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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP39-ZNF34 (FusionGDB2 ID:HG80728TG80778)

Fusion Gene Summary for ARHGAP39-ZNF34

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP39-ZNF34
Fusion gene ID: hg80728tg80778
HgeneTgene
Gene symbol

ARHGAP39

ZNF34

Gene ID

80728

80778

Gene nameRho GTPase activating protein 39zinc finger protein 34
SynonymsCrGAP|VilseKOX32
Cytomap('ARHGAP39')('ZNF34')

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 39RhoGAP93B homologcrossGAP homologzinc finger protein 34zinc finger protein 34 (KOX 32)zinc finger protein KOX32
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000276826, ENST00000377307, 
ENST00000540274, ENST00000528810, 
Fusion gene scores* DoF score9 X 7 X 5=3151 X 1 X 1=1
# samples 81
** MAII scorelog2(8/315*10)=-1.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ARHGAP39 [Title/Abstract] AND ZNF34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP39(145830920)-ZNF34(146003910), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP39-ZNF34 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP39-ZNF34 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP39-ZNF34 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP39-ZNF34 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP39-ZNF34 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP39

GO:0099173

postsynapse organization

24656827


check buttonFusion gene breakpoints across ARHGAP39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PP-01AARHGAP39chr8

145830920

-ZNF34chr8

146003910

-


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Fusion Gene ORF analysis for ARHGAP39-ZNF34

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000276826ENST00000429371ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
5CDS-5UTRENST00000377307ENST00000429371ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
5CDS-5UTRENST00000540274ENST00000429371ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
Frame-shiftENST00000540274ENST00000343459ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
In-frameENST00000276826ENST00000343459ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
In-frameENST00000377307ENST00000343459ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
intron-3CDSENST00000528810ENST00000343459ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-
intron-5UTRENST00000528810ENST00000429371ARHGAP39chr8

145830920

-ZNF34chr8

146003910

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377307ARHGAP39chr8145830920-ENST00000343459ZNF34chr8146003910-19911651831838551
ENST00000276826ARHGAP39chr8145830920-ENST00000343459ZNF34chr8146003910-21082823001955551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377307ENST00000343459ARHGAP39chr8145830920-ZNF34chr8146003910-0.0108176270.9891824
ENST00000276826ENST00000343459ARHGAP39chr8145830920-ZNF34chr8146003910-0.0081018950.99189806

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Fusion Genomic Features for ARHGAP39-ZNF34


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGAP39-ZNF34


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:145830920/chr8:146003910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF34chr8:145830920chr8:146003910ENST000003434591635_1083561.0DomainKRAB
TgeneZNF34chr8:145830920chr8:146003910ENST000004293711635_1080540.0DomainKRAB
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916195_2173561.0Zinc fingerC2H2-type 1
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916251_2733561.0Zinc fingerC2H2-type 2
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916279_3013561.0Zinc fingerC2H2-type 3
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916307_3293561.0Zinc fingerC2H2-type 4
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916335_3573561.0Zinc fingerC2H2-type 5
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916363_3853561.0Zinc fingerC2H2-type 6
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916391_4133561.0Zinc fingerC2H2-type 7
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916419_4413561.0Zinc fingerC2H2-type 8
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916447_4693561.0Zinc fingerC2H2-type 9
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916475_4973561.0Zinc fingerC2H2-type 10
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916503_5253561.0Zinc fingerC2H2-type 11
TgeneZNF34chr8:145830920chr8:146003910ENST0000034345916531_5533561.0Zinc fingerC2H2-type 12
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116195_2170540.0Zinc fingerC2H2-type 1
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116251_2730540.0Zinc fingerC2H2-type 2
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116279_3010540.0Zinc fingerC2H2-type 3
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116307_3290540.0Zinc fingerC2H2-type 4
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116335_3570540.0Zinc fingerC2H2-type 5
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116363_3850540.0Zinc fingerC2H2-type 6
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116391_4130540.0Zinc fingerC2H2-type 7
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116419_4410540.0Zinc fingerC2H2-type 8
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116447_4690540.0Zinc fingerC2H2-type 9
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116475_4970540.0Zinc fingerC2H2-type 10
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116503_5250540.0Zinc fingerC2H2-type 11
TgeneZNF34chr8:145830920chr8:146003910ENST0000042937116531_5530540.0Zinc fingerC2H2-type 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000276826-110234_367261084.0Compositional biasNote=Pro-rich
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000377307-111234_367261115.0Compositional biasNote=Pro-rich
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000540274-211234_367261084.0Compositional biasNote=Pro-rich
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000276826-11025_58261084.0DomainWW 1
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000276826-11063_97261084.0DomainWW 2
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000276826-110722_879261084.0DomainMyTH4
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000276826-110890_1078261084.0DomainRho-GAP
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000377307-11125_58261115.0DomainWW 1
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000377307-11163_97261115.0DomainWW 2
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000377307-111722_879261115.0DomainMyTH4
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000377307-111890_1078261115.0DomainRho-GAP
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000540274-21125_58261084.0DomainWW 1
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000540274-21163_97261084.0DomainWW 2
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000540274-211722_879261084.0DomainMyTH4
HgeneARHGAP39chr8:145830920chr8:146003910ENST00000540274-211890_1078261084.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP39-ZNF34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6107_6107_1_ARHGAP39-ZNF34_ARHGAP39_chr8_145830920_ENST00000276826_ZNF34_chr8_146003910_ENST00000343459_length(transcript)=2108nt_BP=282nt
CACGGGTGCCGTGGAGTCCATCGTCATCCTGCCCAGCCAGTCTGCGGCGGTGGGCTGGGCCGGGTGATTGGTGTGGTGAGGCGTCTTCCA
TATCAGCACTGTTGCTTCTCCCCTCTTGCAGTGCGGCACCTTCCCGTCTGATGCTGGCGTTGTGCGTATGGTGCCCTGACGTCTGTCCAC
GTGGGCGCGGAAGCAAACAGCGATGTCCCAGACGCAGGACTACGAGTGCAGGAGCCATAATGTCGACCTGCCGGAGTCGAGGATTCCAGG
GTCGAACACTCGCTCCTCAGTGACCAGCTCCTGCTCACTGCCCTCAGAAAGCCCAACCCTCAGGCAATGGCGGCCTTGTTCCTGTCTGCC
CCACCCCAGGCCGAGGTGACCTTCGAGGACGTGGCTGTGTACCTCTCCCGGGAGGAATGGGGCCGCCTGGGCCCTGCTCAGAGGGGCCTC
TACAGGGACGTGATGCTGGAGACCTACGGGAACCTAGTCTCACTGGGAGTAGGACCTGCAGGCCCCAAGCCTGGAGTGATCTCGCAGTTG
GAGCGAGGGGATGAGCCCTGGGTCCTGGATGTTCAGGGCACCTCTGGGAAAGAGCACCTGAGAGTCAACAGCCCAGCTCTTGGGACCAGA
ACTGAGTACAAGGAGTTGACTTCACAGGAGACATTTGGTGAGGAAGATCCCCAGGGATCTGAGCCAGTAGAAGCCTGTGACCACATCAGT
AAGTCAGAGGGGAGCCTGGAAAAGCTAGTGGAGCAGAGAGGCCCCAGGGCAGTCACACTGACCAACGGGGAGAGCAGCAGGGAGTCTGGG
GGAAACCTCAGGTTGCTGTCAAGACCTGTTCCTGATCAGAGACCTCACAAATGTGATATATGTGAGCAAAGTTTTGAACAGAGATCATAT
CTCAACAACCATAAGCGTGTACACAGGTCAAAAAAAACAAATACAGTTCGTAACTCTGGGGAAATCTTCAGTGCAAACTTAGTTGTTAAA
GAAGATCAGAAAATTCCTACTGGGAAAAAATTGCATTATTGCAGTTACTGTGGGAAAACATTCAGGTACAGTGCCAACCTTGTCAAGCAT
CAGCGGCTTCACACTGAAGAGAAGCCCTACAAATGTGATGAGTGTGGGAAAGCCTTCAGCCAGAGCTGCGAGTTCATCAATCACCGAAGG
ATGCACTCAGGAGAGATTCCCTACCGGTGTGACGAGTGTGGGAAGACATTCACCCGGAGGCCCAACCTCATGAAGCACCAGAGGATTCAC
ACTGGGGAGAAACCCTACAAGTGTGGGGAGTGTGGGAAGCACTTTAGCGCCTACTCTTCCCTGATTTATCACCAGAGAATCCACACCGGA
GAGAAACCCTATAAATGTAATGACTGCGGGAAAGCCTTCAGTGATGGCTCAATCCTTATCCGACATCGTCGGACTCACACCGGAGAGAAG
CCATTTGAGTGCAAGGAATGTGGCAAAGGCTTTACACAAAGTTCTAACCTTATCCAACATCAGAGAATTCACACTGGAGAGAAACCCTAT
AAATGTAATGAATGTGAGAAAGCTTTCATTCAAAAAACCAAACTCGTGGAACATCAGAGAAGCCACACTGGAGAGAAGCCCTATGAATGC
AATGACTGTGGCAAAGTTTTCAGCCAAAGCACACACCTCATCCAGCACCAGAGAATCCACACAGGAGAGAAGCCCTACAAGTGCAGCGAG
TGTGGGAAGGCCTTCCACAACAGTTCCAGACTCATCCACCACCAGAGGCTGCACCACGGAGAGAAACCCTACAGATGCAGCGATTGCAAG
AAAGCCTTCAGCCAGAGCACGTACTTGATTCAGCACCGGAGGATCCACACCGGGGAGAAGCCCTACAAGTGCAGCGAGTGTGGGAAGGCC
TTCCGGCACAGTTCCAACATGTGTCAGCATCAGCGGATTCACCTCCGGGAGGACTTCTCCATGTAACAGTGGCGCGGTGTCCGAGGGCAG
AGTCCAGCTGAGCACTTCCTGCATGCGCCCCCGGCACCTGACTCTGCCCTTTATGTATTATCCACACGATGTTTTCACAGAGTGAAAGGA
CGTTTCTCATTAAACAAACCTCTTTTCTTAAATCAAAA

>6107_6107_1_ARHGAP39-ZNF34_ARHGAP39_chr8_145830920_ENST00000276826_ZNF34_chr8_146003910_ENST00000343459_length(amino acids)=551AA_BP=232
MLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLD
VQGTSGKEHLRVNSPALGTRTEYKELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPV
PDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPY
KCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCG
KAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQS
THLIQHQRIHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAFRHSSNMCQH
QRIHLREDFSM

--------------------------------------------------------------
>6107_6107_2_ARHGAP39-ZNF34_ARHGAP39_chr8_145830920_ENST00000377307_ZNF34_chr8_146003910_ENST00000343459_length(transcript)=1991nt_BP=165nt
GCAGTGCGGCACCTTCCCGTCTGATGCTGGCGTTGTGCGTATGGTGCCCTGACGTCTGTCCACGTGGGCGCGGAAGCAAACAGCGATGTC
CCAGACGCAGGACTACGAGTGCAGGAGCCATAATGTCGACCTGCCGGAGTCGAGGATTCCAGGGTCGAACACTCGCTCCTCAGTGACCAG
CTCCTGCTCACTGCCCTCAGAAAGCCCAACCCTCAGGCAATGGCGGCCTTGTTCCTGTCTGCCCCACCCCAGGCCGAGGTGACCTTCGAG
GACGTGGCTGTGTACCTCTCCCGGGAGGAATGGGGCCGCCTGGGCCCTGCTCAGAGGGGCCTCTACAGGGACGTGATGCTGGAGACCTAC
GGGAACCTAGTCTCACTGGGAGTAGGACCTGCAGGCCCCAAGCCTGGAGTGATCTCGCAGTTGGAGCGAGGGGATGAGCCCTGGGTCCTG
GATGTTCAGGGCACCTCTGGGAAAGAGCACCTGAGAGTCAACAGCCCAGCTCTTGGGACCAGAACTGAGTACAAGGAGTTGACTTCACAG
GAGACATTTGGTGAGGAAGATCCCCAGGGATCTGAGCCAGTAGAAGCCTGTGACCACATCAGTAAGTCAGAGGGGAGCCTGGAAAAGCTA
GTGGAGCAGAGAGGCCCCAGGGCAGTCACACTGACCAACGGGGAGAGCAGCAGGGAGTCTGGGGGAAACCTCAGGTTGCTGTCAAGACCT
GTTCCTGATCAGAGACCTCACAAATGTGATATATGTGAGCAAAGTTTTGAACAGAGATCATATCTCAACAACCATAAGCGTGTACACAGG
TCAAAAAAAACAAATACAGTTCGTAACTCTGGGGAAATCTTCAGTGCAAACTTAGTTGTTAAAGAAGATCAGAAAATTCCTACTGGGAAA
AAATTGCATTATTGCAGTTACTGTGGGAAAACATTCAGGTACAGTGCCAACCTTGTCAAGCATCAGCGGCTTCACACTGAAGAGAAGCCC
TACAAATGTGATGAGTGTGGGAAAGCCTTCAGCCAGAGCTGCGAGTTCATCAATCACCGAAGGATGCACTCAGGAGAGATTCCCTACCGG
TGTGACGAGTGTGGGAAGACATTCACCCGGAGGCCCAACCTCATGAAGCACCAGAGGATTCACACTGGGGAGAAACCCTACAAGTGTGGG
GAGTGTGGGAAGCACTTTAGCGCCTACTCTTCCCTGATTTATCACCAGAGAATCCACACCGGAGAGAAACCCTATAAATGTAATGACTGC
GGGAAAGCCTTCAGTGATGGCTCAATCCTTATCCGACATCGTCGGACTCACACCGGAGAGAAGCCATTTGAGTGCAAGGAATGTGGCAAA
GGCTTTACACAAAGTTCTAACCTTATCCAACATCAGAGAATTCACACTGGAGAGAAACCCTATAAATGTAATGAATGTGAGAAAGCTTTC
ATTCAAAAAACCAAACTCGTGGAACATCAGAGAAGCCACACTGGAGAGAAGCCCTATGAATGCAATGACTGTGGCAAAGTTTTCAGCCAA
AGCACACACCTCATCCAGCACCAGAGAATCCACACAGGAGAGAAGCCCTACAAGTGCAGCGAGTGTGGGAAGGCCTTCCACAACAGTTCC
AGACTCATCCACCACCAGAGGCTGCACCACGGAGAGAAACCCTACAGATGCAGCGATTGCAAGAAAGCCTTCAGCCAGAGCACGTACTTG
ATTCAGCACCGGAGGATCCACACCGGGGAGAAGCCCTACAAGTGCAGCGAGTGTGGGAAGGCCTTCCGGCACAGTTCCAACATGTGTCAG
CATCAGCGGATTCACCTCCGGGAGGACTTCTCCATGTAACAGTGGCGCGGTGTCCGAGGGCAGAGTCCAGCTGAGCACTTCCTGCATGCG
CCCCCGGCACCTGACTCTGCCCTTTATGTATTATCCACACGATGTTTTCACAGAGTGAAAGGACGTTTCTCATTAAACAAACCTCTTTTC
TTAAATCAAAA

>6107_6107_2_ARHGAP39-ZNF34_ARHGAP39_chr8_145830920_ENST00000377307_ZNF34_chr8_146003910_ENST00000343459_length(amino acids)=551AA_BP=232
MLTALRKPNPQAMAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVMLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLD
VQGTSGKEHLRVNSPALGTRTEYKELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGNLRLLSRPV
PDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPY
KCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQRIHTGEKPYKCNDCG
KAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQS
THLIQHQRIHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYKCSECGKAFRHSSNMCQH
QRIHLREDFSM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP39-ZNF34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP39-ZNF34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP39-ZNF34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource