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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM14B-BAG6 (FusionGDB2 ID:HG81853TG7917)

Fusion Gene Summary for TMEM14B-BAG6

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM14B-BAG6
Fusion gene ID: hg81853tg7917
HgeneTgene
Gene symbol

TMEM14B

BAG6

Gene ID

81853

7917

Gene nametransmembrane protein 14BBAG cochaperone 6
Synonyms-BAG-6|BAT3|D6S52E|G3
Cytomap('TMEM14B')('BAG6')

6p24.2

6p21.33

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 14Blarge proline-rich protein BAG6BAG family molecular chaperone regulator 6BCL2 associated athanogene 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescythe
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000491103, ENST00000379530, 
ENST00000379542, ENST00000461342, 
ENST00000467317, ENST00000473276, 
ENST00000475942, ENST00000481240, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 6 X 3=126
# samples 47
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM14B [Title/Abstract] AND BAG6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM14B(10755465)-BAG6(31619553), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM14B

GO:0061351

neural precursor cell proliferation

29033352

HgeneTMEM14B

GO:2000045

regulation of G1/S transition of mitotic cell cycle

29033352

TgeneBAG6

GO:0002429

immune response-activating cell surface receptor signaling pathway

18852879

TgeneBAG6

GO:0006915

apoptotic process

14960581

TgeneBAG6

GO:0018393

internal peptidyl-lysine acetylation

17403783

TgeneBAG6

GO:0030101

natural killer cell activation

18852879

TgeneBAG6

GO:0030433

ubiquitin-dependent ERAD pathway

23129660|24981174

TgeneBAG6

GO:0071712

ER-associated misfolded protein catabolic process

23129660|24981174

TgeneBAG6

GO:0071816

tail-anchored membrane protein insertion into ER membrane

20676083|25535373



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A0DA-01ATMEM14Bchr6

10755465

+BAG6chr6

31619553

-


Top

Fusion Gene ORF analysis for TMEM14B-BAG6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000491103ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-5UTRENST00000491103ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-5UTRENST00000491103ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-5UTRENST00000491103ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-5UTRENST00000491103ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-5UTRENST00000491103ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000422756TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000425649TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000434446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000442479TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000444402TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000449450TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000451932TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000454478TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000550393TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
3UTR-intronENST00000491103ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379530ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000379542ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000461342ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000467317ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000473276ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000475942ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000211379TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000362049TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000375964TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000375976TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000404765TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-5UTRENST00000481240ENST00000439687TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000422756TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000425649TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000434446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000442479TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000444402TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000449450TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000451932TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000454478TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000550393TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379530ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000422756TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000425649TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000434446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000442479TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000444402TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000449450TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000451932TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000454478TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000550393TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000379542ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000461342ENST00000422756TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000425649TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000434446TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000442479TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000443182TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000444402TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000449450TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000451932TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000454478TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000460147TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000460429TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000461852TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000463220TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000470875TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000471376TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000497694TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000546462TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000550393TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000551350TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000461342ENST00000552116TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000461342ENST00000552467TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000461342ENST00000552605TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000361076TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000383446TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000383448TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000412012TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000413922TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000415345TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000415373TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000417144TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000419847TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000422756TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000425649TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000434446TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000442479TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000443182TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000444402TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000449450TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000451932TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000454478TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000460147TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000460429TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000461852TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000463220TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000470875TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000471376TMEM14Bchr6

10755465

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31619553

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5CDS-intronENST00000467317ENST00000497694TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000546462TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000550393TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000467317ENST00000552116TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000552467TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000467317ENST00000552605TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000361076TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000383446TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000383448TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000412012TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000413922TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000415345TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000415373TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000417144TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000419847TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000422756TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000425649TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000434446TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000442479TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000444402TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000449450TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000451932TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000454478TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000550393TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000551350TMEM14Bchr6

10755465

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31619553

-
5CDS-intronENST00000473276ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000473276ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000422756TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000425649TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000434446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000442479TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000444402TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000449450TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000451932TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000454478TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000550393TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000475942ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000361076TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000383446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000383448TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000412012TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000413922TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000415345TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000415373TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000417144TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000419847TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000422756TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000425649TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000434446TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000442479TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000443182TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000444402TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000449450TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000451932TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000454478TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000460147TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000460429TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000461852TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000463220TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000470875TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000471376TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000497694TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000546462TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000550393TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000551350TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000552116TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000552467TMEM14Bchr6

10755465

+BAG6chr6

31619553

-
5CDS-intronENST00000481240ENST00000552605TMEM14Bchr6

10755465

+BAG6chr6

31619553

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TMEM14B-BAG6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for TMEM14B-BAG6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:10755465/:31619553)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TMEM14B-BAG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TMEM14B-BAG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM14B-BAG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM14B-BAG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource