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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:COL18A1-DAZAP1 (FusionGDB2 ID:HG80781TG26528) |
Fusion Gene Summary for COL18A1-DAZAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL18A1-DAZAP1 | Fusion gene ID: hg80781tg26528 | Hgene | Tgene | Gene symbol | COL18A1 | DAZAP1 | Gene ID | 80781 | 26528 |
| Gene name | collagen type XVIII alpha 1 chain | DAZ associated protein 1 | |
| Synonyms | KNO|KNO1|KS | - | |
| Cytomap | ('COL18A1')('DAZAP1') 21q22.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-1(XVIII) chainantiangiogenic agentcollagen alpha-1(XVIII) chain isoform 1 preproproteincollagen, type XVIII, alpha 1endostatinmulti-functional protein MFP | DAZ-associated protein 1deleted in azoospermia-associated protein 1testicular tissue protein Li 50 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P39060 | Q96EP5 | |
| Ensembl transtripts involved in fusion gene | ENST00000400337, ENST00000355480, ENST00000359759, ENST00000459895, | ||
| Fusion gene scores | * DoF score | 10 X 9 X 9=810 | 23 X 7 X 9=1449 |
| # samples | 11 | 23 | |
| ** MAII score | log2(11/810*10)=-2.88041838424733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/1449*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COL18A1 [Title/Abstract] AND DAZAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | COL18A1(46825388)-DAZAP1(1417498), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | COL18A1-DAZAP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-29-1701 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
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Fusion Gene ORF analysis for COL18A1-DAZAP1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000400337 | ENST00000586579 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| Frame-shift | ENST00000400337 | ENST00000233078 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| Frame-shift | ENST00000400337 | ENST00000336761 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000355480 | ENST00000233078 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000355480 | ENST00000336761 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000359759 | ENST00000233078 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000359759 | ENST00000336761 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000459895 | ENST00000233078 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3CDS | ENST00000459895 | ENST00000336761 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3UTR | ENST00000355480 | ENST00000586579 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3UTR | ENST00000359759 | ENST00000586579 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| intron-3UTR | ENST00000459895 | ENST00000586579 | COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for COL18A1-DAZAP1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + | 0.1428325 | 0.8571675 |
| COL18A1 | chr21 | 46825388 | + | DAZAP1 | chr19 | 1417498 | + | 0.1428325 | 0.8571675 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for COL18A1-DAZAP1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46825388/:1417498) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL18A1 | DAZAP1 |
| FUNCTION: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. {ECO:0000269|PubMed:10942434}.; FUNCTION: [Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. {ECO:0000269|PubMed:11257123}.; FUNCTION: [Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123). {ECO:0000250|UniProtKB:P39061, ECO:0000269|PubMed:11257123, ECO:0000269|PubMed:9459295}. | FUNCTION: RNA-binding protein, which may be required during spermatogenesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for COL18A1-DAZAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for COL18A1-DAZAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COL18A1-DAZAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COL18A1-DAZAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COL18A1 | C4551775 | Knobloch Syndrome, Type I | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | COL18A1 | C1849409 | Knobloch syndrome | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | COL18A1 | C0006663 | Calcinosis | 1 | CTD_human |
| Hgene | COL18A1 | C0018824 | Heart valve disease | 1 | CTD_human |
| Hgene | COL18A1 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
| Hgene | COL18A1 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| Hgene | COL18A1 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| Hgene | COL18A1 | C0263628 | Tumoral calcinosis | 1 | CTD_human |
| Hgene | COL18A1 | C0521174 | Microcalcification | 1 | CTD_human |
| Hgene | COL18A1 | C0917816 | Mental deficiency | 1 | CTD_human |
| Hgene | COL18A1 | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | C0005586 | Bipolar Disorder | 1 | PSYGENET | |
| Tgene | C0036341 | Schizophrenia | 1 | PSYGENET |
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