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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CAPZB-APITD1 (FusionGDB2 ID:HG832TG100526739) |
Fusion Gene Summary for CAPZB-APITD1 |
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Fusion gene information | Fusion gene name: CAPZB-APITD1 | Fusion gene ID: hg832tg100526739 | Hgene | Tgene | Gene symbol | CAPZB | APITD1 | Gene ID | 832 | 100526739 |
Gene name | capping actin protein of muscle Z-line subunit beta | CENPS-CORT readthrough | |
Synonyms | CAPB|CAPPB|CAPZ | APITD1|APITD1-CORT|CENP-S|CENPS|FAAP16|MHF1 | |
Cytomap | ('CAPZB')('APITD1') 1p36.13 | 1p36.22 | |
Type of gene | protein-coding | protein-coding | |
Description | F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein | APITD1-CORT proteinAPITD1-CORT readthroughApoptosis-inducing TAF9-like domain-containing protein 1Centromere protein SFANCM-associated histone fold protein 1FANCM-interacting histone fold protein 1Fanconi anemia-associated polypeptide of 16 kDa | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | P47756 | . | |
Ensembl transtripts involved in fusion gene | ENST00000264202, ENST00000375142, ENST00000401084, ENST00000264203, ENST00000482808, ENST00000375144, ENST00000433834, | ||
Fusion gene scores | * DoF score | 20 X 22 X 11=4840 | 3 X 4 X 3=36 |
# samples | 29 | 5 | |
** MAII score | log2(29/4840*10)=-4.06088224214702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CAPZB [Title/Abstract] AND APITD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CAPZB(19811930)-APITD1(10500404), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-B5-A0JN-01A | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
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Fusion Gene ORF analysis for CAPZB-APITD1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000264202 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-3UTR | ENST00000375142 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-3UTR | ENST00000401084 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000264202 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000264202 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000264202 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000375142 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000375142 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000375142 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000401084 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000401084 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5CDS-intron | ENST00000401084 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-3UTR | ENST00000264203 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-3UTR | ENST00000482808 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000264203 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000264203 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000264203 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000482808 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000482808 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
5UTR-intron | ENST00000482808 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-3UTR | ENST00000375144 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-3UTR | ENST00000433834 | ENST00000462462 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000375144 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000375144 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000375144 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000433834 | ENST00000309048 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000433834 | ENST00000602296 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
intron-intron | ENST00000433834 | ENST00000602787 | CAPZB | chr1 | 19811930 | - | APITD1 | chr1 | 10500404 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CAPZB-APITD1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CAPZB | chr1 | 19811929 | - | APITD1 | chr1 | 10500403 | + | 6.90E-11 | 1 |
CAPZB | chr1 | 19811929 | - | APITD1 | chr1 | 10500403 | + | 6.90E-11 | 1 |
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Fusion Protein Features for CAPZB-APITD1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19811930/:10500404) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CAPZB | . |
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CAPZB-APITD1 |
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Fusion Gene PPI Analysis for CAPZB-APITD1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CAPZB-APITD1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CAPZB-APITD1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CAPZB | C0007097 | Carcinoma | 1 | CTD_human |
Hgene | CAPZB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | CAPZB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | CAPZB | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
Hgene | CAPZB | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
Hgene | CAPZB | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
Hgene | CAPZB | C0205699 | Carcinomatosis | 1 | CTD_human |
Hgene | CAPZB | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | CAPZB | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |