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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOSL1-HN1 (FusionGDB2 ID:HG8061TG100462977)

Fusion Gene Summary for FOSL1-HN1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOSL1-HN1
Fusion gene ID: hg8061tg100462977
HgeneTgene
Gene symbol

FOSL1

HN1

Gene ID

8061

100462977

Gene nameFOS like 1, AP-1 transcription factor subunitMT-RNR2 like 1
SynonymsFRA|FRA1|fra-1HN1
Cytomap('FOSL1')('HN1')

11q13.1

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionfos-related antigen 1FOS like 1, AP-1 trancription factor subunitFOS-like antigen-1humanin-like 1MTRNR2-like 1humanin-like protein 1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312562, ENST00000448083, 
ENST00000531493, ENST00000532401, 
Fusion gene scores* DoF score3 X 2 X 3=1810 X 3 X 6=180
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/180*10)=-0.710493382805015
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOSL1 [Title/Abstract] AND HN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOSL1(65667712)-HN1(73132345), # samples:2
Anticipated loss of major functional domain due to fusion event.FOSL1-HN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FOSL1-HN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FOSL1-HN1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOSL1

GO:0061614

pri-miRNA transcription by RNA polymerase II

21673316

HgeneFOSL1

GO:2000144

positive regulation of DNA-templated transcription, initiation

23027619


check buttonFusion gene breakpoints across FOSL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-AA75-01AFOSL1chr11

65667712

-HN1chr17

73132345

-
ChimerDB4BLCATCGA-DK-AA75FOSL1chr11

65667712

-HN1chr17

73132345

-


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Fusion Gene ORF analysis for FOSL1-HN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000312562ENST00000581874FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-3UTRENST00000448083ENST00000581874FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-3UTRENST00000531493ENST00000581874FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-3UTRENST00000532401ENST00000581874FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-intronENST00000312562ENST00000465454FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-intronENST00000448083ENST00000465454FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-intronENST00000531493ENST00000465454FOSL1chr11

65667712

-HN1chr17

73132345

-
5CDS-intronENST00000532401ENST00000465454FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000356033FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000405458FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000470924FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000476258FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000481647FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000312562ENST00000482348FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000356033FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000405458FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000470924FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000476258FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000481647FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000448083ENST00000482348FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000356033FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000405458FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000470924FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000476258FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000481647FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000531493ENST00000482348FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000356033FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000405458FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000470924FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000476258FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000481647FOSL1chr11

65667712

-HN1chr17

73132345

-
Frame-shiftENST00000532401ENST00000482348FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000312562ENST00000392566FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000312562ENST00000409753FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000448083ENST00000392566FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000448083ENST00000409753FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000531493ENST00000392566FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000531493ENST00000409753FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000532401ENST00000392566FOSL1chr11

65667712

-HN1chr17

73132345

-
In-frameENST00000532401ENST00000409753FOSL1chr11

65667712

-HN1chr17

73132345

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448083FOSL1chr1165667712-ENST00000409753HN1chr1773132345-11821795172172
ENST00000448083FOSL1chr1165667712-ENST00000392566HN1chr1773132345-3301793132104
ENST00000312562FOSL1chr1165667712-ENST00000409753HN1chr1773132345-128928662485179
ENST00000312562FOSL1chr1165667712-ENST00000392566HN1chr1773132345-43728642085111
ENST00000531493FOSL1chr1165667712-ENST00000409753HN1chr1773132345-11821795172172
ENST00000531493FOSL1chr1165667712-ENST00000392566HN1chr1773132345-3301793132104
ENST00000532401FOSL1chr1165667712-ENST00000409753HN1chr1773132345-11821795172172
ENST00000532401FOSL1chr1165667712-ENST00000392566HN1chr1773132345-3301793132104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448083ENST00000409753FOSL1chr1165667712-HN1chr1773132345-0.435106280.56489366
ENST00000448083ENST00000392566FOSL1chr1165667712-HN1chr1773132345-0.615418730.3845813
ENST00000312562ENST00000409753FOSL1chr1165667712-HN1chr1773132345-0.50121440.49878556
ENST00000312562ENST00000392566FOSL1chr1165667712-HN1chr1773132345-0.707731250.29226878
ENST00000531493ENST00000409753FOSL1chr1165667712-HN1chr1773132345-0.435106280.56489366
ENST00000531493ENST00000392566FOSL1chr1165667712-HN1chr1773132345-0.615418730.3845813
ENST00000532401ENST00000409753FOSL1chr1165667712-HN1chr1773132345-0.435106280.56489366
ENST00000532401ENST00000392566FOSL1chr1165667712-HN1chr1773132345-0.615418730.3845813

