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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX59-CEPT1 (FusionGDB2 ID:HG83479TG10390)

Fusion Gene Summary for DDX59-CEPT1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX59-CEPT1
Fusion gene ID: hg83479tg10390
HgeneTgene
Gene symbol

DDX59

CEPT1

Gene ID

83479

10390

Gene nameDEAD-box helicase 59choline/ethanolamine phosphotransferase 1
SynonymsOFD5|ZNHIT5-
Cytomap('DDX59')('CEPT1')

1q32.1

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX59DEAD (Asp-Glu-Ala-Asp) box polypeptide 59DEAD box protein 59zinc finger HIT domain-containing protein 5choline/ethanolaminephosphotransferase 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000331314, ENST00000367348, 
ENST00000447706, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 5 X 4=120
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX59 [Title/Abstract] AND CEPT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX59(200617567)-CEPT1(111724809), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX59-CEPT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX59-CEPT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX59-CEPT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX59-CEPT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX59 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CEPT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A2J0-01ADDX59chr1

200617567

-CEPT1chr1

111724809

+


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Fusion Gene ORF analysis for DDX59-CEPT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000331314ENST00000467362DDX59chr1

200617567

-CEPT1chr1

111724809

+
5CDS-3UTRENST00000367348ENST00000467362DDX59chr1

200617567

-CEPT1chr1

111724809

+
5CDS-3UTRENST00000447706ENST00000467362DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000331314ENST00000357172DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000331314ENST00000545121DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000367348ENST00000357172DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000367348ENST00000545121DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000447706ENST00000357172DDX59chr1

200617567

-CEPT1chr1

111724809

+
In-frameENST00000447706ENST00000545121DDX59chr1

200617567

-CEPT1chr1

111724809

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000447706DDX59chr1200617567-ENST00000545121CEPT1chr1111724809+307717481522284710
ENST00000447706DDX59chr1200617567-ENST00000357172CEPT1chr1111724809+307717481522284710
ENST00000367348DDX59chr1200617567-ENST00000545121CEPT1chr1111724809+303917101142246710
ENST00000367348DDX59chr1200617567-ENST00000357172CEPT1chr1111724809+303917101142246710
ENST00000331314DDX59chr1200617567-ENST00000545121CEPT1chr1111724809+313918102142346710
ENST00000331314DDX59chr1200617567-ENST00000357172CEPT1chr1111724809+313918102142346710

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000447706ENST00000545121DDX59chr1200617567-CEPT1chr1111724809+0.0003341910.99966586
ENST00000447706ENST00000357172DDX59chr1200617567-CEPT1chr1111724809+0.0003341910.99966586
ENST00000367348ENST00000545121DDX59chr1200617567-CEPT1chr1111724809+0.0003144410.9996855
ENST00000367348ENST00000357172DDX59chr1200617567-CEPT1chr1111724809+0.0003144410.9996855
ENST00000331314ENST00000545121DDX59chr1200617567-CEPT1chr1111724809+0.0003253530.9996747
ENST00000331314ENST00000357172DDX59chr1200617567-CEPT1chr1111724809+0.0003253530.9996747

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Fusion Genomic Features for DDX59-CEPT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDX59chr1200617566-CEPT1chr1111724808+0.0001146290.9998853
DDX59chr1200617566-CEPT1chr1111724808+0.0001146290.9998853

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDX59-CEPT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:200617567/chr1:111724809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78234_405532620.0DomainHelicase ATP-binding
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78234_405532581.0DomainHelicase ATP-binding
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78203_231532620.0MotifNote=Q motif
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78353_356532620.0MotifNote=DEAD box
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78203_231532581.0MotifNote=Q motif
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78353_356532581.0MotifNote=DEAD box
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78247_254532620.0Nucleotide bindingATP
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78247_254532581.0Nucleotide bindingATP
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78104_133532620.0Zinc fingerNote=HIT-type
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78104_133532581.0Zinc fingerNote=HIT-type
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249239_259238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249283_303238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249317_337238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249365_385238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149239_259238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149283_303238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149317_337238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149365_385238417.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX59chr1:200617567chr1:111724809ENST00000331314-78416_579532620.0DomainHelicase C-terminal
HgeneDDX59chr1:200617567chr1:111724809ENST00000447706-78416_579532581.0DomainHelicase C-terminal
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249115_135238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249186_206238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000035717249209_229238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST000003571724987_107238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149115_135238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149186_206238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST0000054512149209_229238417.0TransmembraneHelical
TgeneCEPT1chr1:200617567chr1:111724809ENST000005451214987_107238417.0TransmembraneHelical


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Fusion Gene Sequence for DDX59-CEPT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22064_22064_1_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000331314_CEPT1_chr1_111724809_ENST00000357172_length(transcript)=3139nt_BP=1810nt
AAAGCGGGCTGCGGCCCCCTCCCAAAACCCGGGGAAGTGGATTCTACTCTACGCTCCGCTCCGCTCCGCTCCGCACCACCAACCCCGGGC
CGCAGTCCTGACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGGGGAGACGGCCCGAGCGGGAGCGGGAGCG
GACGCGGCCTCAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCAAGAGGAATGCTAATGATGATGGCAAAAG
TTGTGTGGCTAAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATGTTCCCGTTGATGCTGTAGCTACAGAAGC
AGCCACAATAGACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGGCAGAGGTTCATTCAGTAAGTCCCGAGCA
GGGTGCGAAGGACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCTGGGCAGAACCAGGGGAACCCATCTGTGT
TGTCTGTGGTCGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGGAGTGTAAAGCGAAACATCTTCTACAAGT
TAAGGAAAAGGAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGTCTCCACTGAATGCTTCCTATGTCTACAA
AGAGCACCCCTTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGGGAATTTTAGTTCAAGGGCAAGAAGTCAC
CAGGCCCATTATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGAAATCAGGCTATGAGGTGCCAACTCCCAT
TCAAATGCAGATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTGGCTCAGGAAAAACAGCTGCTTTTCTTCT
TCCTGTTATCATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAACCAGAGAGTTAGCCATTCAGATAGAGAG
ACAAGCTAAAGAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCTTACCCTTACCCCCACAGCTTTATCGTCT
GCAACAACATGTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGAGCTCTGTAGAACTCTGTGGTGTAAAGAT
TGTGGTAGTAGATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACATTTTGGAAAACATTCCTAATGATTGTCA
GACCATTTTGGTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGCATAATCCTGTGAGAATTATCACTGGAGA
AAAGAACCTACCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAAAGAAAAAATTATTTGAAATTTTAAATGA
TAAGAAACTCTTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTTTGAGTGAAGCCGTTCAGAAAATCACAGG
GCTGAAAAGCATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGGGATTACTTGAAGGAGACTATGAAGTTGT
AGTGAGCACAGGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATTTTGATATGCCTTCAAGTATGGATGAGTA
TGTCCATCAGATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTTTCCTGTACAAATTA
CTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATC
AGTGATTACATTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATACTGACATTTGGTTT
TGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCGGC
ACTTTTGTTTCTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCTTTCTTTGATTTGAT
CCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAATCAAGGTCTCTACAGCTCATTCTAATCA
TCATTAATGATGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATATTAAGGAGAATGGGGGTGGATAAGAACA
AATATAATTTATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCTAACTATCCTGTGTGAGAATGGGAATTTC
AAGTCCCATCTTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGAAAAAAATGCCATGTGATTGTAATTATCC
TGGATTCAGAATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTGACTGTTTGCAGGCCAAAAGATGATTGCT
TTATAATTTTAACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTTCTTTACTGAGGAATTCAGCTTGTGACAC
AGATACATCCCACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAAAGTTTCCTATCTTTACATTGTTGAGGAA
GTCCTTTTTTTTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGAAATCCTGTTAGCATGCAGAATAATGTGG
TAACTTTGTCAATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTTTCTCAGTTTTACTCAGTGGAAAGATAAA

>22064_22064_1_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000331314_CEPT1_chr1_111724809_ENST00000357172_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

--------------------------------------------------------------
>22064_22064_2_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000331314_CEPT1_chr1_111724809_ENST00000545121_length(transcript)=3139nt_BP=1810nt
AAAGCGGGCTGCGGCCCCCTCCCAAAACCCGGGGAAGTGGATTCTACTCTACGCTCCGCTCCGCTCCGCTCCGCACCACCAACCCCGGGC
CGCAGTCCTGACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGGGGAGACGGCCCGAGCGGGAGCGGGAGCG
GACGCGGCCTCAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCAAGAGGAATGCTAATGATGATGGCAAAAG
TTGTGTGGCTAAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATGTTCCCGTTGATGCTGTAGCTACAGAAGC
AGCCACAATAGACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGGCAGAGGTTCATTCAGTAAGTCCCGAGCA
GGGTGCGAAGGACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCTGGGCAGAACCAGGGGAACCCATCTGTGT
TGTCTGTGGTCGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGGAGTGTAAAGCGAAACATCTTCTACAAGT
TAAGGAAAAGGAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGTCTCCACTGAATGCTTCCTATGTCTACAA
AGAGCACCCCTTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGGGAATTTTAGTTCAAGGGCAAGAAGTCAC
CAGGCCCATTATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGAAATCAGGCTATGAGGTGCCAACTCCCAT
TCAAATGCAGATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTGGCTCAGGAAAAACAGCTGCTTTTCTTCT
TCCTGTTATCATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAACCAGAGAGTTAGCCATTCAGATAGAGAG
ACAAGCTAAAGAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCTTACCCTTACCCCCACAGCTTTATCGTCT
GCAACAACATGTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGAGCTCTGTAGAACTCTGTGGTGTAAAGAT
TGTGGTAGTAGATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACATTTTGGAAAACATTCCTAATGATTGTCA
GACCATTTTGGTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGCATAATCCTGTGAGAATTATCACTGGAGA
AAAGAACCTACCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAAAGAAAAAATTATTTGAAATTTTAAATGA
TAAGAAACTCTTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTTTGAGTGAAGCCGTTCAGAAAATCACAGG
GCTGAAAAGCATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGGGATTACTTGAAGGAGACTATGAAGTTGT
AGTGAGCACAGGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATTTTGATATGCCTTCAAGTATGGATGAGTA
TGTCCATCAGATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTTTCCTGTACAAATTA
CTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATC
AGTGATTACATTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATACTGACATTTGGTTT
TGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCGGC
ACTTTTGTTTCTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCTTTCTTTGATTTGAT
CCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAATCAAGGTCTCTACAGCTCATTCTAATCA
TCATTAATGATGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATATTAAGGAGAATGGGGGTGGATAAGAACA
AATATAATTTATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCTAACTATCCTGTGTGAGAATGGGAATTTC
AAGTCCCATCTTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGAAAAAAATGCCATGTGATTGTAATTATCC
TGGATTCAGAATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTGACTGTTTGCAGGCCAAAAGATGATTGCT
TTATAATTTTAACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTTCTTTACTGAGGAATTCAGCTTGTGACAC
AGATACATCCCACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAAAGTTTCCTATCTTTACATTGTTGAGGAA
GTCCTTTTTTTTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGAAATCCTGTTAGCATGCAGAATAATGTGG
TAACTTTGTCAATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTTTCTCAGTTTTACTCAGTGGAAAGATAAA

>22064_22064_2_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000331314_CEPT1_chr1_111724809_ENST00000545121_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

--------------------------------------------------------------
>22064_22064_3_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000367348_CEPT1_chr1_111724809_ENST00000357172_length(transcript)=3039nt_BP=1710nt
ACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGGGGAGACGGCCCGAGCGGGAGCGGGAGCGGACGCGGCCT
CAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCAAGAGGAATGCTAATGATGATGGCAAAAGTTGTGTGGCT
AAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATGTTCCCGTTGATGCTGTAGCTACAGAAGCAGCCACAATA
GACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGGCAGAGGTTCATTCAGTAAGTCCCGAGCAGGGTGCGAAG
GACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCTGGGCAGAACCAGGGGAACCCATCTGTGTTGTCTGTGGT
CGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGGAGTGTAAAGCGAAACATCTTCTACAAGTTAAGGAAAAG
GAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGTCTCCACTGAATGCTTCCTATGTCTACAAAGAGCACCCC
TTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGGGAATTTTAGTTCAAGGGCAAGAAGTCACCAGGCCCATT
ATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGAAATCAGGCTATGAGGTGCCAACTCCCATTCAAATGCAG
ATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTGGCTCAGGAAAAACAGCTGCTTTTCTTCTTCCTGTTATC
ATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAACCAGAGAGTTAGCCATTCAGATAGAGAGACAAGCTAAA
GAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCTTACCCTTACCCCCACAGCTTTATCGTCTGCAACAACAT
GTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGAGCTCTGTAGAACTCTGTGGTGTAAAGATTGTGGTAGTA
GATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACATTTTGGAAAACATTCCTAATGATTGTCAGACCATTTTG
GTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGCATAATCCTGTGAGAATTATCACTGGAGAAAAGAACCTA
CCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAAAGAAAAAATTATTTGAAATTTTAAATGATAAGAAACTC
TTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTTTGAGTGAAGCCGTTCAGAAAATCACAGGGCTGAAAAGC
ATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGGGATTACTTGAAGGAGACTATGAAGTTGTAGTGAGCACA
GGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATTTTGATATGCCTTCAAGTATGGATGAGTATGTCCATCAG
ATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTTTCCTGTACAAATTACTTCCGTGTA
ATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACA
TTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATACTGACATTTGGTTTTGTGTCTGCT
AAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCGGCACTTTTGTTT
CTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCTTTCTTTGATTTGATCCGCTACTGT
GTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAATCAAGGTCTCTACAGCTCATTCTAATCATCATTAATGA
TGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATATTAAGGAGAATGGGGGTGGATAAGAACAAATATAATTT
ATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCTAACTATCCTGTGTGAGAATGGGAATTTCAAGTCCCATC
TTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGAAAAAAATGCCATGTGATTGTAATTATCCTGGATTCAGA
ATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTGACTGTTTGCAGGCCAAAAGATGATTGCTTTATAATTTT
AACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTTCTTTACTGAGGAATTCAGCTTGTGACACAGATACATCC
CACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAAAGTTTCCTATCTTTACATTGTTGAGGAAGTCCTTTTTT
TTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGAAATCCTGTTAGCATGCAGAATAATGTGGTAACTTTGTC
AATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTTTCTCAGTTTTACTCAGTGGAAAGATAAACTAAGTTTTA

>22064_22064_3_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000367348_CEPT1_chr1_111724809_ENST00000357172_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

--------------------------------------------------------------
>22064_22064_4_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000367348_CEPT1_chr1_111724809_ENST00000545121_length(transcript)=3039nt_BP=1710nt
ACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGGGGAGACGGCCCGAGCGGGAGCGGGAGCGGACGCGGCCT
CAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCAAGAGGAATGCTAATGATGATGGCAAAAGTTGTGTGGCT
AAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATGTTCCCGTTGATGCTGTAGCTACAGAAGCAGCCACAATA
GACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGGCAGAGGTTCATTCAGTAAGTCCCGAGCAGGGTGCGAAG
GACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCTGGGCAGAACCAGGGGAACCCATCTGTGTTGTCTGTGGT
CGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGGAGTGTAAAGCGAAACATCTTCTACAAGTTAAGGAAAAG
GAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGTCTCCACTGAATGCTTCCTATGTCTACAAAGAGCACCCC
TTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGGGAATTTTAGTTCAAGGGCAAGAAGTCACCAGGCCCATT
ATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGAAATCAGGCTATGAGGTGCCAACTCCCATTCAAATGCAG
ATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTGGCTCAGGAAAAACAGCTGCTTTTCTTCTTCCTGTTATC
ATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAACCAGAGAGTTAGCCATTCAGATAGAGAGACAAGCTAAA
GAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCTTACCCTTACCCCCACAGCTTTATCGTCTGCAACAACAT
GTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGAGCTCTGTAGAACTCTGTGGTGTAAAGATTGTGGTAGTA
GATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACATTTTGGAAAACATTCCTAATGATTGTCAGACCATTTTG
GTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGCATAATCCTGTGAGAATTATCACTGGAGAAAAGAACCTA
CCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAAAGAAAAAATTATTTGAAATTTTAAATGATAAGAAACTC
TTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTTTGAGTGAAGCCGTTCAGAAAATCACAGGGCTGAAAAGC
ATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGGGATTACTTGAAGGAGACTATGAAGTTGTAGTGAGCACA
GGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATTTTGATATGCCTTCAAGTATGGATGAGTATGTCCATCAG
ATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTTTCCTGTACAAATTACTTCCGTGTA
ATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACA
TTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATACTGACATTTGGTTTTGTGTCTGCT
AAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCGGCACTTTTGTTT
CTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCTTTCTTTGATTTGATCCGCTACTGT
GTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAATCAAGGTCTCTACAGCTCATTCTAATCATCATTAATGA
TGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATATTAAGGAGAATGGGGGTGGATAAGAACAAATATAATTT
ATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCTAACTATCCTGTGTGAGAATGGGAATTTCAAGTCCCATC
TTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGAAAAAAATGCCATGTGATTGTAATTATCCTGGATTCAGA
ATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTGACTGTTTGCAGGCCAAAAGATGATTGCTTTATAATTTT
AACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTTCTTTACTGAGGAATTCAGCTTGTGACACAGATACATCC
CACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAAAGTTTCCTATCTTTACATTGTTGAGGAAGTCCTTTTTT
TTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGAAATCCTGTTAGCATGCAGAATAATGTGGTAACTTTGTC
AATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTTTCTCAGTTTTACTCAGTGGAAAGATAAACTAAGTTTTA

>22064_22064_4_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000367348_CEPT1_chr1_111724809_ENST00000545121_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

--------------------------------------------------------------
>22064_22064_5_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000447706_CEPT1_chr1_111724809_ENST00000357172_length(transcript)=3077nt_BP=1748nt
GCTCCGCTCCGCACCACCAACCCCGGGCCGCAGTCCTGACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGG
GGAGACGGCCCGAGCGGGAGCGGGAGCGGACGCGGCCTCAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCA
AGAGGAATGCTAATGATGATGGCAAAAGTTGTGTGGCTAAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATG
TTCCCGTTGATGCTGTAGCTACAGAAGCAGCCACAATAGACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGG
CAGAGGTTCATTCAGTAAGTCCCGAGCAGGGTGCGAAGGACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCT
GGGCAGAACCAGGGGAACCCATCTGTGTTGTCTGTGGTCGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGG
AGTGTAAAGCGAAACATCTTCTACAAGTTAAGGAAAAGGAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGT
CTCCACTGAATGCTTCCTATGTCTACAAAGAGCACCCCTTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGG
GAATTTTAGTTCAAGGGCAAGAAGTCACCAGGCCCATTATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGA
AATCAGGCTATGAGGTGCCAACTCCCATTCAAATGCAGATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTG
GCTCAGGAAAAACAGCTGCTTTTCTTCTTCCTGTTATCATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAA
CCAGAGAGTTAGCCATTCAGATAGAGAGACAAGCTAAAGAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCT
TACCCTTACCCCCACAGCTTTATCGTCTGCAACAACATGTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGA
GCTCTGTAGAACTCTGTGGTGTAAAGATTGTGGTAGTAGATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACA
TTTTGGAAAACATTCCTAATGATTGTCAGACCATTTTGGTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGC
ATAATCCTGTGAGAATTATCACTGGAGAAAAGAACCTACCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAA
AGAAAAAATTATTTGAAATTTTAAATGATAAGAAACTCTTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTT
TGAGTGAAGCCGTTCAGAAAATCACAGGGCTGAAAAGCATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGG
GATTACTTGAAGGAGACTATGAAGTTGTAGTGAGCACAGGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATT
TTGATATGCCTTCAAGTATGGATGAGTATGTCCATCAGATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAG
CAGGGACCATATTTTCCTGTACAAATTACTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTG
TCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACATTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATC
CCTGTCTTTATATACTGACATTTGGTTTTGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATT
TGCATGACACAGCATTCATAGGTCCGGCACTTTTGTTTCTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTG
CCCTGGTTTTCTCTTTCTTTGATTTGATCCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAA
TCAAGGTCTCTACAGCTCATTCTAATCATCATTAATGATGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATA
TTAAGGAGAATGGGGGTGGATAAGAACAAATATAATTTATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCT
AACTATCCTGTGTGAGAATGGGAATTTCAAGTCCCATCTTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGA
AAAAAATGCCATGTGATTGTAATTATCCTGGATTCAGAATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTG
ACTGTTTGCAGGCCAAAAGATGATTGCTTTATAATTTTAACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTT
CTTTACTGAGGAATTCAGCTTGTGACACAGATACATCCCACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAA
AGTTTCCTATCTTTACATTGTTGAGGAAGTCCTTTTTTTTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGA
AATCCTGTTAGCATGCAGAATAATGTGGTAACTTTGTCAATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTT
TCTCAGTTTTACTCAGTGGAAAGATAAACTAAGTTTTAATGTTATTTTTTTAAATTTAAGCAAAATTTATTTCTGTTCTTTAATAAATAA

>22064_22064_5_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000447706_CEPT1_chr1_111724809_ENST00000357172_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

--------------------------------------------------------------
>22064_22064_6_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000447706_CEPT1_chr1_111724809_ENST00000545121_length(transcript)=3077nt_BP=1748nt
GCTCCGCTCCGCACCACCAACCCCGGGCCGCAGTCCTGACGAGCGGGTCAGGGCTTGTCGGGCGGAAGCCTGGCCTGGAGCCTGGAAGGG
GGAGACGGCCCGAGCGGGAGCGGGAGCGGACGCGGCCTCAGTCCTGCGCGGAATATTGAAGGATGTTTGTTCCAAGATCTCTAAAAATCA
AGAGGAATGCTAATGATGATGGCAAAAGTTGTGTGGCTAAGATAATTAAACCAGACCCAGAAGACCTTCAGTTGGACAAAAGCAGAGATG
TTCCCGTTGATGCTGTAGCTACAGAAGCAGCCACAATAGACAGGCACATCAGCGAATCATGCCCTTTCCCCAGCCCAGGTGGCCAGTTGG
CAGAGGTTCATTCAGTAAGTCCCGAGCAGGGTGCGAAGGACAGCCATCCTTCTGAAGAGCCCGTTAAGTCATTTTCCAAAACACAGCGCT
GGGCAGAACCAGGGGAACCCATCTGTGTTGTCTGTGGTCGTTATGGAGAGTATATCTGTGATAAGACAGATGAAGATGTGTGTAGTTTGG
AGTGTAAAGCGAAACATCTTCTACAAGTTAAGGAAAAGGAAGAGAAATCAAAACTCAGCAATCCACAGAAGGCTGATTCTGAGCCAGAGT
CTCCACTGAATGCTTCCTATGTCTACAAAGAGCACCCCTTTATTTTGAACCTTCAGGAAGACCAGATTGAAAATCTTAAACAGCAGCTGG
GAATTTTAGTTCAAGGGCAAGAAGTCACCAGGCCCATTATTGACTTTGAACATTGTAGTCTCCCTGAGGTCTTAAATCACAACTTGAAGA
AATCAGGCTATGAGGTGCCAACTCCCATTCAAATGCAGATGATTCCTGTGGGACTTCTGGGAAGAGACATTCTGGCCAGTGCAGATACTG
GCTCAGGAAAAACAGCTGCTTTTCTTCTTCCTGTTATCATGCGAGCTTTATTCGAGAGCAAAACTCCATCTGCGCTCATTCTTACACCAA
CCAGAGAGTTAGCCATTCAGATAGAGAGACAAGCTAAAGAATTGATGAGTGGCCTGCCACGCATGAAAACTGTGCTTCTTGTAGGGGGCT
TACCCTTACCCCCACAGCTTTATCGTCTGCAACAACATGTTAAGGTTATCATAGCAACCCCTGGGCGACTTCTGGATATAATAAAGCAGA
GCTCTGTAGAACTCTGTGGTGTAAAGATTGTGGTAGTAGATGAAGCTGATACCATGTTAAAGATGGGTTTTCAACAACAAGTGCTTGACA
TTTTGGAAAACATTCCTAATGATTGTCAGACCATTTTGGTTTCAGCCACAATTCCAACTAGCATAGAACAGCTAGCAAGCCAGCTTCTGC
ATAATCCTGTGAGAATTATCACTGGAGAAAAGAACCTACCTTGTGCCAATGTACGTCAGATTATTTTGTGGGTAGAAGACCCAGCCAAAA
AGAAAAAATTATTTGAAATTTTAAATGATAAGAAACTCTTTAAGCCTCCAGTGTTAGTATTTGTGGACTGCAAACTAGGAGCAGATCTTT
TGAGTGAAGCCGTTCAGAAAATCACAGGGCTGAAAAGCATATCTATACATTCAGAGAAGTCGCAAATAGAAAGGAAAAACATATTGAAGG
GATTACTTGAAGGAGACTATGAAGTTGTAGTGAGCACAGGAGTCTTGGGACGAGGCCTAGACTTGATCAGTGTCAGGCTGGTTGTCAATT
TTGATATGCCTTCAAGTATGGATGAGTATGTCCATCAGATTCCAGTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAG
CAGGGACCATATTTTCCTGTACAAATTACTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACAATAGCAGGAACAAGTG
TCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACATTAGCTGCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATC
CCTGTCTTTATATACTGACATTTGGTTTTGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACGAAAAGTGAAATGCATT
TGCATGACACAGCATTCATAGGTCCGGCACTTTTGTTTCTGGACCAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTG
CCCTGGTTTTCTCTTTCTTTGATTTGATCCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCACATACATGTCTTCAGAA
TCAAGGTCTCTACAGCTCATTCTAATCATCATTAATGATGTAATTGGTATATAGGAACATCATGTTTTCTGCAGGAAAGAAAGTAACATA
TTAAGGAGAATGGGGGTGGATAAGAACAAATATAATTTATAATAATCAATGTTGTATAACTTTTATTCTTTATTATTGGTAACACGCCCT
AACTATCCTGTGTGAGAATGGGAATTTCAAGTCCCATCTTGTAAATTGTATATGTTGTCATGCAGGGTTTGGGCCAAGAAAGCATGCAGA
AAAAAATGCCATGTGATTGTAATTATCCTGGATTCAGAATAATACTGTGATGGGGAGCCAGATCCGCAGTGGTGGAGAGTTCTAATGTTG
ACTGTTTGCAGGCCAAAAGATGATTGCTTTATAATTTTAACAAATCATTGTCTTTTAGTAACATCCTTGTTTAGTGTCTTCTCAAGCTTT
CTTTACTGAGGAATTCAGCTTGTGACACAGATACATCCCACTAGCTTGTGAGGTGGAACTAGTAATAAAGACCTTGAATTTGGATTGAAA
AGTTTCCTATCTTTACATTGTTGAGGAAGTCCTTTTTTTTTTTTTTTTTTTTTTAATTGCTCAAGAAATGATTCTCTCACAGGCTTGGGA
AATCCTGTTAGCATGCAGAATAATGTGGTAACTTTGTCAATTTCCCATTTTATTTTTTTAAATAAATATATGATCTAAAAGCCAACTTTT
TCTCAGTTTTACTCAGTGGAAAGATAAACTAAGTTTTAATGTTATTTTTTTAAATTTAAGCAAAATTTATTTCTGTTCTTTAATAAATAA

>22064_22064_6_DDX59-CEPT1_DDX59_chr1_200617567_ENST00000447706_CEPT1_chr1_111724809_ENST00000545121_length(amino acids)=710AA_BP=532
MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEP
VKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQED
QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK
TPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK
MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVF
VDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIPVLNIQM
KIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVV

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Fusion Gene PPI Analysis for DDX59-CEPT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX59-CEPT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX59-CEPT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDX59C1868118Orofaciodigital syndrome 54CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDDX59C0029294Orofaciodigital Syndromes1GENOMICS_ENGLAND
HgeneDDX59C0152427Polydactyly1GENOMICS_ENGLAND