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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAP1-TCEA3 (FusionGDB2 ID:HG8314TG6920)

Fusion Gene Summary for BAP1-TCEA3

check button Fusion gene summary
Fusion gene informationFusion gene name: BAP1-TCEA3
Fusion gene ID: hg8314tg6920
HgeneTgene
Gene symbol

BAP1

TCEA3

Gene ID

8314

6920

Gene nameBRCA1 associated protein 1transcription elongation factor A3
SynonymsHUCEP-13|UCHL2|hucep-6TFIIS|TFIIS.H
Cytomap('BAP1')('TCEA3')

3p21.1

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase BAP1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)cerebral protein 6cerebral protein-13transcription elongation factor A protein 3rhabdomyosarcoma antigen MU-RMS-40.22transcription elongation factor A (SII), 3transcription elongation factor S-II protein 3transcription elongation factor TFIIS.h
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296288, ENST00000460680, 
Fusion gene scores* DoF score12 X 13 X 7=10927 X 8 X 4=224
# samples 138
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAP1 [Title/Abstract] AND TCEA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAP1(52439781)-TCEA3(23745632), # samples:2
BAP1(52440269)-TCEA3(23745632), # samples:2
Anticipated loss of major functional domain due to fusion event.BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BAP1-TCEA3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAP1

GO:0016579

protein deubiquitination

18757409|19815555

HgeneBAP1

GO:0035520

monoubiquitinated protein deubiquitination

24703950

HgeneBAP1

GO:0035522

monoubiquitinated histone H2A deubiquitination

20436459|25451922

HgeneBAP1

GO:0045892

negative regulation of transcription, DNA-templated

25451922


check buttonFusion gene breakpoints across BAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TCEA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-MQ-A4LC-01ABAP1chr3

52439781

-TCEA3chr1

23745632

-
ChimerDB4MESOTCGA-MQ-A4LC-01ABAP1chr3

52440269

-TCEA3chr1

23745632

-


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Fusion Gene ORF analysis for BAP1-TCEA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000296288ENST00000461794BAP1chr3

52439781

-TCEA3chr1

23745632

-
5CDS-5UTRENST00000296288ENST00000461794BAP1chr3

52440269

-TCEA3chr1

23745632

-
5CDS-5UTRENST00000460680ENST00000461794BAP1chr3

52439781

-TCEA3chr1

23745632

-
5CDS-5UTRENST00000460680ENST00000461794BAP1chr3

52440269

-TCEA3chr1

23745632

-
Frame-shiftENST00000296288ENST00000374601BAP1chr3

52439781

-TCEA3chr1

23745632

-
Frame-shiftENST00000296288ENST00000450454BAP1chr3

52439781

-TCEA3chr1

23745632

-
Frame-shiftENST00000460680ENST00000374601BAP1chr3

52439781

-TCEA3chr1

23745632

-
Frame-shiftENST00000460680ENST00000450454BAP1chr3

52439781

-TCEA3chr1

23745632

-
In-frameENST00000296288ENST00000374601BAP1chr3

52440269

-TCEA3chr1

23745632

-
In-frameENST00000296288ENST00000450454BAP1chr3

52440269

-TCEA3chr1

23745632

-
In-frameENST00000460680ENST00000374601BAP1chr3

52440269

-TCEA3chr1

23745632

-
In-frameENST00000460680ENST00000450454BAP1chr3

52440269

-TCEA3chr1

23745632

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000460680BAP1chr352440269-ENST00000450454TCEA3chr123745632-263812554722232586
ENST00000460680BAP1chr352440269-ENST00000374601TCEA3chr123745632-23091255123031399
ENST00000296288BAP1chr352440269-ENST00000450454TCEA3chr123745632-2148765361742568
ENST00000296288BAP1chr352440269-ENST00000374601TCEA3chr123745632-1819765361160374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000460680ENST00000450454BAP1chr352440269-TCEA3chr123745632-0.0082552820.9917447
ENST00000460680ENST00000374601BAP1chr352440269-TCEA3chr123745632-0.0067449930.993255
ENST00000296288ENST00000450454BAP1chr352440269-TCEA3chr123745632-0.0084001480.9915999
ENST00000296288ENST00000374601BAP1chr352440269-TCEA3chr123745632-0.0045704920.9954295