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Fusion Genomic Features for FOSL1-HN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FOSL1-HN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65667712/chr17:73132345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOSL1chr11:65667712chr17:73132345ENST00000312562-14103_10633272.0Compositional biasNote=Poly-Glu
HgeneFOSL1chr11:65667712chr17:73132345ENST00000312562-14251_25533272.0Compositional biasNote=Poly-Ser
HgeneFOSL1chr11:65667712chr17:73132345ENST00000312562-14105_16833272.0DomainbZIP
HgeneFOSL1chr11:65667712chr17:73132345ENST00000312562-14107_12733272.0RegionBasic motif
HgeneFOSL1chr11:65667712chr17:73132345ENST00000312562-14133_16133272.0RegionLeucine-zipper


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Fusion Gene Sequence for FOSL1-HN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31027_31027_1_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000312562_HN1_chr17_73132345_ENST00000392566_length(transcript)=437nt_BP=286nt
ACGGGCCAAGGCGGCGCGTCTCGGGGGTGGAGCCTGGAGGTGACCGCGCCGCTGCAACGCCCCCACCCCCCGCGGTCGCAGTGGTTCAGC
CCGAGAACTTTTCATTCATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGC
CCCGGGCATGTTCCGAGACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGC
GCAGGCAGCCCAGCAGAGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGC
CCAGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG

>31027_31027_1_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000312562_HN1_chr17_73132345_ENST00000392566_length(amino acids)=111AA_BP=1
MDLPPGGFLLDGTGAGATGLGTGAAGTGFSSLCPRLPGKSVSTFSLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGC
WVLTHPRRAESFLFMNEKFSG

--------------------------------------------------------------
>31027_31027_2_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000312562_HN1_chr17_73132345_ENST00000409753_length(transcript)=1289nt_BP=286nt
ACGGGCCAAGGCGGCGCGTCTCGGGGGTGGAGCCTGGAGGTGACCGCGCCGCTGCAACGCCCCCACCCCCCGCGGTCGCAGTGGTTCAGC
CCGAGAACTTTTCATTCATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGC
CCCGGGCATGTTCCGAGACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGC
GCAGGCAGCCCAGCAGAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCC
AGCCCGGTGGCCCCGGCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAGCTCTGACTGTCCTGA
ACGCTGTCGTTCTGTCTGTTTCCTCCATGCTTGTGAACTGCACAACTTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGA
AGCACTTTATGTACTGCTGTCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGCCATGGCAT
GAGTGTTTTCTAGTAGTAGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTGTTTTTAAGAAGAAATAATTTGGTTCCAGATGTGTTA
GAGGATCTTTTGTACTGAGGTTTTTAACACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACCGTTC
CTGCCAGGCCCCAACCCACAGGGAGTCTCTCCGCAGAGCCTTCTTGGTGTTGCCCTAACTTGCCAGTGGCCTTTGCTCAGAGCCTCCTCC
TGTGACATGTGAACAATGAAGAGGCCTGCGCCTCCTGCCTTGCCGCCTGCAAAGCAAAGAAACTGCCTTTTATTTTTTAACCTTAAAAAG
TAGCCAGATAGTAACAAGACTGGCTGGCTGATGAGCAAAGCCTTTGCTCTCACGCAGAGGAAGGCTTGGATGTACAATGAAACTGCCTGG
AACTAAAAGCAGTGAAGCAAGGGAGGCAATCACACTGAAGCGGGTCTTCCTCCAGGAACGGGGTCCCACAGGCGTGTTGTTTTAAATAAC
CTGATGCTGTGTGCATGATGCTGGTGCTTGACCATGAAAGGAAAGTCTCATCCTTAAAATGTGTTGTACTTCACAATCCTGGACTGTTGC
TTCAAGTAAACAATATCCACATTTTGAAA

>31027_31027_2_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000312562_HN1_chr17_73132345_ENST00000409753_length(amino acids)=179AA_BP=0
MAHRPKSQGQRETCSSKEKKKRQQYIKCFFLMKQIQEMYSQAQVVQFTSMEETDRTTAFRTVRANPRRGWTCRQGDFFWMALGPGPPGWA
QAQQARASLHSAPGCLASLCPHFLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGCWVLTHPRRAESFLFMNEKFSG

--------------------------------------------------------------
>31027_31027_3_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000448083_HN1_chr17_73132345_ENST00000392566_length(transcript)=330nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
GAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCG
GCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG

>31027_31027_3_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000448083_HN1_chr17_73132345_ENST00000392566_length(amino acids)=104AA_BP=1
MDLPPGGFLLDGTGAGATGLGTGAAGTGFSSLCPRLPGKSVSTFSLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGC
WVLTHPRRAESFLF

--------------------------------------------------------------
>31027_31027_4_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000448083_HN1_chr17_73132345_ENST00000409753_length(transcript)=1182nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
AAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGC
CCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAGCTCTGACTGTCCTGAACGCTGTCGTTCTGTCT
GTTTCCTCCATGCTTGTGAACTGCACAACTTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGC
TGTCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGCCATGGCATGAGTGTTTTCTAGTAGT
AGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTGTTTTTAAGAAGAAATAATTTGGTTCCAGATGTGTTAGAGGATCTTTTGTACTG
AGGTTTTTAACACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACCGTTCCTGCCAGGCCCCAACCC
ACAGGGAGTCTCTCCGCAGAGCCTTCTTGGTGTTGCCCTAACTTGCCAGTGGCCTTTGCTCAGAGCCTCCTCCTGTGACATGTGAACAAT
GAAGAGGCCTGCGCCTCCTGCCTTGCCGCCTGCAAAGCAAAGAAACTGCCTTTTATTTTTTAACCTTAAAAAGTAGCCAGATAGTAACAA
GACTGGCTGGCTGATGAGCAAAGCCTTTGCTCTCACGCAGAGGAAGGCTTGGATGTACAATGAAACTGCCTGGAACTAAAAGCAGTGAAG
CAAGGGAGGCAATCACACTGAAGCGGGTCTTCCTCCAGGAACGGGGTCCCACAGGCGTGTTGTTTTAAATAACCTGATGCTGTGTGCATG
ATGCTGGTGCTTGACCATGAAAGGAAAGTCTCATCCTTAAAATGTGTTGTACTTCACAATCCTGGACTGTTGCTTCAAGTAAACAATATC
CACATTTTGAAA

>31027_31027_4_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000448083_HN1_chr17_73132345_ENST00000409753_length(amino acids)=172AA_BP=0
MAHRPKSQGQRETCSSKEKKKRQQYIKCFFLMKQIQEMYSQAQVVQFTSMEETDRTTAFRTVRANPRRGWTCRQGDFFWMALGPGPPGWA
QAQQARASLHSAPGCLASLCPHFLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGCWVLTHPRRAESFLF

--------------------------------------------------------------
>31027_31027_5_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000531493_HN1_chr17_73132345_ENST00000392566_length(transcript)=330nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
GAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCG
GCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG

>31027_31027_5_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000531493_HN1_chr17_73132345_ENST00000392566_length(amino acids)=104AA_BP=1
MDLPPGGFLLDGTGAGATGLGTGAAGTGFSSLCPRLPGKSVSTFSLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGC
WVLTHPRRAESFLF

--------------------------------------------------------------
>31027_31027_6_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000531493_HN1_chr17_73132345_ENST00000409753_length(transcript)=1182nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
AAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGC
CCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAGCTCTGACTGTCCTGAACGCTGTCGTTCTGTCT
GTTTCCTCCATGCTTGTGAACTGCACAACTTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGC
TGTCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGCCATGGCATGAGTGTTTTCTAGTAGT
AGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTGTTTTTAAGAAGAAATAATTTGGTTCCAGATGTGTTAGAGGATCTTTTGTACTG
AGGTTTTTAACACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACCGTTCCTGCCAGGCCCCAACCC
ACAGGGAGTCTCTCCGCAGAGCCTTCTTGGTGTTGCCCTAACTTGCCAGTGGCCTTTGCTCAGAGCCTCCTCCTGTGACATGTGAACAAT
GAAGAGGCCTGCGCCTCCTGCCTTGCCGCCTGCAAAGCAAAGAAACTGCCTTTTATTTTTTAACCTTAAAAAGTAGCCAGATAGTAACAA
GACTGGCTGGCTGATGAGCAAAGCCTTTGCTCTCACGCAGAGGAAGGCTTGGATGTACAATGAAACTGCCTGGAACTAAAAGCAGTGAAG
CAAGGGAGGCAATCACACTGAAGCGGGTCTTCCTCCAGGAACGGGGTCCCACAGGCGTGTTGTTTTAAATAACCTGATGCTGTGTGCATG
ATGCTGGTGCTTGACCATGAAAGGAAAGTCTCATCCTTAAAATGTGTTGTACTTCACAATCCTGGACTGTTGCTTCAAGTAAACAATATC
CACATTTTGAAA

