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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FLAD1-PRUNE (FusionGDB2 ID:HG80308TG58497)

Fusion Gene Summary for FLAD1-PRUNE

check button Fusion gene summary
Fusion gene informationFusion gene name: FLAD1-PRUNE
Fusion gene ID: hg80308tg58497
HgeneTgene
Gene symbol

FLAD1

PRUNE

Gene ID

80308

58497

Gene nameflavin adenine dinucleotide synthetase 1prune exopolyphosphatase 1
SynonymsFAD1|FADS|LSMFLAD|PP591DRES-17|DRES17|H-PRUNE|HTCD37|NMIHBA|PRUNE
Cytomap('FLAD1')('PRUNE')

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionFAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homologexopolyphosphatase PRUNE1Drosophila-related expressed sequence 17protein prune homologprotein prune homolog 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000487371, ENST00000292180, 
ENST00000315144, ENST00000368432, 
ENST00000368433, ENST00000368431, 
ENST00000295530, ENST00000368428, 
ENST00000405236, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 3 X 2=12
# samples 73
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FLAD1 [Title/Abstract] AND PRUNE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFLAD1(154956542)-PRUNE(150999708), # samples:1
FLAD1(154956542)-PRUNE(150999709), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6822-01AFLAD1chr1

154956542

+PRUNEchr1

150999709

+
ChimerDB4STADTCGA-D7-6822FLAD1chr1

154956542

+PRUNEchr1

150999708

+


Top

Fusion Gene ORF analysis for FLAD1-PRUNE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000487371ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-3UTRENST00000487371ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-3UTRENST00000487371ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-3UTRENST00000487371ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-3UTRENST00000487371ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-3UTRENST00000487371ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-3UTRENST00000487371ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-3UTRENST00000487371ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-3UTRENST00000487371ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-3UTRENST00000487371ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-5UTRENST00000487371ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-5UTRENST00000487371ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
3UTR-5UTRENST00000487371ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
3UTR-5UTRENST00000487371ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000292180ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000292180ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000292180ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000292180ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000292180ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000292180ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000292180ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000292180ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000292180ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000292180ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000315144ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000315144ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000315144ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000315144ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000315144ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000315144ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000315144ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000315144ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000315144ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000315144ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368432ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368432ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368432ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368432ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368432ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368432ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368432ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368432ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368432ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368432ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368433ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368433ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368433ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368433ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368433ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368433ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368433ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368433ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-3UTRENST00000368433ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-3UTRENST00000368433ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000292180ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000292180ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000292180ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000292180ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000315144ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000315144ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000315144ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000315144ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000368432ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000368432ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000368432ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000368432ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000368433ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000368433ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5CDS-5UTRENST00000368433ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5CDS-5UTRENST00000368433ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-3UTRENST00000368431ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-3UTRENST00000368431ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-3UTRENST00000368431ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-3UTRENST00000368431ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-3UTRENST00000368431ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-3UTRENST00000368431ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-3UTRENST00000368431ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-3UTRENST00000368431ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-3UTRENST00000368431ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-3UTRENST00000368431ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-5UTRENST00000368431ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-5UTRENST00000368431ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
5UTR-5UTRENST00000368431ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
5UTR-5UTRENST00000368431ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000295530ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000295530ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000295530ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000295530ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000295530ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000295530ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000295530ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000295530ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000295530ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000295530ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000368428ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000368428ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000368428ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000368428ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000368428ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000368428ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000368428ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000368428ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000368428ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000368428ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000405236ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000405236ENST00000271619FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000405236ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000405236ENST00000271620FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000405236ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000405236ENST00000368936FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000405236ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000405236ENST00000368937FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-3UTRENST00000405236ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-3UTRENST00000405236ENST00000467771FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000295530ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000295530ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000295530ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000295530ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000368428ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000368428ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000368428ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000368428ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000405236ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000405236ENST00000368934FLAD1chr1

154956542

+PRUNEchr1

150999708

+
intron-5UTRENST00000405236ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999709

+
intron-5UTRENST00000405236ENST00000368935FLAD1chr1

154956542

+PRUNEchr1

150999708

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for FLAD1-PRUNE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FLAD1chr1154956542+PRUNEchr1150999708+1.95E-081
FLAD1chr1154956542+PRUNEchr1150999708+1.95E-081
FLAD1chr1154956542+PRUNEchr1150999708+1.95E-081
FLAD1chr1154956542+PRUNEchr1150999708+1.95E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FLAD1-PRUNE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:154956542/:150999708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FLAD1-PRUNE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FLAD1-PRUNE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FLAD1-PRUNE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FLAD1-PRUNE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLAD1C4310822LIPID STORAGE MYOPATHY DUE TO FLAVIN ADENINE DINUCLEOTIDE SYNTHETASE DEFICIENCY4CLINGEN;GENOMICS_ENGLAND;UNIPROT