Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ACTN4-TIMM50 (FusionGDB2 ID:HG81TG92609)

Fusion Gene Summary for ACTN4-TIMM50

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTN4-TIMM50
Fusion gene ID: hg81tg92609
HgeneTgene
Gene symbol

ACTN4

TIMM50

Gene ID

81

92609

Gene nameactinin alpha 4translocase of inner mitochondrial membrane 50
SynonymsACTININ-4|FSGS|FSGS1MGCA9|TIM50|TIM50L
Cytomap('ACTN4')('TIMM50')

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4mitochondrial import inner membrane translocase subunit TIM50Tim50-like proteinhomolog of yeast Tim50
Modification date2020032720200327
UniProtAcc

O43707

.
Ensembl transtripts involved in fusion geneENST00000252699, ENST00000390009, 
ENST00000424234, ENST00000497637, 
Fusion gene scores* DoF score42 X 60 X 18=453601 X 4 X 1=4
# samples 771
** MAII scorelog2(77/45360*10)=-5.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/4*10)=1.32192809488736
Context

PubMed: ACTN4 [Title/Abstract] AND TIMM50 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTN4(39138547)-TIMM50(39976327), # samples:2
ACTN4(39138547)-TIMM50(39978700), # samples:2
Anticipated loss of major functional domain due to fusion event.ACTN4-TIMM50 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-TIMM50 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-TIMM50 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-TIMM50 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0033209

tumor necrosis factor-mediated signaling pathway

25411248

HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771

TgeneTIMM50

GO:0001836

release of cytochrome c from mitochondria

15044455

TgeneTIMM50

GO:0006470

protein dephosphorylation

15044455


check buttonFusion gene breakpoints across ACTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TIMM50 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9L1ACTN4chr19

39138547

+TIMM50chr19

39976327

+
ChimerDB4PRADTCGA-ZG-A9L1ACTN4chr19

39138547

+TIMM50chr19

39976328

+
ChimerDB4PRADTCGA-ZG-A9L1ACTN4chr19

39138547

+TIMM50chr19

39978700

+
ChimerDB4PRADTCGA-ZG-A9L1ACTN4chr19

39138547

+TIMM50chr19

39978701

+


Top

Fusion Gene ORF analysis for ACTN4-TIMM50

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252699ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000252699ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000252699ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000252699ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000252699ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000252699ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000252699ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978700

+
5CDS-intronENST00000252699ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978701

+
5CDS-intronENST00000390009ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000390009ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000390009ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000390009ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000390009ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000390009ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000390009ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978700

+
5CDS-intronENST00000390009ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978701

+
5CDS-intronENST00000424234ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000424234ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000424234ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000424234ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000424234ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976327

+
5CDS-intronENST00000424234ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976328

+
5CDS-intronENST00000424234ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978700

+
5CDS-intronENST00000424234ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000252699ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000252699ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000252699ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000252699ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000252699ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000252699ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000252699ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000252699ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000252699ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000252699ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000252699ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000252699ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000390009ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000390009ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000390009ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000390009ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000390009ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000390009ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000390009ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000390009ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000390009ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000390009ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000390009ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000390009ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000424234ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000424234ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000424234ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000424234ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000424234ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000424234ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000424234ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000424234ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978701

+
In-frameENST00000424234ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976327

+
In-frameENST00000424234ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976328

+
In-frameENST00000424234ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978700

+
In-frameENST00000424234ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978701

+
intron-3CDSENST00000497637ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976327

+
intron-3CDSENST00000497637ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39976328

+
intron-3CDSENST00000497637ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978700

+
intron-3CDSENST00000497637ENST00000314349ACTN4chr19

39138547

+TIMM50chr19

39978701

+
intron-3CDSENST00000497637ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978700

+
intron-3CDSENST00000497637ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39978701

+
intron-3CDSENST00000497637ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978700

+
intron-3CDSENST00000497637ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39978701

+
intron-3CDSENST00000497637ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976327

+
intron-3CDSENST00000497637ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39976328

+
intron-3CDSENST00000497637ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978700

+
intron-3CDSENST00000497637ENST00000607714ACTN4chr19

39138547

+TIMM50chr19

39978701

+
intron-intronENST00000497637ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976327

+
intron-intronENST00000497637ENST00000544017ACTN4chr19

39138547

+TIMM50chr19

39976328

+
intron-intronENST00000497637ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976327

+
intron-intronENST00000497637ENST00000599794ACTN4chr19

39138547

+TIMM50chr19

39976328

+
intron-intronENST00000497637ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976327

+
intron-intronENST00000497637ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39976328

+
intron-intronENST00000497637ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978700

+
intron-intronENST00000497637ENST00000600878ACTN4chr19

39138547

+TIMM50chr19

39978701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000252699ACTN4chr1939138547+ENST00000314349TIMM50chr1939976327+103623876927283
ENST00000252699ACTN4chr1939138547+ENST00000607714TIMM50chr1939976327+118223876927283
ENST00000424234ACTN4chr1939138547+ENST00000314349TIMM50chr1939976327+101922159910283
ENST00000424234ACTN4chr1939138547+ENST00000607714TIMM50chr1939976327+116522159910283
ENST00000390009ACTN4chr1939138547+ENST00000314349TIMM50chr1939976327+9681708859283
ENST00000390009ACTN4chr1939138547+ENST00000607714TIMM50chr1939976327+11141708859283
ENST00000252699ACTN4chr1939138547+ENST00000314349TIMM50chr1939978700+71223876603175
ENST00000252699ACTN4chr1939138547+ENST00000607714TIMM50chr1939978700+85823876603175
ENST00000252699ACTN4chr1939138547+ENST00000599794TIMM50chr1939978700+90323876603175
ENST00000252699ACTN4chr1939138547+ENST00000544017TIMM50chr1939978700+70523876603175
ENST00000424234ACTN4chr1939138547+ENST00000314349TIMM50chr1939978700+69522159586175
ENST00000424234ACTN4chr1939138547+ENST00000607714TIMM50chr1939978700+84122159586175
ENST00000424234ACTN4chr1939138547+ENST00000599794TIMM50chr1939978700+88622159586175
ENST00000424234ACTN4chr1939138547+ENST00000544017TIMM50chr1939978700+68822159586175
ENST00000390009ACTN4chr1939138547+ENST00000314349TIMM50chr1939978700+6441708535175
ENST00000390009ACTN4chr1939138547+ENST00000607714TIMM50chr1939978700+7901708535175
ENST00000390009ACTN4chr1939138547+ENST00000599794TIMM50chr1939978700+8351708535175
ENST00000390009ACTN4chr1939138547+ENST00000544017TIMM50chr1939978700+6371708535175
ENST00000252699ACTN4chr1939138547+ENST00000314349TIMM50chr1939978701+71223876603175
ENST00000252699ACTN4chr1939138547+ENST00000607714TIMM50chr1939978701+85823876603175
ENST00000252699ACTN4chr1939138547+ENST00000599794TIMM50chr1939978701+90323876603175
ENST00000252699ACTN4chr1939138547+ENST00000544017TIMM50chr1939978701+70523876603175
ENST00000424234ACTN4chr1939138547+ENST00000314349TIMM50chr1939978701+69522159586175
ENST00000424234ACTN4chr1939138547+ENST00000607714TIMM50chr1939978701+84122159586175
ENST00000424234ACTN4chr1939138547+ENST00000599794TIMM50chr1939978701+88622159586175
ENST00000424234ACTN4chr1939138547+ENST00000544017TIMM50chr1939978701+68822159586175
ENST00000390009ACTN4chr1939138547+ENST00000314349TIMM50chr1939978701+6441708535175
ENST00000390009ACTN4chr1939138547+ENST00000607714TIMM50chr1939978701+7901708535175
ENST00000390009ACTN4chr1939138547+ENST00000599794TIMM50chr1939978701+8351708535175
ENST00000390009ACTN4chr1939138547+ENST00000544017TIMM50chr1939978701+6371708535175
ENST00000252699ACTN4chr1939138547+ENST00000314349TIMM50chr1939976328+103623876927283
ENST00000252699ACTN4chr1939138547+ENST00000607714TIMM50chr1939976328+118223876927283
ENST00000424234ACTN4chr1939138547+ENST00000314349TIMM50chr1939976328+101922159910283
ENST00000424234ACTN4chr1939138547+ENST00000607714TIMM50chr1939976328+116522159910283
ENST00000390009ACTN4chr1939138547+ENST00000314349TIMM50chr1939976328+9681708859283
ENST00000390009ACTN4chr1939138547+ENST00000607714TIMM50chr1939976328+11141708859283

