Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ADAMTS12-ZFR (FusionGDB2 ID:HG81792TG51663)

Fusion Gene Summary for ADAMTS12-ZFR

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS12-ZFR
Fusion gene ID: hg81792tg51663
HgeneTgene
Gene symbol

ADAMTS12

ZFR

Gene ID

81792

51663

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 12zinc finger RNA binding protein
SynonymsPRO4389SPG71|ZFR1
Cytomap('ADAMTS12')('ZFR')

5p13.3-p13.2

5p13.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12zinc finger RNA-binding proteinM-phase phosphoprotein homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000352040, ENST00000504830, 
ENST00000504582, ENST00000515401, 
Fusion gene scores* DoF score6 X 6 X 4=1448 X 8 X 6=384
# samples 612
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/384*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS12 [Title/Abstract] AND ZFR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS12(33662021)-ZFR(32356045), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAMTS12-ZFR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-ZFR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-ZFR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-ZFR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

HgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

HgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

HgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

HgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

HgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

HgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

HgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370


check buttonFusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZFR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0XU-01AADAMTS12chr5

33662021

-ZFRchr5

32356045

-


Top

Fusion Gene ORF analysis for ADAMTS12-ZFR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000352040ENST00000510369ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
5CDS-5UTRENST00000504830ENST00000510369ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
5UTR-3CDSENST00000504582ENST00000265069ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
5UTR-5UTRENST00000504582ENST00000510369ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
In-frameENST00000352040ENST00000265069ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
In-frameENST00000504830ENST00000265069ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
intron-3CDSENST00000515401ENST00000265069ADAMTS12chr5

33662021

-ZFRchr5

32356045

-
intron-5UTRENST00000515401ENST00000510369ADAMTS12chr5

33662021

-ZFRchr5

32356045

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000504830ADAMTS12chr533662021-ENST00000265069ZFRchr532356045-296613763361385349
ENST00000352040ADAMTS12chr533662021-ENST00000265069ZFRchr532356045-27151125851134349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504830ENST00000265069ADAMTS12chr533662021-ZFRchr532356045-0.0003541030.99964595
ENST00000352040ENST00000265069ADAMTS12chr533662021-ZFRchr532356045-0.0003254450.99967456

Top

Fusion Genomic Features for ADAMTS12-ZFR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ADAMTS12-ZFR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33662021/chr5:32356045)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622302_3053461510.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624302_3053461595.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622208_2133461510.0MotifCysteine switch
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624208_2133461595.0MotifCysteine switch

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622597_7003461510.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624597_7003461595.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-6221313_13663461510.0DomainTSP type-1 5
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-6221368_14223461510.0DomainTSP type-1 6
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-6221423_14713461510.0DomainTSP type-1 7
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-6221472_15323461510.0DomainTSP type-1 8
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-6221535_15753461510.0DomainPLAC
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622246_4563461510.0DomainPeptidase M12B
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622465_5443461510.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622542_5973461510.0DomainTSP type-1 1
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622823_8833461510.0DomainTSP type-1 2
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622887_9433461510.0DomainTSP type-1 3
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622944_9973461510.0DomainTSP type-1 4
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-6241313_13663461595.0DomainTSP type-1 5
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-6241368_14223461595.0DomainTSP type-1 6
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-6241423_14713461595.0DomainTSP type-1 7
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-6241472_15323461595.0DomainTSP type-1 8
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-6241535_15753461595.0DomainPLAC
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624246_4563461595.0DomainPeptidase M12B
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624465_5443461595.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624542_5973461595.0DomainTSP type-1 1
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624823_8833461595.0DomainTSP type-1 2
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624887_9433461595.0DomainTSP type-1 3
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624944_9973461595.0DomainTSP type-1 4
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622701_8273461510.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000352040-622997_13163461510.0RegionNote=Spacer 2
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624701_8273461595.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33662021chr5:32356045ENST00000504830-624997_13163461595.0RegionNote=Spacer 2
TgeneZFRchr5:33662021chr5:32356045ENST00000265069182036_30210151075.0Compositional biasNote=Ala-rich
TgeneZFRchr5:33662021chr5:32356045ENST000002650691820703_107310151075.0DomainDZF


Top

Fusion Gene Sequence for ADAMTS12-ZFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2046_2046_1_ADAMTS12-ZFR_ADAMTS12_chr5_33662021_ENST00000352040_ZFR_chr5_32356045_ENST00000265069_length(transcript)=2715nt_BP=1125nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC
ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC
AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC
CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA
CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG
ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT
TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA
TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA
CAGTGTTAACATCTCCCAGAAGCAAGAGCTATGGCGGGAGAAGTGGGAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCAT
CAGCAAGGAGAGATGGGTGGAGACACTGGTGGTGGCCGACACAAAGATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCT
CACCATCATGAACATGGTCACTGGGTTGTTCCATAACCCAAGCATTGGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGA
AGAAGAAGAGCAAGGACTGAAAATAGTTCACCATGCAGAAAAGACACTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAG
TGACCTCAATCCTGTTCATCACGACGTGGCTGTCCTTCTCACCAGTTTGCATTGAGACTCCTTGCATTCCGCCAGATACACAAAGTTCTA
GGCATGGATCCATTACCGCAAATGAGCCAACGTTTTAACATCCACAACAACAGGAAACGAAGAAGAGATAGTGATGGAGTTGATGGATTT
GAAGCTGAGGGGAAAAAAGACAAAAAAGATTATGATAACTTTTAAAAAGTGTCTGTAAATCTTCAGTGTTAAAAAAACAGATGCCCATTT
GTTGGCTGTTTTTCATTCATAATAATGTCTACATTGAAAAATTTATCAAGAATTTAAAGGATTTCATGGAAGAACCAAGTTTTTCTATGA
TATTAAAAAATGTACAGTGTTAGGTATTATTTGAATGGAAAGACACCCAAAAAAAAAAATGTGCTCCGACTAGGGGGAAAACAGTAGTTC
CGATTTTTTCCCATTATTTTTATTTTATTTTCTGGTTGCCCTAGCTTCCCCCCCTATTTTTGTGTCTTTTATTAACTAGTGCATTGTCTT
ATTAAATCTTCACTGTATTTAATGCAGGATGTGTGCTTCAGTTGCTCTGTGTATTTTGATATTTTAATTTAGAGGTTTTGTTTGCTTTTT
GACACTAGTTGTAAGTTACTTTGTTATAGATGGTATCCTTTACCCCTTCTTAATATTTTACAGCAGTACGTTTTTTTGTAACGTGAGACT
GCAGAGTTTGTTTTTCTATATGTGAAGGATTACAACACAAAAAGTTATCCTGCCATTCGAGTGCTCAGAACTGAATGTTTCTGCAGATCT
TGTGGCATTTGTCTCTAGTGTGATATATAAAGGTGTAATTAAGACAGAGTTCTGTTAATCTAATCAAGTTTGCTGTTAGTTGTGCATTAG
CAGTATAAAAGCTAATATATACTATATGGTCTTGCAACAGTTTTAAAGCCTCTGCATAATTGATAATAAAAATGCATGACATTCTTGTTT
TTAATAGACTTTTAAAATCATAATTTTAGGTTTAACACGTAGATCTTTGTACAGTTGACTTTTTGACATAGCAAGGCCAAAAATAACTTT
CTGAATATTTTTTTCTTGTGTATAAGTGGAAAGGGCATTTTTCACATATAAGTGGGCTAACCAATATTTTCAAAAGAACTTCATCATTGT
ACAACTAACAACAGTAACTAGCCCTTAATTATGGTGACAGTTCCTTATTGGTGTGTGTGAGATTACTCTAGCAACTATTACAGTATAACA
CAGATGATCTTCTCCACACACCCCATCACCCAGATAATTTACAGTTCTGTTAACAGTGAGGTTGATAAAGTATTACTGATAAAAAATTAT
CTAAGGAAAAAAACAGAAAATTATTTGGTGTGGCCATCTTACCTGCTTATGTCTCCTACACAAAGCTAAATATTCTAGCAGTGATGTAAT
GAAAAATTACATCTTACTGTTGATATATGTATGCTCTGGTACACAGATGTCATTTTGTTGTCACAGCACTACAGTGAAATACACAAAAAA
TGAAATTCATATAATGACTTAAATGTATTATATGTTAGAATTGACAACATAAACTACTTTTGCTTTGAAATGATGTATGCTTCAGTAAAA

>2046_2046_1_ADAMTS12-ZFR_ADAMTS12_chr5_33662021_ENST00000352040_ZFR_chr5_32356045_ENST00000265069_length(amino acids)=349AA_BP=
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESY

--------------------------------------------------------------
>2046_2046_2_ADAMTS12-ZFR_ADAMTS12_chr5_33662021_ENST00000504830_ZFR_chr5_32356045_ENST00000265069_length(transcript)=2966nt_BP=1376nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA
CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA
AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG
AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG
CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA
TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG
GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT
GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT
GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG
TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGACAGTGTTAACATCTCCCAG
AAGCAAGAGCTATGGCGGGAGAAGTGGGAGAGGCACAACTTGCCAAGCAGAAGCCTCTCTCGGCGTTCCATCAGCAAGGAGAGATGGGTG
GAGACACTGGTGGTGGCCGACACAAAGATGATTGAATACCATGGGAGTGAGAATGTGGAGTCCTACATCCTCACCATCATGAACATGGTC
ACTGGGTTGTTCCATAACCCAAGCATTGGCAATGCAATTCACATTGTTGTGGTTCGGCTCATTCTACTCGAAGAAGAAGAGCAAGGACTG
AAAATAGTTCACCATGCAGAAAAGACACTGTCTAGCTTCTGCAAGTGGCAGAAGAGTATCAATCCCAAGAGTGACCTCAATCCTGTTCAT
CACGACGTGGCTGTCCTTCTCACCAGTTTGCATTGAGACTCCTTGCATTCCGCCAGATACACAAAGTTCTAGGCATGGATCCATTACCGC
AAATGAGCCAACGTTTTAACATCCACAACAACAGGAAACGAAGAAGAGATAGTGATGGAGTTGATGGATTTGAAGCTGAGGGGAAAAAAG
ACAAAAAAGATTATGATAACTTTTAAAAAGTGTCTGTAAATCTTCAGTGTTAAAAAAACAGATGCCCATTTGTTGGCTGTTTTTCATTCA
TAATAATGTCTACATTGAAAAATTTATCAAGAATTTAAAGGATTTCATGGAAGAACCAAGTTTTTCTATGATATTAAAAAATGTACAGTG
TTAGGTATTATTTGAATGGAAAGACACCCAAAAAAAAAAATGTGCTCCGACTAGGGGGAAAACAGTAGTTCCGATTTTTTCCCATTATTT
TTATTTTATTTTCTGGTTGCCCTAGCTTCCCCCCCTATTTTTGTGTCTTTTATTAACTAGTGCATTGTCTTATTAAATCTTCACTGTATT
TAATGCAGGATGTGTGCTTCAGTTGCTCTGTGTATTTTGATATTTTAATTTAGAGGTTTTGTTTGCTTTTTGACACTAGTTGTAAGTTAC
TTTGTTATAGATGGTATCCTTTACCCCTTCTTAATATTTTACAGCAGTACGTTTTTTTGTAACGTGAGACTGCAGAGTTTGTTTTTCTAT
ATGTGAAGGATTACAACACAAAAAGTTATCCTGCCATTCGAGTGCTCAGAACTGAATGTTTCTGCAGATCTTGTGGCATTTGTCTCTAGT
GTGATATATAAAGGTGTAATTAAGACAGAGTTCTGTTAATCTAATCAAGTTTGCTGTTAGTTGTGCATTAGCAGTATAAAAGCTAATATA
TACTATATGGTCTTGCAACAGTTTTAAAGCCTCTGCATAATTGATAATAAAAATGCATGACATTCTTGTTTTTAATAGACTTTTAAAATC
ATAATTTTAGGTTTAACACGTAGATCTTTGTACAGTTGACTTTTTGACATAGCAAGGCCAAAAATAACTTTCTGAATATTTTTTTCTTGT
GTATAAGTGGAAAGGGCATTTTTCACATATAAGTGGGCTAACCAATATTTTCAAAAGAACTTCATCATTGTACAACTAACAACAGTAACT
AGCCCTTAATTATGGTGACAGTTCCTTATTGGTGTGTGTGAGATTACTCTAGCAACTATTACAGTATAACACAGATGATCTTCTCCACAC
ACCCCATCACCCAGATAATTTACAGTTCTGTTAACAGTGAGGTTGATAAAGTATTACTGATAAAAAATTATCTAAGGAAAAAAACAGAAA
ATTATTTGGTGTGGCCATCTTACCTGCTTATGTCTCCTACACAAAGCTAAATATTCTAGCAGTGATGTAATGAAAAATTACATCTTACTG
TTGATATATGTATGCTCTGGTACACAGATGTCATTTTGTTGTCACAGCACTACAGTGAAATACACAAAAAATGAAATTCATATAATGACT

>2046_2046_2_ADAMTS12-ZFR_ADAMTS12_chr5_33662021_ENST00000504830_ZFR_chr5_32356045_ENST00000265069_length(amino acids)=349AA_BP=
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAMTS12-ZFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ADAMTS12-ZFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ADAMTS12-ZFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS12C0036341Schizophrenia1PSYGENET