>31027_31027_6_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000531493_HN1_chr17_73132345_ENST00000409753_length(amino acids)=172AA_BP=0
MAHRPKSQGQRETCSSKEKKKRQQYIKCFFLMKQIQEMYSQAQVVQFTSMEETDRTTAFRTVRANPRRGWTCRQGDFFWMALGPGPPGWA
QAQQARASLHSAPGCLASLCPHFLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGCWVLTHPRRAESFLF

--------------------------------------------------------------
>31027_31027_7_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000532401_HN1_chr17_73132345_ENST00000392566_length(transcript)=330nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
GAAAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCG
GCCCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAG

>31027_31027_7_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000532401_HN1_chr17_73132345_ENST00000392566_length(amino acids)=104AA_BP=1
MDLPPGGFLLDGTGAGATGLGTGAAGTGFSSLCPRLPGKSVSTFSLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGC
WVLTHPRRAESFLF

--------------------------------------------------------------
>31027_31027_8_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000532401_HN1_chr17_73132345_ENST00000409753_length(transcript)=1182nt_BP=179nt
ATAAAAAGAAAAGACTCCGCACGGCGCGGGTGAGTCAGAACCCAGCAGCCGTGTACCCCGCAGAGCCGCCAGCCCCGGGCATGTTCCGAG
ACTTCGGGGAACCCGGCCCGAGCTCCGGGAACGGCGGCGGGTACGGCGGCCCCGCGCAGCCCCCGGCCGCAGCGCAGGCAGCCCAGCAGA
AAATGTGGACACAGACTTGCCAGGCAGCCTGGGGCAGAGTGAAGAGAAGCCCGTGCCTGCTGCGCCTGTGCCCAGCCCGGTGGCCCCGGC
CCCAGTGCCATCCAGAAGAAATCCCCCTGGCGGCAAGTCCAGCCTCGTCTTGGGTTAGCTCTGACTGTCCTGAACGCTGTCGTTCTGTCT
GTTTCCTCCATGCTTGTGAACTGCACAACTTGAGCCTGACTGTACATCTCTTGGATTTGTTTCATTAAAAAGAAGCACTTTATGTACTGC
TGTCTTTTTTTTTTTTCTTTTGAAGAACAGGTTTCTCTCTGTCCTTGACTCTTGGGTCTGTGGGCCATGGCATGAGTGTTTTCTAGTAGT
AGATTGGAGGGAAAGCTTTGTGACACTTAGTACTGTGTTTTTAAGAAGAAATAATTTGGTTCCAGATGTGTTAGAGGATCTTTTGTACTG
AGGTTTTTAACACTTTACTTGGGTTTACCAAGCCTCAACTGGACAGACCATAAACAGTCCACAGGCACCGTTCCTGCCAGGCCCCAACCC
ACAGGGAGTCTCTCCGCAGAGCCTTCTTGGTGTTGCCCTAACTTGCCAGTGGCCTTTGCTCAGAGCCTCCTCCTGTGACATGTGAACAAT
GAAGAGGCCTGCGCCTCCTGCCTTGCCGCCTGCAAAGCAAAGAAACTGCCTTTTATTTTTTAACCTTAAAAAGTAGCCAGATAGTAACAA
GACTGGCTGGCTGATGAGCAAAGCCTTTGCTCTCACGCAGAGGAAGGCTTGGATGTACAATGAAACTGCCTGGAACTAAAAGCAGTGAAG
CAAGGGAGGCAATCACACTGAAGCGGGTCTTCCTCCAGGAACGGGGTCCCACAGGCGTGTTGTTTTAAATAACCTGATGCTGTGTGCATG
ATGCTGGTGCTTGACCATGAAAGGAAAGTCTCATCCTTAAAATGTGTTGTACTTCACAATCCTGGACTGTTGCTTCAAGTAAACAATATC
CACATTTTGAAA

>31027_31027_8_FOSL1-HN1_FOSL1_chr11_65667712_ENST00000532401_HN1_chr17_73132345_ENST00000409753_length(amino acids)=172AA_BP=0
MAHRPKSQGQRETCSSKEKKKRQQYIKCFFLMKQIQEMYSQAQVVQFTSMEETDRTTAFRTVRANPRRGWTCRQGDFFWMALGPGPPGWA
QAQQARASLHSAPGCLASLCPHFLLGCLRCGRGLRGAAVPAAVPGARAGFPEVSEHARGWRLCGVHGCWVLTHPRRAESFLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOSL1-HN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOSL1-HN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOSL1-HN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource