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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:APOL3-ARPP19 (FusionGDB2 ID:HG80833TG10776) |
Fusion Gene Summary for APOL3-ARPP19 |
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Fusion gene information | Fusion gene name: APOL3-ARPP19 | Fusion gene ID: hg80833tg10776 | Hgene | Tgene | Gene symbol | APOL3 | ARPP19 | Gene ID | 80833 | 10776 |
Gene name | apolipoprotein L3 | cAMP regulated phosphoprotein 19 | |
Synonyms | APOLIII|CG121|CG12_1|apoL-III | ARPP-16|ARPP-19|ARPP16|ENSAL | |
Cytomap | ('APOL3')('ARPP19') 22q12.3 | 15q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | apolipoprotein L3TNF-inducible protein CG12-1apolipoprotein L, 3apolipoprotein L-IIIapolipoprotein L-III splice variant alphaapolipoprotein L-III splice variant beta | cAMP-regulated phosphoprotein 19cAMP-regulated phosphoprotein 19kDacyclic AMP phosphoprotein, 19 kD | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | O95236 | P56211 | |
Ensembl transtripts involved in fusion gene | ENST00000349314, ENST00000361710, ENST00000397287, ENST00000397293, ENST00000424878, ENST00000487423, | ||
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 6 X 2=60 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: APOL3 [Title/Abstract] AND ARPP19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | APOL3(36536419)-ARPP19(52841742), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARPP19 | GO:0045722 | positive regulation of gluconeogenesis | 9653196 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for APOL3-ARPP19 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for APOL3-ARPP19 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for APOL3-ARPP19 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36536419/:52841742) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
APOL3 | ARPP19 |
FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for APOL3-ARPP19 |
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Fusion Gene PPI Analysis for APOL3-ARPP19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for APOL3-ARPP19 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for APOL3-ARPP19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |