
GCCTATGGGCCAGTTTTGTGACCTGCGCCGCTGACCATCCTAAGAACCAGGTCTTGGCCTTCCCTCTGAGCACTGATAGAGGTCCCCAAG
GCTCTCTGGCCTGAGGAGGGTGTGGGGTCTGCCCAGCCCCAAGCAGAGAGCACAGTCTGGGCCCCTGACCAACAGCTTTGGCATTCTGGG
TTCCATGGGGACCCTAGAGCTCAGGCACAAGAACAACACCATACCTGCTGCCAGGACGCAGCTGTCTCCCAGGCCCTCCCCACAGCCCAG
CTCCCACTGGCAGGAACTGGACACATCCCTGCCCTCCATGGTCTGCACTGGTCTTCTCTGAGTATTCTTAGGAGCAGAGGCAGCCCCAAG
TTCCAACTTGCAAGCCCTGTAACTAAGCTGTCTATAAACCCCAGCAGGGAAGGCCAAGGGATGGTCTCACCCATGCCCTTCCCTTTGGCC
AACATGAGTCCTGCAGTGGGGAGCTTAGCCCCTGCTCCCACCTAACACTCTACAGTTAGCACCCAGGGGTTGATTCAGGAAGTTCTTCCT
TTTTCTAGCCTGCATCCTTCCTGGCCACCCCCTTTATTTCTCAGTCTGACCTGGTGCACTCTTGGCAAGTGAGTCCATTGCAGTCCCAGG
TGGATATTTAATGAGCACTCGGACTGTTTCCTCCAAGTCAGCTAGTGGCCTGCCCTCCTCCTTTTCAAGAAGTCTGGGGCACAGAGCCTC
CTCTGGCTGCCTCTTCTCTTCTCTGAGCCTCTGGGAGCCTTCAGGCAAAACCTGGCAGTTCTCAGGAACCCAGACCTGAGGCTCCAGCTC
CGCGGCCACCAGAGATTCAGTGTGCAGTGCCGAAGGCAGTCACCCCCAGGCAGTTCCTGCTGTCAGGCCGCAAGCCTAGAGCGCAGGATC
CCAGCAGCCCAGGGAACAGGGCCGGCGTGTGAGCTGCTGCCGTGGGGTCTGTGGTAGGGCTCCCCATCTCCCACCCCTCAGCAAGAAGAG
TCCTGACCCCTGACCCCACCCTGCCCAGAGAGGAGCTGGGGCCTCCAGACAGACCCCACTGCAGCCAGATGAAGGCCCCTGTCAAAGAAG
GGGCAGGCTGGGGGAAAAGCAGAAAGAATGGCCCCCAGTCCAAACTCCTGGATCCCCTCCATGAGAGAGGGGCTCCCCCTGGAACAGAAG
CTCTCATCCCCAGGCCCAGTGCACAAGACCACCAGCAGAGACCCACCGCCCTTCCTGGCAGAGCACCACTTCCTGGCAGTGCAGCTCCGA
GGCACCACTACTGTCCTCCCCTTCCCTCCCCACCCCTCCCCTCCCTTTCCCTCCTCTCCCCTCCCCTCCACACCTGCCCTGTTACTCCCA
CAGCTCTGGGCAGCCAGGCCCTCCCCTCCTGCCTCCTGGTCTTCTCTACTCCGCTGGTTCTGACCCATCCCCTGGCTCTGCCCGCCGTCC
CCCACCCTGCCCCTGCTGAGTATCTTCTTCCTCCCCACGCACCCCCCTCCCCCATCTAGGCGAGGTGGGCTCGGGCGTCCCAGGCCCTCC
TTAGAAAAGCCGTCTCTCTCGAGTGCAGTGGTCCCACCTCCCAACCCCATCACTGCTGCCCACCCCATATTAACTGTAATTTTGTAAGAA
GAGTGACTTGTTGGTTTAATAAATCTCTAGTTATTGTAATAATTTATTGGCTGCCATAATGTATTTATTAGTCGCCTACCGTTAATAAAA
AGTGCCCGCTTTCCTA

>11022_11022_4_C16orf70-GNAO1_C16orf70_chr16_67159945_ENST00000569600_GNAO1_chr16_56362543_ENST00000262494_length(amino acids)=358AA_BP=105
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQ
DGIKLMFDAFNQRLKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDIL
RTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSII
LFLNKKDIFEEKIKKSPLTICFPEYTGPSAFTEAVAYIQAQYESKNKSAHKEIYTHVTCATDTNNIQFVFDAVTDVIIAKNLRGCGLY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C16orf70-GNAO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C16orf70-GNAO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C16orf70-GNAO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0393706Early infantile epileptic encephalopathy with suppression bursts13CLINGEN;ORPHANET
TgeneC3463992EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 113CLINGEN
TgeneC4552072X-linked infantile spasms13CLINGEN
TgeneC0026650Movement Disorders6CLINGEN
TgeneC4479569NEURODEVELOPMENTAL DISORDER WITH INVOLUNTARY MOVEMENTS6GENOMICS_ENGLAND;UNIPROT
TgeneC3809606EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 175CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0014544Epilepsy1CTD_human
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0086237Epilepsy, Cryptogenic1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0236018Aura1CTD_human
TgeneC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneC0751111Awakening Epilepsy1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC2239176Liver carcinoma1CTD_human