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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CMIP-NEDD4L (FusionGDB2 ID:HG80790TG23327)

Fusion Gene Summary for CMIP-NEDD4L

check button Fusion gene summary
Fusion gene informationFusion gene name: CMIP-NEDD4L
Fusion gene ID: hg80790tg23327
HgeneTgene
Gene symbol

CMIP

NEDD4L

Gene ID

80790

23327

Gene namec-Maf inducing proteinNEDD4 like E3 ubiquitin protein ligase
SynonymsTCMIPNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap('CMIP')('NEDD4L')

16q23.2-q23.3

18q21.31

Type of geneprotein-codingprotein-coding
DescriptionC-Maf-inducing proteintc-MipE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000537098, ENST00000398040, 
ENST00000539778, ENST00000566513, 
Fusion gene scores* DoF score23 X 18 X 9=372627 X 28 X 6=4536
# samples 2832
** MAII scorelog2(28/3726*10)=-3.73412894199667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/4536*10)=-3.82527683005487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMIP [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCMIP(81479146)-NEDD4L(55833020), # samples:1
Anticipated loss of major functional domain due to fusion event.CMIP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CMIP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CMIP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CMIP-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check buttonFusion gene breakpoints across CMIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ACMIPchr16

81479146

+NEDD4Lchr18

55833020

+


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Fusion Gene ORF analysis for CMIP-NEDD4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000537098ENST00000588516CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000256830CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000256832CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000357895CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000382850CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000435432CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000456986CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000537098ENST00000586263CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000537098ENST00000431212CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000537098ENST00000456173CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000537098ENST00000589054CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
In-frameENST00000537098ENST00000356462CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
In-frameENST00000537098ENST00000400345CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000398040ENST00000356462CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000398040ENST00000400345CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000539778ENST00000356462CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000539778ENST00000400345CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000566513ENST00000356462CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000566513ENST00000400345CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3UTRENST00000398040ENST00000588516CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3UTRENST00000539778ENST00000588516CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-3UTRENST00000566513ENST00000588516CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000256830CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000256832CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000357895CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000382850CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000435432CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000456986CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000398040ENST00000586263CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000256830CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000256832CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000357895CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000382850CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000435432CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000456986CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000539778ENST00000586263CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000256830CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000256832CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000357895CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000382850CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000435432CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000456986CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000566513ENST00000586263CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000398040ENST00000431212CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000398040ENST00000456173CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000398040ENST00000589054CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000539778ENST00000431212CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000539778ENST00000456173CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000539778ENST00000589054CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000566513ENST00000431212CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000566513ENST00000456173CMIPchr16

81479146

+NEDD4Lchr18

55833020

+
intron-intronENST00000566513ENST00000589054CMIPchr16

81479146

+NEDD4Lchr18

55833020

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537098CMIPchr1681479146+ENST00000356462NEDD4Lchr1855833020+3365372723059995
ENST00000537098CMIPchr1681479146+ENST00000400345NEDD4Lchr1855833020+36883727232511059

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537098ENST00000356462CMIPchr1681479146+NEDD4Lchr1855833020+0.0006249220.99937505
ENST00000537098ENST00000400345CMIPchr1681479146+NEDD4Lchr1855833020+0.0003631760.99963677

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Fusion Genomic Features for CMIP-NEDD4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CMIPchr1681479146+NEDD4Lchr1855833019+3.82E-070.99999964
CMIPchr1681479146+NEDD4Lchr1855833019+3.82E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CMIP-NEDD4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:81479146/chr18:55833020)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000256830028193_22616872.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000256830028385_41816872.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000256830028497_53016872.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000256830028548_58116872.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000256830028640_97416872.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000356462029193_22616912.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000356462029385_41816912.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000356462029497_53016912.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000356462029548_58116912.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000356462029640_97416912.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000357895031193_2268968.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000357895031385_4188968.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000357895031497_5308968.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000357895031548_5818968.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000357895031640_9748968.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000382850030193_22616956.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000382850030385_41816956.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000382850030497_53016956.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000382850030548_58116956.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000382850030640_97416956.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000400345031193_22616976.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000400345031385_41816976.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000400345031497_53016976.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000400345031548_58116976.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000400345031640_97416976.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000431212030193_2260855.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000431212030385_4180855.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000431212030497_5300855.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000004312120304_1260855.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000431212030548_5810855.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000431212030640_9740855.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000435432031193_2260835.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000435432031385_4180835.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000435432031497_5300835.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000004354320314_1260835.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000435432031548_5810835.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000435432031640_9740835.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456173029193_2260835.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456173029385_4180835.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456173029497_5300835.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000004561730294_1260835.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456173029548_5810835.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456173029640_9740835.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456986031193_2260855.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456986031385_4180855.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456986031497_5300855.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000004569860314_1260855.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456986031548_5810855.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000456986031640_9740855.0DomainHECT
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000586263030193_2268948.0DomainWW 1
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000586263030385_4188948.0DomainWW 2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000586263030497_5308948.0DomainWW 3
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000586263030548_5818948.0DomainWW 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST00000586263030640_9748948.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCMIPchr16:81479146chr18:55833020ENST00000398040+11954_1630621.0DomainNote=PH
HgeneCMIPchr16:81479146chr18:55833020ENST00000537098+12154_163100774.0DomainNote=PH
HgeneCMIPchr16:81479146chr18:55833020ENST00000539778+12154_1630680.0DomainNote=PH
HgeneCMIPchr16:81479146chr18:55833020ENST00000398040+119663_6860621.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr18:55833020ENST00000398040+119687_7070621.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr18:55833020ENST00000398040+119712_7320621.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr18:55833020ENST00000398040+119736_7560621.0RepeatNote=LRR 4
HgeneCMIPchr16:81479146chr18:55833020ENST00000537098+121663_686100774.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr18:55833020ENST00000537098+121687_707100774.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr18:55833020ENST00000537098+121712_732100774.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr18:55833020ENST00000537098+121736_756100774.0RepeatNote=LRR 4
HgeneCMIPchr16:81479146chr18:55833020ENST00000539778+121663_6860680.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr18:55833020ENST00000539778+121687_7070680.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr18:55833020ENST00000539778+121712_7320680.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr18:55833020ENST00000539778+121736_7560680.0RepeatNote=LRR 4
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000002568300284_12616872.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000003564620294_12616912.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000003578950314_1268968.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000003828500304_12616956.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000004003450314_12616976.0DomainC2
TgeneNEDD4Lchr16:81479146chr18:55833020ENST000005862630304_1268948.0DomainC2


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Fusion Gene Sequence for CMIP-NEDD4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17529_17529_1_CMIP-NEDD4L_CMIP_chr16_81479146_ENST00000537098_NEDD4L_chr18_55833020_ENST00000356462_length(transcript)=3365nt_BP=372nt
GGGGGCCCCGCCGCCCCAGCAGCCCAGGACAGCCCCCTCTCCCCGCCCCCAGCCCCCTCCCCCGGCGCGGCCATGGATGTGACCAGCAGC
TCGGGCGGCGGCGGCGACCCCCGGCAGATCGAGGAGACCAAGCCGCTGCTGGGGGGCGACGTGTCGGCCCCCGAAGGCACGAAGATGGGC
GCCGTGCCCTGCCGCCGGGCTCTTCTGCTTTGCAACGGGATGAGGTACAAACTGCTGCAGGAGGGCGACATTCAGGTCTGTGTCATCCGG
CACCCGCGGACCTTTCTCAGCAAGATCCTCACCTCGAAATTCCTGAGGCGCTGGGAGCCGCACCACCTAACGCTGGCCGACAACAGCCTG
GCGTCCGCCACGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGAT
CCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCA
AAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGAC
GACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTC
CTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAA
AACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCT
CCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCAC
AGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGC
AGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATC
GCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGC
AGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGT
GTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTA
ATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTA
CGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAG
AGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAA
GATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAA
AGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATT
ACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAAT
AGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCT
AGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTC
AACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCAT
TTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTAC
AAGATGATGTTGGGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAAT
GACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAA
ATAATGGTCACAAATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCC
TTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGT
GATGTGGATGTGAATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCT
GTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTT
TATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTT
GACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAA
GCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCA
GAGAGCAGCTGCAGGCATGGTCCCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTT
CCTGCCTTTCCCACCACAAATTATCAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTATGTTGTGCCTCTG
CAGGCAAAGCCCTTAATAAATATTTTACATCCTTT

>17529_17529_1_CMIP-NEDD4L_CMIP_chr16_81479146_ENST00000537098_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=995AA_BP=100
MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRALLLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLT
LADNSLASATGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDE
NRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQH
QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETI
SEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSAT
NSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNT
KTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKK
PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSG
LCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDL
KPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVI
QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQG
FEGVD

--------------------------------------------------------------
>17529_17529_2_CMIP-NEDD4L_CMIP_chr16_81479146_ENST00000537098_NEDD4L_chr18_55833020_ENST00000400345_length(transcript)=3688nt_BP=372nt
GGGGGCCCCGCCGCCCCAGCAGCCCAGGACAGCCCCCTCTCCCCGCCCCCAGCCCCCTCCCCCGGCGCGGCCATGGATGTGACCAGCAGC
TCGGGCGGCGGCGGCGACCCCCGGCAGATCGAGGAGACCAAGCCGCTGCTGGGGGGCGACGTGTCGGCCCCCGAAGGCACGAAGATGGGC
GCCGTGCCCTGCCGCCGGGCTCTTCTGCTTTGCAACGGGATGAGGTACAAACTGCTGCAGGAGGGCGACATTCAGGTCTGTGTCATCCGG
CACCCGCGGACCTTTCTCAGCAAGATCCTCACCTCGAAATTCCTGAGGCGCTGGGAGCCGCACCACCTAACGCTGGCCGACAACAGCCTG
GCGTCCGCCACGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGAT
CCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCA
AAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGAC
GACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTC
CTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAA
AACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCT
CCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCAC
AGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGC
AGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATC
GCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGC
AGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGT
GTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAG
GAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATAC
TATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGT
AACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAG
GACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACAC
AAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACT
ACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCT
GGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAG
AACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCT
GATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGAT
GTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCC
AAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGT
AATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATT
AGACCATTTTACAAGATGATGTTGGGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGG
ATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCC
AATGGGTCAGAAATAATGGTCACAAATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAG
CAGATGAACGCCTTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATG
TGCGGCCTCGGTGATGTGGATGTGAATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGG
TTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGA
TTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGC
TTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAA
GGGGTGGATTAAGCACCCTGTGCCTCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCA
GAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTCCCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTC
CCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTATCAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTAT
GTTGTGCCTCTGCAGGCAAAGCCCTTAATAAATATTTTACATCCTTTCTAATGACAATGAATGGAATTAATCACTCAACAGGTATAGTAT
TACGACTCATGTTTACTTTTTAAAATGATTTAGACCGATTTTCAGATTTTATTTCGTTATGATTAAAGATGTCTCATGTACTTGGAAA

>17529_17529_2_CMIP-NEDD4L_CMIP_chr16_81479146_ENST00000537098_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1059AA_BP=100
MDVTSSSGGGGDPRQIEETKPLLGGDVSAPEGTKMGAVPCRRALLLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLT
LADNSLASATGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDE
NRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQH
QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETI
SEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSS
TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA
PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPND
LGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIM
SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKL
LDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRF
VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS
RVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CMIP-NEDD4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CMIP-NEDD4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CMIP-NEDD4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCMIPC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0020538Hypertensive disease2CTD_human
TgeneC4310669PERIVENTRICULAR NODULAR HETEROTOPIA 72GENOMICS_ENGLAND;UNIPROT
TgeneC0008925Cleft Palate1CTD_human;GENOMICS_ENGLAND
TgeneC0014175Endometriosis1CTD_human
TgeneC0039075Syndactyly1CTD_human
TgeneC0265553Polysyndactyly1CTD_human
TgeneC0269102Endometrioma1CTD_human
TgeneC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneC1837218Cleft palate, isolated1CTD_human
TgeneC1848213Periventricular Heterotopia, X-Linked1CTD_human
TgeneC1868720Periventricular Nodular Heterotopia1CTD_human;ORPHANET
TgeneC4551969Bilateral Periventricular Nodular Heterotopia1CTD_human