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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C16orf70-ATP6V0D1 (FusionGDB2 ID:HG80262TG9114)

Fusion Gene Summary for C16orf70-ATP6V0D1

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf70-ATP6V0D1
Fusion gene ID: hg80262tg9114
HgeneTgene
Gene symbol

C16orf70

ATP6V0D1

Gene ID

80262

9114

Gene namechromosome 16 open reading frame 70ATPase H+ transporting V0 subunit d1
SynonymsC16orf6|LIN10|lin-10ATP6D|ATP6DV|P39|VATX|VMA6|VPATPD
Cytomap('C16orf70')('ATP6V0D1')

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionUPF0183 protein C16orf70lin-10 homologV-type proton ATPase subunit d 132 kDa accessory proteinATPase, H+ transporting, lysosomal (vacuolar proton pump), member DATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1H(+)-transporting two-sector ATPase, subunit DV-ATPase 40 KDa accessory
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000569683, ENST00000219139, 
ENST00000569600, 
Fusion gene scores* DoF score10 X 8 X 8=6408 X 7 X 4=224
# samples 128
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C16orf70 [Title/Abstract] AND ATP6V0D1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC16orf70(67144142)-ATP6V0D1(67487618), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C16orf70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATP6V0D1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PDC16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-


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Fusion Gene ORF analysis for C16orf70-ATP6V0D1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000569683ENST00000290949C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
3UTR-3CDSENST00000569683ENST00000540149C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
3UTR-5UTRENST00000569683ENST00000602876C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
3UTR-intronENST00000569683ENST00000567694C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
5CDS-5UTRENST00000219139ENST00000602876C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
5CDS-5UTRENST00000569600ENST00000602876C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
5CDS-intronENST00000219139ENST00000567694C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
5CDS-intronENST00000569600ENST00000567694C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
In-frameENST00000219139ENST00000290949C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
In-frameENST00000219139ENST00000540149C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
In-frameENST00000569600ENST00000290949C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-
In-frameENST00000569600ENST00000540149C16orf70chr16

67144142

+ATP6V0D1chr16

67487618

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000569600C16orf70chr1667144142+ENST00000290949ATP6V0D1chr1667487618-158314801073357
ENST00000569600C16orf70chr1667144142+ENST00000540149ATP6V0D1chr1667487618-124914801196398
ENST00000219139C16orf70chr1667144142+ENST00000290949ATP6V0D1chr1667487618-16872521431177344
ENST00000219139C16orf70chr1667144142+ENST00000540149ATP6V0D1chr1667487618-13532521431300385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569600ENST00000290949C16orf70chr1667144142+ATP6V0D1chr1667487618-0.0080733180.99192667
ENST00000569600ENST00000540149C16orf70chr1667144142+ATP6V0D1chr1667487618-0.0024075360.9975924
ENST00000219139ENST00000290949C16orf70chr1667144142+ATP6V0D1chr1667487618-0.0065277730.9934722
ENST00000219139ENST00000540149C16orf70chr1667144142+ATP6V0D1chr1667487618-0.0029428460.9970572

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Fusion Genomic Features for C16orf70-ATP6V0D1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C16orf70-ATP6V0D1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67144142/chr16:67487618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C16orf70-ATP6V0D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11018_11018_1_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000219139_ATP6V0D1_chr16_67487618_ENST00000290949_length(transcript)=1687nt_BP=252nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGACTTGAAACTGCATCTGC
AGAGCACTGATTATGGTAACTTCCTGGCCAACGAGGCATCACCTCTGACGGTGTCAGTCATCGATGACCGGCTCAAGGAGAAGATGGTGG
TGGAGTTCCGCCACATGAGGAACCATGCCTATGAGCCACTCGCCAGCTTCCTAGACTTCATTACTTACAGTTACATGATCGACAACGTGA
TCCTGCTCATCACAGGCACGCTGCACCAGCGCTCCATCGCTGAGCTCGTGCCCAAGTGCCACCCACTAGGCAGCTTCGAGCAGATGGAGG
CCGTGAACATTGCTCAGACACCTGCTGAGCTCTACAATGCCATTCTGGTGGACACGCCTCTTGCGGCTTTTTTCCAGGACTGCATTTCAG
AGCAGGACCTTGACGAGATGAACATCGAGATCATCCGCAACACCCTCTACAAGGCCTACCTGGAGTCCTTCTACAAGTTCTGCACCCTAC
TGGGCGGGACTACGGCTGATGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCCGCGCCTTCATCATCACCATCAATTCTTTCGGCA
CAGAGCTGTCCAAAGAGGACCGTGCCAAGCTCTTTCCACACTGTGGGCGGCTCTACCCTGAGGGCCTGGCGCAGCTGGCTCGGGCTGACG
ACTATGAACAGGTCAAGAACGTGGCCGATTACTACCCGGAGTACAAGCTGCTCTTCGAGGGTGCAGGTAGCAACCCTGGAGACAAGACGC
TGGAGGACCGATTCTTTGAGCACGAGGTAAAGCTGAACAAGTTGGCCTTCCTGAACCAGTTCCACTTTGGTGTCTTCTATGCCTTCGTGA
AGCTCAAGGAGCAGGAGTGTCGCAACATCGTGTGGATCGCTGAATGTATCGCCCAGCGCCACCGCGCCAAAATCGACAACTACATCCCTA
TCTTCTAGCGTCCTGGCCCAAGGCTCTCAATTGCACTCTTTGTGTGTGTGTGTGTGTGTGTGCGCGTGTGTGTGCGTGTGTGTGTATGTG
GTCTGTGACAAGCCTGTGGCTCACCTGCCTGTCCGGGGTGTAGTACGCTGTCCTAGCGGCTGCCCAGTTCTCCTGACCCTCTTAGAGACT
GTTCTTAGGCCTGAAAAGGGGCTGGGCACCCCCCCCCACCAAGGATGGACGAAGACCCCCTCCAGAGCAAGGAGGCCCCCTCAGCCCTGT
GGTTACAGCCGCTGATGTATCTAAGAAGCATGTCACTTTCATGTTCCTCCCTAACTCCCTGACCTGAGAACCCTGGGGCCTGGGGGCAGT
TTGAGCCTCCTCTCCCTTCTGTGGGTCGCTCCCAGAGCCATGGCCCATGGGAAGGACAGAGTGTGTGTGTCCTTGGGGCCTGGGGGGATG

>11018_11018_1_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000219139_ATP6V0D1_chr16_67487618_ENST00000290949_length(amino acids)=344AA_BP=36
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFL
DFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYK
AYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLL

--------------------------------------------------------------
>11018_11018_2_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000219139_ATP6V0D1_chr16_67487618_ENST00000540149_length(transcript)=1353nt_BP=252nt
AGGTGAGGTGAAGTGAGGTGAGGTGTGGTGTTGGGCCGGTGCTGCTGCCGCTGCCGCCGGGGAGGAGGTGGAAAGCGGGGCTGTGGCGGG
CCGGCGGGGGCGGCCTGTCAGCCGCTGCTTTGTCTCCTTAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAG
CCGAACCAATGCTGGACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGACTTGAAACTGCATCTGC
AGAGCACTGATTATGGTAACTTCCTGGCCAACGAGGCATCACCTCTGACGGTGTCAGTCATCGATGACCGGCTCAAGGAGAAGATGGTGG
TGGAGTTCCGCCACATGAGGAACCATGCCTATGAGCCACTCGCCAGCTTCCTAGACTTCATTACGCAGGAGTCAGAGGCTGGGACACCTG
AAGGGCCAGGGAACATGCCCAAGCTAGGAAGCAGGCCCTCTCCTGGCCACAGGCCTCCTTTCCTGAGAGTCTCCTTGCTGCCCTGGCCTC
CATCAAGTTACAGTTACATGATCGACAACGTGATCCTGCTCATCACAGGCACGCTGCACCAGCGCTCCATCGCTGAGCTCGTGCCCAAGT
GCCACCCACTAGGCAGCTTCGAGCAGATGGAGGCCGTGAACATTGCTCAGACACCTGCTGAGCTCTACAATGCCATTCTGGTGGACACGC
CTCTTGCGGCTTTTTTCCAGGACTGCATTTCAGAGCAGGACCTTGACGAGATGAACATCGAGATCATCCGCAACACCCTCTACAAGGCCT
ACCTGGAGTCCTTCTACAAGTTCTGCACCCTACTGGGCGGGACTACGGCTGATGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCC
GCGCCTTCATCATCACCATCAATTCTTTCGGCACAGAGCTGTCCAAAGAGGACCGTGCCAAGCTCTTTCCACACTGTGGGCGGCTCTACC
CTGAGGGCCTGGCGCAGCTGGCTCGGGCTGACGACTATGAACAGGTCAAGAACGTGGCCGATTACTACCCGGAGTACAAGCTGCTCTTCG
AGGGTGCAGGTAGCAACCCTGGAGACAAGACGCTGGAGGACCGATTCTTTGAGCACGAGGTAAAGCTGAACAAGTTGGCCTTCCTGAACC
AGTTCCACTTTGGTGTCTTCTATGCCTTCGTGAAGCTCAAGGAGCAGGAGTGTCGCAACATCGTGTGGATCGCTGAATGTATCGCCCAGC
GCCACCGCGCCAAAATCGACAACTACATCCCTATCTTCTAGCGTCCTGGCCCAAGGCTCTCAATTGCACTCTTTGTGTGTGTGTGTGTGT

>11018_11018_2_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000219139_ATP6V0D1_chr16_67487618_ENST00000540149_length(amino acids)=385AA_BP=36
MRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFL
DFITQESEAGTPEGPGNMPKLGSRPSPGHRPPFLRVSLLPWPPSSYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQT
PAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKED
RAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQEC

--------------------------------------------------------------
>11018_11018_3_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000569600_ATP6V0D1_chr16_67487618_ENST00000290949_length(transcript)=1583nt_BP=148nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGACTTGAAACTGCATCTGCAGAGCACTGATTAT
GGTAACTTCCTGGCCAACGAGGCATCACCTCTGACGGTGTCAGTCATCGATGACCGGCTCAAGGAGAAGATGGTGGTGGAGTTCCGCCAC
ATGAGGAACCATGCCTATGAGCCACTCGCCAGCTTCCTAGACTTCATTACTTACAGTTACATGATCGACAACGTGATCCTGCTCATCACA
GGCACGCTGCACCAGCGCTCCATCGCTGAGCTCGTGCCCAAGTGCCACCCACTAGGCAGCTTCGAGCAGATGGAGGCCGTGAACATTGCT
CAGACACCTGCTGAGCTCTACAATGCCATTCTGGTGGACACGCCTCTTGCGGCTTTTTTCCAGGACTGCATTTCAGAGCAGGACCTTGAC
GAGATGAACATCGAGATCATCCGCAACACCCTCTACAAGGCCTACCTGGAGTCCTTCTACAAGTTCTGCACCCTACTGGGCGGGACTACG
GCTGATGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCCGCGCCTTCATCATCACCATCAATTCTTTCGGCACAGAGCTGTCCAAA
GAGGACCGTGCCAAGCTCTTTCCACACTGTGGGCGGCTCTACCCTGAGGGCCTGGCGCAGCTGGCTCGGGCTGACGACTATGAACAGGTC
AAGAACGTGGCCGATTACTACCCGGAGTACAAGCTGCTCTTCGAGGGTGCAGGTAGCAACCCTGGAGACAAGACGCTGGAGGACCGATTC
TTTGAGCACGAGGTAAAGCTGAACAAGTTGGCCTTCCTGAACCAGTTCCACTTTGGTGTCTTCTATGCCTTCGTGAAGCTCAAGGAGCAG
GAGTGTCGCAACATCGTGTGGATCGCTGAATGTATCGCCCAGCGCCACCGCGCCAAAATCGACAACTACATCCCTATCTTCTAGCGTCCT
GGCCCAAGGCTCTCAATTGCACTCTTTGTGTGTGTGTGTGTGTGTGTGCGCGTGTGTGTGCGTGTGTGTGTATGTGGTCTGTGACAAGCC
TGTGGCTCACCTGCCTGTCCGGGGTGTAGTACGCTGTCCTAGCGGCTGCCCAGTTCTCCTGACCCTCTTAGAGACTGTTCTTAGGCCTGA
AAAGGGGCTGGGCACCCCCCCCCACCAAGGATGGACGAAGACCCCCTCCAGAGCAAGGAGGCCCCCTCAGCCCTGTGGTTACAGCCGCTG
ATGTATCTAAGAAGCATGTCACTTTCATGTTCCTCCCTAACTCCCTGACCTGAGAACCCTGGGGCCTGGGGGCAGTTTGAGCCTCCTCTC
CCTTCTGTGGGTCGCTCCCAGAGCCATGGCCCATGGGAAGGACAGAGTGTGTGTGTCCTTGGGGCCTGGGGGGATGTTGCTCCTCAGCTC

>11018_11018_3_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000569600_ATP6V0D1_chr16_67487618_ENST00000290949_length(amino acids)=357AA_BP=49
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRH
MRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLD
EMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQV

--------------------------------------------------------------
>11018_11018_4_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000569600_ATP6V0D1_chr16_67487618_ENST00000540149_length(transcript)=1249nt_BP=148nt
TTGCCCCCGCTGCCGCGGCTGCTGCAGCTCGGGTCCCTTCTGCGCTGCCGCAGGGAGGCCGCCCGGGCCAGGCGAGCCGAACCAATGCTG
GACCTGGAGGTAGTGCCCGAACGCTCTCTGGGGAACGAGCAATGGGAATTCACGCTGGACTTGAAACTGCATCTGCAGAGCACTGATTAT
GGTAACTTCCTGGCCAACGAGGCATCACCTCTGACGGTGTCAGTCATCGATGACCGGCTCAAGGAGAAGATGGTGGTGGAGTTCCGCCAC
ATGAGGAACCATGCCTATGAGCCACTCGCCAGCTTCCTAGACTTCATTACGCAGGAGTCAGAGGCTGGGACACCTGAAGGGCCAGGGAAC
ATGCCCAAGCTAGGAAGCAGGCCCTCTCCTGGCCACAGGCCTCCTTTCCTGAGAGTCTCCTTGCTGCCCTGGCCTCCATCAAGTTACAGT
TACATGATCGACAACGTGATCCTGCTCATCACAGGCACGCTGCACCAGCGCTCCATCGCTGAGCTCGTGCCCAAGTGCCACCCACTAGGC
AGCTTCGAGCAGATGGAGGCCGTGAACATTGCTCAGACACCTGCTGAGCTCTACAATGCCATTCTGGTGGACACGCCTCTTGCGGCTTTT
TTCCAGGACTGCATTTCAGAGCAGGACCTTGACGAGATGAACATCGAGATCATCCGCAACACCCTCTACAAGGCCTACCTGGAGTCCTTC
TACAAGTTCTGCACCCTACTGGGCGGGACTACGGCTGATGCCATGTGCCCCATCCTGGAGTTTGAAGCAGACCGCCGCGCCTTCATCATC
ACCATCAATTCTTTCGGCACAGAGCTGTCCAAAGAGGACCGTGCCAAGCTCTTTCCACACTGTGGGCGGCTCTACCCTGAGGGCCTGGCG
CAGCTGGCTCGGGCTGACGACTATGAACAGGTCAAGAACGTGGCCGATTACTACCCGGAGTACAAGCTGCTCTTCGAGGGTGCAGGTAGC
AACCCTGGAGACAAGACGCTGGAGGACCGATTCTTTGAGCACGAGGTAAAGCTGAACAAGTTGGCCTTCCTGAACCAGTTCCACTTTGGT
GTCTTCTATGCCTTCGTGAAGCTCAAGGAGCAGGAGTGTCGCAACATCGTGTGGATCGCTGAATGTATCGCCCAGCGCCACCGCGCCAAA

>11018_11018_4_C16orf70-ATP6V0D1_C16orf70_chr16_67144142_ENST00000569600_ATP6V0D1_chr16_67487618_ENST00000540149_length(amino acids)=398AA_BP=49
LPPLPRLLQLGSLLRCRREAARARRAEPMLDLEVVPERSLGNEQWEFTLDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRH
MRNHAYEPLASFLDFITQESEAGTPEGPGNMPKLGSRPSPGHRPPFLRVSLLPWPPSSYSYMIDNVILLITGTLHQRSIAELVPKCHPLG
SFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFII
TINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C16orf70-ATP6V0D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C16orf70-ATP6V0D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C16orf70-ATP6V0D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource