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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAMTS10-MLLT1 (FusionGDB2 ID:HG81794TG4298)

Fusion Gene Summary for ADAMTS10-MLLT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS10-MLLT1
Fusion gene ID: hg81794tg4298
HgeneTgene
Gene symbol

ADAMTS10

MLLT1

Gene ID

81794

4298

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 10MLLT1 super elongation complex subunit
SynonymsADAM-TS10|ADAMTS-10|WMS|WMS1ENL|LTG19|YEATS1
Cytomap('ADAMTS10')('MLLT1')

19p13.2

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 10ADAM-TS 10a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10zinc metalloendopeptidaseprotein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homol
Modification date2020031320200313
UniProtAcc

Q9H324

Q03111

Ensembl transtripts involved in fusion geneENST00000270328, ENST00000597188, 
ENST00000596709, ENST00000595838, 
Fusion gene scores* DoF score2 X 3 X 2=1212 X 23 X 7=1932
# samples 330
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(30/1932*10)=-2.68706068833989
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS10 [Title/Abstract] AND MLLT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAMTS10(8665812)-MLLT1(6270770), # samples:3
Anticipated loss of major functional domain due to fusion event.ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ADAMTS10-MLLT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADAMTS10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MLLT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2B8-01AADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
ChimerDB4BRCATCGA-AC-A2B8ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-


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Fusion Gene ORF analysis for ADAMTS10-MLLT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000270328ENST00000585588ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
5CDS-intronENST00000270328ENST00000585588ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
5CDS-intronENST00000597188ENST00000585588ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
5CDS-intronENST00000597188ENST00000585588ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
5UTR-3CDSENST00000596709ENST00000252674ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
5UTR-3CDSENST00000596709ENST00000252674ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
5UTR-intronENST00000596709ENST00000585588ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
5UTR-intronENST00000596709ENST00000585588ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
Frame-shiftENST00000270328ENST00000252674ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
Frame-shiftENST00000270328ENST00000252674ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
In-frameENST00000597188ENST00000252674ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
In-frameENST00000597188ENST00000252674ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
intron-3CDSENST00000595838ENST00000252674ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
intron-3CDSENST00000595838ENST00000252674ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-
intron-intronENST00000595838ENST00000585588ADAMTS10chr19

8665812

-MLLT1chr19

6270770

-
intron-intronENST00000595838ENST00000585588ADAMTS10chr19

8665811

-MLLT1chr19

6270770

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000597188ADAMTS10chr198665812-ENST00000252674MLLT1chr196270770-283610812712748825
ENST00000597188ADAMTS10chr198665811-ENST00000252674MLLT1chr196270770-283610812712748825

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000597188ENST00000252674ADAMTS10chr198665812-MLLT1chr196270770-0.0118652640.98813474
ENST00000597188ENST00000252674ADAMTS10chr198665811-MLLT1chr196270770-0.0118652640.98813474

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Fusion Genomic Features for ADAMTS10-MLLT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADAMTS10-MLLT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:8665812/chr19:6270770)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS10

Q9H324

MLLT1

Q03111

FUNCTION: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. {ECO:0000269|PubMed:21402694}.FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-52558_612701104.0Compositional biasNote=Poly-Pro
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-62658_612701104.0Compositional biasNote=Poly-Pro
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-52558_612701104.0Compositional biasNote=Poly-Pro
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-62658_612701104.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665811chr19:6270770ENST00000252674012272_2804560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665811chr19:6270770ENST00000252674012319_3254560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:8665811chr19:6270770ENST00000252674012374_3894560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:8665811chr19:6270770ENST00000252674012457_4604560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665811chr19:6270770ENST00000252674012463_4664560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665812chr19:6270770ENST00000252674012272_2804560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665812chr19:6270770ENST00000252674012319_3254560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:8665812chr19:6270770ENST00000252674012374_3894560.0Compositional biasNote=Poly-Ser
TgeneMLLT1chr19:8665812chr19:6270770ENST00000252674012457_4604560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665812chr19:6270770ENST00000252674012463_4664560.0Compositional biasNote=Poly-Pro
TgeneMLLT1chr19:8665811chr19:6270770ENST000002526740121_1384560.0DomainYEATS
TgeneMLLT1chr19:8665812chr19:6270770ENST000002526740121_1384560.0DomainYEATS
TgeneMLLT1chr19:8665811chr19:6270770ENST0000025267401256_584560.0RegionAcylated histone binding
TgeneMLLT1chr19:8665811chr19:6270770ENST0000025267401278_804560.0RegionAcylated histone binding
TgeneMLLT1chr19:8665812chr19:6270770ENST0000025267401256_584560.0RegionAcylated histone binding
TgeneMLLT1chr19:8665812chr19:6270770ENST0000025267401278_804560.0RegionAcylated histone binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525568_5712701104.0Compositional biasNote=Poly-Ser
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525604_7052701104.0Compositional biasNote=Cys-rich
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626568_5712701104.0Compositional biasNote=Poly-Ser
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626604_7052701104.0Compositional biasNote=Cys-rich
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525568_5712701104.0Compositional biasNote=Poly-Ser
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525604_7052701104.0Compositional biasNote=Cys-rich
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626568_5712701104.0Compositional biasNote=Poly-Ser
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626604_7052701104.0Compositional biasNote=Cys-rich
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-5251003_10582701104.0DomainTSP type-1 5
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-5251065_11032701104.0DomainPLAC
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525239_4572701104.0DomainPeptidase M12B
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525460_5462701104.0DomainNote=Disintegrin
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525547_6022701104.0DomainTSP type-1 1
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525825_8832701104.0DomainTSP type-1 2
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525884_9452701104.0DomainTSP type-1 3
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525947_10012701104.0DomainTSP type-1 4
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-6261003_10582701104.0DomainTSP type-1 5
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-6261065_11032701104.0DomainPLAC
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626239_4572701104.0DomainPeptidase M12B
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626460_5462701104.0DomainNote=Disintegrin
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626547_6022701104.0DomainTSP type-1 1
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626825_8832701104.0DomainTSP type-1 2
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626884_9452701104.0DomainTSP type-1 3
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626947_10012701104.0DomainTSP type-1 4
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-5251003_10582701104.0DomainTSP type-1 5
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-5251065_11032701104.0DomainPLAC
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525239_4572701104.0DomainPeptidase M12B
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525460_5462701104.0DomainNote=Disintegrin
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525547_6022701104.0DomainTSP type-1 1
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525825_8832701104.0DomainTSP type-1 2
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525884_9452701104.0DomainTSP type-1 3
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525947_10012701104.0DomainTSP type-1 4
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-6261003_10582701104.0DomainTSP type-1 5
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-6261065_11032701104.0DomainPLAC
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626239_4572701104.0DomainPeptidase M12B
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626460_5462701104.0DomainNote=Disintegrin
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626547_6022701104.0DomainTSP type-1 1
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626825_8832701104.0DomainTSP type-1 2
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626884_9452701104.0DomainTSP type-1 3
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626947_10012701104.0DomainTSP type-1 4
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000270328-525706_8282701104.0RegionNote=Spacer
HgeneADAMTS10chr19:8665811chr19:6270770ENST00000597188-626706_8282701104.0RegionNote=Spacer
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000270328-525706_8282701104.0RegionNote=Spacer
HgeneADAMTS10chr19:8665812chr19:6270770ENST00000597188-626706_8282701104.0RegionNote=Spacer


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Fusion Gene Sequence for ADAMTS10-MLLT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2040_2040_1_ADAMTS10-MLLT1_ADAMTS10_chr19_8665811_ENST00000597188_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2836nt_BP=1081nt
CGCGCGGGGCGGCGAGACAGCGGCGGCGACGGCGCGGAGGCCCCGGGCGCGGCGCAGGCTCCAAAGAAGAAGAAACCAAGGCCCAGAGAG
GGAGGCCCAGGTGCAGGGAGCAGGCGAGGGAAGGATCCGTACAGGGGCCCAACACTACTCCACCAACCGAAGCCCCCAAAAGGAGCCCGG
TGATGCTGCGAAGGCTGTGAACAGGGGAGGCGGCACTGTGGGGGCTGCCGGCAGCCGGGGCTGGGGAGAGACATGTGGACACGTGGCCTC
TATGGCTCCCGCCTGCCAGATCCTCCGCTGGGCCCTCGCCCTGGGGCTGGGCCTCATGTTCGAGGTCACGCACGCCTTCCGGTCTCAAGA
TGAGTTCCTGTCCAGTCTGGAGAGCTATGAGATCGCCTTCCCCACCCGCGTGGACCACAACGGGGCACTGCTGGCCTTCTCGCCACCTCC
TCCCCGGAGGCAGCGCCGCGGCACGGGGGCCACAGCCGAGTCCCGCCTCTTCTACAAAGTGGCCTCGCCCAGCACCCACTTCCTGCTGAA
CCTGACCCGCAGCTCCCGTCTACTGGCAGGGCACGTCTCCGTGGAGTACTGGACACGGGAGGGCCTGGCCTGGCAGAGGGCGGCCCGGCC
CCACTGCCTCTACGCTGGTCACCTGCAGGGCCAGGCCAGCACCTCCCATGTGGCCATCAGCACCTGTGGAGGCCTGCACGGCCTGATCGT
GGCAGACGAGGAAGAGTACCTGATTGAGCCCCTGCACGGTGGGCCCAAGGGTTCTCGGAGCCCGGAGGAAAGTGGACCACATGTGGTGTA
CAAGCGTTCCTCTCTGCGTCACCCCCACCTGGACACAGCCTGTGGAGTGAGAGATGAGAAACCGTGGAAAGGGCGGCCATGGTGGCTGCG
GACCTTGAAGCCACCGCCTGCCAGGCCCCTGGGGAATGAAACAGAGCGTGGCCAGCCAGGCCTGAAGCGATCGGTCAGCCGAGAGCGCTA
CGTGGAGACCCTGGTGGTGGCTGACAAGATGATGGTGGCCTATCACGGGCGCCGGGATGTGGAGCAGTATGTCCTGGCCATCATGAACAT
TTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGT
GTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACG
CGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGA
GCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTT
CAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCC
CAGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGC
CAACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTC
CTCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGC
GCCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACC
CCCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAG
CTCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAG
CAGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGA
GGCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATC
CCAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGA
GGCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAG
CCGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAA
GATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGT
GCTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGA
GACCACCGTGCGCAAACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGG

>2040_2040_1_ADAMTS10-MLLT1_ADAMTS10_chr19_8665811_ENST00000597188_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=825AA_BP=0
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLN
LTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNI
CTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEE
PRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDA
NKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPP
PPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDE
ASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPS
REPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDE

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>2040_2040_2_ADAMTS10-MLLT1_ADAMTS10_chr19_8665812_ENST00000597188_MLLT1_chr19_6270770_ENST00000252674_length(transcript)=2836nt_BP=1081nt
CGCGCGGGGCGGCGAGACAGCGGCGGCGACGGCGCGGAGGCCCCGGGCGCGGCGCAGGCTCCAAAGAAGAAGAAACCAAGGCCCAGAGAG
GGAGGCCCAGGTGCAGGGAGCAGGCGAGGGAAGGATCCGTACAGGGGCCCAACACTACTCCACCAACCGAAGCCCCCAAAAGGAGCCCGG
TGATGCTGCGAAGGCTGTGAACAGGGGAGGCGGCACTGTGGGGGCTGCCGGCAGCCGGGGCTGGGGAGAGACATGTGGACACGTGGCCTC
TATGGCTCCCGCCTGCCAGATCCTCCGCTGGGCCCTCGCCCTGGGGCTGGGCCTCATGTTCGAGGTCACGCACGCCTTCCGGTCTCAAGA
TGAGTTCCTGTCCAGTCTGGAGAGCTATGAGATCGCCTTCCCCACCCGCGTGGACCACAACGGGGCACTGCTGGCCTTCTCGCCACCTCC
TCCCCGGAGGCAGCGCCGCGGCACGGGGGCCACAGCCGAGTCCCGCCTCTTCTACAAAGTGGCCTCGCCCAGCACCCACTTCCTGCTGAA
CCTGACCCGCAGCTCCCGTCTACTGGCAGGGCACGTCTCCGTGGAGTACTGGACACGGGAGGGCCTGGCCTGGCAGAGGGCGGCCCGGCC
CCACTGCCTCTACGCTGGTCACCTGCAGGGCCAGGCCAGCACCTCCCATGTGGCCATCAGCACCTGTGGAGGCCTGCACGGCCTGATCGT
GGCAGACGAGGAAGAGTACCTGATTGAGCCCCTGCACGGTGGGCCCAAGGGTTCTCGGAGCCCGGAGGAAAGTGGACCACATGTGGTGTA
CAAGCGTTCCTCTCTGCGTCACCCCCACCTGGACACAGCCTGTGGAGTGAGAGATGAGAAACCGTGGAAAGGGCGGCCATGGTGGCTGCG
GACCTTGAAGCCACCGCCTGCCAGGCCCCTGGGGAATGAAACAGAGCGTGGCCAGCCAGGCCTGAAGCGATCGGTCAGCCGAGAGCGCTA
CGTGGAGACCCTGGTGGTGGCTGACAAGATGATGGTGGCCTATCACGGGCGCCGGGATGTGGAGCAGTATGTCCTGGCCATCATGAACAT
TTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGT
GTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACG
CGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGA
GCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTT
CAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCC
CAGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGC
CAACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTC
CTCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGC
GCCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACC
CCCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAG
CTCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAG
CAGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGA
GGCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATC
CCAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGA
GGCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAG
CCGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAA
GATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGT
GCTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGA
GACCACCGTGCGCAAACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGG

>2040_2040_2_ADAMTS10-MLLT1_ADAMTS10_chr19_8665812_ENST00000597188_MLLT1_chr19_6270770_ENST00000252674_length(amino acids)=825AA_BP=0
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLN
LTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNI
CTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEE
PRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDA
NKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPP
PPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDE
ASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPS
REPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDE

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Fusion Gene PPI Analysis for ADAMTS10-MLLT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAMTS10-MLLT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAMTS10-MLLT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS10C4552002WEILL-MARCHESANI SYNDROME 13GENOMICS_ENGLAND;UNIPROT
HgeneADAMTS10C0265313Weill-Marchesani syndrome1CTD_human;GENOMICS_ENGLAND
TgeneC0027708Nephroblastoma1CTD_human
TgeneC2930471Bilateral Wilms Tumor1CTD_human