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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTN4-APLP1 (FusionGDB2 ID:HG81TG333)

Fusion Gene Summary for ACTN4-APLP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4-APLP1
Fusion gene ID: hg81tg333
HgeneTgene
Gene symbol

ACTN4

APLP1

Gene ID

81

333

Gene nameactinin alpha 4amyloid beta precursor like protein 1
SynonymsACTININ-4|FSGS|FSGS1APLP
Cytomap('ACTN4')('APLP1')

19q13.2

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4amyloid-like protein 1amyloid beta (A4) precursor-like protein 1amyloid precursor-like protein 1
Modification date2020032720200313
UniProtAcc

O43707

P51693

Ensembl transtripts involved in fusion geneENST00000252699, ENST00000390009, 
ENST00000424234, ENST00000497637, 
Fusion gene scores* DoF score42 X 60 X 18=453602 X 3 X 2=12
# samples 773
** MAII scorelog2(77/45360*10)=-5.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACTN4 [Title/Abstract] AND APLP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTN4(39138547)-APLP1(36360569), # samples:2
Anticipated loss of major functional domain due to fusion event.ACTN4-APLP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-APLP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-APLP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-APLP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0033209

tumor necrosis factor-mediated signaling pathway

25411248

HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771

TgeneAPLP1

GO:0071874

cellular response to norepinephrine stimulus

16531006

TgeneAPLP1

GO:0106072

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

16531006


check buttonFusion gene breakpoints across ACTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across APLP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5241-01AACTN4chr19

39138547

+APLP1chr19

36360569

+
ChimerDB4LUSCTCGA-34-5241ACTN4chr19

39138547

+APLP1chr19

36360569

+
ChimerDB4LUSCTCGA-34-5241ACTN4chr19

39138547

+APLP1chr19

36361798

+


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Fusion Gene ORF analysis for ACTN4-APLP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252699ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36360569

+
5CDS-intronENST00000252699ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36361798

+
5CDS-intronENST00000390009ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36360569

+
5CDS-intronENST00000390009ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36361798

+
5CDS-intronENST00000424234ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36360569

+
5CDS-intronENST00000424234ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36361798

+
Frame-shiftENST00000252699ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36360569

+
Frame-shiftENST00000390009ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36360569

+
Frame-shiftENST00000424234ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000252699ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000252699ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000252699ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000252699ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000252699ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000390009ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000390009ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000390009ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000390009ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000390009ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000424234ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000424234ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000424234ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36360569

+
In-frameENST00000424234ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36361798

+
In-frameENST00000424234ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36361798

+
intron-3CDSENST00000497637ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36360569

+
intron-3CDSENST00000497637ENST00000221891ACTN4chr19

39138547

+APLP1chr19

36361798

+
intron-3CDSENST00000497637ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36360569

+
intron-3CDSENST00000497637ENST00000537454ACTN4chr19

39138547

+APLP1chr19

36361798

+
intron-3CDSENST00000497637ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36360569

+
intron-3CDSENST00000497637ENST00000586861ACTN4chr19

39138547

+APLP1chr19

36361798

+
intron-intronENST00000497637ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36360569

+
intron-intronENST00000497637ENST00000589298ACTN4chr19

39138547

+APLP1chr19

36361798

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252699ACTN4chr1939138547+ENST00000537454APLP1chr1936360569+2129238762043655
ENST00000252699ACTN4chr1939138547+ENST00000221891APLP1chr1936360569+2394238762046656
ENST00000424234ACTN4chr1939138547+ENST00000537454APLP1chr1936360569+2112221592026655
ENST00000424234ACTN4chr1939138547+ENST00000221891APLP1chr1936360569+2377221592029656
ENST00000390009ACTN4chr1939138547+ENST00000537454APLP1chr1936360569+206117081975655
ENST00000390009ACTN4chr1939138547+ENST00000221891APLP1chr1936360569+232617081978656
ENST00000252699ACTN4chr1939138547+ENST00000537454APLP1chr1936361798+1985238761899607
ENST00000252699ACTN4chr1939138547+ENST00000221891APLP1chr1936361798+2250238761902608
ENST00000252699ACTN4chr1939138547+ENST00000586861APLP1chr1936361798+1952238761899607
ENST00000424234ACTN4chr1939138547+ENST00000537454APLP1chr1936361798+1968221591882607
ENST00000424234ACTN4chr1939138547+ENST00000221891APLP1chr1936361798+2233221591885608
ENST00000424234ACTN4chr1939138547+ENST00000586861APLP1chr1936361798+1935221591882607
ENST00000390009ACTN4chr1939138547+ENST00000537454APLP1chr1936361798+191717081831607
ENST00000390009ACTN4chr1939138547+ENST00000221891APLP1chr1936361798+218217081834608
ENST00000390009ACTN4chr1939138547+ENST00000586861APLP1chr1936361798+188417081831607

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252699ENST00000537454ACTN4chr1939138547+APLP1chr1936360569+0.038197030.96180296
ENST00000252699ENST00000221891ACTN4chr1939138547+APLP1chr1936360569+0.0207568180.97924316
ENST00000424234ENST00000537454ACTN4chr1939138547+APLP1chr1936360569+0.0357674730.9642325
ENST00000424234ENST00000221891ACTN4chr1939138547+APLP1chr1936360569+0.0194746680.9805253
ENST00000390009ENST00000537454ACTN4chr1939138547+APLP1chr1936360569+0.036371720.9636283
ENST00000390009ENST00000221891ACTN4chr1939138547+APLP1chr1936360569+0.019529340.98047066
ENST00000252699ENST00000537454ACTN4chr1939138547+APLP1chr1936361798+0.0182303710.9817696
ENST00000252699ENST00000221891ACTN4chr1939138547+APLP1chr1936361798+0.0104449820.989555
ENST00000252699ENST00000586861ACTN4chr1939138547+APLP1chr1936361798+0.0170824840.9829175
ENST00000424234ENST00000537454ACTN4chr1939138547+APLP1chr1936361798+0.0173796280.9826203
ENST00000424234ENST00000221891ACTN4chr1939138547+APLP1chr1936361798+0.0095368340.9904632
ENST00000424234ENST00000586861ACTN4chr1939138547+APLP1chr1936361798+0.0162985180.9837015
ENST00000390009ENST00000537454ACTN4chr1939138547+APLP1chr1936361798+0.0171448920.9828551
ENST00000390009ENST00000221891ACTN4chr1939138547+APLP1chr1936361798+0.0099183940.9900816
ENST00000390009ENST00000586861ACTN4chr1939138547+APLP1chr1936361798+0.0160556660.98394436

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Fusion Genomic Features for ACTN4-APLP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTN4chr1939138547+APLP1chr1936360568+1.20E-081
ACTN4chr1939138547+APLP1chr1936361797+1.65E-141
ACTN4chr1939138547+APLP1chr1936360568+1.20E-081
ACTN4chr1939138547+APLP1chr1936360568+1.20E-081
ACTN4chr1939138547+APLP1chr1936361797+1.65E-141
ACTN4chr1939138547+APLP1chr1936360568+1.20E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACTN4-APLP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39138547/chr19:36360569)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

APLP1

P51693

FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.FUNCTION: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.; FUNCTION: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017241_24749652.0Compositional biasNote=Poly-Glu
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017264_26849652.0Compositional biasNote=Poly-Glu
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117241_24797652.0Compositional biasNote=Poly-Glu
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117264_26897652.0Compositional biasNote=Poly-Glu
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017293_48449652.0DomainE2
TgeneAPLP1chr19:39138547chr19:36360569ENST0000022189101750_21249652.0DomainE1
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117293_48497652.0DomainE2
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017604_61549652.0MotifBasolateral sorting signal
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017640_64349652.0MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117604_61597652.0MotifBasolateral sorting signal
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117640_64397652.0MotifNote=NPXY motif%3B contains endocytosis signal
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017154_21249652.0RegionCuBD subdomain
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017158_17849652.0RegionCopper-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017204_21149652.0RegionNote=Zinc-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017285_30549652.0RegionNote=O-glycosylated at three sites
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017310_34249652.0RegionHeparin-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017410_44149652.0RegionHeparin-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017442_45949652.0RegionCollagen-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST0000022189101750_14649652.0RegionGFLD subdomain
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117154_21297652.0RegionCuBD subdomain
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117158_17897652.0RegionCopper-binding
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117204_21197652.0RegionNote=Zinc-binding
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117285_30597652.0RegionNote=O-glycosylated at three sites
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117310_34297652.0RegionHeparin-binding
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117410_44197652.0RegionHeparin-binding
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117442_45997652.0RegionCollagen-binding
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017604_65049652.0Topological domainCytoplasmic
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117604_65097652.0Topological domainCytoplasmic
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017581_60349652.0TransmembraneHelical
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117581_60397652.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114649_75254693.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114649_75254693.0RepeatSpectrin 4
TgeneAPLP1chr19:39138547chr19:36361798ENST0000022189111750_21297652.0DomainE1
TgeneAPLP1chr19:39138547chr19:36361798ENST0000022189111750_14697652.0RegionGFLD subdomain
TgeneAPLP1chr19:39138547chr19:36360569ENST0000022189101739_58049652.0Topological domainExtracellular
TgeneAPLP1chr19:39138547chr19:36361798ENST0000022189111739_58097652.0Topological domainExtracellular


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Fusion Gene Sequence for ACTN4-APLP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1763_1763_1_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36360569_ENST00000221891_length(transcript)=2394nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATG
CGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCG
CGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTG
CGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCT
GCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGC
CTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTG
TCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGC
TGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGT
CCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCAT
GCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCG
TGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGAC
TCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGC
TGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGA
GCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCA
TACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCA
AATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCT
GCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAA
GATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGA
GCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTC
CATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCA
GCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAG
CCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACC
CTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCC
CACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCT

>1763_1763_1_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36360569_ENST00000221891_length(amino acids)=656AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS
PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT

--------------------------------------------------------------
>1763_1763_2_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36360569_ENST00000537454_length(transcript)=2129nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATG
CGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCG
CGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTG
CGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCT
GCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGC
CTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTG
TCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGC
TGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGT
CCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCAT
GCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCG
TGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGAC
TCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGC
TGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGA
GCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCA
TACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCA
AATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCT
GCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGAT
GAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCT
GGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCAT
GCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCT
CCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCG

>1763_1763_2_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36360569_ENST00000537454_length(amino acids)=655AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP
EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL

--------------------------------------------------------------
>1763_1763_3_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000221891_length(transcript)=2250nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGA
GCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTT
CCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGA
GAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGG
CTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCAC
CCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGT
GGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCC
GAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGA
GGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACA
GGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCAC
CCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCG
TGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGA
TCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGA
CCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCC
TGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTC
CACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGG
TTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGAT
CATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGT
GGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGA
GGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTA
GGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCA
TCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTA
AGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCTGGAATTCACCCTCTCATGTTTCCCTACTAACATCCCAATAAAGTCCTCTTCCCT

>1763_1763_3_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000221891_length(amino acids)=608AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAV

--------------------------------------------------------------
>1763_1763_4_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000537454_length(transcript)=1985nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGA
GCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTT
CCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGA
GAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGG
CTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCAC
CCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGT
GGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCC
GAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGA
GGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACA
GGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCAC
CCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCG
TGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGA
TCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGA
CCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCC
TGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCAC
AGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTT
CCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCAT
GGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGA
GGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGA
ACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGG

>1763_1763_4_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000537454_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------
>1763_1763_5_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000586861_length(transcript)=1952nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGA
GCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTT
CCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGA
GAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGG
CTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCAC
CCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGT
GGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCC
GAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGA
GGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACA
GGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCAC
CCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCG
TGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGA
TCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGA
CCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCC
TGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCAC
AGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTT
CCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCAT
GGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGA
GGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGA

>1763_1763_5_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000252699_APLP1_chr19_36361798_ENST00000586861_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------
>1763_1763_6_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36360569_ENST00000221891_length(transcript)=2326nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGT
CGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGAC
GCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGG
CCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTG
GTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGA
GGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCC
GTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCC
CGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGG
CTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACG
GTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGC
GCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGC
ACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCC
TTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCC
TGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCAC
AGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACC
TGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCA
GCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATG
CTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACT
CATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCG
GAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCA
TGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGAC
CCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGT
CTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCC
CAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACC

>1763_1763_6_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36360569_ENST00000221891_length(amino acids)=656AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS
PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT

--------------------------------------------------------------
>1763_1763_7_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36360569_ENST00000537454_length(transcript)=2061nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGT
CGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTCACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGAC
GCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCAGACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGG
CCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTG
GTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGA
GGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCC
GTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCC
CGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGG
CTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACG
GTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGC
GCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGC
ACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCC
TTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCC
TGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCAC
AGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACC
TGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCA
GCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTG
CATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCAT
CGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAG
GCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGC
TGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCG

>1763_1763_7_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36360569_ENST00000537454_length(amino acids)=655AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP
EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL

--------------------------------------------------------------
>1763_1763_8_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000221891_length(transcript)=2182nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGG
AGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACC
CCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACC
AGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCT
CGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGA
CAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCAC
AGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGG
TCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCC
TGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGA
ACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGC
GCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGG
CAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACT
ACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGA
ATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGG
GTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCC
CCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGG
TGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTG
AGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACG
GGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGA
ACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCC
CAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTGGAAATTCTTATTTCC
CCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCACCTTAATTTATTTTT
TAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCTGGAATTCACCCTCTCATGTTTCCCTACTAACA

>1763_1763_8_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000221891_length(amino acids)=608AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAV

--------------------------------------------------------------
>1763_1763_9_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000537454_length(transcript)=1917nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGG
AGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACC
CCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACC
AGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCT
CGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGA
CAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCAC
AGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGG
TCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCC
TGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGA
ACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGC
GCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGG
CAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACT
ACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGA
ATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGG
GTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCA
TGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGA
ATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGG
CTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGG
CTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACC
CCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAG

>1763_1763_9_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000537454_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------
>1763_1763_10_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000586861_length(transcript)=1884nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGG
AGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACC
CCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACC
AGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCT
CGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGA
CAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCAC
AGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGG
TCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCC
TGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGA
ACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGC
GCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGG
CAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACT
ACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGA
ATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGG
GTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCA
TGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGA
ATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGG
CTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGG
CTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACC

>1763_1763_10_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000390009_APLP1_chr19_36361798_ENST00000586861_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------
>1763_1763_11_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36360569_ENST00000221891_length(transcript)=2377nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTC
ACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCA
GACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCG
GCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCT
GCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCC
TCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCC
CCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGG
AGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCC
ATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTG
AGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAG
ACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGT
CTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCC
TGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGC
ACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGA
TTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCC
ACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCA
AGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAAC
AGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGA
CAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCA
GGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGC
GGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCC
CTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTTGAAGTGATCATTTCACACCCTTTTGTGAGACGGCTG
GAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAGATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCA
CCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTGGTCCTAGTGTCTATTCCCTGGAATTCACCCTCTCAT

>1763_1763_11_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36360569_ENST00000221891_length(amino acids)=656AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAAS
PEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT

--------------------------------------------------------------
>1763_1763_12_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36360569_ENST00000537454_length(transcript)=2112nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCCCCGGGGTCGGCCCAGGTGGCTGGACTATGCGGGCGCCTAACCCTTC
ACCGGGACCTGCGCACCGGCCGCTGGGAACCAGACCCACAGCGCTCTCGACGCTGTCTCCGGGACCCGCAGCGCGTGCTGGAGTACTGCA
GACAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCATCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCG
GCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTGAATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCT
GCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGCATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCC
TCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTGGTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCC
CCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGGGGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGG
AGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTGAAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCC
ATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTGTGGATATTTACTTTGGCATGCCTGGGGAAATCAGTG
AGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCCAGATTAATGAGGTGATGCGTGAATGGGCCATGGCAG
ACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACTTCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGT
CTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTATCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCC
TGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGCGGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGC
ACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGCAGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGA
TTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGGCTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCC
ACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCAGCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCA
AGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGT
ATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAG
GGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGA
AGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGC
ACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTC

>1763_1763_12_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36360569_ENST00000537454_length(amino acids)=655AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCL
RDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQ
EAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEE
EEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQ
SILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQM
RFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASP
EKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTL

--------------------------------------------------------------
>1763_1763_13_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000221891_length(transcript)=2233nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCA
TCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTG
AATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGC
ATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTG
GTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGG
GGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTG
AAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTG
TGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCC
AGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACT
TCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTA
TCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGC
GGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGC
AGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGG
CTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCA
GCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGCAGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTG
CATCCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCAT
CGGAGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAG
GCTCCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGC
TGACCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCG
GCCCCCTTCACCCCTTCAGCCGAGCCCAGACCTCCCCTCTTCCTGGAGCCCCAGAACCCCAACTCCCAGCCTAGGGCAGCAGGGAGTCTT
GAAGTGATCATTTCACACCCTTTTGTGAGACGGCTGGAAATTCTTATTTCCCCTTTCCAATTCCAAAATTCCATCCCTAAGAATTCCCAG
ATAGTCCCAGCAGCCTCCCCACGTGGCACCTCCTCACCTTAATTTATTTTTTAAGTTTATTTATGGCTCTTTAAGGTGACCGCCACCTTG

>1763_1763_13_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000221891_length(amino acids)=608AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAV

--------------------------------------------------------------
>1763_1763_14_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000537454_length(transcript)=1968nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCA
TCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTG
AATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGC
ATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTG
GTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGG
GGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTG
AAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTG
TGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCC
AGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACT
TCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTA
TCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGC
GGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGC
AGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGG
CTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCA
GCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCAT
CCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGG
AGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCT
CCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGA
CCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCC

>1763_1763_14_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000537454_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------
>1763_1763_15_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000586861_length(transcript)=1935nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGTACCCGGAGCTGCAGATTGCACGTGTGGAGCAGGCTACGCAGGCCA
TCCCCATGGAGCGCTGGTGCGGGGGTTCCCGGAGCGGCAGCTGCGCCCACCCCCACCACCAGGTTGTGCCCTTCCGCTGCCTGCCTGGTG
AATTTGTGAGTGAGGCCCTGCTGGTGCCTGAAGGCTGCCGGTTCTTGCACCAGGAGCGCATGGACCAATGTGAGAGTTCAACCCGGAGGC
ATCAGGAGGCACAGGAGGCCTGCAGCTCCCAGGGCCTCATCCTGCACGGCTCGGGCATGCTCTTACCCTGTGGCTCGGATCGGTTCCGTG
GTGTGGAGTATGTGTGCTGTCCCCCTCCAGGGACCCCCGACCCATCTGGGACAGCAGTTGGTGACCCCTCCACCCGGTCCTGGCCCCCGG
GGAGCAGAGTAGAGGGGGCTGAGGACGAGGAAGAGGAGGAATCCTTCCCACAGCCAGTAGATGATTACTTCGTGGAGCCTCCGCAGGCTG
AAGAGGAAGAGGAAACGGTCCCACCCCCAAGCTCCCATACACTTGCAGTGGTCGGCAAAGTCACTCCCACCCCGAGGCCCACAGACGGTG
TGGATATTTACTTTGGCATGCCTGGGGAAATCAGTGAGCACGAGGGGTTCCTGAGGGCCAAGATGGACCTGGAGGAGCGTAGGATGCGCC
AGATTAATGAGGTGATGCGTGAATGGGCCATGGCAGACAACCAGTCCAAGAACCTGCCTAAAGCCGACAGACAGGCCCTGAATGAGCACT
TCCAGTCCATTCTGCAGACTCTGGAGGAGCAGGTGTCTGGTGAGCGACAGCGCCTGGTGGAAACCCACGCCACCCGCGTCATCGCCCTTA
TCAACGACCAGCGCCGGGCTGCCTTGGAGGGCTTCCTGGCAGCCCTGCAGGCAGATCCGCCTCAGGCGGAGCGTGTCCTGTTGGCCCTGC
GGCGCTACCTGCGTGCGGAGCAGAAGGAACAGAGGCACACGCTGCGCCACTACCAGCATGTGGCCGCCGTGGATCCCGAGAAGGCACAGC
AGATGCGCTTCCAGGTGCATACCCACCTTCAAGTGATTGAGGAGAGGGTGAATCAGAGCCTGGGCCTGCTTGACCAGAACCCCCACCTGG
CTCAGGAGCTGCGGCCCCAAATCCAGGAACTCCTCCACTCTGAACACCTGGGTCCCAGTGAATTGGAAGCCCCTGCCCCTGGGGGCAGCA
GCGAGGACAAGGGTGGGCTGCAGCCTCCAGATTCCAAGGATGACACCCCCATGACCCTTCCAAAAGGGTCCACAGAACAAGATGCTGCAT
CCCCTGAGAAAGAGAAGATGAACCCGCTGGAACAGTATGAGCGAAAGGTGAATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGG
AGATTCAGAGGGATGAGCTGGCACCAGCTGGGACAGGGGTGTCCCGTGAGGCTGTGTCGGGTCTGCTGATCATGGGAGCGGGCGGAGGCT
CCCTCATCGTCCTCTCCATGCTGCTCCTGCGCAGGAAGAAGCCCTACGGGGCTATCAGCCATGGCGTGGTGGAGGTGGACCCCATGCTGA
CCCTGGAGGAGCAGCAGCTCCGCGAACTGCAGCGGCACGGCTATGAGAACCCCACTTACCGCTTCCTGGAGGAACGACCCTGACCCGGCC

>1763_1763_15_ACTN4-APLP1_ACTN4_chr19_39138547_ENST00000424234_APLP1_chr19_36361798_ENST00000586861_length(amino acids)=607AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHH
QVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAV
GDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRA
KMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP
PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPS
ELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACTN4-APLP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+11412_2654.0693.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+11412_2654.0693.0VCL
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017632_64949.0652.0DAB1
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117632_64997.0652.0DAB1
TgeneAPLP1chr19:39138547chr19:36360569ENST00000221891017636_65049.0652.0DAB2
TgeneAPLP1chr19:39138547chr19:36361798ENST00000221891117636_65097.0652.0DAB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:36360569ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:36360569ENST00000390009+11440_6154.0693.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:36361798ENST00000390009+11440_6154.0693.0VCL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTN4-APLP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAPLP1P51693DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
TgeneAPLP1P51693DB01593ZincCofactorSmall moleculeApproved|Investigational
TgeneAPLP1P51693DB09130CopperCofactorSmall moleculeApproved|Investigational
TgeneAPLP1P51693DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneAPLP1P51693DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational

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Related Diseases for ACTN4-APLP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C4551527Focal segmental glomerulosclerosis 19GENOMICS_ENGLAND;UNIPROT
HgeneACTN4C0007097Carcinoma1CTD_human
HgeneACTN4C0019193Hepatitis, Toxic1CTD_human
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTN4C0205696Anaplastic carcinoma1CTD_human
HgeneACTN4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneACTN4C0205698Undifferentiated carcinoma1CTD_human
HgeneACTN4C0205699Carcinomatosis1CTD_human
HgeneACTN4C0860207Drug-Induced Liver Disease1CTD_human
HgeneACTN4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneACTN4C1262760Hepatitis, Drug-Induced1CTD_human
HgeneACTN4C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneACTN4C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneACTN4C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneACTN4C4279912Chemically-Induced Liver Toxicity1CTD_human