Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CANX-CCT4 (FusionGDB2 ID:HG821TG10575)

Fusion Gene Summary for CANX-CCT4

check button Fusion gene summary
Fusion gene informationFusion gene name: CANX-CCT4
Fusion gene ID: hg821tg10575
HgeneTgene
Gene symbol

CANX

CCT4

Gene ID

821

10575

Gene namecalnexinchaperonin containing TCP1 subunit 4
SynonymsCNX|IP90|P90CCT-DELTA|Cctd|SRB
Cytomap('CANX')('CCT4')

5q35.3

2p15

Type of geneprotein-codingprotein-coding
Descriptioncalnexinepididymis secretory sperm binding proteinmajor histocompatibility complex class I antigen-binding protein p88T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding
Modification date2020031320200313
UniProtAcc

P27824

.
Ensembl transtripts involved in fusion geneENST00000503126, ENST00000247461, 
ENST00000415618, ENST00000452673, 
ENST00000504734, ENST00000512607, 
Fusion gene scores* DoF score15 X 16 X 11=26408 X 9 X 6=432
# samples 219
** MAII scorelog2(21/2640*10)=-3.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CANX [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCANX(179136060)-CCT4(62099723), # samples:1
Anticipated loss of major functional domain due to fusion event.CANX-CCT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CANX-CCT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CANX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CCT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2795-01ACANXchr5

179136060

+CCT4chr2

62099723

-


Top

Fusion Gene ORF analysis for CANX-CCT4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000503126ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-
3UTR-intronENST00000503126ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
3UTR-intronENST00000503126ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
3UTR-intronENST00000503126ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
3UTR-intronENST00000503126ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000247461ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000247461ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000247461ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000247461ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000415618ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000415618ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000415618ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000415618ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000452673ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000452673ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000452673ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000452673ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000504734ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000504734ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000504734ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000504734ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000512607ENST00000461540CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000512607ENST00000538252CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000512607ENST00000544079CANXchr5

179136060

+CCT4chr2

62099723

-
5CDS-intronENST00000512607ENST00000544185CANXchr5

179136060

+CCT4chr2

62099723

-
In-frameENST00000247461ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-
In-frameENST00000415618ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-
In-frameENST00000452673ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-
In-frameENST00000504734ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-
In-frameENST00000512607ENST00000394440CANXchr5

179136060

+CCT4chr2

62099723

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000504734CANXchr5179136060+ENST00000394440CCT4chr262099723-1816718371212391
ENST00000415618CANXchr5179136060+ENST00000394440CCT4chr262099723-1806708271202391
ENST00000452673CANXchr5179136060+ENST00000394440CCT4chr262099723-17736751471169340
ENST00000247461CANXchr5179136060+ENST00000394440CCT4chr262099723-18267282001222340
ENST00000512607CANXchr5179136060+ENST00000394440CCT4chr262099723-16855872661081271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504734ENST00000394440CANXchr5179136060+CCT4chr262099723-6.14E-050.9999386
ENST00000415618ENST00000394440CANXchr5179136060+CCT4chr262099723-6.20E-050.999938
ENST00000452673ENST00000394440CANXchr5179136060+CCT4chr262099723-0.0001522190.99984777
ENST00000247461ENST00000394440CANXchr5179136060+CCT4chr262099723-0.0001629170.99983704
ENST00000512607ENST00000394440CANXchr5179136060+CCT4chr262099723-0.0002218010.9997782

Top

Fusion Genomic Features for CANX-CCT4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for CANX-CCT4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179136060/chr2:62099723)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CANX

P27824

.
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615276_409176593.0RegionP domain (Extended arm)
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615278_345176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615348_405176593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615278_290176593.0RepeatNote=1-1
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615295_307176593.0RepeatNote=1-2
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615314_326176593.0RepeatNote=1-3
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615333_345176593.0RepeatNote=1-4
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615348_358176593.0RepeatNote=2-1
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615367_377176593.0RepeatNote=2-2
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615381_391176593.0RepeatNote=2-3
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615395_405176593.0RepeatNote=2-4
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+61521_481176593.0Topological domainLumenal
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615482_502176593.0TransmembraneHelical
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615482_502176593.0TransmembraneHelical
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615482_502176593.0TransmembraneHelical


Top

Fusion Gene Sequence for CANX-CCT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12791_12791_1_CANX-CCT4_CANX_chr5_179136060_ENST00000247461_CCT4_chr2_62099723_ENST00000394440_length(transcript)=1826nt_BP=728nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCACCCCCGCGG
TCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGAC
ATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTT
CATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGA
TTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGC
TTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCA
AGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAAC
TCAACCTGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGC
GCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGG
CCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCAT
CTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCA
TTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAA
CTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAAACACTCGATAATCTGGATAACTGACTAGCACCATTATGATCACCAGTA
TTGTGGCTGGAATGGAAGAAGATCACCTTGGTGTTCCTTGTTTGGAAGATTATTTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCA
TTTGCCTGAAGTTGTATTGAAACAATTTAATGAAAATATTAAATATTTGGTTTCAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTAT
TTCTGATACTTTTGAAAAACTAATAAAAACTAATAAAAGAAGCGTAAAAAGTGAGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCT
CATCACTGATAAATGCTCCCTGGCCTTAAAAACTACCAACATATAATATATATGCTGTCTTAAAAGTTAATGATCCAAGTGGCACCTCTC
TGAACCTACTTTGGCTTGGGAGGCTGCCCAGTTAAAACAAAAATAAGTTAATGGTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTA
TCCTATCATCCTAATTCCTTTTCCCAGTAATAATGACTGCTGTGTTGGATTCCTTCTGCAAATAAAAGTGTATACATATATGTAGCAAAT

>12791_12791_1_CANX-CCT4_CANX_chr5_179136060_ENST00000247461_CCT4_chr2_62099723_ENST00000394440_length(amino acids)=340AA_BP=176
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLITGC
ASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENA

--------------------------------------------------------------
>12791_12791_2_CANX-CCT4_CANX_chr5_179136060_ENST00000415618_CCT4_chr2_62099723_ENST00000394440_length(transcript)=1806nt_BP=708nt
AATCCGGCCAGGCGCTCGCGCTGGGTTCTGCTCACGCCCGTAGGGGCCCGCGTTCGCTGCAACGGGCCCTTCCTGATGGCCGATCGTCGG
ACTCCTACCCCTTTTGCCGGCTGCCGTTTGCCCCGTCAGCGAAGGGCGCGCGATGCGTCCCAAGTCTCGGCTCCAGGAACCAGACGGATC
ATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGAT
ATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTAC
AAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAA
GACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTT
GTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTAT
GAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGATTACAGGCTGT
GCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTA
TGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATTAACTGAATAT
TCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCATCTACACTAGCTGAAAATGCC
GGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGT
ATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATT
CTGAAAATAGATGATGTGGTAAACACTCGATAATCTGGATAACTGACTAGCACCATTATGATCACCAGTATTGTGGCTGGAATGGAAGAA
GATCACCTTGGTGTTCCTTGTTTGGAAGATTATTTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCATTTGCCTGAAGTTGTATTGA
AACAATTTAATGAAAATATTAAATATTTGGTTTCAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTATTTCTGATACTTTTGAAAAAC
TAATAAAAACTAATAAAAGAAGCGTAAAAAGTGAGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCTCATCACTGATAAATGCTCCC
TGGCCTTAAAAACTACCAACATATAATATATATGCTGTCTTAAAAGTTAATGATCCAAGTGGCACCTCTCTGAACCTACTTTGGCTTGGG
AGGCTGCCCAGTTAAAACAAAAATAAGTTAATGGTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTATCCTATCATCCTAATTCCTT
TTCCCAGTAATAATGACTGCTGTGTTGGATTCCTTCTGCAAATAAAAGTGTATACATATATGTAGCAAATCTTACTTAAACAAAAGGGTT

>12791_12791_2_CANX-CCT4_CANX_chr5_179136060_ENST00000415618_CCT4_chr2_62099723_ENST00000394440_length(amino acids)=391AA_BP=227
MLTPVGARVRCNGPFLMADRRTPTPFAGCRLPRQRRARDASQVSAPGTRRIMEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVI
EEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHH
AISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKK
RALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELV

--------------------------------------------------------------
>12791_12791_3_CANX-CCT4_CANX_chr5_179136060_ENST00000452673_CCT4_chr2_62099723_ENST00000394440_length(transcript)=1773nt_BP=675nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTG
GTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAG
GTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTT
GCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGAT
GGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATC
TCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGT
GGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTT
CGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCT
CTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGC
GTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTA
AGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAG
CCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAAACACTCGATAA
TCTGGATAACTGACTAGCACCATTATGATCACCAGTATTGTGGCTGGAATGGAAGAAGATCACCTTGGTGTTCCTTGTTTGGAAGATTAT
TTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCATTTGCCTGAAGTTGTATTGAAACAATTTAATGAAAATATTAAATATTTGGTTT
CAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTATTTCTGATACTTTTGAAAAACTAATAAAAACTAATAAAAGAAGCGTAAAAAGTG
AGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCTCATCACTGATAAATGCTCCCTGGCCTTAAAAACTACCAACATATAATATATAT
GCTGTCTTAAAAGTTAATGATCCAAGTGGCACCTCTCTGAACCTACTTTGGCTTGGGAGGCTGCCCAGTTAAAACAAAAATAAGTTAATG
GTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTATCCTATCATCCTAATTCCTTTTCCCAGTAATAATGACTGCTGTGTTGGATTCC

>12791_12791_3_CANX-CCT4_CANX_chr5_179136060_ENST00000452673_CCT4_chr2_62099723_ENST00000394440_length(amino acids)=340AA_BP=176
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLITGC
ASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENA

--------------------------------------------------------------
>12791_12791_4_CANX-CCT4_CANX_chr5_179136060_ENST00000504734_CCT4_chr2_62099723_ENST00000394440_length(transcript)=1816nt_BP=718nt
AGTGCACGCCAATCCGGCCAGGCGCTCGCGCTGGGTTCTGCTCACGCCCGTAGGGGCCCGCGTTCGCTGCAACGGGCCCTTCCTGATGGC
CGATCGTCGGACTCCTACCCCTTTTGCCGGCTGCCGTTTGCCCCGTCAGCGAAGGGCGCGCGATGCGTCCCAAGTCTCGGCTCCAGGAAC
CAGACGGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGA
TGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAA
GGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAA
AGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGA
TAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCAT
TGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGAT
TACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTGTTCGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGCGCTCCATTCA
TGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGGCTCTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATT
AACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACTGCGTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCATCTACACTAGC
TGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAACTAAGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCATTAATGTCCG
AAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCCAGCCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAACTGAAACTGT
TCGGAGCATTCTGAAAATAGATGATGTGGTAAACACTCGATAATCTGGATAACTGACTAGCACCATTATGATCACCAGTATTGTGGCTGG
AATGGAAGAAGATCACCTTGGTGTTCCTTGTTTGGAAGATTATTTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCATTTGCCTGAA
GTTGTATTGAAACAATTTAATGAAAATATTAAATATTTGGTTTCAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTATTTCTGATACT
TTTGAAAAACTAATAAAAACTAATAAAAGAAGCGTAAAAAGTGAGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCTCATCACTGAT
AAATGCTCCCTGGCCTTAAAAACTACCAACATATAATATATATGCTGTCTTAAAAGTTAATGATCCAAGTGGCACCTCTCTGAACCTACT
TTGGCTTGGGAGGCTGCCCAGTTAAAACAAAAATAAGTTAATGGTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTATCCTATCATC
CTAATTCCTTTTCCCAGTAATAATGACTGCTGTGTTGGATTCCTTCTGCAAATAAAAGTGTATACATATATGTAGCAAATCTTACTTAAA

>12791_12791_4_CANX-CCT4_CANX_chr5_179136060_ENST00000504734_CCT4_chr2_62099723_ENST00000394440_length(amino acids)=391AA_BP=227
MLTPVGARVRCNGPFLMADRRTPTPFAGCRLPRQRRARDASQVSAPGTRRIMEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVI
EEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHH
AISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKK
RALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELV

--------------------------------------------------------------
>12791_12791_5_CANX-CCT4_CANX_chr5_179136060_ENST00000512607_CCT4_chr2_62099723_ENST00000394440_length(transcript)=1685nt_BP=587nt
GTTCTGCGGCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCAC
CCCCGCGGTCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCA
TGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGC
TCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTC
AGGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCA
TCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTG
GTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGATTACAGGCTGTGCCAGCCCTGGAAAAACAGTTACAATTGTTG
TTCGTGGTTCTAACAAACTGGTGATTGAAGAAGCTGAGCGCTCCATTCATGATGCCCTATGTGTTATTCGTTGTTTAGTGAAGAAGAGGG
CTCTTATTGCAGGAGGTGGTGCTCCAGAAATAGAGTTGGCCCTACGATTAACTGAATATTCACGAACACTGAGTGGTATGGAATCCTACT
GCGTTCGTGCTTTTGCAGATGCTATGGAGGTCATTCCATCTACACTAGCTGAAAATGCCGGCCTGAATCCCATTTCTACAGTAACAGAAC
TAAGAAACCGGCATGCCCAGGGAGAAAAAACTGCAGGCATTAATGTCCGAAAGGGTGGTATTTCCAACATTTTGGAGGAACTGGTTGTCC
AGCCTCTGTTGGTATCAGTCAGTGCTCTGACTCTTGCAACTGAAACTGTTCGGAGCATTCTGAAAATAGATGATGTGGTAAACACTCGAT
AATCTGGATAACTGACTAGCACCATTATGATCACCAGTATTGTGGCTGGAATGGAAGAAGATCACCTTGGTGTTCCTTGTTTGGAAGATT
ATTTCCTCTGAATTTCTGGGCTTGGTCTTCCAGTTGGCATTTGCCTGAAGTTGTATTGAAACAATTTAATGAAAATATTAAATATTTGGT
TTCAAAAGGCAGATTTATCTTCTCCCAACATTCTGTTATTTCTGATACTTTTGAAAAACTAATAAAAACTAATAAAAGAAGCGTAAAAAG
TGAGTTTACATGTTGAGGAAAAAAATGGCCCAATATGCTCATCACTGATAAATGCTCCCTGGCCTTAAAAACTACCAACATATAATATAT
ATGCTGTCTTAAAAGTTAATGATCCAAGTGGCACCTCTCTGAACCTACTTTGGCTTGGGAGGCTGCCCAGTTAAAACAAAAATAAGTTAA
TGGTACAGAAAGAGAATGAAAAATGAAAGCCTCCTTTTATCCTATCATCCTAATTCCTTTTCCCAGTAATAATGACTGCTGTGTTGGATT

>12791_12791_5_CANX-CCT4_CANX_chr5_179136060_ENST00000512607_CCT4_chr2_62099723_ENST00000394440_length(amino acids)=271AA_BP=107
MLLLHLPRLLTKLQFQQGKYILLILLTEELCQGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIE
CGGAYVKLLSKTPELNLITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMES
YCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CANX-CCT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCANXchr5:179136060chr2:62099723ENST00000247461+615326_359176.0593.0PPIB
HgeneCANXchr5:179136060chr2:62099723ENST00000452673+615326_359176.0593.0PPIB
HgeneCANXchr5:179136060chr2:62099723ENST00000504734+615326_359176.0593.0PPIB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CANX-CCT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCANXP27824DB00031TenecteplaseBiotechApproved
HgeneCANXP27824DB11348Calcium PhosphateLigandSmall moleculeApproved
HgeneCANXP27824DB13999Moroctocog alfaChaperoneBiotechApproved
HgeneCANXP27824DB14481Calcium phosphate dihydrateSmall moleculeApproved
HgeneCANXP27824DB00025Antihemophilic factor, human recombinantChaperoneBiotechApproved|Investigational
HgeneCANXP27824DB11093Calcium citrateLigandSmall moleculeApproved|Investigational
HgeneCANXP27824DB13998Lonoctocog alfaChaperoneBiotechApproved|Investigational

Top

Related Diseases for CANX-CCT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANXC0019193Hepatitis, Toxic1CTD_human
HgeneCANXC0151744Myocardial Ischemia1CTD_human
HgeneCANXC0860207Drug-Induced Liver Disease1CTD_human
HgeneCANXC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCANXC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCANXC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCANXC4279912Chemically-Induced Liver Toxicity1CTD_human