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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAMK4-PTPRK (FusionGDB2 ID:HG814TG5796)

Fusion Gene Summary for CAMK4-PTPRK

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMK4-PTPRK
Fusion gene ID: hg814tg5796
HgeneTgene
Gene symbol

CAMK4

PTPRK

Gene ID

814

5796

Gene namecalcium/calmodulin dependent protein kinase IVprotein tyrosine phosphatase receptor type K
SynonymsCaMK IV|CaMK-GR|CaMKIV|caMKR-PTP-kappa
Cytomap('CAMK4')('PTPRK')

5q22.1

6q22.33

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type IVCAM kinase IVCAM kinase- GRbrain Ca(2+)-calmodulin-dependent protein kinase type IVbrain Ca++-calmodulin-dependent protein kinase type IVcalcium/calmodulin-dependent protein kinase type IV catalytic receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha
Modification date2020032220200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282356, ENST00000512453, 
ENST00000512890, 
Fusion gene scores* DoF score2 X 2 X 2=817 X 12 X 9=1836
# samples 221
** MAII scorelog2(2/8*10)=1.32192809488736log2(21/1836*10)=-3.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAMK4 [Title/Abstract] AND PTPRK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAMK4(110712640)-PTPRK(128563747), # samples:1
Anticipated loss of major functional domain due to fusion event.CAMK4-PTPRK seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CAMK4-PTPRK seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CAMK4-PTPRK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CAMK4-PTPRK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CAMK4-PTPRK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CAMK4-PTPRK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK4

GO:0045893

positive regulation of transcription, DNA-templated

8855261

TgenePTPRK

GO:0006470

protein dephosphorylation

16263724

TgenePTPRK

GO:0007165

signal transduction

16849327

TgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

TgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

TgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

TgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

TgenePTPRK

GO:0034394

protein localization to cell surface

18276111

TgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

TgenePTPRK

GO:0034644

cellular response to UV

16849327

TgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

TgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01ACAMK4chr5

110712640

+PTPRKchr6

128563747

-


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Fusion Gene ORF analysis for CAMK4-PTPRK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000282356ENST00000524481CAMK4chr5

110712640

+PTPRKchr6

128563747

-
5CDS-5UTRENST00000512453ENST00000524481CAMK4chr5

110712640

+PTPRKchr6

128563747

-
5CDS-intronENST00000282356ENST00000525459CAMK4chr5

110712640

+PTPRKchr6

128563747

-
5CDS-intronENST00000512453ENST00000525459CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368207CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368210CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368213CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368215CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368226CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000368227CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000282356ENST00000532331CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368207CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368210CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368213CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368215CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368226CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000368227CAMK4chr5

110712640

+PTPRKchr6

128563747

-
Frame-shiftENST00000512453ENST00000532331CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368207CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368210CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368213CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368215CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368226CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000368227CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-3CDSENST00000512890ENST00000532331CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-5UTRENST00000512890ENST00000524481CAMK4chr5

110712640

+PTPRKchr6

128563747

-
intron-intronENST00000512890ENST00000525459CAMK4chr5

110712640

+PTPRKchr6

128563747

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CAMK4-PTPRK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CAMK4-PTPRK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:110712640/:128563747)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CAMK4-PTPRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CAMK4-PTPRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAMK4-PTPRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAMK4-PTPRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAMK4C0009171Cocaine Abuse1CTD_human
HgeneCAMK4C0236736Cocaine-Related Disorders1CTD_human
HgeneCAMK4C0600427Cocaine Dependence1CTD_human;PSYGENET
TgeneC0025202melanoma2CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human