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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTN4-CAPZB (FusionGDB2 ID:HG81TG832)

Fusion Gene Summary for ACTN4-CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4-CAPZB
Fusion gene ID: hg81tg832
HgeneTgene
Gene symbol

ACTN4

CAPZB

Gene ID

81

832

Gene nameactinin alpha 4capping actin protein of muscle Z-line subunit beta
SynonymsACTININ-4|FSGS|FSGS1CAPB|CAPPB|CAPZ
Cytomap('ACTN4')('CAPZB')

19q13.2

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020032720200320
UniProtAcc

O43707

P47756

Ensembl transtripts involved in fusion geneENST00000252699, ENST00000390009, 
ENST00000424234, ENST00000497637, 
Fusion gene scores* DoF score42 X 60 X 18=4536023 X 15 X 8=2760
# samples 7727
** MAII scorelog2(77/45360*10)=-5.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTN4 [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTN4(39207956)-CAPZB(19712120), # samples:3
Anticipated loss of major functional domain due to fusion event.ACTN4-CAPZB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-CAPZB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-CAPZB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-CAPZB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0033209

tumor necrosis factor-mediated signaling pathway

25411248

HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771


check buttonFusion gene breakpoints across ACTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B9-01AACTN4chr19

39207956

-CAPZBchr1

19712120

-
ChimerDB4BRCATCGA-BH-A0B9-01AACTN4chr19

39207956

+CAPZBchr1

19712120

-
ChimerDB4BRCATCGA-BH-A0B9ACTN4chr19

39207956

+CAPZBchr1

19712120

-


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Fusion Gene ORF analysis for ACTN4-CAPZB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000252699ENST00000375144ACTN4chr19

39207956

+CAPZBchr1

19712120

-
5CDS-5UTRENST00000252699ENST00000482808ACTN4chr19

39207956

+CAPZBchr1

19712120

-
5CDS-5UTRENST00000390009ENST00000375144ACTN4chr19

39207956

+CAPZBchr1

19712120

-
5CDS-5UTRENST00000390009ENST00000482808ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000252699ENST00000264202ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000252699ENST00000264203ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000252699ENST00000375142ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000252699ENST00000401084ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000252699ENST00000433834ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000390009ENST00000264202ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000390009ENST00000264203ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000390009ENST00000375142ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000390009ENST00000401084ACTN4chr19

39207956

+CAPZBchr1

19712120

-
In-frameENST00000390009ENST00000433834ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000424234ENST00000264202ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000424234ENST00000264203ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000424234ENST00000375142ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000424234ENST00000401084ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000424234ENST00000433834ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000497637ENST00000264202ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000497637ENST00000264203ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000497637ENST00000375142ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000497637ENST00000401084ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-3CDSENST00000497637ENST00000433834ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-5UTRENST00000424234ENST00000375144ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-5UTRENST00000424234ENST00000482808ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-5UTRENST00000497637ENST00000375144ACTN4chr19

39207956

+CAPZBchr1

19712120

-
intron-5UTRENST00000497637ENST00000482808ACTN4chr19

39207956

+CAPZBchr1

19712120

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252699ACTN4chr1939207956+ENST00000401084CAPZBchr119712120-27021219761944622
ENST00000252699ACTN4chr1939207956+ENST00000264203CAPZBchr119712120-26221219761830584
ENST00000252699ACTN4chr1939207956+ENST00000375142CAPZBchr119712120-27651219761959627
ENST00000252699ACTN4chr1939207956+ENST00000433834CAPZBchr119712120-21161219761944622
ENST00000252699ACTN4chr1939207956+ENST00000264202CAPZBchr119712120-19601219761959628
ENST00000390009ACTN4chr1939207956+ENST00000401084CAPZBchr119712120-197749481219403
ENST00000390009ACTN4chr1939207956+ENST00000264203CAPZBchr119712120-189749481105365
ENST00000390009ACTN4chr1939207956+ENST00000375142CAPZBchr119712120-204049481234408
ENST00000390009ACTN4chr1939207956+ENST00000433834CAPZBchr119712120-139149481219403
ENST00000390009ACTN4chr1939207956+ENST00000264202CAPZBchr119712120-123549481234409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252699ENST00000401084ACTN4chr1939207956+CAPZBchr119712120-0.0065977080.9934023
ENST00000252699ENST00000264203ACTN4chr1939207956+CAPZBchr119712120-0.0076472750.9923528
ENST00000252699ENST00000375142ACTN4chr1939207956+CAPZBchr119712120-0.0078448320.99215513
ENST00000252699ENST00000433834ACTN4chr1939207956+CAPZBchr119712120-0.013126120.9868739
ENST00000252699ENST00000264202ACTN4chr1939207956+CAPZBchr119712120-0.0135152470.9864848
ENST00000390009ENST00000401084ACTN4chr1939207956+CAPZBchr119712120-0.0026783540.99732167
ENST00000390009ENST00000264203ACTN4chr1939207956+CAPZBchr119712120-0.0033515320.9966485
ENST00000390009ENST00000375142ACTN4chr1939207956+CAPZBchr119712120-0.0029982220.9970017
ENST00000390009ENST00000433834ACTN4chr1939207956+CAPZBchr119712120-0.0045636420.9954364
ENST00000390009ENST00000264202ACTN4chr1939207956+CAPZBchr119712120-0.0048389850.995161

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Fusion Genomic Features for ACTN4-CAPZB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACTN4-CAPZB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39207956/chr1:19712120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

CAPZB

P47756

FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+102119_26381912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+31419_26162693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021163_269381912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+102150_154381912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+31450_154162693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+102184_88381912.0MotifLXXLL motif
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+31484_88162693.0MotifLXXLL motif
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021177_192381912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+10211_269381912.0RegionNote=Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021778_789381912.0Calcium binding1
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021819_830381912.0Calcium binding2
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314778_789162693.0Calcium binding1
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314819_830162693.0Calcium binding2
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021765_800381912.0DomainEF-hand 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021806_841381912.0DomainEF-hand 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314163_269162693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314765_800162693.0DomainEF-hand 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314806_841162693.0DomainEF-hand 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314177_192162693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+3141_269162693.0RegionNote=Actin-binding
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021293_403381912.0RepeatSpectrin 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021413_518381912.0RepeatSpectrin 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021528_639381912.0RepeatSpectrin 3
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021649_752381912.0RepeatSpectrin 4
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314293_403162693.0RepeatSpectrin 1
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314413_518162693.0RepeatSpectrin 2
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314528_639162693.0RepeatSpectrin 3
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314649_752162693.0RepeatSpectrin 4


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Fusion Gene Sequence for ACTN4-CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1766_1766_1_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000264202_length(transcript)=1960nt_BP=1219nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGA
CATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGA
AACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCT
CCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTT
CCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCG
CCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCA
GCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATG
GAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGA
CCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAA
GAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGC
CCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAG
ACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAG
AAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTT

>1766_1766_1_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000264202_length(amino acids)=628AA_BP=381
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------
>1766_1766_2_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000264203_length(transcript)=2622nt_BP=1219nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGA
CATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGA
AACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCT
CCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTT
CCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCG
CCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCA
GCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATG
GAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGA
CCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAA
GAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGC
CCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAG
ACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTTTGCAG
ACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAG
ACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAAC
AGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACAC
CTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTAT
AGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGA
ACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGA
CAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGG
GGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTT
TTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAAC

>1766_1766_2_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000264203_length(amino acids)=584AA_BP=381
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------
>1766_1766_3_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000375142_length(transcript)=2765nt_BP=1219nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGA
CATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGA
AACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCT
CCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTT
CCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCG
CCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCA
GCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATG
GAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGA
CCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAA
GAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGC
CCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAG
ACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAG
AAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTT
TAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTGTGCAG
ACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCA
TGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAG
GTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCT
TCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCC
CCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAA
AATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGG
GTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTG
GGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTT

>1766_1766_3_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000375142_length(amino acids)=627AA_BP=381
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------
>1766_1766_4_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000401084_length(transcript)=2702nt_BP=1219nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGA
CATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGA
AACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCT
CCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTT
CCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCG
CCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCA
GCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATG
GAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGA
CCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAA
GAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGC
CCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAG
ACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAG
AAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACA
AGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCAC
TCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTG
ACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTT
CTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCC
ACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTG
TGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTC
TGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGA
CCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCT
TAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGGCGCAGTTA

>1766_1766_4_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000401084_length(amino acids)=622AA_BP=381
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------
>1766_1766_5_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000433834_length(transcript)=2116nt_BP=1219nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGACCTTCACGGCATGGTGCAACTCCCACCTGCG
GAAGGCAGGCACACAGATCGAGAACATTGATGAGGACTTCCGAGACGGGCTCAAGCTCATGCTGCTCCTGGAGGTCATATCAGGGGAGCG
GTTACCTAAGCCGGAGCGGGGGAAGATGAGAGTGCACAAAATCAACAATGTGAACAAAGCGCTGGACTTTATTGCCAGCAAAGGCGTCAA
GCTGGTCTCCATCGGGGCAGAAGAGATTGTGGACGGCAACGCAAAGATGACCCTGGGAATGATCTGGACCATCATCCTTAGGTTCGCCAT
CCAGGACATCTCCGTGGAAGAGACCTCGGCCAAGGAAGGGCTCCTTCTCTGGTGCCAGAGAAAGACAGCCCCGTATAAGAACGTCAATGT
GCAGAACTTCCACATCAGCTGGAAGGATGGTCTTGCCTTCAATGCCCTGATCCACCGGCACAGACCAGAGCTGATTGAGTATGACAAGCT
GAGGAAGGACGACCCTGTCACCAACCTGAACAATGCCTTCGAAGTGGCTGAGAAATACCTCGACATCCCCAAGATGCTGGATGCAGAGGA
CATCGTGAACACGGCCCGGCCCGACGAGAAGGCCATAATGACCTATGTGTCCAGCTTCTACCATGCCTTTTCAGGAGCGCAGAAGGCTGA
AACTGCCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCT
CCTGGAGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTT
CCGCGACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCG
CCTCAGCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCA
GCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATG
GAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGA
CCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAA
GAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGC
CCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAG
ACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAG
AAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACA
AGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCAC
TCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTG

>1766_1766_5_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000252699_CAPZB_chr1_19712120_ENST00000433834_length(amino acids)=622AA_BP=381
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------
>1766_1766_6_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000264202_length(transcript)=1235nt_BP=494nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCTGAAACTG
CCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGG
AGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCG
ACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCA
GCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCAC
TGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTA
ACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGT
ATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGG
CTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATT
ACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGA
TGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTA
CGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGC

>1766_1766_6_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000264202_length(amino acids)=409AA_BP=162
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKI
ARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGD
GSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLN

--------------------------------------------------------------
>1766_1766_7_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000264203_length(transcript)=1897nt_BP=494nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCTGAAACTG
CCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGG
AGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCG
ACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCA
GCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCAC
TGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTA
ACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGT
ATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGG
CTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATT
ACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGA
TGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTTTGCAGACAAA
TCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACG
CCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTG
CATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGC
TCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCA
TAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAA
CTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGG
GACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGT
GCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTT
GTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGG

>1766_1766_7_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000264203_length(amino acids)=365AA_BP=162
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKI
ARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGD
GSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEVCADFCRQIKT

--------------------------------------------------------------
>1766_1766_8_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000375142_length(transcript)=2040nt_BP=494nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCTGAAACTG
CCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGG
AGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCG
ACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCA
GCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCAC
TGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTA
ACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGT
ATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGG
CTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATT
ACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGA
TGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTA
CGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGC
AGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTGTGCAGACTTT
TGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTA
ACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCAC
ATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGC
CACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCA
TTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTT
TATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGT
GGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGC
TGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATT

>1766_1766_8_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000375142_length(amino acids)=408AA_BP=162
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKI
ARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGD
GSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLN

--------------------------------------------------------------
>1766_1766_9_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000401084_length(transcript)=1977nt_BP=494nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCTGAAACTG
CCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGG
AGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCG
ACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCA
GCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCAC
TGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTA
ACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGT
ATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGG
CTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATT
ACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGA
TGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTA
CGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAG
CTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTT
AGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGC
ACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTC
CACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGT
CTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGA
AAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGA
GCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTT
CCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGA

>1766_1766_9_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000401084_length(amino acids)=403AA_BP=162
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKI
ARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGD
GSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLN

--------------------------------------------------------------
>1766_1766_10_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000433834_length(transcript)=1391nt_BP=494nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGCTGAAACTG
CCGCCAACCGGATCTGTAAGGTGCTGGCTGTCAACCAAGAGAACGAGCACCTGATGGAGGACTACGAGAAGCTGGCCAGCGACCTCCTGG
AGTGGATCCGGCGCACCATCCCCTGGCTGGAGGACCGTGTGCCCCAAAAGACTATCCAGGAGATGCAGCAGAAGCTGGAGGACTTCCGCG
ACTACCGGCGTGTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGCCTCA
GCAACCGGCCCGCCTTCATGCCCTCCGAGGGCAAGATGGTCTCGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCAC
TGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTA
ACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGT
ATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGG
CTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATT
ACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGA
TGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTA
CGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAG
CTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTT
AGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGC

>1766_1766_10_ACTN4-CAPZB_ACTN4_chr19_39207956_ENST00000390009_CAPZB_chr1_19712120_ENST00000433834_length(amino acids)=403AA_BP=162
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSVPSLCEDLLSSVDQPLKI
ARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGD
GSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACTN4-CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+1021108_126381.0912.0VCL
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+102112_26381.0912.0VCL
HgeneACTN4chr19:39207956chr1:19712120ENST00000252699+102140_61381.0912.0VCL
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+314108_126162.0693.0VCL
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+31412_26162.0693.0VCL
HgeneACTN4chr19:39207956chr1:19712120ENST00000390009+31440_61162.0693.0VCL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTN4-CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTN4-CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C4551527Focal segmental glomerulosclerosis 19GENOMICS_ENGLAND;UNIPROT
HgeneACTN4C0007097Carcinoma1CTD_human
HgeneACTN4C0019193Hepatitis, Toxic1CTD_human
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTN4C0205696Anaplastic carcinoma1CTD_human
HgeneACTN4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneACTN4C0205698Undifferentiated carcinoma1CTD_human
HgeneACTN4C0205699Carcinomatosis1CTD_human
HgeneACTN4C0860207Drug-Induced Liver Disease1CTD_human
HgeneACTN4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneACTN4C1262760Hepatitis, Drug-Induced1CTD_human
HgeneACTN4C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneACTN4C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneACTN4C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneACTN4C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human