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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ANKRD13C-PTGER3 (FusionGDB2 ID:HG81573TG5733)

Fusion Gene Summary for ANKRD13C-PTGER3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD13C-PTGER3
Fusion gene ID: hg81573tg5733
HgeneTgene
Gene symbol

ANKRD13C

PTGER3

Gene ID

81573

5733

Gene nameankyrin repeat domain 13Cprostaglandin E receptor 3
SynonymsdJ677H15.3EP3|EP3-I|EP3-II|EP3-III|EP3-IV|EP3-VI|EP3e|PGE2-R|lnc003875
Cytomap('ANKRD13C')('PTGER3')

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 13Cprostaglandin E2 receptor EP3 subtypePGE receptor, EP3 subtypePGE2 receptor EP3 subtypeprostaglandin E receotor EP3 subtype 3 isoformprostaglandin E receptor 3 (subtype EP3)prostaglandin receptor (PGE-2)prostanoid EP3 receptor
Modification date2020031320200313
UniProtAcc

Q8N6S4

.
Ensembl transtripts involved in fusion geneENST00000262346, ENST00000370944, 
ENST00000464236, 
Fusion gene scores* DoF score6 X 4 X 6=1446 X 4 X 4=96
# samples 65
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD13C [Title/Abstract] AND PTGER3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD13C(70766447)-PTGER3(71440071), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD13C-PTGER3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD13C-PTGER3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD13C

GO:0010869

regulation of receptor biosynthetic process

20959461

HgeneANKRD13C

GO:2000209

regulation of anoikis

20959461


check buttonFusion gene breakpoints across ANKRD13C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PTGER3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-MB-A5Y8-01AANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-


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Fusion Gene ORF analysis for ANKRD13C-PTGER3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262346ENST00000306666ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000351052ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000354608ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000356595ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000370924ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000370932ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000414819ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000262346ENST00000460330ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000306666ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000351052ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000354608ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000356595ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000370924ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000370932ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000414819ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
5CDS-intronENST00000370944ENST00000460330ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
In-frameENST00000262346ENST00000370931ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
In-frameENST00000370944ENST00000370931ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-3CDSENST00000464236ENST00000370931ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000306666ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000351052ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000354608ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000356595ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000370924ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000370932ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000414819ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-
intron-intronENST00000464236ENST00000460330ANKRD13Cchr1

70766447

-PTGER3chr1

71440071

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370944ANKRD13Cchr170766447-ENST00000370931PTGER3chr171440071-186112352961330344
ENST00000262346ANKRD13Cchr170766447-ENST00000370931PTGER3chr171440071-176811423081237309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370944ENST00000370931ANKRD13Cchr170766447-PTGER3chr171440071-0.0145312090.9854688
ENST00000262346ENST00000370931ANKRD13Cchr170766447-PTGER3chr171440071-0.02364170.9763583

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Fusion Genomic Features for ANKRD13C-PTGER3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD13C-PTGER3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:70766447/chr1:71440071)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD13C

Q8N6S4

.
FUNCTION: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. {ECO:0000269|PubMed:20959461}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000262346-61230_33272507.0Compositional biasNote=Poly-Ala
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000370944-71330_33307542.0Compositional biasNote=Poly-Ala
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000262346-612111_142272507.0RepeatNote=ANK 1
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000262346-612143_172272507.0RepeatNote=ANK 2
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000262346-612176_205272507.0RepeatNote=ANK 3
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000370944-713111_142307542.0RepeatNote=ANK 1
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000370944-713143_172307542.0RepeatNote=ANK 2
HgeneANKRD13Cchr1:70766447chr1:71440071ENST00000370944-713176_205307542.0RepeatNote=ANK 3
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402113_1310389.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402154_1750389.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402198_2270389.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000370924021_530389.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402254_2830389.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402308_3270389.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402350_3900389.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000003709240279_910389.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203113_1310366.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203154_1750366.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203198_2270366.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000370932031_530366.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203254_2830366.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203308_3270366.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203350_3900366.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000003709320379_910366.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004113_1310375.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004154_1750375.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004198_2270375.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000460330041_530375.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004254_2830375.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004308_3270375.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004350_3900375.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000004603300479_910375.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402132_1530389.0TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402176_1970389.0TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402228_2530389.0TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402284_3070389.0TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000037092402328_3490389.0TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000003709240254_780389.0TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000003709240292_1120389.0TransmembraneHelical%3B Name%3D2
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203132_1530366.0TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203176_1970366.0TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203228_2530366.0TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203284_3070366.0TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093203328_3490366.0TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000003709320354_780366.0TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000003709320392_1120366.0TransmembraneHelical%3B Name%3D2
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004132_1530375.0TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004176_1970375.0TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004228_2530375.0TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004284_3070375.0TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000046033004328_3490375.0TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000004603300454_780375.0TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000004603300492_1120375.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614113_131359391.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614154_175359391.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614198_227359391.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000306666141_53359391.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614254_283359391.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614308_327359391.0Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614350_390359391.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000003066661479_91359391.0Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115113_131359139.66666666666666Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115154_175359139.66666666666666Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115198_227359139.66666666666666Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000370931151_53359139.66666666666666Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115254_283359139.66666666666666Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115308_327359139.66666666666666Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115350_390359139.66666666666666Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000003709311579_91359139.66666666666666Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915113_131359173.33333333333334Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915154_175359173.33333333333334Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915198_227359173.33333333333334Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST00000414819151_53359173.33333333333334Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915254_283359173.33333333333334Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915308_327359173.33333333333334Topological domainExtracellular
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915350_390359173.33333333333334Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST000004148191579_91359173.33333333333334Topological domainCytoplasmic
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614132_153359391.0TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614176_197359391.0TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614228_253359391.0TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614284_307359391.0TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000030666614328_349359391.0TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000003066661454_78359391.0TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000003066661492_112359391.0TransmembraneHelical%3B Name%3D2
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115132_153359139.66666666666666TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115176_197359139.66666666666666TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115228_253359139.66666666666666TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115284_307359139.66666666666666TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000037093115328_349359139.66666666666666TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000003709311554_78359139.66666666666666TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000003709311592_112359139.66666666666666TransmembraneHelical%3B Name%3D2
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915132_153359173.33333333333334TransmembraneHelical%3B Name%3D3
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915176_197359173.33333333333334TransmembraneHelical%3B Name%3D4
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915228_253359173.33333333333334TransmembraneHelical%3B Name%3D5
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915284_307359173.33333333333334TransmembraneHelical%3B Name%3D6
TgenePTGER3chr1:70766447chr1:71440071ENST0000041481915328_349359173.33333333333334TransmembraneHelical%3B Name%3D7
TgenePTGER3chr1:70766447chr1:71440071ENST000004148191554_78359173.33333333333334TransmembraneHelical%3B Name%3D1
TgenePTGER3chr1:70766447chr1:71440071ENST000004148191592_112359173.33333333333334TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for ANKRD13C-PTGER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4596_4596_1_ANKRD13C-PTGER3_ANKRD13C_chr1_70766447_ENST00000262346_PTGER3_chr1_71440071_ENST00000370931_length(transcript)=1768nt_BP=1142nt
CTCTCGCGAGAGGAGCAAGAGGAAGATGGCCGTGCCCTGTTTTTCGGTGTAAGGCAGCGACGGCGGCTGCGACGGCGAGACTGAGATCCT
GGTGTCGTGGGCACCTGAGTTCTAGCTTCCCCCAGCGAGCGCGCGTCCCTTCGTGCCTAGGCGAGAGCCGGCTCTTCCCCGGGAGATGCG
TTTGTCCCAGGCTCGGGGGCTCAGTGGGAGTTCATGCTGCGCTGGAGGCTCTTGGCCACCGCTCTAATCGCCTTGTGCCGCCGCAGCGCC
AGCTCCGTCGCCAGCGGTGAGCCTCCCGATTCCCCCCCTTGCCCCTGGCGGCGGCGATGACCGGGGAGAAGATCCGCTCACTGCGGAGGG
ACCACAAGCCCAGCAAAGAAGAAGGGGACCTGCTGGAGCCCGGGGATGAGGAAGCGGCGGCTGCCCTCGGCGGTACCTTTACCAGAAGCA
GGATTGGCAAGGGCGGCAAAGCTTGTCATAAGATCTTCAGTAACCATCACCACCGGCTACAGCTGAAGGCAGCTCCGGCCTCCTCCAATC
CCCCCGGCGCCCCGGCTCTGCCGCTGCACAATTCCTCCGTGACTGCCAACTCCCAGTCCCCGGCCCTTCTGGCCGGCACCAACCCCGTTG
CTGTCGTCGCGGATGGAGGCAGTTGCCCCGCACACTACCCGGTGCACGAGTGCGTCTTCAAGGGGGATGTGAGGAGACTCTCCTCTCTCA
TCCGCACGCACAATATCGGGCAGAAAGATAATCACGGAAATACTCCTTTACACCTTGCTGTGATGTTAGGAAATAAAGTTACAGCTCTTT
TGAGGAAGCTTAAGCAGCAATCCAGGGAAAGTGTTGAAGAAAAACGACCTCGATTATTAAAAGCCCTGAAAGAGCTAGGTGACTTTTATC
TAGAACTTCACTGGGATTTTCAAAGCTGGGTGCCTTTACTTTCCCGAATTCTGCCTTCCGATGCATGTAAAATATACAAACAAGGTATCA
ATATCAGGCTTGACACAACTCTCATAGACTTTACTGACATGAAGTGCCAACGAGGGGATCTAAGCTTCATTTTCAATGGGGATGCGGCGC
CCTCTGAATCTTTTGTAGTATTAGACAATGAACAAAAAGTTTATCAGCGAATACATCATGAGATCAGGTACCACACAAACAACTATGCAT
CCAGCTCCACCTCCTTACCCTGCCAGTGTTCCTCAACCTTGATGTGGAGCGACCATTTGGAAAGATGAGAAAAAGAAGACTCAGAGAGCA
AGAGGAATTTTGGGGAAATTAAAACCTGCCTTTCTGCCAGGATCACATCACTGGAAGCTCCATGACTCTCTTTTTGTAAAAGAAAAAAAA
ATCACAGAAACACCCACCTCCCAAACTATTCTCTTTTACTTCTTCCCCCAAGCCCACCCCCAAATATAACTGTTATCCAGAAGCTGTTAT
GTCCTGTTTCCATACATGTTTTTGTACTTTTACTATATCTACATACATCAATTAAACTTATGTCCTATTGTTTTGTGAATTTATATTTGC
GTATACATTATCATATGTAAAATTTGCATTTTTTTATTGAAAATTATGTTTCTTGAGATTTATCCACATTGAAACATGGAGCTCTAAATC
GTTAATTTTAACCGCTATAGAGTATTCCATAATTTGAATAAAGCATAATTTGTTTGTACAATCTCCCGCCAAGGGAAAATTATTTCCACA

>4596_4596_1_ANKRD13C-PTGER3_ANKRD13C_chr1_70766447_ENST00000262346_PTGER3_chr1_71440071_ENST00000370931_length(amino acids)=309AA_BP=278
MPLAAAMTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLHNSS
VTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKVTALLRKLKQQSRESVE
EKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTLIDFTDMKCQRGDLSFIFNGDAAPSESFVVLDNEQK

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>4596_4596_2_ANKRD13C-PTGER3_ANKRD13C_chr1_70766447_ENST00000370944_PTGER3_chr1_71440071_ENST00000370931_length(transcript)=1861nt_BP=1235nt
GAGCAAGAGGAAGATGGCCGTGCCCTGTTTTTCGGTGTAAGGCAGCGACGGCGGCTGCGACGGCGAGACTGAGATCCTGGTGTCGTGGGC
ACCTGAGTTCTAGCTTCCCCCAGCGAGCGCGCGTCCCTTCGTGCCTAGGCGAGAGCCGGCTCTTCCCCGGGAGATGCGTTTGTCCCAGGC
TCGGGGGCTCAGTGGGAGTTCATGCTGCGCTGGAGGCTCTTGGCCACCGCTCTAATCGCCTTGTGCCGCCGCAGCGCCAGCTCCGTCGCC
AGCGGTGAGCCTCCCGATTCCCCCCCTTGCCCCTGGCGGCGGCGATGACCGGGGAGAAGATCCGCTCACTGCGGAGGGACCACAAGCCCA
GCAAAGAAGAAGGGGACCTGCTGGAGCCCGGGGATGAGGAAGCGGCGGCTGCCCTCGGCGGTACCTTTACCAGAAGCAGGATTGGCAAGG
GCGGCAAAGCTTGTCATAAGATCTTCAGTAACCATCACCACCGGCTACAGCTGAAGGCAGCTCCGGCCTCCTCCAATCCCCCCGGCGCCC
CGGCTCTGCCGCTGCACAATTCCTCCGTGACTGCCAACTCCCAGTCCCCGGCCCTTCTGGCCGGCACCAACCCCGTTGCTGTCGTCGCGG
ATGGAGGCAGTTGCCCCGCACACTACCCGGTGCACGAGTGCGTCTTCAAGGGGGATGTGAGGAGACTCTCCTCTCTCATCCGCACGCACA
ATATCGGGCAGAAAGATAATCACGGAAATACTCCTTTACACCTTGCTGTGATGTTAGGAAATAAAGAATGTGCCCATTTACTTTTGGCTC
ACAATGCTCCAGTCAAGGTGAAAAATGCTCAGGGATGGAGCCCTCTGGCGGAAGCCATCAGCTATGGAGATAGGCAGATGATTACAGCTC
TTTTGAGGAAGCTTAAGCAGCAATCCAGGGAAAGTGTTGAAGAAAAACGACCTCGATTATTAAAAGCCCTGAAAGAGCTAGGTGACTTTT
ATCTAGAACTTCACTGGGATTTTCAAAGCTGGGTGCCTTTACTTTCCCGAATTCTGCCTTCCGATGCATGTAAAATATACAAACAAGGTA
TCAATATCAGGCTTGACACAACTCTCATAGACTTTACTGACATGAAGTGCCAACGAGGGGATCTAAGCTTCATTTTCAATGGGGATGCGG
CGCCCTCTGAATCTTTTGTAGTATTAGACAATGAACAAAAAGTTTATCAGCGAATACATCATGAGATCAGGTACCACACAAACAACTATG
CATCCAGCTCCACCTCCTTACCCTGCCAGTGTTCCTCAACCTTGATGTGGAGCGACCATTTGGAAAGATGAGAAAAAGAAGACTCAGAGA
GCAAGAGGAATTTTGGGGAAATTAAAACCTGCCTTTCTGCCAGGATCACATCACTGGAAGCTCCATGACTCTCTTTTTGTAAAAGAAAAA
AAAATCACAGAAACACCCACCTCCCAAACTATTCTCTTTTACTTCTTCCCCCAAGCCCACCCCCAAATATAACTGTTATCCAGAAGCTGT
TATGTCCTGTTTCCATACATGTTTTTGTACTTTTACTATATCTACATACATCAATTAAACTTATGTCCTATTGTTTTGTGAATTTATATT
TGCGTATACATTATCATATGTAAAATTTGCATTTTTTTATTGAAAATTATGTTTCTTGAGATTTATCCACATTGAAACATGGAGCTCTAA
ATCGTTAATTTTAACCGCTATAGAGTATTCCATAATTTGAATAAAGCATAATTTGTTTGTACAATCTCCCGCCAAGGGAAAATTATTTCC

>4596_4596_2_ANKRD13C-PTGER3_ANKRD13C_chr1_70766447_ENST00000370944_PTGER3_chr1_71440071_ENST00000370931_length(amino acids)=344AA_BP=313
MPLAAAMTGEKIRSLRRDHKPSKEEGDLLEPGDEEAAAALGGTFTRSRIGKGGKACHKIFSNHHHRLQLKAAPASSNPPGAPALPLHNSS
VTANSQSPALLAGTNPVAVVADGGSCPAHYPVHECVFKGDVRRLSSLIRTHNIGQKDNHGNTPLHLAVMLGNKECAHLLLAHNAPVKVKN
AQGWSPLAEAISYGDRQMITALLRKLKQQSRESVEEKRPRLLKALKELGDFYLELHWDFQSWVPLLSRILPSDACKIYKQGINIRLDTTL

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Fusion Gene PPI Analysis for ANKRD13C-PTGER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD13C-PTGER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD13C-PTGER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0013182Drug Allergy1CTD_human
TgeneC0014518Toxic Epidermal Necrolysis1CTD_human
TgeneC0030804Pemphigoid, Benign Mucous Membrane1CTD_human
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0038325Stevens-Johnson Syndrome1CTD_human
TgeneC0040053Thrombosis1CTD_human
TgeneC0087086Thrombus1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human
TgeneC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneC1282359Ocular Cicatricial Pemphigoid1CTD_human
TgeneC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human