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Fusion Genomic Features for BAP1-TCEA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BAP1-TCEA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52439781/chr1:23745632)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTCEA3chr3:52440269chr1:23745632ENST00000450454011130_17323349.0Compositional biasNote=Ser-rich
TgeneTCEA3chr3:52440269chr1:23745632ENST00000450454011187_30323349.0DomainTFIIS central
TgeneTCEA3chr3:52440269chr1:23745632ENST00000450454011306_34623349.0Zinc fingerTFIIS-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAP1chr3:52440269chr1:23745632ENST00000460680-917630_661261730.0Coiled coilOntology_term=ECO:0000255
TgeneTCEA3chr3:52440269chr1:23745632ENST000004504540115_8223349.0DomainTFIIS N-terminal


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Fusion Gene Sequence for BAP1-TCEA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8975_8975_1_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000296288_TCEA3_chr1_23745632_ENST00000374601_length(transcript)=1819nt_BP=765nt
CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC
GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC
CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT
AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG
GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC
AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC
CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG
GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT
GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGGAAGGGGCCCTGGACCTTCTGAAGAAGCTGCACAGCTGCCAGATG
TCCATCCAGCTACTACAGACAACCAGGATTGGAGTTGCTGTTAATGGGGTCCGCAAGCACTGCTCAGACAAGGAGGTGGTGTCCTTGGCC
AAAGTCCTTATCAAAAACTGGAAGCGGCTGCTAGACTCCCCTGGACCCCCAAAAGGAGAAAAAGGAGAGGAAAGAGAAAAGGCAAAGAAG
AAGGAAAAAGGGCTTGAGTGTTCAGACTGGAAGCCAGAAGCAGGCCTTTCTCCACCAAGGAAAAAACGAGAAGACCCCAAAACCAGGAGA
GACTCTGTGGACTCCAAGTCTTCTGCCTCCTCCTCTCCAAAAAGACCATCGGTGGAAAGAGCATGCTCGCTGATGCAGTAACTGAAATGC
CCTCGAGGTGGCGCACAGAAGCAGCGGGCCCGGCCTCCAGATGCCTCTACTCAGACCTGGGGCAGGAGGATTTTCTAAGGACTGGTGCGG
TGCGGGCACATCCGGGGAGCAGAAGGAAGCTGTTGATAAATCCAACCTCCCACCCCGGCCGATGATGCCCTCTCTGCAGTTTGGCTCAGT
TCCCAGGCGTGTGCATTGAAAGCAAAATGAGTGTGGCTGCCTGAAATGCTGCCCAGACACGAATTCCAGCCAGCCAGCCAGCTCCTAACC
GGGGAGGCGGGACCAGGGCTGGGTGTGCCCTGCCAGGAAGGTGGGAAGAAATGCTCCAAACAGCCTAGTCTTGCTCAGGTAGGAGGACTC
TGGAAACCTCTCTTTTAAAGACACAGTTGATGTGTTGAAAAGAATTTGGAAGGGCGACAGGCAGGTTCGTGGTCTGACTATACCCTTTGC
TAGTTGGATGGATAACTTGGGGCAGTAACTTGGATGGATAATTCAGTTCAGCTCTCTGAGCTTCAGTCTACTGATCTGTAAAATGGAGAC
AATTATGAACCCCTTTCAAGGTCATTGTGAGGATTAAATGAGGTAATGAAATACCCAGCACTGTTCCCAAACCATGTAAATGCTCAATAA

>8975_8975_1_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000296288_TCEA3_chr1_23745632_ENST00000374601_length(amino acids)=374AA_BP=240
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS
CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL
FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQEGALDLLKKLHSCQMSIQLLQTTRIGV
AVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPGPPKGEKGEEREKAKKKEKGLECSDWKPEAGLSPPRKKREDPKTRRDSVDSKSSASSS

--------------------------------------------------------------
>8975_8975_2_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000296288_TCEA3_chr1_23745632_ENST00000450454_length(transcript)=2148nt_BP=765nt
CCTGGACATGGCGCTGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTC
GTGGAAGATTTCGGTGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTC
CTGTTCAAATGGATCGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAAT
AACATGTTCTTTGCCCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTG
GGACCCACCCTGAGTCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCC
AAGGCCCATAATAGCCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTC
CACTTTGTCAGCTATGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAG
GACGAGGAGTGGACAGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGATCAAGTATGAGGCCAGGCTGCAT
GTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGGAAGGGGCCCTGGACCTTCTGAAGAAGCTGCACAGCTGCCAGATG
TCCATCCAGCTACTACAGACAACCAGGATTGGAGTTGCTGTTAATGGGGTCCGCAAGCACTGCTCAGACAAGGAGGTGGTGTCCTTGGCC
AAAGTCCTTATCAAAAACTGGAAGCGGCTGCTAGACTCCCCTGGACCCCCAAAAGGAGAAAAAGGAGAGGAAAGAGAAAAGGCAAAGAAG
AAGGAAAAAGGGCTTGAGTGTTCAGACTGGAAGCCAGAAGCAGGCCTTTCTCCACCAAGGAAAAAACGAGAAGACCCCAAAACCAGGAGA
GACTCTGTGGACTCCAAGTCTTCTGCCTCCTCCTCTCCAAAAAGACCATCGGTGGAAAGATCAAACAGCAGCAAATCAAAAGCGGAGAGC
CCCAAAACACCTAGCAGCCCCTTGACCCCCACGTTTGCCTCTTCCATGTGTCTCCTGGCCCCCTGCTATCTCACAGGGGACTCTGTCCGG
GACAAGTGTGTGGAGATGCTGTCAGCAGCCCTGAAGGCGGACGATGATTACAAGGACTATGGAGTCAACTGTGACAAGATGGCATCAGAA
ATCGAAGATCATATCTACCAAGAGCTCAAGAGCACGGACATGAAGTACCGGAACCGCGTGCGCAGCCGCATAAGCAACCTCAAGGACCCC
AGGAACCCCGGCCTGCGGCGGAACGTGCTCAGTGGGGCCATCTCCGCAGGGCTTATAGCCAAGATGACGGCAGAGGAAATGGCCAGTGAT
GAACTGAGGGAGTTGAGGAATGCCATGACCCAGGAGGCCATCCGTGAGCACCAGATGGCCAAGACTGGCGGCACCACCACTGACCTCTTC
CAGTGCAGCAAATGCAAGAAGAAGAACTGCACCTATAACCAGGTGCAGACACGCAGTGCTGATGAGCCCATGACTACCTTTGTCTTATGC
AATGAATGTGGCAATCGCTGGAAGTTCTGCTGATGGAACAGCCAGCCATGAACAAGGTGAGGAAGAAGAAAGAGGAAGCGCTGAATTATC
TGAACTGGAGAAGCAATAAAAATTAAAGTGAAGGAAAATACTGAACTCTGTCTGAGTGGGATGGTATGAGTTAGAGGAAGAATTCTCTTG
CAAATTAATAATCGGTCATTAGAAACAATTGGTTAATGGGGGAGCCTAATTGGAGAATGATGCTGAGAATTTGTATTGATGAACCTCTTT
TAGAAACTGCAGAGGGCTGGGCACGGTGGTTTATGGCTGTAATCTGCAAACTCTGGGAGGCTGAGGTGGGAGAATCGCTTAACCCCAGAA

>8975_8975_2_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000296288_TCEA3_chr1_23745632_ENST00000450454_length(amino acids)=568AA_BP=240
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS
CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL
FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQEGALDLLKKLHSCQMSIQLLQTTRIGV
AVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPGPPKGEKGEEREKAKKKEKGLECSDWKPEAGLSPPRKKREDPKTRRDSVDSKSSASSS
PKRPSVERSNSSKSKAESPKTPSSPLTPTFASSMCLLAPCYLTGDSVRDKCVEMLSAALKADDDYKDYGVNCDKMASEIEDHIYQELKST
DMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISAGLIAKMTAEEMASDELRELRNAMTQEAIREHQMAKTGGTTTDLFQCSKCKKKNCTY

--------------------------------------------------------------
>8975_8975_3_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000460680_TCEA3_chr1_23745632_ENST00000374601_length(transcript)=2309nt_BP=1255nt
CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC
CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG
CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC
GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC
CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC
TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG
TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT
CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC
CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG
TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG
CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA
TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC
AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT
GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGGAAGG
GGCCCTGGACCTTCTGAAGAAGCTGCACAGCTGCCAGATGTCCATCCAGCTACTACAGACAACCAGGATTGGAGTTGCTGTTAATGGGGT
CCGCAAGCACTGCTCAGACAAGGAGGTGGTGTCCTTGGCCAAAGTCCTTATCAAAAACTGGAAGCGGCTGCTAGACTCCCCTGGACCCCC
AAAAGGAGAAAAAGGAGAGGAAAGAGAAAAGGCAAAGAAGAAGGAAAAAGGGCTTGAGTGTTCAGACTGGAAGCCAGAAGCAGGCCTTTC
TCCACCAAGGAAAAAACGAGAAGACCCCAAAACCAGGAGAGACTCTGTGGACTCCAAGTCTTCTGCCTCCTCCTCTCCAAAAAGACCATC
GGTGGAAAGAGCATGCTCGCTGATGCAGTAACTGAAATGCCCTCGAGGTGGCGCACAGAAGCAGCGGGCCCGGCCTCCAGATGCCTCTAC
TCAGACCTGGGGCAGGAGGATTTTCTAAGGACTGGTGCGGTGCGGGCACATCCGGGGAGCAGAAGGAAGCTGTTGATAAATCCAACCTCC
CACCCCGGCCGATGATGCCCTCTCTGCAGTTTGGCTCAGTTCCCAGGCGTGTGCATTGAAAGCAAAATGAGTGTGGCTGCCTGAAATGCT
GCCCAGACACGAATTCCAGCCAGCCAGCCAGCTCCTAACCGGGGAGGCGGGACCAGGGCTGGGTGTGCCCTGCCAGGAAGGTGGGAAGAA
ATGCTCCAAACAGCCTAGTCTTGCTCAGGTAGGAGGACTCTGGAAACCTCTCTTTTAAAGACACAGTTGATGTGTTGAAAAGAATTTGGA
AGGGCGACAGGCAGGTTCGTGGTCTGACTATACCCTTTGCTAGTTGGATGGATAACTTGGGGCAGTAACTTGGATGGATAATTCAGTTCA
GCTCTCTGAGCTTCAGTCTACTGATCTGTAAAATGGAGACAATTATGAACCCCTTTCAAGGTCATTGTGAGGATTAAATGAGGTAATGAA

>8975_8975_3_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000460680_TCEA3_chr1_23745632_ENST00000374601_length(amino acids)=399AA_BP=
MTVHLQHMQPGLILDPAVGHHCHQVEADVVVGLPCSGEADTLHDDPPGLVCPLLVLPPGPMVNGVDLQPIQLKEPACDRHIADKVERLHG
PHCTKAILLLREVAWLGPGMAIMGLGQLRGIANRISFALRAETLGEVLHATQGGSQVHAAAVQEHAQQGMSCTRVGYQLVGKEHVIHNII
INHGRIIHQGRDLSPGPALFDPFEQEDKSIYRALTFALKVVDLLHLHPLDTEIFHEQGEEAWVALQLQPALIHLPAGRPLSAMSRPSLPT
AAPTGSPHRPRGPSVPHTDNGPSRVTRPRRRQTSPRRDGPAPPLGSSSACRTADAGMRSKANAHARRDGGEGEGRGRRGGAGRDGTGAKG

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>8975_8975_4_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000460680_TCEA3_chr1_23745632_ENST00000450454_length(transcript)=2638nt_BP=1255nt
CGCTCCGCCCCTCCCCTCGCAGCACCCGGGCCTAGTACTGCCCGTCCCGCCCCTCCTCTCGAGCCTCAGCGCTCAGCATCGCCCGGACCC
CCTCTTCCCTTCGCCCGCCTCGTCCCGACCCTCCCCTTCGCCCCCGTCCCGCCCCGCCCCTCCCCTTCGCCCCCGTCCCGTCCCGCCCCG
CCCCTCCCCTTCGCCCCCGTCCCTCCCCTTCGCCCCCGTCCCTCCGCGCGTGCGCGTTCGCCTTCGAGCGCATGCCCGCATCTGCTGTCC
GACAGGCGGAAGACGAGCCCAGAGGCGGAGCAGGGCCGTCGCGCCTTGGTGACGTCTGCCGCCGGCGCGGGCGGGTGACGCGACTGGGCC
CGTTGTCTGTGTGTGGGACTGAGGGGCCCCGGGGGCGGTGGGGGCTCCCGGTGGGGGCAGCGGTGGGGAGGGAGGGCCTGGACATGGCGC
TGAGGGGCCGCCCCGCGGGAAGATGAATAAGGGCTGGCTGGAGCTGGAGAGCGACCCAGGCCTCTTCACCCTGCTCGTGGAAGATTTCGG
TGTCAAGGGGGTGCAAGTGGAGGAGATCTACGACCTTCAGAGCAAATGTCAGGGCCCTGTATATGGATTTATCTTCCTGTTCAAATGGAT
CGAAGAGCGCCGGTCCCGGCGAAAGGTCTCTACCTTGGTGGATGATACGTCCGTGATTGATGATGATATTGTGAATAACATGTTCTTTGC
CCACCAGCTGATACCCAACTCTTGTGCAACTCATGCCTTGCTGAGCGTGCTCCTGAACTGCAGCAGCGTGGACCTGGGACCCACCCTGAG
TCGCATGAAGGACTTCACCAAGGGTTTCAGCCCTGAGAGCAAAGGATATGCGATTGGCAATGCCCCGGAGTTGGCCAAGGCCCATAATAG
CCATGCCAGGCCCGAGCCACGCCACCTCCCTGAGAAGCAGAATGGCCTTAGTGCAGTGCGGACCATGGAGGCGTTCCACTTTGTCAGCTA
TGTGCCTATCACAGGCCGGCTCTTTGAGCTGGATGGGCTGAAGGTCTACCCCATTGACCATGGGCCCTGGGGGGAGGACGAGGAGTGGAC
AGACAAGGCCCGGCGGGTCATCATGGAGCGTATCGGCCTCGCCACTGCAGGGGAGCCCTACCACGACATCCGCTTCAACCTGATGGCAGT
GGTGCCCGACCGCAGGATCAAGTATGAGGCCAGGCTGCATGTGCTGAAGGTGAACCGTCAGACAGTACTAGAGGCTCTGCAGCAGGAAGG
GGCCCTGGACCTTCTGAAGAAGCTGCACAGCTGCCAGATGTCCATCCAGCTACTACAGACAACCAGGATTGGAGTTGCTGTTAATGGGGT
CCGCAAGCACTGCTCAGACAAGGAGGTGGTGTCCTTGGCCAAAGTCCTTATCAAAAACTGGAAGCGGCTGCTAGACTCCCCTGGACCCCC
AAAAGGAGAAAAAGGAGAGGAAAGAGAAAAGGCAAAGAAGAAGGAAAAAGGGCTTGAGTGTTCAGACTGGAAGCCAGAAGCAGGCCTTTC
TCCACCAAGGAAAAAACGAGAAGACCCCAAAACCAGGAGAGACTCTGTGGACTCCAAGTCTTCTGCCTCCTCCTCTCCAAAAAGACCATC
GGTGGAAAGATCAAACAGCAGCAAATCAAAAGCGGAGAGCCCCAAAACACCTAGCAGCCCCTTGACCCCCACGTTTGCCTCTTCCATGTG
TCTCCTGGCCCCCTGCTATCTCACAGGGGACTCTGTCCGGGACAAGTGTGTGGAGATGCTGTCAGCAGCCCTGAAGGCGGACGATGATTA
CAAGGACTATGGAGTCAACTGTGACAAGATGGCATCAGAAATCGAAGATCATATCTACCAAGAGCTCAAGAGCACGGACATGAAGTACCG
GAACCGCGTGCGCAGCCGCATAAGCAACCTCAAGGACCCCAGGAACCCCGGCCTGCGGCGGAACGTGCTCAGTGGGGCCATCTCCGCAGG
GCTTATAGCCAAGATGACGGCAGAGGAAATGGCCAGTGATGAACTGAGGGAGTTGAGGAATGCCATGACCCAGGAGGCCATCCGTGAGCA
CCAGATGGCCAAGACTGGCGGCACCACCACTGACCTCTTCCAGTGCAGCAAATGCAAGAAGAAGAACTGCACCTATAACCAGGTGCAGAC
ACGCAGTGCTGATGAGCCCATGACTACCTTTGTCTTATGCAATGAATGTGGCAATCGCTGGAAGTTCTGCTGATGGAACAGCCAGCCATG
AACAAGGTGAGGAAGAAGAAAGAGGAAGCGCTGAATTATCTGAACTGGAGAAGCAATAAAAATTAAAGTGAAGGAAAATACTGAACTCTG
TCTGAGTGGGATGGTATGAGTTAGAGGAAGAATTCTCTTGCAAATTAATAATCGGTCATTAGAAACAATTGGTTAATGGGGGAGCCTAAT
TGGAGAATGATGCTGAGAATTTGTATTGATGAACCTCTTTTAGAAACTGCAGAGGGCTGGGCACGGTGGTTTATGGCTGTAATCTGCAAA
CTCTGGGAGGCTGAGGTGGGAGAATCGCTTAACCCCAGAAGTTTGAGTCCAGCCCAGGCAACACAGCAAGACCCCATCTCTATAAAAAGA

>8975_8975_4_BAP1-TCEA3_BAP1_chr3_52440269_ENST00000460680_TCEA3_chr1_23745632_ENST00000450454_length(amino acids)=586AA_BP=258
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNS
CATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRL
FELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQEGALDLLKK
LHSCQMSIQLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPGPPKGEKGEEREKAKKKEKGLECSDWKPEAGLSPPRKKRE
DPKTRRDSVDSKSSASSSPKRPSVERSNSSKSKAESPKTPSSPLTPTFASSMCLLAPCYLTGDSVRDKCVEMLSAALKADDDYKDYGVNC
DKMASEIEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISAGLIAKMTAEEMASDELRELRNAMTQEAIREHQMAKTGG

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Fusion Gene PPI Analysis for BAP1-TCEA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBAP1chr3:52440269chr1:23745632ENST00000460680-917596_721261.0730.0BRCA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAP1-TCEA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAP1-TCEA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAP1C3280492TUMOR PREDISPOSITION SYNDROME7CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneBAP1C0220633Uveal melanoma5CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneBAP1C0345967Malignant mesothelioma5CTD_human
HgeneBAP1C0007134Renal Cell Carcinoma4CTD_human
HgeneBAP1C0025500Mesothelioma4CGI;CTD_human
HgeneBAP1C0279702Conventional (Clear Cell) Renal Cell Carcinoma4CGI;CTD_human
HgeneBAP1C1266042Chromophobe Renal Cell Carcinoma4CTD_human
HgeneBAP1C1266043Sarcomatoid Renal Cell Carcinoma4CTD_human
HgeneBAP1C1266044Collecting Duct Carcinoma of the Kidney4CTD_human
HgeneBAP1C1306837Papillary Renal Cell Carcinoma4CTD_human
HgeneBAP1C0006142Malignant neoplasm of breast2CGI;CTD_human
HgeneBAP1C0024623Malignant neoplasm of stomach2CTD_human
HgeneBAP1C0038356Stomach Neoplasms2CTD_human
HgeneBAP1C0151779Cutaneous Melanoma2CGI;CTD_human;GENOMICS_ENGLAND
HgeneBAP1C0206698Cholangiocarcinoma2CTD_human
HgeneBAP1C0345905Intrahepatic Cholangiocarcinoma2CTD_human
HgeneBAP1C0346373Malignant melanoma of iris2ORPHANET
HgeneBAP1C0346388Malignant melanoma of choroid2ORPHANET
HgeneBAP1C0678222Breast Carcinoma2CGI;CTD_human
HgeneBAP1C1257931Mammary Neoplasms, Human2CTD_human
HgeneBAP1C1458155Mammary Neoplasms2CTD_human
HgeneBAP1C1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneBAP1C3805278Extrahepatic Cholangiocarcinoma2CTD_human
HgeneBAP1C4704874Mammary Carcinoma, Human2CTD_human
HgeneBAP1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneBAP1C0005695Bladder Neoplasm1CTD_human
HgeneBAP1C0005967Bone neoplasms1CTD_human
HgeneBAP1C0007102Malignant tumor of colon1CTD_human
HgeneBAP1C0009375Colonic Neoplasms1CTD_human
HgeneBAP1C0018671Head and Neck Neoplasms1CTD_human
HgeneBAP1C0018675Head Neoplasms1CTD_human
HgeneBAP1C0022665Kidney Neoplasm1CGI;CTD_human
HgeneBAP1C0023418leukemia1CTD_human
HgeneBAP1C0023798Lipoma1CTD_human
HgeneBAP1C0023903Liver neoplasms1CTD_human
HgeneBAP1C0024121Lung Neoplasms1CTD_human
HgeneBAP1C0025286Meningioma1CTD_human;GENOMICS_ENGLAND
HgeneBAP1C0027533Neck Neoplasms1CTD_human
HgeneBAP1C0030297Pancreatic Neoplasm1CTD_human
HgeneBAP1C0030421Paraganglioma1CTD_human
HgeneBAP1C0033578Prostatic Neoplasms1CTD_human
HgeneBAP1C0039590Testicular Neoplasms1CTD_human
HgeneBAP1C0040100Thymoma1CTD_human
HgeneBAP1C0042138Uterine Neoplasms1CTD_human
HgeneBAP1C0085136Central Nervous System Neoplasms1CTD_human
HgeneBAP1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneBAP1C0153567Uterine Cancer1CTD_human
HgeneBAP1C0153594Malignant neoplasm of testis1CTD_human
HgeneBAP1C0205822Hibernoma1CTD_human
HgeneBAP1C0205823Pleomorphic Lipoma1CTD_human
HgeneBAP1C0205834Meningiomas, Multiple1CTD_human
HgeneBAP1C0205969Thymic Carcinoma1CTD_human
HgeneBAP1C0206686Adrenocortical carcinoma1CTD_human
HgeneBAP1C0206694Mucoepidermoid Carcinoma1CTD_human
HgeneBAP1C0206739Epithelioid and spindle cell nevus1CTD_human
HgeneBAP1C0206754Neuroendocrine Tumors1CTD_human
HgeneBAP1C0206769Nevi and Melanomas1CTD_human
HgeneBAP1C0242379Malignant neoplasm of lung1CTD_human;UNIPROT
HgeneBAP1C0259785Malignant Meningioma1CTD_human
HgeneBAP1C0278996Malignant Head and Neck Neoplasm1CTD_human
HgeneBAP1C0279530Malignant Bone Neoplasm1CTD_human
HgeneBAP1C0281784Benign Meningioma1CTD_human
HgeneBAP1C0334605Meningothelial meningioma1CTD_human
HgeneBAP1C0334606Fibrous Meningioma1CTD_human
HgeneBAP1C0334607Psammomatous Meningioma1CTD_human
HgeneBAP1C0334608Angiomatous Meningioma1CTD_human
HgeneBAP1C0334609Hemangioblastic Meningioma1CTD_human
HgeneBAP1C0334610Hemangiopericytic Meningioma1CTD_human
HgeneBAP1C0334611Transitional Meningioma1CTD_human
HgeneBAP1C0345904Malignant neoplasm of liver1CTD_human
HgeneBAP1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneBAP1C0347515Spinal Meningioma1CTD_human
HgeneBAP1C0349604Intracranial Meningioma1CTD_human
HgeneBAP1C0376358Malignant neoplasm of prostate1CTD_human
HgeneBAP1C0431121Clear Cell Meningioma1CTD_human
HgeneBAP1C0457190Xanthomatous Meningioma1CTD_human
HgeneBAP1C0740457Malignant neoplasm of kidney1CGI;CTD_human
HgeneBAP1C0746787Cancer of Neck1CTD_human
HgeneBAP1C0751177Cancer of Head1CTD_human
HgeneBAP1C0751303Cerebral Convexity Meningioma1CTD_human
HgeneBAP1C0751304Parasagittal Meningioma1CTD_human
HgeneBAP1C0751620Central Nervous System Neoplasms, Primary1CTD_human
HgeneBAP1C0887900Upper Aerodigestive Tract Neoplasms1CTD_human
HgeneBAP1C0919267ovarian neoplasm1CTD_human
HgeneBAP1C1140680Malignant neoplasm of ovary1CTD_human
HgeneBAP1C1334261Intraorbital Meningioma1CTD_human
HgeneBAP1C1334271Intraventricular Meningioma1CTD_human
HgeneBAP1C1335107Olfactory Groove Meningioma1CTD_human
HgeneBAP1C1368275Pigmented Basal Cell Carcinoma1CTD_human
HgeneBAP1C1384406Secretory meningioma1CTD_human
HgeneBAP1C1384408Microcystic meningioma1CTD_human
HgeneBAP1C1527197Angioblastic Meningioma1CTD_human
HgeneBAP1C1565950Posterior Fossa Meningioma1CTD_human
HgeneBAP1C1565951Sphenoid Wing Meningioma1CTD_human
HgeneBAP1C1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
HgeneBAP1C1720811Tumor of Rete Testis1CTD_human
HgeneBAP1C2314896Familial Atypical Mole Melanoma Syndrome1ORPHANET
HgeneBAP1C2931822Nasopharyngeal carcinoma1CTD_human
HgeneBAP1C3163622Papillary Meningioma1CTD_human
HgeneBAP1C3489413Lipomatosis, Multiple1CTD_human
HgeneBAP1C4721806Carcinoma, Basal Cell1CTD_human