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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG10-RPS6 (FusionGDB2 ID:HG83734TG6194)

Fusion Gene Summary for ATG10-RPS6

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG10-RPS6
Fusion gene ID: hg83734tg6194
HgeneTgene
Gene symbol

ATG10

RPS6

Gene ID

83734

6194

Gene nameautophagy related 10ribosomal protein S6
SynonymsAPG10|APG10L|pp12616S6
Cytomap('ATG10')('RPS6')

5q14.1-q14.2

9p22.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 1040S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000514253, ENST00000282185, 
ENST00000355178, ENST00000458350, 
ENST00000513443, ENST00000513634, 
Fusion gene scores* DoF score8 X 6 X 6=28815 X 15 X 4=900
# samples 817
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/900*10)=-2.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG10 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG10(81572049)-RPS6(19376617), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG10

GO:0032446

protein modification by small protein conjugation

16963840

TgeneRPS6

GO:0031929

TOR signaling

16428328

TgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3870-01AATG10chr5

81572049

+RPS6chr9

19376617

-


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Fusion Gene ORF analysis for ATG10-RPS6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000514253ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
3UTR-5UTRENST00000514253ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
3UTR-5UTRENST00000514253ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
3UTR-5UTRENST00000514253ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
3UTR-intronENST00000514253ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-3CDSENST00000282185ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-3CDSENST00000355178ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-3CDSENST00000458350ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-3CDSENST00000513443ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-3CDSENST00000513634ENST00000380394ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000282185ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000282185ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000282185ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000355178ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000355178ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000355178ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000458350ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000458350ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000458350ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513443ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513443ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513443ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513634ENST00000315377ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513634ENST00000380384ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-5UTRENST00000513634ENST00000498815ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-intronENST00000282185ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-intronENST00000355178ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-intronENST00000458350ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-intronENST00000513443ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-
intron-intronENST00000513634ENST00000380381ATG10chr5

81572049

+RPS6chr9

19376617

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATG10-RPS6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ATG10-RPS6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81572049/:19376617)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATG10-RPS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATG10-RPS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG10-RPS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG10-RPS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATG10C0006142Malignant neoplasm of breast1CTD_human
HgeneATG10C0678222Breast Carcinoma1CTD_human
HgeneATG10C1257931Mammary Neoplasms, Human1CTD_human
HgeneATG10C1458155Mammary Neoplasms1CTD_human
HgeneATG10C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human