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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CANX-MLIP (FusionGDB2 ID:HG821TG90523) |
Fusion Gene Summary for CANX-MLIP |
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Fusion gene information | Fusion gene name: CANX-MLIP | Fusion gene ID: hg821tg90523 | Hgene | Tgene | Gene symbol | CANX | MLIP | Gene ID | 821 | 90523 |
Gene name | calnexin | muscular LMNA interacting protein | |
Synonyms | CNX|IP90|P90 | C6orf142|CIP | |
Cytomap | ('CANX')('MLIP') 5q35.3 | 6p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calnexinepididymis secretory sperm binding proteinmajor histocompatibility complex class I antigen-binding protein p88 | muscular LMNA-interacting proteincardiac ISL1-interacting proteinmuscle-enriched A-type lamin interacting proteinmuscular-enriched A-type laminin-interacting protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P27824 | . | |
Ensembl transtripts involved in fusion gene | ENST00000247461, ENST00000452673, ENST00000415618, ENST00000503126, ENST00000504734, ENST00000512607, | ||
Fusion gene scores | * DoF score | 15 X 16 X 11=2640 | 8 X 7 X 8=448 |
# samples | 21 | 11 | |
** MAII score | log2(21/2640*10)=-3.65207669657969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/448*10)=-2.02599520853294 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CANX [Title/Abstract] AND MLIP [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CANX(179156344)-MLIP(53986265), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CANX-MLIP |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CANX-MLIP |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CANX-MLIP |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:179156344/:53986265) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CANX | . |
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CANX-MLIP |
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Fusion Gene PPI Analysis for CANX-MLIP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CANX-MLIP |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CANX | P27824 | DB00031 | Tenecteplase | Biotech | Approved | |
Hgene | CANX | P27824 | DB11348 | Calcium Phosphate | Ligand | Small molecule | Approved |
Hgene | CANX | P27824 | DB13999 | Moroctocog alfa | Chaperone | Biotech | Approved |
Hgene | CANX | P27824 | DB14481 | Calcium phosphate dihydrate | Small molecule | Approved | |
Hgene | CANX | P27824 | DB00025 | Antihemophilic factor, human recombinant | Chaperone | Biotech | Approved|Investigational |
Hgene | CANX | P27824 | DB11093 | Calcium citrate | Ligand | Small molecule | Approved|Investigational |
Hgene | CANX | P27824 | DB13998 | Lonoctocog alfa | Chaperone | Biotech | Approved|Investigational |
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Related Diseases for CANX-MLIP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CANX | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | CANX | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | CANX | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | CANX | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | CANX | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | CANX | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | CANX | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |