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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AXIN1-DNMT3A (FusionGDB2 ID:HG8312TG1788)

Fusion Gene Summary for AXIN1-DNMT3A

check button Fusion gene summary
Fusion gene informationFusion gene name: AXIN1-DNMT3A
Fusion gene ID: hg8312tg1788
HgeneTgene
Gene symbol

AXIN1

DNMT3A

Gene ID

8312

1788

Gene nameaxin 1DNA methyltransferase 3 alpha
SynonymsAXIN|PPP1R49DNMT3A2|HESJAS|M.HsaIIIA|TBRS
Cytomap('AXIN1')('DNMT3A')

16p13.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionaxin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49DNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2
Modification date2020032220200322
UniProtAcc.

Q9Y6K1

Ensembl transtripts involved in fusion geneENST00000262320, ENST00000354866, 
ENST00000481769, 
Fusion gene scores* DoF score16 X 10 X 9=14404 X 4 X 3=48
# samples 234
** MAII scorelog2(23/1440*10)=-2.6463630453853
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AXIN1 [Title/Abstract] AND DNMT3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAXIN1(354303)-DNMT3A(25523112), # samples:1
Anticipated loss of major functional domain due to fusion event.AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAXIN1

GO:0001934

positive regulation of protein phosphorylation

9601641

HgeneAXIN1

GO:0032147

activation of protein kinase activity

9601641

HgeneAXIN1

GO:0034622

cellular protein-containing complex assembly

16601693

HgeneAXIN1

GO:0045732

positive regulation of protein catabolic process

9601641

HgeneAXIN1

GO:0090090

negative regulation of canonical Wnt signaling pathway

10644691

TgeneDNMT3A

GO:0006306

DNA methylation

12138111|19786833|23042785


check buttonFusion gene breakpoints across AXIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DNMT3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8686AXIN1chr16

354303

-DNMT3Achr2

25523112

-


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Fusion Gene ORF analysis for AXIN1-DNMT3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262320ENST00000380746AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5CDS-intronENST00000262320ENST00000402667AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5CDS-intronENST00000262320ENST00000474887AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5CDS-intronENST00000354866ENST00000380746AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5CDS-intronENST00000354866ENST00000402667AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5CDS-intronENST00000354866ENST00000474887AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-3CDSENST00000481769ENST00000264709AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-3CDSENST00000481769ENST00000321117AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-3CDSENST00000481769ENST00000406659AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-intronENST00000481769ENST00000380746AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-intronENST00000481769ENST00000402667AXIN1chr16

354303

-DNMT3Achr2

25523112

-
5UTR-intronENST00000481769ENST00000474887AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000262320ENST00000264709AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000262320ENST00000321117AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000262320ENST00000406659AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000354866ENST00000264709AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000354866ENST00000321117AXIN1chr16

354303

-DNMT3Achr2

25523112

-
In-frameENST00000354866ENST00000406659AXIN1chr16

354303

-DNMT3Achr2

25523112

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262320AXIN1chr16354303-ENST00000321117DNMT3Achr225523112-559616262142921423
ENST00000262320AXIN1chr16354303-ENST00000264709DNMT3Achr225523112-559616262142921423
ENST00000262320AXIN1chr16354303-ENST00000406659DNMT3Achr225523112-29911626212054677
ENST00000354866AXIN1chr16354303-ENST00000321117DNMT3Achr225523112-538614161540821355
ENST00000354866AXIN1chr16354303-ENST00000264709DNMT3Achr225523112-538614161540821355
ENST00000354866AXIN1chr16354303-ENST00000406659DNMT3Achr225523112-27811416151844609

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262320ENST00000321117AXIN1chr16354303-DNMT3Achr225523112-0.0008805620.99911946
ENST00000262320ENST00000264709AXIN1chr16354303-DNMT3Achr225523112-0.0008805620.99911946
ENST00000262320ENST00000406659AXIN1chr16354303-DNMT3Achr225523112-0.0084652350.99153477
ENST00000354866ENST00000321117AXIN1chr16354303-DNMT3Achr225523112-0.0006311290.99936885
ENST00000354866ENST00000264709AXIN1chr16354303-DNMT3Achr225523112-0.0006311290.99936885
ENST00000354866ENST00000406659AXIN1chr16354303-DNMT3Achr225523112-0.0068640310.9931359

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Fusion Genomic Features for AXIN1-DNMT3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AXIN1-DNMT3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:354303/chr2:25523112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNMT3A

Q9Y6K1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-51188_211418863.0DomainRGS
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-51088_211418827.0DomainRGS
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-51120_29418863.0MotifNote=Tankyrase-binding motif
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-51020_29418827.0MotifNote=Tankyrase-binding motif
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123292_35024913.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123482_61424913.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123634_91224913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123292_35024913.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123482_61424913.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123634_91224913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019292_3500724.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019482_6140724.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019634_9120724.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018292_3500690.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018482_6140690.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018634_9120690.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914292_35024167.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914482_61424167.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914634_91224167.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123641_64524913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123686_68824913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123891_89324913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123641_64524913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123686_68824913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123891_89324913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019641_6450724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019686_6880724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019891_8930724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018641_6450690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018686_6880690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018891_8930690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914641_64524167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914686_68824167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914891_89324167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123493_52324913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123534_59024913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123493_52324913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123534_59024913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019493_5230724.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019534_5900724.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018493_5230690.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018534_5900690.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914493_52324167.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914534_59024167.0Zinc fingerPHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511780_862418863.0DomainDIX
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510780_862418827.0DomainDIX


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Fusion Gene Sequence for AXIN1-DNMT3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8555_8555_1_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000264709_length(transcript)=5596nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG
AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA
GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC
GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC
CGAGGAGCCCCTGCAGAAGCGGGCAAAGAACAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGT
GGCTTGGGCTGGGAGTCCAGCCTCCGTCAGCGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAG
CGGGACGAGTGGCTGGCACGCTGGAAAAGGGAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGG
CCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCT
GAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATT
GGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCT
GAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGT
GCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAG
CTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGG
GGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAA
CCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGAT
GAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTT
ACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGC
TACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGT
GTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTAC
GGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTT
TACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGAC
TTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATG
TACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGAC
CTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGG
CCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTT
CTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAAC
AGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACC
ATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACT
GAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCA
TGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCG
ACACAAAGTTAAACAAACAAACAAAAAACACAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAG
AAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTC
AATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTT
CTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAAC
AAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTT
TTTGTTTTTTGTTTTTTTTTTTTGGGTTTTTTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCA
GGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACA
GAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGA
AAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAA
CTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTT
TCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGA
GAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACT
CATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTT
TAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAA

>8555_8555_1_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1423AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE
GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR
WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK
LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD
SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL
VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP
GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR
YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR
PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS

--------------------------------------------------------------
>8555_8555_2_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000321117_length(transcript)=5596nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG
AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA
GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC
GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC
CGAGGAGCCCCTGCAGAAGCGGGCAAAGAACAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGT
GGCTTGGGCTGGGAGTCCAGCCTCCGTCAGCGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAG
CGGGACGAGTGGCTGGCACGCTGGAAAAGGGAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGG
CCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCT
GAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATT
GGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCT
GAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGT
GCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAG
CTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGG
GGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAA
CCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGAT
GAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTT
ACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGC
TACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGT
GTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTAC
GGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTT
TACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGAC
TTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATG
TACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGAC
CTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGG
CCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTT
CTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAAC
AGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACC
ATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACT
GAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCA
TGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCG
ACACAAAGTTAAACAAACAAACAAAAAACACAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAG
AAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTC
AATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTT
CTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAAC
AAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTT
TTTGTTTTTTGTTTTTTTTTTTTGGGTTTTTTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCA
GGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACA
GAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGA
AAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAA
CTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTT
TCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGA
GAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACT
CATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTT
TAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAA

>8555_8555_2_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1423AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE
GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR
WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK
LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD
SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL
VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP
GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR
YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR
PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS

--------------------------------------------------------------
>8555_8555_3_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000406659_length(transcript)=2991nt_BP=1626nt
CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTG
GCGGCTGGGCCCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGG
GCCGCGCCCCCGCCGGGTCCCGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGG
TCCCGCCACCACCGCGCGCGGGACAGATTGATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACG
CAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCT
GGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACT
TCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCT
GAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGAC
TTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGA
AAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG
ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATT
TATTTGGAATATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGA
TACCTGCCGACCTTAAATGAAGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGA
CTCCCTCAGAAGCTGCTCCTGGAGACAGCTGCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCC
TGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTG
TCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATG
CAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAG
AAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTG
CGCATGGACGGAGAGGAGCAGGAGGAGCCGCGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGG
AGGAAGCGCAAGCACCCCCCGGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCA
GGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGC
GGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGC
CGAGGAGCCCCTGCAGAAGCGGGTGAGTCCTCAGCACCAGGGGCAGCCTCTTCTGGGCCCACCAGCATACCCTGAGAGTCAGGGACTTGG
CTCTCCAGCAGGTCCCAGGAAGGATGGTCTGGGTCGTGGCTAAAGGTCTGCTTGCCAAGGCTATGGCCTGGAGGCTACTGGCTGGATGCA
GCCTGCGCATATGTTTTATTTGGCCCATAGAGTGTTTTAAACATTTAAAAAATTAGTTGCCAGTATTTAAAAATCAAAAAATTTCACATA
AAAATCTGGAGTTTTGGCTTCTCATGAAAAAAAAAAAAGCTAGATCTGGCAACAGCGGGCTTTCATAACGCCAACGATTGCTAGACTGGG
ATAATGGCGGTCCCTCCATCGCCTTCTGTGGCTGGTTGTGGGCCTTAGTTTTCTGCAGCTCTACCTGGCCTGCTTACTCTCCCACGTGCC
ATGCAGTTCCTGGGGGTTGCTGTATTTGTAGCCCCTGGCCTGGGCACTCAAGGGCAGCAGATACCCTGTTTGCCTCCCTGAGTGCAGAGG
TCCTGAGCCCACCCTAGTTGGGCTGACTCAACTGGAAATTTGGTTGTGACAGTGGCGTGGGGAGAGGGCTGGGTGATTGTATTCTGTGTA
CTGCCCAGCCCAGGCCTCTTCATCTGGGGACTTTTTGGCCTAACCCTGGAAGCCTGGAAAGTTGCCCACTTTTCTCTTTCAGGTTAAGCC
AGCAATTTCAGGGCCAACCGAGCTGTAAACATGTTAGTAATGAGGACAACTAGCATTTGTACAGGGCTTCACAGTTTACAAAGCGCTTTC
TCATACATTATCACATTTGATCCTCCCAGGGCCCTGCCAGGTTGTTTTGCATATGTGCATTTTAATTTCAAAAAGTCTTCCTTCCAAGCG
TGTATGATGAAATGAGTAAATTGATTAATTGGCGTAACTTATTTTGCATGGATCCAACCTAATGTTCATGCAGGATAGAGAACATTTCCA

>8555_8555_3_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=677AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE

--------------------------------------------------------------
>8555_8555_4_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000264709_length(transcript)=5386nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG
CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC
GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC
TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT
GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGCAAAGAA
CAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGTGGCTTGGGCTGGGAGTCCAGCCTCCGTCAG
CGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAGCGGGACGAGTGGCTGGCACGCTGGAAAAGG
GAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCC
AGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAG
AATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGC
TTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGA
GACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAG
CCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAG
AGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTG
GAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCA
CCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAG
GTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGA
ATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGG
GGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCC
CAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCC
TCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAG
CCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCC
TCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAG
AAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGC
CTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTC
TGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCC
AAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAG
CTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAG
GGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTC
CACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTC
GCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTAAACAAACAAACAAAAAACA
CAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAG
GCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACA
AAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGT
TTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAA
AGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTTTTTGTTTTTTGTTTTTTTTTTTTGGGTTTT
TTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGG
CAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAAC
ACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTC
TTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGC
TTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTT
GCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAA
AAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAA
AGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGA

>8555_8555_4_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1355AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS
EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR
LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA
GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK
AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP
RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL
MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL
SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE
CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE

--------------------------------------------------------------
>8555_8555_5_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000321117_length(transcript)=5386nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG
CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC
GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC
TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT
GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGCAAAGAA
CAGAAGGAGACCAACATCGAATCCATGAAAATGGAGGGCTCCCGGGGCCGGCTGCGGGGTGGCTTGGGCTGGGAGTCCAGCCTCCGTCAG
CGGCCCATGCCGAGGCTCACCTTCCAGGCGGGGGACCCCTACTACATCAGCAAGCGCAAGCGGGACGAGTGGCTGGCACGCTGGAAAAGG
GAGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCC
AGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAG
AATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGC
TTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGA
GACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAG
CCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAG
AGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTG
GAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCA
CCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAG
GTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGA
ATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGG
GGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCC
CAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCC
TCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAG
CCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCC
TCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAG
AAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGC
CTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTC
TGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCC
AAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAG
CTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAG
GGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTC
CACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTC
GCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTAAACAAACAAACAAAAAACA
CAAAACATAATAAAACACCAAGAACATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAG
GCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACA
AAACCAAGCTCCCTTCCCTTCCTCCCCCTTCCCTTTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGT
TTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAA
AGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGTTGTTTTTTTTTTTGTTTTTTGTTTTTTTTTTTTGGGTTTT
TTTTTTTACTATATATCTTTTTTTTGTTGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGG
CAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAAC
ACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTC
TTGTTTACAGTTTATATATATATGATAGATATGAGATATATATATAAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGC
TTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTT
GCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAA
AAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAA
AGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGA

>8555_8555_5_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1355AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS
EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR
LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA
GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK
AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP
RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL
MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL
SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE
CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE

--------------------------------------------------------------
>8555_8555_6_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000406659_length(transcript)=2781nt_BP=1416nt
GCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG
ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAG
GGTTTCCCCTTGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGAC
CCGAGGCCCGCCAGCTACAGTTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTG
GACCTGGGGTATGAGCCTGAGGGCAGTGCCTCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAA
GATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGGGCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAG
CTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGCCATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTG
TCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTGATCGATCCTGCCATGTTTGACCAGGCCCAG
ACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAATATACGAGGACAGGCTCGGAG
AGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGAAGATGAGGAA
TGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT
GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTC
AATGCCGGCTATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACG
GACAGCAGCGTGGATGGGATCCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTG
CCCCTACCTCACATTCCCCGCACGTACCGGGTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTG
GAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGGAGGAGCGGCTGAAGCGCGTGCGCATGGACGGAGAGGAGCAGGAGGAGCCG
CGTGGCAAGGAGGAGCGCCAAGAGCCCAGCACCACGGCACGGAAGGTGGGGCGGCCTGGGAGGAAGCGCAAGCACCCCCCGGTGGAAAGC
GGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGTCCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGAC
TTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGAGCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCT
GAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATGGCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGTGAGTCC
TCAGCACCAGGGGCAGCCTCTTCTGGGCCCACCAGCATACCCTGAGAGTCAGGGACTTGGCTCTCCAGCAGGTCCCAGGAAGGATGGTCT
GGGTCGTGGCTAAAGGTCTGCTTGCCAAGGCTATGGCCTGGAGGCTACTGGCTGGATGCAGCCTGCGCATATGTTTTATTTGGCCCATAG
AGTGTTTTAAACATTTAAAAAATTAGTTGCCAGTATTTAAAAATCAAAAAATTTCACATAAAAATCTGGAGTTTTGGCTTCTCATGAAAA
AAAAAAAAGCTAGATCTGGCAACAGCGGGCTTTCATAACGCCAACGATTGCTAGACTGGGATAATGGCGGTCCCTCCATCGCCTTCTGTG
GCTGGTTGTGGGCCTTAGTTTTCTGCAGCTCTACCTGGCCTGCTTACTCTCCCACGTGCCATGCAGTTCCTGGGGGTTGCTGTATTTGTA
GCCCCTGGCCTGGGCACTCAAGGGCAGCAGATACCCTGTTTGCCTCCCTGAGTGCAGAGGTCCTGAGCCCACCCTAGTTGGGCTGACTCA
ACTGGAAATTTGGTTGTGACAGTGGCGTGGGGAGAGGGCTGGGTGATTGTATTCTGTGTACTGCCCAGCCCAGGCCTCTTCATCTGGGGA
CTTTTTGGCCTAACCCTGGAAGCCTGGAAAGTTGCCCACTTTTCTCTTTCAGGTTAAGCCAGCAATTTCAGGGCCAACCGAGCTGTAAAC
ATGTTAGTAATGAGGACAACTAGCATTTGTACAGGGCTTCACAGTTTACAAAGCGCTTTCTCATACATTATCACATTTGATCCTCCCAGG
GCCCTGCCAGGTTGTTTTGCATATGTGCATTTTAATTTCAAAAAGTCTTCCTTCCAAGCGTGTATGATGAAATGAGTAAATTGATTAATT

>8555_8555_6_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=609AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS

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Top

Fusion Gene PPI Analysis for AXIN1-DNMT3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511209_338418.0863.0TP53
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510209_338418.0827.0TP53
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123199_40324.0913.0DNMT1 and DNMT3B
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123199_40324.0913.0DNMT1 and DNMT3B
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019199_4030724.0DNMT1 and DNMT3B
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018199_4030690.0DNMT1 and DNMT3B
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914199_40324.0167.0DNMT1 and DNMT3B
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123494_58624.0913.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123494_58624.0913.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019494_5860724.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018494_5860690.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914494_58624.0167.0the PRC2/EED-EZH2 complex


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511434_502418.0863.0CTNNB1
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510434_502418.0827.0CTNNB1
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511348_433418.0863.0GSK3B
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510348_433418.0827.0GSK3B
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511677_752418.0863.0HIPK2
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510677_752418.0827.0HIPK2
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511575_789418.0863.0PPP2CA
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510575_789418.0827.0PPP2CA
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511507_757418.0863.0RNF111
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510507_757418.0827.0RNF111


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AXIN1-DNMT3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDNMT3AQ9Y6K1DB01262DecitabineInhibitorSmall moleculeApproved|Investigational
TgeneDNMT3AQ9Y6K1DB00721ProcaineInhibitorSmall moleculeApproved|Investigational|Vet_approved

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Related Diseases for AXIN1-DNMT3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAXIN1C2239176Liver carcinoma2CGI;CTD_human;UNIPROT
HgeneAXIN1C0279607Adult Hepatocellular Carcinoma1ORPHANET
TgeneC4014545Tatton Brown Rahman syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0018273Growth Disorders2CTD_human
TgeneC0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0010346Crohn Disease1CTD_human
TgeneC0013336Dwarfism1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0020981Angioimmunoblastic Lymphadenopathy1CTD_human
TgeneC0023465Acute monocytic leukemia1CTD_human
TgeneC0023487Acute Promyelocytic Leukemia1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0025958Microcephaly1CTD_human
TgeneC0027643Neoplasm Recurrence, Local1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneC0156147Crohn's disease of large bowel1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0265202Seckel syndrome1GENOMICS_ENGLAND
TgeneC0267380Crohn's disease of the ileum1CTD_human
TgeneC0282631Facies1CTD_human
TgeneC0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneC0376407Granulomatous Slack Skin1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0678202Regional enteritis1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC0949272IIeocolitis1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1510586Autism Spectrum Disorders1CTD_human
TgeneC1956147Microlissencephaly1CTD_human
TgeneC2931852Clear-cell metastatic renal cell carcinoma1CTD_human
TgeneC3496069cocaine use1PSYGENET
TgeneC3714756Intellectual Disability1CTD_human
TgeneC3853041Severe Congenital Microcephaly1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human