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252699ENST00000314349ACTN4chr1939138547+TIMM50chr1939976327+0.0137829030.98621714
ENST00000252699ENST00000607714ACTN4chr1939138547+TIMM50chr1939976327+0.013364130.98663586
ENST00000424234ENST00000314349ACTN4chr1939138547+TIMM50chr1939976327+0.0140263790.9859736
ENST00000424234ENST00000607714ACTN4chr1939138547+TIMM50chr1939976327+0.0134300760.98656994
ENST00000390009ENST00000314349ACTN4chr1939138547+TIMM50chr1939976327+0.0110388270.98896116
ENST00000390009ENST00000607714ACTN4chr1939138547+TIMM50chr1939976327+0.0113782990.98862165
ENST00000252699ENST00000314349ACTN4chr1939138547+TIMM50chr1939978700+0.0063578570.99364215
ENST00000252699ENST00000607714ACTN4chr1939138547+TIMM50chr1939978700+0.0064239010.9935761
ENST00000252699ENST00000599794ACTN4chr1939138547+TIMM50chr1939978700+0.0078504130.9921496
ENST00000252699ENST00000544017ACTN4chr1939138547+TIMM50chr1939978700+0.0060041990.9939958
ENST00000424234ENST00000314349ACTN4chr1939138547+TIMM50chr1939978700+0.0068996810.9931003
ENST00000424234ENST00000607714ACTN4chr1939138547+TIMM50chr1939978700+0.0067937470.99320626
ENST00000424234ENST00000599794ACTN4chr1939138547+TIMM50chr1939978700+0.0077752040.9922248
ENST00000424234ENST00000544017ACTN4chr1939138547+TIMM50chr1939978700+0.0066904740.9933095
ENST00000390009ENST00000314349ACTN4chr1939138547+TIMM50chr1939978700+0.0040419110.99595803
ENST00000390009ENST00000607714ACTN4chr1939138547+TIMM50chr1939978700+0.0050971530.99490285
ENST00000390009ENST00000599794ACTN4chr1939138547+TIMM50chr1939978700+0.0070102650.99298966
ENST00000390009ENST00000544017ACTN4chr1939138547+TIMM50chr1939978700+0.0037640230.996236
ENST00000252699ENST00000314349ACTN4chr1939138547+TIMM50chr1939978701+0.0063578570.99364215
ENST00000252699ENST00000607714ACTN4chr1939138547+TIMM50chr1939978701+0.0064239010.9935761
ENST00000252699ENST00000599794ACTN4chr1939138547+TIMM50chr1939978701+0.0078504130.9921496
ENST00000252699ENST00000544017ACTN4chr1939138547+TIMM50chr1939978701+0.0060041990.9939958
ENST00000424234ENST00000314349ACTN4chr1939138547+TIMM50chr1939978701+0.0068996810.9931003
ENST00000424234ENST00000607714ACTN4chr1939138547+TIMM50chr1939978701+0.0067937470.99320626
ENST00000424234ENST00000599794ACTN4chr1939138547+TIMM50chr1939978701+0.0077752040.9922248
ENST00000424234ENST00000544017ACTN4chr1939138547+TIMM50chr1939978701+0.0066904740.9933095
ENST00000390009ENST00000314349ACTN4chr1939138547+TIMM50chr1939978701+0.0040419110.99595803
ENST00000390009ENST00000607714ACTN4chr1939138547+TIMM50chr1939978701+0.0050971530.99490285
ENST00000390009ENST00000599794ACTN4chr1939138547+TIMM50chr1939978701+0.0070102650.99298966
ENST00000390009ENST00000544017ACTN4chr1939138547+TIMM50chr1939978701+0.0037640230.996236
ENST00000252699ENST00000314349ACTN4chr1939138547+TIMM50chr1939976328+0.0137829030.98621714
ENST00000252699ENST00000607714ACTN4chr1939138547+TIMM50chr1939976328+0.013364130.98663586
ENST00000424234ENST00000314349ACTN4chr1939138547+TIMM50chr1939976328+0.0140263790.9859736
ENST00000424234ENST00000607714ACTN4chr1939138547+TIMM50chr1939976328+0.0134300760.98656994
ENST00000390009ENST00000314349ACTN4chr1939138547+TIMM50chr1939976328+0.0110388270.98896116
ENST00000390009ENST00000607714ACTN4chr1939138547+TIMM50chr1939976328+0.0113782990.98862165

Top

Fusion Genomic Features for ACTN4-TIMM50


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTN4chr1939138547+TIMM50chr1939976327+6.23E-121
ACTN4chr1939138547+TIMM50chr1939978700+1.38E-131
ACTN4chr1939138547+TIMM50chr1939976327+6.23E-121
ACTN4chr1939138547+TIMM50chr1939978700+1.38E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ACTN4-TIMM50


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39138547/chr19:39976327)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

.
FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+12119_2654912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+11419_2654693.0Compositional biasPoly-Gly
TgeneTIMM50chr19:39138547chr19:39976327ENST00000544017310143_28611241.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976327ENST00000607714411143_286124354.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976328ENST00000544017310143_28611241.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976328ENST00000607714411143_286124354.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978700ENST00000544017610143_286119241.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978701ENST00000544017610143_286119241.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976327ENST0000054401731045_6511241.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976327ENST0000054401731087_35311241.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976328ENST0000054401731045_6511241.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976328ENST0000054401731087_35311241.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976327ENST0000054401731066_8611241.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39976328ENST0000054401731066_8611241.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121778_78954912.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121819_83054912.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114778_78954693.0Calcium binding1
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114819_83054693.0Calcium binding2
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121163_26954912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+12150_15454912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121765_80054912.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121806_84154912.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114163_26954693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+11450_15454693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114765_80054693.0DomainEF-hand 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114806_84154693.0DomainEF-hand 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+12184_8854912.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+11484_8854693.0MotifLXXLL motif
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121177_19254912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+1211_26954912.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114177_19254693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+1141_26954693.0RegionNote=Actin-binding
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114649_75254693.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114649_75254693.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114649_75254693.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121293_40354912.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121413_51854912.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121528_63954912.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121649_75254912.0RepeatSpectrin 4
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114293_40354693.0RepeatSpectrin 1
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114413_51854693.0RepeatSpectrin 2
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114528_63954693.0RepeatSpectrin 3
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114649_75254693.0RepeatSpectrin 4
TgeneTIMM50chr19:39138547chr19:39976327ENST00000314349411143_286227457.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976328ENST00000314349411143_286227457.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978700ENST00000314349711143_286335457.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978700ENST00000607714711143_286232354.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978701ENST00000314349711143_286335457.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39978701ENST00000607714711143_286232354.0DomainFCP1 homology
TgeneTIMM50chr19:39138547chr19:39976327ENST0000031434941145_65227457.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976327ENST0000031434941187_353227457.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976327ENST0000060771441145_65124354.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976327ENST0000060771441187_353124354.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976328ENST0000031434941145_65227457.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976328ENST0000031434941187_353227457.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976328ENST0000060771441145_65124354.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39976328ENST0000060771441187_353124354.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978700ENST0000031434971145_65335457.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978700ENST0000031434971187_353335457.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978700ENST0000054401761045_65119241.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978700ENST0000054401761087_353119241.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978700ENST0000060771471145_65232354.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978700ENST0000060771471187_353232354.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978701ENST0000031434971145_65335457.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978701ENST0000031434971187_353335457.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978701ENST0000054401761045_65119241.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978701ENST0000054401761087_353119241.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39978701ENST0000060771471145_65232354.0Topological domainMitochondrial matrix
TgeneTIMM50chr19:39138547chr19:39978701ENST0000060771471187_353232354.0Topological domainMitochondrial intermembrane
TgeneTIMM50chr19:39138547chr19:39976327ENST0000031434941166_86227457.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39976327ENST0000060771441166_86124354.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39976328ENST0000031434941166_86227457.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39976328ENST0000060771441166_86124354.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978700ENST0000031434971166_86335457.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978700ENST0000054401761066_86119241.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978700ENST0000060771471166_86232354.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978701ENST0000031434971166_86335457.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978701ENST0000054401761066_86119241.0TransmembraneHelical
TgeneTIMM50chr19:39138547chr19:39978701ENST0000060771471166_86232354.0TransmembraneHelical


Top

Fusion Gene Sequence for ACTN4-TIMM50


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1804_1804_1_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976327_ENST00000314349_length(transcript)=1036nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCT
CCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCT
GGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTC
AGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATA
CATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCG
CCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGAC
CATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCA
AAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCG
CTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACT

>1804_1804_1_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976327_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_2_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976327_ENST00000607714_length(transcript)=1182nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCT
CCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCT
GGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTC
AGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATA
CATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCG
CCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGAC
CATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCA
AAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCG
CTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACT
TGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCC
GGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTG

>1804_1804_2_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976327_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_3_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976328_ENST00000314349_length(transcript)=1036nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCT
CCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCT
GGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTC
AGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATA
CATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCG
CCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGAC
CATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCA
AAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCG
CTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACT

>1804_1804_3_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976328_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_4_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976328_ENST00000607714_length(transcript)=1182nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCT
CCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCT
GGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTC
AGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATA
CATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCG
CCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGAC
CATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCA
AAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCG
CTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACT
TGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCC
GGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTG

>1804_1804_4_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39976328_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_5_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000314349_length(transcript)=712nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC

>1804_1804_5_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_6_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000544017_length(transcript)=705nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC

>1804_1804_6_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_7_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000599794_length(transcript)=903nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC
CTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCC
CGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGG
GGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTGGTCTCGGAATCTAAAAACCCTCGCTGTGTCTTCCTGTGTGTTGCGTGATCTGTG

>1804_1804_7_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_8_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000607714_length(transcript)=858nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC
CTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCC
CGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGG

>1804_1804_8_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978700_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_9_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000314349_length(transcript)=712nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC

>1804_1804_9_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_10_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000544017_length(transcript)=705nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC

>1804_1804_10_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_11_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000599794_length(transcript)=903nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC
CTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCC
CGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGG
GGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTGGTCTCGGAATCTAAAAACCCTCGCTGTGTCTTCCTGTGTGTTGCGTGATCTGTG

>1804_1804_11_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_12_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000607714_length(transcript)=858nt_BP=238nt
GCGGCGGCGGCTCGGGCAGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCA
CGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGA
GGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCG
AGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGA
CCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCT
GGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAA
CAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGC
CTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCC
CGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGG

>1804_1804_12_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000252699_TIMM50_chr19_39978701_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_13_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976327_ENST00000314349_length(transcript)=968nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCG
AGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCC
TCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTAT
ATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCC
TATTCCGGGACGCCACAAGATACATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGG
ACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGG
ATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGC
TGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCT
TCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCC

>1804_1804_13_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976327_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_14_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976327_ENST00000607714_length(transcript)=1114nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCG
AGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCC
TCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTAT
ATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCC
TATTCCGGGACGCCACAAGATACATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGG
ACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGG
ATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGC
TGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCT
TCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCC
CCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGA
TGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGA

>1804_1804_14_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976327_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_15_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976328_ENST00000314349_length(transcript)=968nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCG
AGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCC
TCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTAT
ATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCC
TATTCCGGGACGCCACAAGATACATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGG
ACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGG
ATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGC
TGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCT
TCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCC

>1804_1804_15_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976328_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_16_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976328_ENST00000607714_length(transcript)=1114nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCG
AGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGGAACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCC
TCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGTTTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTAT
ATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTGCGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCC
TATTCCGGGACGCCACAAGATACATGGATGGACACCATGTAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGG
ACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGG
ATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGC
TGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCT
TCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCC
CCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGA
TGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGA

>1804_1804_16_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39976328_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_17_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000314349_length(transcript)=644nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC

>1804_1804_17_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_18_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000544017_length(transcript)=637nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC

>1804_1804_18_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_19_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000599794_length(transcript)=835nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC
AGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTG
ATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTGGTCTCGGAATCTAAAAACCCTCGCTGTGTCTT

>1804_1804_19_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_20_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000607714_length(transcript)=790nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC
AGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTG

>1804_1804_20_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978700_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_21_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000314349_length(transcript)=644nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC

>1804_1804_21_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_22_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000544017_length(transcript)=637nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC

>1804_1804_22_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_23_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000599794_length(transcript)=835nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC
AGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTG
ATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCAGAGCAGATTTTTCACCCTGGTCTCGGAATCTAAAAACCCTCGCTGTGTCTT

>1804_1804_23_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_24_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000607714_length(transcript)=790nt_BP=170nt
GCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGTACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCA
TGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGGACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCAT
GTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGC
CCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAA
CCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCC
TGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTC
TGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCC
AGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTG

>1804_1804_24_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000390009_TIMM50_chr19_39978701_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_25_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976327_ENST00000314349_length(transcript)=1019nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGG
AACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGT
TTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTG
CGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATACATGGATGGACACCATG
TAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACG
GCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTG
TGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGG
AGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCA
AACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCC

>1804_1804_25_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976327_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_26_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976327_ENST00000607714_length(transcript)=1165nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGG
AACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGT
TTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTG
CGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATACATGGATGGACACCATG
TAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACG
GCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTG
TGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGG
AGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCA
AACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCC
AATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATC

>1804_1804_26_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976327_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_27_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976328_ENST00000314349_length(transcript)=1019nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGG
AACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGT
TTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTG
CGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATACATGGATGGACACCATG
TAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACG
GCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTG
TGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGG
AGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCA
AACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCC

>1804_1804_27_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976328_ENST00000314349_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_28_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976328_ENST00000607714_length(transcript)=1165nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGATGATCATCGAGCCCACCAGCCCTTGCCTTCTCCCAGACCCTCTGCAGG
AACCGTACTACCAGCCACCCTACACGCTCGTTTTGGAGCTCACCGGCGTCCTCTTGCATCCTGAGTGGTCGCTGGCCACTGGCTGGAGGT
TTAAGAAGCGCCCAGGCATCGAGACCTTGTTCCAGCAGCTTGCCCCTTTATATGAAATTGTCATCTTTACGTCAGAGACTGGCATGACTG
CGTTTCCACTCATTGATAGTGTGGACCCCCATGGCTTCATCTCCTACCGCCTATTCCGGGACGCCACAAGATACATGGATGGACACCATG
TAAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACTGCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACG
GCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATCTGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTG
TGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGGCGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGG
AGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCCTTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCA
AACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCAGTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCC
AATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGGGGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATC

>1804_1804_28_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39976328_ENST00000607714_length(amino acids)=283AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLH
PEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCK
KEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLG

--------------------------------------------------------------
>1804_1804_29_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000314349_length(transcript)=695nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA

>1804_1804_29_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_30_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000544017_length(transcript)=688nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA

>1804_1804_30_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_31_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000599794_length(transcript)=886nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA
GTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGG
GGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCA

>1804_1804_31_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_32_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000607714_length(transcript)=841nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA
GTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGG
GGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCA

>1804_1804_32_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978700_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_33_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000314349_length(transcript)=695nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA

>1804_1804_33_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000314349_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_34_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000544017_length(transcript)=688nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA

>1804_1804_34_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000544017_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_35_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000599794_length(transcript)=886nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA
GTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGG
GGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCA

>1804_1804_35_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000599794_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------
>1804_1804_36_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000607714_length(transcript)=841nt_BP=221nt
AGAGGGGCGGGAGCTGAGGCGGGAGCGGACAGGCTGGTGGGCGAGCGAGAGGCGGCGGAATGGTGGACTACCACGCGGCGAACCAGTCGT
ACCAGTACGGCCCCAGCAGCGCGGGCAATGGCGCTGGCGGCGGGGGCAGCATGGGCGACTACATGGCCCAGGAGGACGACTGGGACCGGG
ACCTGCTGCTGGACCCGGCCTGGGAGAAGCAGCAGCGCAAGGATATTTCATGTCTGAATCGGGACCCAGCTCGAGTAGTAGTTGTGGACT
GCAAGAAGGAAGCCTTCCGCCTGCAGCCCTATAACGGCGTTGCCCTGCGGCCCTGGGACGGCAACTCTGATGACCGGGTCTTGTTGGATC
TGTCTGCCTTCCTCAAGACCATTGCACTGAATGGTGTGGAGGACGTGCGAACCGTGCTGGAGCACTATGCCCTGGAGGATGACCCGCTGG
CGGCTTTCAAACAGCGGCAAAGCCGGCTAGAGCAGGAGGAGCAGCAGCGCCTGGCCGAGCTCTCCAAGTCCAACAAGCAGAACCTCTTCC
TTGGCTCCCTCACCAGCCGCTTGTGGCCTCGCTCCAAACAGCCCTGAACTCTGGGCCTCCTCAAACTCAGTGCCTGGGTCCAGGGCCCCA
GTGCTTCCAGACCAAGACTTGGGCCACCACTTGTCCAATAAAGTACATCCCAGACGCCACACCTGCTGTGTCCCGAGAGTCTCCAGATGG
GGGCATCAGGGTGAGGTCCGGGACTCTTGGGTCATCGTCCCACAGTGGCTGATCGGCTGCCAAGCACAGTGGGGGTGCTTTGTTGGATCA

>1804_1804_36_ACTN4-TIMM50_ACTN4_chr19_39138547_ENST00000424234_TIMM50_chr19_39978701_ENST00000607714_length(amino acids)=175AA_BP=54
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACTN4-TIMM50


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+11412_2654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+11412_2654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+11412_2654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+12112_2654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+11412_2654.0693.0VCL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976327ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39976327ENST00000390009+11440_6154.0693.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39976328ENST00000390009+11440_6154.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978700ENST00000390009+11440_6154.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+121108_12654.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000252699+12140_6154.0912.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+114108_12654.0693.0VCL
HgeneACTN4chr19:39138547chr19:39978701ENST00000390009+11440_6154.0693.0VCL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ACTN4-TIMM50


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ACTN4-TIMM50


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C4551527Focal segmental glomerulosclerosis 19GENOMICS_ENGLAND;UNIPROT
HgeneACTN4C0007097Carcinoma1CTD_human
HgeneACTN4C0019193Hepatitis, Toxic1CTD_human
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTN4C0205696Anaplastic carcinoma1CTD_human
HgeneACTN4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneACTN4C0205698Undifferentiated carcinoma1CTD_human
HgeneACTN4C0205699Carcinomatosis1CTD_human
HgeneACTN4C0860207Drug-Induced Liver Disease1CTD_human
HgeneACTN4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneACTN4C1262760Hepatitis, Drug-Induced1CTD_human
HgeneACTN4C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneACTN4C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneACTN4C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneACTN4C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC45401713-METHYLGLUTACONIC ACIDURIA, TYPE IX2GENOMICS_ENGLAND;ORPHANET;UNIPROT