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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARID1A-MAST2 (FusionGDB2 ID:HG8289TG23139) |
Fusion Gene Summary for ARID1A-MAST2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARID1A-MAST2 | Fusion gene ID: hg8289tg23139 | Hgene | Tgene | Gene symbol | ARID1A | MAST2 | Gene ID | 8289 | 23139 |
| Gene name | AT-rich interaction domain 1A | microtubule associated serine/threonine kinase 2 | |
| Synonyms | B120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1 | MAST205|MTSSK | |
| Cytomap | ('ARID1A')('MAST2') 1p36.11 | 1p34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, | microtubule-associated serine/threonine-protein kinase 2microtubule associated testis specific serine/threonine protein kinase | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | O14497 | Q6P0Q8 | |
| Ensembl transtripts involved in fusion gene | ENST00000324856, ENST00000457599, ENST00000374152, ENST00000540690, | ||
| Fusion gene scores | * DoF score | 29 X 19 X 15=8265 | 14 X 16 X 10=2240 |
| # samples | 45 | 17 | |
| ** MAII score | log2(45/8265*10)=-4.19901791296264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/2240*10)=-3.71989208080727 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARID1A [Title/Abstract] AND MAST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARID1A | GO:0006337 | nucleosome disassembly | 8895581 |
| Hgene | ARID1A | GO:0006338 | chromatin remodeling | 11726552 |
| Hgene | ARID1A | GO:0030520 | intracellular estrogen receptor signaling pathway | 12200431 |
| Hgene | ARID1A | GO:0030521 | androgen receptor signaling pathway | 12200431 |
| Hgene | ARID1A | GO:0042921 | glucocorticoid receptor signaling pathway | 12200431 |
| Hgene | ARID1A | GO:0045893 | positive regulation of transcription, DNA-templated | 12200431 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
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Fusion Gene ORF analysis for ARID1A-MAST2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000324856 | ENST00000477968 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| 5CDS-intron | ENST00000457599 | ENST00000477968 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| In-frame | ENST00000324856 | ENST00000361297 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| In-frame | ENST00000324856 | ENST00000372009 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| In-frame | ENST00000457599 | ENST00000361297 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| In-frame | ENST00000457599 | ENST00000372009 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-3CDS | ENST00000374152 | ENST00000361297 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-3CDS | ENST00000374152 | ENST00000372009 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-3CDS | ENST00000540690 | ENST00000361297 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-3CDS | ENST00000540690 | ENST00000372009 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-intron | ENST00000374152 | ENST00000477968 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| intron-intron | ENST00000540690 | ENST00000477968 | ARID1A | chr1 | 27024031 | + | MAST2 | chr1 | 46290104 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000324856 | ARID1A | chr1 | 27024031 | + | ENST00000372009 | MAST2 | chr1 | 46290104 | + | 6158 | 1508 | 371 | 6157 | 1929 |
| ENST00000324856 | ARID1A | chr1 | 27024031 | + | ENST00000361297 | MAST2 | chr1 | 46290104 | + | 6786 | 1508 | 371 | 6727 | 2118 |
| ENST00000457599 | ARID1A | chr1 | 27024031 | + | ENST00000372009 | MAST2 | chr1 | 46290104 | + | 5787 | 1137 | 0 | 5786 | 1928 |
| ENST00000457599 | ARID1A | chr1 | 27024031 | + | ENST00000361297 | MAST2 | chr1 | 46290104 | + | 6415 | 1137 | 0 | 6356 | 2118 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ARID1A-MAST2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ARID1A-MAST2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:/chr1:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID1A | MAST2 |
| FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. | FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ARID1A-MAST2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6380_6380_1_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000324856_MAST2_chr1_46290104_ENST00000361297_length(transcript)=6786nt_BP=1508nt GAAAGCGGAGAGTCACAGCGGGGCCAGGCCCTGGGGAGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAATGAG CCGGGAGAGCCGGGTCCCGAGCCTACAGAGCCGGGAGCAGCTGAGCCGCCGGCGCCTCGGCCGCCGCCGCCGCCTCCTCCTCCTCCGCCG CCGCCAGCCCGGAGCCTGAGCCGGCGGGGCGGGGGGGAGAGGAGCGAGCGCAGCGCAGCAGCGGAGCCCCGCGAGGCCCGCCCGGGCGGG TGGGGAGGGCAGCCCGGGGGACTGGGCCCCGGGGCGGGGTGGGAGGGGGGGAGAAGACGAAGACAGGGCCGGGTCTCTCCGCGGACGAGA CAGCGGGGATCATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAG CCGAGCAGCAGCAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGG AAAGCGAGGGCCCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCG GAGCCGGCAGCGGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACC TCACGGAGCCGCCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAG CCTACGGCTTCGGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAAC AAAGCCCTGGCCTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCT TCCCCAACCACCAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTG GCACTCCGGGCTCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCG CTCAGCAGCGCTTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACC AACTGCTCACGTCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCA AGGGCCCGGCGGACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGA GCCACCACGCGCCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGATGTAGTAACTGGAGTTAGTC CCCTGCTCTTCAGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAAACTTCAGCGACAACTGAGTCAGGATGATTGTA AGTTATGGAGAGGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTCCAGCAGTGTACATAGCAGTGTGGGACAGGTGA CTTGGCAGTCGTCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGGACAGTCTGCACCTTCTCTTACTGCTGGCCTGA AGGAGTTGAGCCTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTTGATTGTGACCTCTAGCACATCACCTACACTAC CACGGCCACACTCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCGGAATTTCTCTCCAAATGCACCTGCTCACTTTT CTTTTGTTCCTGCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTCTTCAGGATATGGAACTAACACTCCTAGCTCCA CTGTCTCATCATCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTACAGCTGATGAGCTGCACTTTTTGACGAAGCATT TCAGCACAGAGAGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCGCTCCCGGAGCCTCAGTCCCGGACGATCCCCAG TATCCTTTGACAGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAAGGCCACCGCACAAATGGAAGAGCGACTAGCAG AGTTTATTTCCTCCAACACTCCAGACAGCGTGCTGCCCTTGGCAGATGGAGCCCTGAGCTTTATTCATCATCAGGTGATTGAGATGGCCC GAGACTGCCTGGATAAATCTCGGAGTGGCCTCATTACATCACAATACTTCTACGAACTTCAAGATAATTTGGAGAAACTTTTACAAGATG CTCATGAGCGCTCAGAGAGCTCAGAAGTGGCTTTTGTGATGCAGCTGGTGAAAAAGCTGATGATTATCATTGCCCGCCCAGCACGTCTCC TGGAATGCCTGGAGTTTGACCCTGAAGAGTTCTACCACCTTTTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATGTG ACATTCCCCGCTACATCGTTAGCCAGCTGGGCCTCACCCGGGATCCCCTAGAAGAAATGGCCCAGTTGAGCAGCTGTGACAGTCCTGACA CTCCAGAGACAGATGATTCTATTGAGGGCCATGGGGCATCTCTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAAGC TCATCAGCAATGGCGCCTATGGGGCTGTATTTCTGGTGCGGCACAAGTCCACCCGGCAGCGCTTTGCCATGAAGAAGATCAACAAGCAGA ACCTGATCCTACGGAACCAGATCCAGCAGGCCTTCGTGGAGCGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTTCT GCTCCTTTGATACCAAGCGCCACTTGTGCATGGTGATGGAGTACGTTGAAGGGGGAGACTGTGCCACTCTGCTGAAGAATATTGGGGCCC TGCCTGTGGACATGGTGCGTCTATACTTTGCGGAAACTGTGCTGGCCCTGGAGTACTTACACAACTATGGCATCGTGCACCGTGACCTCA AGCCTGACAACCTCCTAATTACATCCATGGGGCACATCAAGCTCACGGACTTTGGACTGTCCAAAATTGGCCTCATGAGTCTGACAACGA ACTTGTATGAGGGTCATATTGAAAAGGATGCCCGGGAATTCCTGGACAAGCAGGTATGCGGGACCCCAGAATACATTGCGCCTGAGGTGA TCCTGCGCCAGGGCTATGGGAAGCCAGTGGACTGGTGGGCCATGGGCATTATCCTGTATGAGTTCCTGGTGGGCTGCGTCCCTTTTTTTG GAGATACTCCGGAGGAGCTCTTTGGGCAGGTGATCAGTGATGAGATTGTGTGGCCTGAGGGTGATGAGGCACTGCCCCCAGACGCCCAGG ACCTCACCTCCAAACTGCTCCACCAGAACCCTCTGGAGAGACTTGGCACAGGCAGTGCCTATGAGGTGAAGCAGCACCCATTCTTTACTG GTCTGGACTGGACAGGACTTCTCCGCCAGAAGGCTGAATTTATTCCTCAGTTGGAGTCAGAGGATGATACTAGCTATTTTGACACCCGCT CAGAGCGATACCACCACATGGACTCGGAGGATGAGGAAGAAGTGAGTGAGGATGGCTGCCTTGAGATCCGCCAGTTCTCTTCCTGCTCTC CAAGGTTCAACAAGGTGTACAGCAGCATGGAGCGGCTCTCACTGCTCGAGGAGCGCCGGACACCACCCCCGACCAAGCGCAGCCTGAGTG AGGAGAAGGAGGACCATTCAGATGGCCTGGCAGGGCTCAAAGGCCGAGACCGGAGCTGGGTGATTGGCTCCCCTGAGATATTACGGAAGC GGCTGTCGGTGTCTGAGTCATCCCACACAGAGAGTGACTCAAGCCCTCCAATGACAGTGCGACGCCGCTGCTCAGGCCTCCTGGATGCGC CTCGGTTCCCGGAGGGCCCTGAGGAGGCCAGCAGCACCCTCAGGAGGCAACCACAGGAGGGTATATGGGTCCTGACACCCCCATCTGGAG AGGGGGTATCTGGGCCTGTCACTGAACACTCAGGGGAGCAGCGGCCAAAGCTGGATGAGGAAGCTGTTGGCCGGAGCAGTGGTTCCAGTC CAGCTATGGAGACCCGAGGCCGTGGGACCTCACAGCTGGCTGAGGGAGCCACAGCCAAGGCCATCAGTGACCTGGCTGTGCGTAGGGCCC GCCACCGGCTGCTCTCTGGGGACTCAACAGAGAAGCGCACTGCTCGCCCTGTCAACAAAGTGATCAAGTCCGCCTCAGCCACAGCCCTCT CACTCCTCATTCCTTCGGAACACCACACCTGCTCCCCGTTGGCCAGCCCCATGTCCCCACATTCTCAGTCGTCCAACCCATCATCCCGGG ACTCTTCTCCAAGCAGGGACTTCTTGCCAGCCCTTGGCAGCATGAGGCCTCCCATCATCATCCACCGAGCTGGCAAGAAGTATGGCTTCA CCCTGCGGGCCATTCGCGTCTACATGGGTGACTCCGATGTCTACACCGTGCACCATATGGTGTGGCACGTGGAGGATGGAGGTCCGGCCA GTGAGGCAGGGCTTCGTCAAGGTGACCTCATCACCCATGTCAATGGGGAACCTGTGCATGGCCTGGTGCACACGGAGGTGGTAGAGCTGA TCCTGAAGAGTGGAAACAAGGTGGCCATTTCAACAACTCCCCTGGAGAACACATCCATTAAAGTGGGGCCAGCTCGGAAGGGCAGCTACA AGGCCAAGATGGCCCGAAGGAGCAAGAGGAGCCGCGGCAAGGATGGGCAAGAAAGCAGAAAAAGGAGCTCCCTGTTCCGCAAGATCACCA AGCAAGCATCCCTGCTCCACACCAGCCGCAGCCTTTCTTCCCTTAACCGCTCCTTGTCATCAGGGGAGAGTGGGCCAGGCTCTCCCACAC ACAGCCACAGCCTTTCCCCCCGATCTCCCACTCAAGGCTACCGGGTGACCCCCGATGCTGTGCATTCAGTGGGAGGGAATTCATCACAGA GCAGCTCCCCCAGCTCCAGCGTGCCCAGTTCCCCAGCCGGCTCTGGGCACACACGGCCCAGCTCCCTCCACGGTCTGGCACCCAAGCTCC AACGCCAGTACCGCTCTCCACGGCGCAAGTCAGCAGGCAGCATCCCACTGTCACCACTGGCCCACACCCCTTCTCCCCCACCCCCAACAG CTTCACCTCAGCGGTCCCCATCGCCCCTGTCTGGCCATGTAGCCCAGGCCTTTCCCACAAAGCTTCACTTGTCACCTCCCCTGGGCAGGC AACTCTCACGGCCCAAGAGTGCGGAGCCACCCCGTTCACCACTACTCAAGAGGGTGCAGTCGGCTGAGAAACTGGCAGCAGCACTTGCCG CCTCTGAGAAGAAGCTAGCCACTTCTCGCAAGCACAGCCTTGACCTGCCCCACTCTGAACTAAAGAAGGAACTGCCGCCCAGGGAAGTGA GCCCTCTGGAGGTAGTTGGAGCCAGGAGTGTGCTGTCTGGCAAGGGGGCCCTGCCAGGGAAGGGGGTGCTGCAGCCTGCTCCCTCACGGG CCCTAGGCACCCTCCGGCAGGACCGAGCCGAACGACGGGAGTCGCTGCAGAAGCAAGAAGCCATTCGTGAGGTGGACTCCTCAGAGGACG ACACCGAGGAAGGGCCTGAGAACAGCCAGGGTGCACAGGAGCTGAGCTTGGCACCTCACCCAGAAGTGAGCCAGAGTGTGGCCCCTAAAG GAGCAGGAGAGAGTGGGGAAGAGGATCCTTTCCCGTCCAGAGACCCTAGGAGCCTGGGCCCAATGGTCCCAAGCCTATTGACAGGGATCA CACTGGGGCCTCCCAGAATGGAAAGTCCCAGTGGTCCCCACAGGAGGCTCGGGAGCCCACAAGCCATTGAGGAGGCTGCCAGCTCCTCCT CAGCAGGCCCCAACCTAGGTCAGTCTGGAGCCACAGACCCCATCCCTCCTGAAGGTTGCTGGAAGGCCCAGCACCTCCACACCCAGGCAC TAACAGCACTTTCTCCCAGCACTTCGGGACTCACCCCCACCAGCAGTTGCTCTCCTCCCAGCTCCACCTCTGGGAAGCTGAGCATGTGGT CCTGGAAATCCCTTATTGAGGGCCCAGACAGGGCATCCCCAAGCAGAAAGGCAACCATGGCAGGTGGGCTAGCCAACCTCCAGGATTTGG AAAACACAACTCCAGCCCAGCCTAAGAACCTGTCTCCCAGGGAGCAGGGGAAGACACAGCCACCTAGTGCCCCCAGACTGGCCCATCCAT CTTATGAGGATCCCAGCCAGGGCTGGCTATGGGAGTCTGAGTGTGCACAAGCAGTGAAAGAGGATCCAGCCCTGAGCATCACCCAAGTGC CTGATGCCTCAGGTGACAGAAGGCAGGACGTTCCATGCCGAGGCTGCCCCCTCACCCAGAAGTCTGAGCCCAGCCTCAGGAGGGGCCAAG AACCAGGGGGCCATCAAAAGCATCGGGATTTGGCATTGGTTCCAGATGAGCTTTTAAAGCAAACATAGCAGTTGTTTGCCATTTCTTGCA >6380_6380_1_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000324856_MAST2_chr1_46290104_ENST00000361297_length(amino acids)=2118AA_BP=367 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA PMSPGSSGGGGQPLARTPQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQS SGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFD SEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHER SESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPET DDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFD TKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTS KLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFN KVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFP EGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRL LSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRA IRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKM ARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSP SSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSR PKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGT LRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGP PRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKS LIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDAS -------------------------------------------------------------- >6380_6380_2_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000324856_MAST2_chr1_46290104_ENST00000372009_length(transcript)=6158nt_BP=1508nt GAAAGCGGAGAGTCACAGCGGGGCCAGGCCCTGGGGAGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAATGAG CCGGGAGAGCCGGGTCCCGAGCCTACAGAGCCGGGAGCAGCTGAGCCGCCGGCGCCTCGGCCGCCGCCGCCGCCTCCTCCTCCTCCGCCG CCGCCAGCCCGGAGCCTGAGCCGGCGGGGCGGGGGGGAGAGGAGCGAGCGCAGCGCAGCAGCGGAGCCCCGCGAGGCCCGCCCGGGCGGG TGGGGAGGGCAGCCCGGGGGACTGGGCCCCGGGGCGGGGTGGGAGGGGGGGAGAAGACGAAGACAGGGCCGGGTCTCTCCGCGGACGAGA CAGCGGGGATCATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAG CCGAGCAGCAGCAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGG AAAGCGAGGGCCCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCG GAGCCGGCAGCGGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACC TCACGGAGCCGCCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAG CCTACGGCTTCGGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAAC AAAGCCCTGGCCTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCT TCCCCAACCACCAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTG GCACTCCGGGCTCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCG CTCAGCAGCGCTTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACC AACTGCTCACGTCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCA AGGGCCCGGCGGACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGA GCCACCACGCGCCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGATGTAGTAACTGGAGTTAGTC CCCTGCTCTTCAGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAAACTTCAGCGACAACTGAGTCAGGATGATTGTA AGTTATGGAGAGGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTCCAGCAGTGTACATAGCAGTGTGGGACAGGTGA CTTGGCAGTCGTCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGGACAGTCTGCACCTTCTCTTACTGCTGGCCTGA AGGAGTTGAGCCTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTTGATTGTGACCTCTAGCACATCACCTACACTAC CACGGCCACACTCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCGGAATTTCTCTCCAAATGCACCTGCTCACTTTT CTTTTGTTCCTGCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTCTTCAGGATATGGAACTAACACTCCTAGCTCCA CTGTCTCATCATCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTACAGCTGATGAGCTGCACTTTTTGACGAAGCATT TCAGCACAGAGAGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCGCTCCCGGAGCCTCAGTCCCGGACGATCCCCAG TATCCTTTGACAGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAAGGCTCATGAGCGCTCAGAGAGCTCAGAAGTGG CTTTTGTGATGCAGCTGGTGAAAAAGCTGATGATTATCATTGCCCGCCCAGCACGTCTCCTGGAATGCCTGGAGTTTGACCCTGAAGAGT TCTACCACCTTTTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATGTGACATTCCCCGCTACATCGTTAGCCAGCTGG GCCTCACCCGGGATCCCCTAGAAGAAATGGCCCAGTTGAGCAGCTGTGACAGTCCTGACACTCCAGAGACAGATGATTCTATTGAGGGCC ATGGGGCATCTCTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAAGCTCATCAGCAATGGCGCCTATGGGGCTGTAT TTCTGGTGCGGCACAAGTCCACCCGGCAGCGCTTTGCCATGAAGAAGATCAACAAGCAGAACCTGATCCTACGGAACCAGATCCAGCAGG CCTTCGTGGAGCGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGATACCAAGCGCCACTTGTGCA TGGTGATGGAGTACGTTGAAGGGGGAGACTGTGCCACTCTGCTGAAGAATATTGGGGCCCTGCCTGTGGACATGGTGCGTCTATACTTTG CGGAAACTGTGCTGGCCCTGGAGTACTTACACAACTATGGCATCGTGCACCGTGACCTCAAGCCTGACAACCTCCTAATTACATCCATGG GGCACATCAAGCTCACGGACTTTGGACTGTCCAAAATTGGCCTCATGAGTCTGACAACGAACTTGTATGAGGGTCATATTGAAAAGGATG CCCGGGAATTCCTGGACAAGCAGGTATGCGGGACCCCAGAATACATTGCGCCTGAGGTGATCCTGCGCCAGGGCTATGGGAAGCCAGTGG ACTGGTGGGCCATGGGCATTATCCTGTATGAGTTCCTGGTGGGCTGCGTCCCTTTTTTTGGAGATACTCCGGAGGAGCTCTTTGGGCAGG TGATCAGTGATGAGATTGTGTGGCCTGAGGGTGATGAGGCACTGCCCCCAGACGCCCAGGACCTCACCTCCAAACTGCTCCACCAGAACC CTCTGGAGAGACTTGGCACAGGCAGTGCCTATGAGGTGAAGCAGCACCCATTCTTTACTGGTCTGGACTGGACAGGACTTCTCCGCCAGA AGGCTGAATTTATTCCTCAGTTGGAGTCAGAGGATGATACTAGCTATTTTGACACCCGCTCAGAGCGATACCACCACATGGACTCGGAGG ATGAGGAAGAAGTGAGTGAGGATGGCTGCCTTGAGATCCGCCAGTTCTCTTCCTGCTCTCCAAGGTTCAACAAGGTGTACAGCAGCATGG AGCGGCTCTCACTGCTCGAGGAGCGCCGGACACCACCCCCGACCAAGCGCAGCCTGAGTGAGGAGAAGGAGGACCATTCAGATGGCCTGG CAGGGCTCAAAGGCCGAGACCGGAGCTGGGTGATTGGCTCCCCTGAGATATTACGGAAGCGGCTGTCGGTGTCTGAGTCATCCCACACAG AGAGTGACTCAAGCCCTCCAATGACAGTGCGACGCCGCTGCTCAGGCCTCCTGGATGCGCCTCGGTTCCCGGAGGGCCCTGAGGAGGCCA GCAGCACCCTCAGGAGGCAACCACAGGAGGGTATATGGGTCCTGACACCCCCATCTGGAGAGGGGGTATCTGGGCCTGTCACTGAACACT CAGGGGAGCAGCGGCCAAAGCTGGATGAGGAAGCTGTTGGCCGGAGCAGTGGTTCCAGTCCAGCTATGGAGACCCGAGGCCGTGGGACCT CACAGCTGGCTGAGGGAGCCACAGCCAAGGCCATCAGTGACCTGGCTGTGCGTAGGGCCCGCCACCGGCTGCTCTCTGGGGACTCAACAG AGAAGCGCACTGCTCGCCCTGTCAACAAAGTGATCAAGTCCGCCTCAGCCACAGCCCTCTCACTCCTCATTCCTTCGGAACACCACACCT GCTCCCCGTTGGCCAGCCCCATGTCCCCACATTCTCAGTCGTCCAACCCATCATCCCGGGACTCTTCTCCATATGGCTTCACCCTGCGGG CCATTCGCGTCTACATGGGTGACTCCGATGTCTACACCGTGCACCATATGGTGTGGCACGTGGAGGATGGAGGTCCGGCCAGTGAGGCAG GGCTTCGTCAAGGTGACCTCATCACCCATGTCAATGGGGAACCTGTGCATGGCCTGGTGCACACGGAGGTGGTAGAGCTGATCCTGAAGA GTGGAAACAAGGTGGCCATTTCAACAACTCCCCTGGAGAACACATCCATTAAAGTGGGGCCAGCTCGGAAGGGCAGCTACAAGGCCAAGA TGGCCCGAAGGAGCAAGAGGAGCCGCGGCAAGGATGGGCAAGAAAGCAGAAAAAGGAGCTCCCTGTTCCGCAAGATCACCAAGCAAGCAT CCCTGCTCCACACCAGCCGCAGCCTTTCTTCCCTTAACCGCTCCTTGTCATCAGGGGAGAGTGGGCCAGGCTCTCCCACACACAGCCACA GCCTTTCCCCCCGATCTCCCACTCAAGGCTACCGGGTGACCCCCGATGCTGTGCATTCAGAACTCTCACGGCCCAAGAGTGCGGAGCCAC CCCGTTCACCACTACTCAAGAGGGTGCAGTCGGCTGAGAAACTGGCAGCAGCACTTGCCGCCTCTGAGAAGAAGCTAGCCACTTCTCGCA AGCACAGCCTTGACCTGCCCCACTCTGAACTAAAGAAGGAACTGCCGCCCAGGGAAGTGAGCCCTCTGGAGGTAGTTGGAGCCAGGAGTG TGCTGTCTGGCAAGGGGGCCCTGCCAGGGAAGGGGGTGCTGCAGCCTGCTCCCTCACGGGCCCTAGGCACCCTCCGGCAGGACCGAGCCG AACGACGGGAGTCGCTGCAGAAGCAAGAAGCCATTCGTGAGGTGGACTCCTCAGAGGACGACACCGAGGAAGGGCCTGAGAACAGCCAGG GTGCACAGGAGCTGAGCTTGGCACCTCACCCAGAAGTGAGCCAGAGTGTGGCCCCTAAAGGAGCAGGAGAGAGTGGGGAAGAGGATCCTT TCCCGTCCAGAGACCCTAGGAGCCTGGGCCCAATGGTCCCAAGCCTATTGACAGGGATCACACTGGGGCCTCCCAGAATGGAAAGTCCCA GTGGTCCCCACAGGAGGCTCGGGAGCCCACAAGCCATTGAGGAGGCTGCCAGCTCCTCCTCAGCAGGCCCCAACCTAGGTCAGTCTGGAG CCACAGACCCCATCCCTCCTGAAGGTTGCTGGAAGGCCCAGCACCTCCACACCCAGGCACTAACAGCACTTTCTCCCAGCACTTCGGGAC TCACCCCCACCAGCAGTTGCTCTCCTCCCAGCTCCACCTCTGGGAAGCTGAGCATGTGGTCCTGGAAATCCCTTATTGAGGGCCCAGACA GGGCATCCCCAAGCAGAAAGGCAACCATGGCAGGTGGGCTAGCCAACCTCCAGGATTTGGAAAACACAACTCCAGCCCAGCCTAAGAACC TGTCTCCCAGGGAGCAGGGGAAGACACAGCCACCTAGTGCCCCCAGACTGGCCCATCCATCTTATGAGGATCCCAGCCAGGGCTGGCTAT GGGAGTCTGAGTGTGCACAAGCAGTGAAAGAGGATCCAGCCCTGAGCATCACCCAAGTGCCTGATGCCTCAGGTGACAGAAGGCAGGACG TTCCATGCCGAGGCTGCCCCCTCACCCAGAAGTCTGAGCCCAGCCTCAGGAGGGGCCAAGAACCAGGGGGCCATCAAAAGCATCGGGATT >6380_6380_2_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000324856_MAST2_chr1_46290104_ENST00000372009_length(amino acids)=1929AA_BP=367 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA PMSPGSSGGGGQPLARTPQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQS SGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFD SEIIMMNHVYKERFPKAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTR DPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVE RDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIK LTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD EIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEE VSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDS SPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLA EGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPYGFTLRAIRV YMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARR SKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSELSRPKSAEPPRSP LLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRE SLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPH RRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASP SRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCR -------------------------------------------------------------- >6380_6380_3_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000457599_MAST2_chr1_46290104_ENST00000361297_length(transcript)=6415nt_BP=1137nt ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGATGTAGTAACTGGAGTTAGTCCCCTGCTCTTC AGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAAACTTCAGCGACAACTGAGTCAGGATGATTGTAAGTTATGGAGA GGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTCCAGCAGTGTACATAGCAGTGTGGGACAGGTGACTTGGCAGTCG TCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGGACAGTCTGCACCTTCTCTTACTGCTGGCCTGAAGGAGTTGAGC CTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTTGATTGTGACCTCTAGCACATCACCTACACTACCACGGCCACAC TCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCGGAATTTCTCTCCAAATGCACCTGCTCACTTTTCTTTTGTTCCT GCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTCTTCAGGATATGGAACTAACACTCCTAGCTCCACTGTCTCATCA TCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTACAGCTGATGAGCTGCACTTTTTGACGAAGCATTTCAGCACAGAG AGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCGCTCCCGGAGCCTCAGTCCCGGACGATCCCCAGTATCCTTTGAC AGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAAGGCCACCGCACAAATGGAAGAGCGACTAGCAGAGTTTATTTCC TCCAACACTCCAGACAGCGTGCTGCCCTTGGCAGATGGAGCCCTGAGCTTTATTCATCATCAGGTGATTGAGATGGCCCGAGACTGCCTG GATAAATCTCGGAGTGGCCTCATTACATCACAATACTTCTACGAACTTCAAGATAATTTGGAGAAACTTTTACAAGATGCTCATGAGCGC TCAGAGAGCTCAGAAGTGGCTTTTGTGATGCAGCTGGTGAAAAAGCTGATGATTATCATTGCCCGCCCAGCACGTCTCCTGGAATGCCTG GAGTTTGACCCTGAAGAGTTCTACCACCTTTTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATGTGACATTCCCCGC TACATCGTTAGCCAGCTGGGCCTCACCCGGGATCCCCTAGAAGAAATGGCCCAGTTGAGCAGCTGTGACAGTCCTGACACTCCAGAGACA GATGATTCTATTGAGGGCCATGGGGCATCTCTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAAGCTCATCAGCAAT GGCGCCTATGGGGCTGTATTTCTGGTGCGGCACAAGTCCACCCGGCAGCGCTTTGCCATGAAGAAGATCAACAAGCAGAACCTGATCCTA CGGAACCAGATCCAGCAGGCCTTCGTGGAGCGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGAT ACCAAGCGCCACTTGTGCATGGTGATGGAGTACGTTGAAGGGGGAGACTGTGCCACTCTGCTGAAGAATATTGGGGCCCTGCCTGTGGAC ATGGTGCGTCTATACTTTGCGGAAACTGTGCTGGCCCTGGAGTACTTACACAACTATGGCATCGTGCACCGTGACCTCAAGCCTGACAAC CTCCTAATTACATCCATGGGGCACATCAAGCTCACGGACTTTGGACTGTCCAAAATTGGCCTCATGAGTCTGACAACGAACTTGTATGAG GGTCATATTGAAAAGGATGCCCGGGAATTCCTGGACAAGCAGGTATGCGGGACCCCAGAATACATTGCGCCTGAGGTGATCCTGCGCCAG GGCTATGGGAAGCCAGTGGACTGGTGGGCCATGGGCATTATCCTGTATGAGTTCCTGGTGGGCTGCGTCCCTTTTTTTGGAGATACTCCG GAGGAGCTCTTTGGGCAGGTGATCAGTGATGAGATTGTGTGGCCTGAGGGTGATGAGGCACTGCCCCCAGACGCCCAGGACCTCACCTCC AAACTGCTCCACCAGAACCCTCTGGAGAGACTTGGCACAGGCAGTGCCTATGAGGTGAAGCAGCACCCATTCTTTACTGGTCTGGACTGG ACAGGACTTCTCCGCCAGAAGGCTGAATTTATTCCTCAGTTGGAGTCAGAGGATGATACTAGCTATTTTGACACCCGCTCAGAGCGATAC CACCACATGGACTCGGAGGATGAGGAAGAAGTGAGTGAGGATGGCTGCCTTGAGATCCGCCAGTTCTCTTCCTGCTCTCCAAGGTTCAAC AAGGTGTACAGCAGCATGGAGCGGCTCTCACTGCTCGAGGAGCGCCGGACACCACCCCCGACCAAGCGCAGCCTGAGTGAGGAGAAGGAG GACCATTCAGATGGCCTGGCAGGGCTCAAAGGCCGAGACCGGAGCTGGGTGATTGGCTCCCCTGAGATATTACGGAAGCGGCTGTCGGTG TCTGAGTCATCCCACACAGAGAGTGACTCAAGCCCTCCAATGACAGTGCGACGCCGCTGCTCAGGCCTCCTGGATGCGCCTCGGTTCCCG GAGGGCCCTGAGGAGGCCAGCAGCACCCTCAGGAGGCAACCACAGGAGGGTATATGGGTCCTGACACCCCCATCTGGAGAGGGGGTATCT GGGCCTGTCACTGAACACTCAGGGGAGCAGCGGCCAAAGCTGGATGAGGAAGCTGTTGGCCGGAGCAGTGGTTCCAGTCCAGCTATGGAG ACCCGAGGCCGTGGGACCTCACAGCTGGCTGAGGGAGCCACAGCCAAGGCCATCAGTGACCTGGCTGTGCGTAGGGCCCGCCACCGGCTG CTCTCTGGGGACTCAACAGAGAAGCGCACTGCTCGCCCTGTCAACAAAGTGATCAAGTCCGCCTCAGCCACAGCCCTCTCACTCCTCATT CCTTCGGAACACCACACCTGCTCCCCGTTGGCCAGCCCCATGTCCCCACATTCTCAGTCGTCCAACCCATCATCCCGGGACTCTTCTCCA AGCAGGGACTTCTTGCCAGCCCTTGGCAGCATGAGGCCTCCCATCATCATCCACCGAGCTGGCAAGAAGTATGGCTTCACCCTGCGGGCC ATTCGCGTCTACATGGGTGACTCCGATGTCTACACCGTGCACCATATGGTGTGGCACGTGGAGGATGGAGGTCCGGCCAGTGAGGCAGGG CTTCGTCAAGGTGACCTCATCACCCATGTCAATGGGGAACCTGTGCATGGCCTGGTGCACACGGAGGTGGTAGAGCTGATCCTGAAGAGT GGAAACAAGGTGGCCATTTCAACAACTCCCCTGGAGAACACATCCATTAAAGTGGGGCCAGCTCGGAAGGGCAGCTACAAGGCCAAGATG GCCCGAAGGAGCAAGAGGAGCCGCGGCAAGGATGGGCAAGAAAGCAGAAAAAGGAGCTCCCTGTTCCGCAAGATCACCAAGCAAGCATCC CTGCTCCACACCAGCCGCAGCCTTTCTTCCCTTAACCGCTCCTTGTCATCAGGGGAGAGTGGGCCAGGCTCTCCCACACACAGCCACAGC CTTTCCCCCCGATCTCCCACTCAAGGCTACCGGGTGACCCCCGATGCTGTGCATTCAGTGGGAGGGAATTCATCACAGAGCAGCTCCCCC AGCTCCAGCGTGCCCAGTTCCCCAGCCGGCTCTGGGCACACACGGCCCAGCTCCCTCCACGGTCTGGCACCCAAGCTCCAACGCCAGTAC CGCTCTCCACGGCGCAAGTCAGCAGGCAGCATCCCACTGTCACCACTGGCCCACACCCCTTCTCCCCCACCCCCAACAGCTTCACCTCAG CGGTCCCCATCGCCCCTGTCTGGCCATGTAGCCCAGGCCTTTCCCACAAAGCTTCACTTGTCACCTCCCCTGGGCAGGCAACTCTCACGG CCCAAGAGTGCGGAGCCACCCCGTTCACCACTACTCAAGAGGGTGCAGTCGGCTGAGAAACTGGCAGCAGCACTTGCCGCCTCTGAGAAG AAGCTAGCCACTTCTCGCAAGCACAGCCTTGACCTGCCCCACTCTGAACTAAAGAAGGAACTGCCGCCCAGGGAAGTGAGCCCTCTGGAG GTAGTTGGAGCCAGGAGTGTGCTGTCTGGCAAGGGGGCCCTGCCAGGGAAGGGGGTGCTGCAGCCTGCTCCCTCACGGGCCCTAGGCACC CTCCGGCAGGACCGAGCCGAACGACGGGAGTCGCTGCAGAAGCAAGAAGCCATTCGTGAGGTGGACTCCTCAGAGGACGACACCGAGGAA GGGCCTGAGAACAGCCAGGGTGCACAGGAGCTGAGCTTGGCACCTCACCCAGAAGTGAGCCAGAGTGTGGCCCCTAAAGGAGCAGGAGAG AGTGGGGAAGAGGATCCTTTCCCGTCCAGAGACCCTAGGAGCCTGGGCCCAATGGTCCCAAGCCTATTGACAGGGATCACACTGGGGCCT CCCAGAATGGAAAGTCCCAGTGGTCCCCACAGGAGGCTCGGGAGCCCACAAGCCATTGAGGAGGCTGCCAGCTCCTCCTCAGCAGGCCCC AACCTAGGTCAGTCTGGAGCCACAGACCCCATCCCTCCTGAAGGTTGCTGGAAGGCCCAGCACCTCCACACCCAGGCACTAACAGCACTT TCTCCCAGCACTTCGGGACTCACCCCCACCAGCAGTTGCTCTCCTCCCAGCTCCACCTCTGGGAAGCTGAGCATGTGGTCCTGGAAATCC CTTATTGAGGGCCCAGACAGGGCATCCCCAAGCAGAAAGGCAACCATGGCAGGTGGGCTAGCCAACCTCCAGGATTTGGAAAACACAACT CCAGCCCAGCCTAAGAACCTGTCTCCCAGGGAGCAGGGGAAGACACAGCCACCTAGTGCCCCCAGACTGGCCCATCCATCTTATGAGGAT CCCAGCCAGGGCTGGCTATGGGAGTCTGAGTGTGCACAAGCAGTGAAAGAGGATCCAGCCCTGAGCATCACCCAAGTGCCTGATGCCTCA GGTGACAGAAGGCAGGACGTTCCATGCCGAGGCTGCCCCCTCACCCAGAAGTCTGAGCCCAGCCTCAGGAGGGGCCAAGAACCAGGGGGC CATCAAAAGCATCGGGATTTGGCATTGGTTCCAGATGAGCTTTTAAAGCAAACATAGCAGTTGTTTGCCATTTCTTGCACTCAGACCTGT >6380_6380_3_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000457599_MAST2_chr1_46290104_ENST00000361297_length(amino acids)=2118AA_BP=367 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA PMSPGSSGGGGQPLARTPQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQS SGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFD SEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHER SESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPET DDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFD TKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYE GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTS KLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFN KVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFP EGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRL LSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRA IRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKM ARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSP SSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSR PKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGT LRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGP PRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKS LIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDAS -------------------------------------------------------------- >6380_6380_4_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000457599_MAST2_chr1_46290104_ENST00000372009_length(transcript)=5787nt_BP=1137nt ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGATGTAGTAACTGGAGTTAGTCCCCTGCTCTTC AGGAAACTCAGTAATCCTGACATATTTTCATCCACTGGAAAAGTTAAACTTCAGCGACAACTGAGTCAGGATGATTGTAAGTTATGGAGA GGAAACCTGGCCAGCTCTCTATCGGGTAAGCAGCTGCTCCCTTTGTCCAGCAGTGTACATAGCAGTGTGGGACAGGTGACTTGGCAGTCG TCAGGAGAAGCATCAAACCTGGTTCGAATGAGAAACCAGTCCCTTGGACAGTCTGCACCTTCTCTTACTGCTGGCCTGAAGGAGTTGAGC CTTCCAAGAAGAGGCAGCTTTTGTCGGACAAGTAACCGCAAGAGCTTGATTGTGACCTCTAGCACATCACCTACACTACCACGGCCACAC TCACCACTCCATGGCCACACAGGTAACAGTCCTTTGGACAGCCCCCGGAATTTCTCTCCAAATGCACCTGCTCACTTTTCTTTTGTTCCT GCCCGTAGGACTGATGGGCGGCGCTGGTCTTTGGCCTCTTTGCCCTCTTCAGGATATGGAACTAACACTCCTAGCTCCACTGTCTCATCA TCATGCTCCTCACAGGAAAAGCTGCATCAGTTGCCTTTCCAGCCTACAGCTGATGAGCTGCACTTTTTGACGAAGCATTTCAGCACAGAG AGCGTACCAGATGAGGAAGGACGGCAGTCCCCAGCCATGCGGCCTCGCTCCCGGAGCCTCAGTCCCGGACGATCCCCAGTATCCTTTGAC AGTGAAATAATAATGATGAATCATGTTTACAAAGAAAGATTCCCAAAGGCTCATGAGCGCTCAGAGAGCTCAGAAGTGGCTTTTGTGATG CAGCTGGTGAAAAAGCTGATGATTATCATTGCCCGCCCAGCACGTCTCCTGGAATGCCTGGAGTTTGACCCTGAAGAGTTCTACCACCTT TTAGAAGCAGCTGAGGGCCACGCCAAAGAGGGACAAGGGATTAAATGTGACATTCCCCGCTACATCGTTAGCCAGCTGGGCCTCACCCGG GATCCCCTAGAAGAAATGGCCCAGTTGAGCAGCTGTGACAGTCCTGACACTCCAGAGACAGATGATTCTATTGAGGGCCATGGGGCATCT CTGCCATCTAAAAAGACACCCTCTGAAGAGGACTTCGAGACCATTAAGCTCATCAGCAATGGCGCCTATGGGGCTGTATTTCTGGTGCGG CACAAGTCCACCCGGCAGCGCTTTGCCATGAAGAAGATCAACAAGCAGAACCTGATCCTACGGAACCAGATCCAGCAGGCCTTCGTGGAG CGTGACATACTGACTTTCGCTGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGATACCAAGCGCCACTTGTGCATGGTGATGGAG TACGTTGAAGGGGGAGACTGTGCCACTCTGCTGAAGAATATTGGGGCCCTGCCTGTGGACATGGTGCGTCTATACTTTGCGGAAACTGTG CTGGCCCTGGAGTACTTACACAACTATGGCATCGTGCACCGTGACCTCAAGCCTGACAACCTCCTAATTACATCCATGGGGCACATCAAG CTCACGGACTTTGGACTGTCCAAAATTGGCCTCATGAGTCTGACAACGAACTTGTATGAGGGTCATATTGAAAAGGATGCCCGGGAATTC CTGGACAAGCAGGTATGCGGGACCCCAGAATACATTGCGCCTGAGGTGATCCTGCGCCAGGGCTATGGGAAGCCAGTGGACTGGTGGGCC ATGGGCATTATCCTGTATGAGTTCCTGGTGGGCTGCGTCCCTTTTTTTGGAGATACTCCGGAGGAGCTCTTTGGGCAGGTGATCAGTGAT GAGATTGTGTGGCCTGAGGGTGATGAGGCACTGCCCCCAGACGCCCAGGACCTCACCTCCAAACTGCTCCACCAGAACCCTCTGGAGAGA CTTGGCACAGGCAGTGCCTATGAGGTGAAGCAGCACCCATTCTTTACTGGTCTGGACTGGACAGGACTTCTCCGCCAGAAGGCTGAATTT ATTCCTCAGTTGGAGTCAGAGGATGATACTAGCTATTTTGACACCCGCTCAGAGCGATACCACCACATGGACTCGGAGGATGAGGAAGAA GTGAGTGAGGATGGCTGCCTTGAGATCCGCCAGTTCTCTTCCTGCTCTCCAAGGTTCAACAAGGTGTACAGCAGCATGGAGCGGCTCTCA CTGCTCGAGGAGCGCCGGACACCACCCCCGACCAAGCGCAGCCTGAGTGAGGAGAAGGAGGACCATTCAGATGGCCTGGCAGGGCTCAAA GGCCGAGACCGGAGCTGGGTGATTGGCTCCCCTGAGATATTACGGAAGCGGCTGTCGGTGTCTGAGTCATCCCACACAGAGAGTGACTCA AGCCCTCCAATGACAGTGCGACGCCGCTGCTCAGGCCTCCTGGATGCGCCTCGGTTCCCGGAGGGCCCTGAGGAGGCCAGCAGCACCCTC AGGAGGCAACCACAGGAGGGTATATGGGTCCTGACACCCCCATCTGGAGAGGGGGTATCTGGGCCTGTCACTGAACACTCAGGGGAGCAG CGGCCAAAGCTGGATGAGGAAGCTGTTGGCCGGAGCAGTGGTTCCAGTCCAGCTATGGAGACCCGAGGCCGTGGGACCTCACAGCTGGCT GAGGGAGCCACAGCCAAGGCCATCAGTGACCTGGCTGTGCGTAGGGCCCGCCACCGGCTGCTCTCTGGGGACTCAACAGAGAAGCGCACT GCTCGCCCTGTCAACAAAGTGATCAAGTCCGCCTCAGCCACAGCCCTCTCACTCCTCATTCCTTCGGAACACCACACCTGCTCCCCGTTG GCCAGCCCCATGTCCCCACATTCTCAGTCGTCCAACCCATCATCCCGGGACTCTTCTCCATATGGCTTCACCCTGCGGGCCATTCGCGTC TACATGGGTGACTCCGATGTCTACACCGTGCACCATATGGTGTGGCACGTGGAGGATGGAGGTCCGGCCAGTGAGGCAGGGCTTCGTCAA GGTGACCTCATCACCCATGTCAATGGGGAACCTGTGCATGGCCTGGTGCACACGGAGGTGGTAGAGCTGATCCTGAAGAGTGGAAACAAG GTGGCCATTTCAACAACTCCCCTGGAGAACACATCCATTAAAGTGGGGCCAGCTCGGAAGGGCAGCTACAAGGCCAAGATGGCCCGAAGG AGCAAGAGGAGCCGCGGCAAGGATGGGCAAGAAAGCAGAAAAAGGAGCTCCCTGTTCCGCAAGATCACCAAGCAAGCATCCCTGCTCCAC ACCAGCCGCAGCCTTTCTTCCCTTAACCGCTCCTTGTCATCAGGGGAGAGTGGGCCAGGCTCTCCCACACACAGCCACAGCCTTTCCCCC CGATCTCCCACTCAAGGCTACCGGGTGACCCCCGATGCTGTGCATTCAGAACTCTCACGGCCCAAGAGTGCGGAGCCACCCCGTTCACCA CTACTCAAGAGGGTGCAGTCGGCTGAGAAACTGGCAGCAGCACTTGCCGCCTCTGAGAAGAAGCTAGCCACTTCTCGCAAGCACAGCCTT GACCTGCCCCACTCTGAACTAAAGAAGGAACTGCCGCCCAGGGAAGTGAGCCCTCTGGAGGTAGTTGGAGCCAGGAGTGTGCTGTCTGGC AAGGGGGCCCTGCCAGGGAAGGGGGTGCTGCAGCCTGCTCCCTCACGGGCCCTAGGCACCCTCCGGCAGGACCGAGCCGAACGACGGGAG TCGCTGCAGAAGCAAGAAGCCATTCGTGAGGTGGACTCCTCAGAGGACGACACCGAGGAAGGGCCTGAGAACAGCCAGGGTGCACAGGAG CTGAGCTTGGCACCTCACCCAGAAGTGAGCCAGAGTGTGGCCCCTAAAGGAGCAGGAGAGAGTGGGGAAGAGGATCCTTTCCCGTCCAGA GACCCTAGGAGCCTGGGCCCAATGGTCCCAAGCCTATTGACAGGGATCACACTGGGGCCTCCCAGAATGGAAAGTCCCAGTGGTCCCCAC AGGAGGCTCGGGAGCCCACAAGCCATTGAGGAGGCTGCCAGCTCCTCCTCAGCAGGCCCCAACCTAGGTCAGTCTGGAGCCACAGACCCC ATCCCTCCTGAAGGTTGCTGGAAGGCCCAGCACCTCCACACCCAGGCACTAACAGCACTTTCTCCCAGCACTTCGGGACTCACCCCCACC AGCAGTTGCTCTCCTCCCAGCTCCACCTCTGGGAAGCTGAGCATGTGGTCCTGGAAATCCCTTATTGAGGGCCCAGACAGGGCATCCCCA AGCAGAAAGGCAACCATGGCAGGTGGGCTAGCCAACCTCCAGGATTTGGAAAACACAACTCCAGCCCAGCCTAAGAACCTGTCTCCCAGG GAGCAGGGGAAGACACAGCCACCTAGTGCCCCCAGACTGGCCCATCCATCTTATGAGGATCCCAGCCAGGGCTGGCTATGGGAGTCTGAG TGTGCACAAGCAGTGAAAGAGGATCCAGCCCTGAGCATCACCCAAGTGCCTGATGCCTCAGGTGACAGAAGGCAGGACGTTCCATGCCGA GGCTGCCCCCTCACCCAGAAGTCTGAGCCCAGCCTCAGGAGGGGCCAAGAACCAGGGGGCCATCAAAAGCATCGGGATTTGGCATTGGTT >6380_6380_4_ARID1A-MAST2_ARID1A_chr1_27024031_ENST00000457599_MAST2_chr1_46290104_ENST00000372009_length(amino acids)=1928AA_BP=367 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA PMSPGSSGGGGQPLARTPQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQS SGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFD SEIIMMNHVYKERFPKAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTR DPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVE RDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIK LTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD EIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEE VSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDS SPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLA EGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPYGFTLRAIRV YMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARR SKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSELSRPKSAEPPRSP LLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRE SLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPH RRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASP SRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARID1A-MAST2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARID1A-MAST2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARID1A-MAST2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ARID1A | C0024623 | Malignant neoplasm of stomach | 3 | CTD_human |
| Hgene | ARID1A | C0038356 | Stomach Neoplasms | 3 | CTD_human |
| Hgene | ARID1A | C1708349 | Hereditary Diffuse Gastric Cancer | 3 | CTD_human |
| Hgene | ARID1A | C2239176 | Liver carcinoma | 3 | CTD_human |
| Hgene | ARID1A | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | ARID1A | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| Hgene | ARID1A | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Hgene | ARID1A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | ARID1A | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
| Hgene | ARID1A | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | ARID1A | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | ARID1A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | ARID1A | C0027708 | Nephroblastoma | 1 | CTD_human |
| Hgene | ARID1A | C0027819 | Neuroblastoma | 1 | CTD_human |
| Hgene | ARID1A | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Hgene | ARID1A | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Hgene | ARID1A | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | ARID1A | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| Hgene | ARID1A | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| Hgene | ARID1A | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| Hgene | ARID1A | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| Hgene | ARID1A | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| Hgene | ARID1A | C0206656 | Embryonal Rhabdomyosarcoma | 1 | CTD_human |
| Hgene | ARID1A | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0265338 | Coffin-Siris syndrome | 1 | CTD_human;GENOMICS_ENGLAND |
| Hgene | ARID1A | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
| Hgene | ARID1A | C0343640 | African Burkitt's lymphoma | 1 | CTD_human |
| Hgene | ARID1A | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
| Hgene | ARID1A | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
| Hgene | ARID1A | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Hgene | ARID1A | C1721098 | Replication Error Phenotype | 1 | CTD_human |
| Hgene | ARID1A | C2930471 | Bilateral Wilms Tumor | 1 | CTD_human |
| Hgene | ARID1A | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
| Hgene | ARID1A | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |
| Hgene | ARID1A | C4721444 | Burkitt Leukemia | 1 | CTD_human |
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